EKS-ORA-00350
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORA-00350
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR397.85.4E-119596860265
StatusUnreviewed
Ensembl ProteinENSOANP00000006000
UniProt AccessionF6V0P7;
Protein Name
Protein Synonyms/Alias
Gene NamePDGFRA
Gene Synonyms/Alias PDGFRA;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOANG00000003786ENSOANP00000006000ENSOANT00000006002
OrganismOrnithorhynchus anatinus
Functional Description
Protein Length872
Protein Sequence
(FASTA)
MGPSPWTCLI LGYLLSGLRR GACQPPFPTI VPDEEELVVS LHMSFSLRCT GDSEVSWQFP 60
TLDDGSPGVS VRSEENNSGS FVAVLEVANA SAVHTGLYTC YYNHTQTQEA EAEGRDVYVY 120
VPDPDVAFVP SVMVDHFIVV EEDDSTVIPC RSTDPQARVT LHASDGKEVS AFYDSRQGFL 180
GHFDMGSYTC ETTIRGRKFQ TLEFNVYTLR ATPEIVVEME APKTVYKTGE TIVVTCAVLD 240
NEVVDFQWNY PGKVRDKGII KLDEIKVPSI KLVYTLTVPE ATAKDGGDYE CAARHATKEA 300
KQIKKVTITV HERGFVRLQP GFGPVEAVNL HEVRHFGVEL EAYPPPRVSW LKNDVSLTEN 360
LTEITTSLEK IQEIRYQSKL KLIRAKEEDS GHYTIVVQNE DDIMNYTFEL LVQVPASILD 420
LVDDHHGSAG GQTVRCVAEG TPLPDVDWMV CRDIKKCNNE TSWTLLTANA SDIAVEAHVG 480
DRDTMESQVT FQQVEETLAV RCLAKNHLGA VTRELKLVAP AQPLRSELTV AAAVLVLLVI 540
VIVSLIVLVI IWKQKPRYEI RWRVIESISP DGHEYIYVDP MQLPYDSRWE FPRDGLVLGR 600
ILGSGAFGKV VEGTAYGLSR SQPVMKVAVK MLKPTARSSE KQALMSELKI MTHLGPHLNI 660
VNLLGACTKS GPIYIITEYC FYGDLVNYLH KNRDNFLTRH PEKTKKELDI FGMSPADEST 720
RSYVILSFEN NGDYMDMKQA DATQYVSMLE RKESSKYSDI QRSLYNRPAS YKKKSVSDSE 780
VTDLLSDDGS EGLGLLDLLS FTYQVSRGME FLASKNCVHR DLAARNVLLA QGKIVKICDF 840
GLARDIMHDS NYVSKGSVRM SSGRARGVRG WA 872
Nucleotide Sequence
(FASTA)
ATGGGTCCTT CCCCATGGAC ATGCCTGATC TTGGGGTATC TGCTGTCAGG GCTACGACGC 60
GGGGCCTGCC AGCCCCCGTT TCCCACCATC GTGCCGGACG AGGAGGAGCT GGTGGTGTCC 120
CTGCACATGT CCTTCTCCCT GCGGTGCACC GGGGACAGCG AGGTCAGCTG GCAGTTCCCC 180
ACGCTGGACG ACGGGAGCCC CGGCGTGTCC GTCCGCAGTG AGGAGAACAA CAGCGGCTCC 240
TTCGTGGCCG TGCTGGAGGT GGCCAACGCC TCGGCCGTGC ACACCGGCCT CTACACCTGC 300
TATTACAACC ACACGCAGAC CCAGGAGGCC GAGGCCGAAG GCCGGGATGT CTACGTCTAC 360
GTGCCTGACC CCGACGTCGC CTTCGTGCCC TCGGTCATGG TCGACCACTT CATCGTCGTG 420
GAGGAAGACG ATTCCACCGT GATCCCCTGT CGCTCCACCG ACCCGCAGGC GCGGGTGACC 480
CTGCACGCCA GCGACGGCAA GGAGGTCTCT GCCTTCTACG ACAGCCGCCA AGGTTTCCTG 540
GGTCACTTCG ACATGGGGTC CTACACGTGC GAGACGACCA TCCGCGGCAG GAAGTTCCAG 600
ACCCTCGAGT TCAACGTCTA CACCTTGCGA GCCACCCCGG AGATCGTCGT GGAGATGGAG 660
GCCCCGAAGA CGGTGTACAA GACGGGCGAG ACCATCGTGG TCACCTGCGC CGTCCTGGAC 720
AACGAGGTGG TCGATTTCCA GTGGAACTAC CCGGGGAAGG TGAGGGACAA GGGCATCATC 780
AAGCTGGACG AGATTAAGGT CCCGTCCATC AAGCTGGTGT ACACCCTGAC GGTGCCCGAG 840
GCCACGGCCA AGGACGGCGG CGATTACGAG TGTGCTGCCC GCCACGCCAC CAAGGAGGCG 900
AAGCAGATAA AGAAGGTCAC CATCACCGTC CACGAGAGAG GCTTCGTCCG GCTCCAGCCC 960
GGCTTCGGCC CCGTGGAGGC CGTGAACCTG CACGAGGTCC GGCATTTTGG CGTGGAGCTG 1020
GAGGCCTACC CCCCGCCCAG GGTGTCCTGG CTGAAGAACG ACGTGTCGCT CACCGAGAAC 1080
CTGACCGAGA TCACCACCAG CCTGGAGAAG ATCCAGGAGA TCAGGTATCA GAGCAAGCTG 1140
AAGCTAATCC GAGCAAAGGA GGAAGACAGT GGGCACTACA CAATCGTGGT GCAAAACGAG 1200
GATGATATTA TGAACTACAC CTTTGAGCTG CTGGTTCAAG TGCCGGCCTC CATCTTGGAT 1260
CTGGTGGACG ACCACCATGG CTCGGCGGGG GGCCAGACCG TCCGCTGTGT CGCCGAAGGG 1320
ACGCCGCTGC CCGACGTCGA CTGGATGGTT TGCAGGGACA TTAAAAAATG CAACAACGAG 1380
ACCTCGTGGA CCCTCCTCAC CGCCAACGCG TCCGACATCG CCGTGGAGGC CCACGTGGGT 1440
GACAGGGACA CGATGGAGAG TCAGGTGACC TTCCAGCAGG TGGAGGAGAC GCTGGCGGTG 1500
CGCTGCTTGG CCAAGAACCA CCTTGGGGCC GTGACGCGGG AGCTGAAGCT GGTGGCCCCT 1560
GCCCAGCCCC TGCGCTCTGA GTTGACCGTG GCTGCTGCCG TCCTGGTGCT CCTGGTGATC 1620
GTCATCGTCT CCCTCATCGT GCTGGTCATC ATCTGGAAAC AGAAGCCGCG CTATGAGATC 1680
CGATGGCGGG TCATCGAGTC CATCAGCCCG GACGGCCACG AGTATATCTA CGTGGACCCG 1740
ATGCAGCTCC CCTACGACTC GCGCTGGGAG TTTCCGAGGG ACGGGCTGGT GCTGGGCCGA 1800
ATCCTTGGGT CCGGAGCATT TGGGAAGGTG GTGGAAGGCA CTGCATACGG GCTGAGCCGC 1860
TCCCAGCCCG TGATGAAGGT GGCCGTGAAA ATGTTAAAAC CCACGGCTCG ATCCAGCGAG 1920
AAGCAGGCCC TCATGTCGGA GCTGAAGATC ATGACGCATC TGGGCCCCCA TCTGAACATC 1980
GTGAACCTCC TGGGGGCCTG CACCAAATCA GGACCCATCT ACATCATCAC CGAGTACTGC 2040
TTCTACGGCG ACCTGGTCAA CTACCTGCAC AAGAACCGCG ATAACTTCCT GACTCGCCAC 2100
CCGGAGAAGA CGAAGAAAGA GCTGGACATC TTCGGCATGA GCCCTGCCGA CGAGAGCACC 2160
AGGAGCTACG TCATCCTCTC ATTTGAAAAC AACGGGGACT ACATGGACAT GAAGCAGGCG 2220
GACGCCACAC AGTACGTGTC CATGTTGGAG AGGAAGGAGT CGTCCAAGTA CTCGGACATC 2280
CAGCGATCCC TGTACAACCG GCCGGCCTCC TACAAGAAGA AGTCCGTGTC GGACTCTGAA 2340
GTCACGGACC TCCTGTCGGA CGATGGTTCG GAAGGCCTTG GCCTGCTGGA CCTGCTGAGC 2400
TTTACCTACC AGGTGTCTCG CGGGATGGAG TTCCTAGCTT CGAAAAACTG CGTCCACCGG 2460
GATCTGGCTG CGCGGAACGT CCTGCTGGCC CAAGGGAAGA TCGTGAAGAT CTGCGACTTC 2520
GGGCTGGCGA GGGACATCAT GCACGACTCC AACTACGTGT CCAAGGGCAG CGTACGTATG 2580
AGCTCAGGCC GGGCCCGCGG TGTCCGGGGG TGGGCA 2616
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l+lG++lGsGafGkvve+tayGls+s++v+kvavkmlk+tarssek+almselki++hlG
Q: 596   LVLGRILGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLG  655
         78**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+nivnllGactk+Gpiy+iteyc+yGdl+nyl+++r++fl+++ ek   +++eld+++
Q: 656   PHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDNFLTRHPEK---TKKELDIFG  712
         *********************************************999...678899999
S: 121   l.ladkslrsksslssesseeyvdlkkd................vsdvssskadklasek  163
         + +ad+s+rs+++ls+e++++y+d+k++                +sd+++s ++++as+k
Q: 713   MsPADESTRSYVILSFENNGDYMDMKQAdatqyvsmlerkesskYSDIQRSLYNRPASYK  772
         989************************99*******************************
S: 164   kksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteG  223
         kks+ ++ev++ l+++ se+l l dllsf+yqv++Gmeflaskncvhrdlaarnvll++G
Q: 773   KKSVSDSEVTDLLSDDGSEGLGLLDLLSFTYQVSRGMEFLASKNCVHRDLAARNVLLAQG  832
         ************************************************************
S: 224   kvvkicdfGlardimkdsnyvvkGnarl  251
         k+vkicdfGlardim+dsnyv+kG+ r+
Q: 833   KIVKICDFGLARDIMHDSNYVSKGSVRM  860
         ************************9886
Domain Sequence
(FASTA)
LVLGRILGSG AFGKVVEGTA YGLSRSQPVM KVAVKMLKPT ARSSEKQALM SELKIMTHLG 60
PHLNIVNLLG ACTKSGPIYI ITEYCFYGDL VNYLHKNRDN FLTRHPEKTK KELDIFGMSP 120
ADESTRSYVI LSFENNGDYM DMKQADATQY VSMLERKESS KYSDIQRSLY NRPASYKKKS 180
VSDSEVTDLL SDDGSEGLGL LDLLSFTYQV SRGMEFLASK NCVHRDLAAR NVLLAQGKIV 240
KICDFGLARD IMHDSNYVSK GSVRM 265
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00373
EKS-ANC-00388
EKS-BOT-00401
EKS-CAJ-00405
EKS-CAF-00401
EKS-CAP-00430
EKS-DAR-00792
EKS-EQC-00393
EKS-FEC-00385
EKS-GAG-00339
EKS-GAA-00490
EKS-GOG-00393
EKS-HOS-00407
EKS-ICT-00380
EKS-LAC-00417
EKS-LOA-00410
EKS-MAM-00400
EKS-MEG-00333
EKS-MOD-00390
EKS-MUM-00433
EKS-MUP-00395
EKS-MYL-00396
EKS-NOL-00366
EKS-OCP-00085
EKS-ORN-00512
EKS-ORC-00376
EKS-ORL-00470
EKS-OTG-00403
EKS-PAT-00380
EKS-PES-00356
EKS-POA-00392
EKS-RAN-00416
EKS-SAH-00370
EKS-TAG-00476
EKS-TAR-00508
EKS-TEN-00509
EKS-TUT-00117
EKS-XET-00512
EKS-XIM-00505
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005021; F:vascular endothelial growth factor-activated receptor activity
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
GO:0038084; P:vascular endothelial growth factor signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
IPR009134; Tyr_kinase_VEGFR_rcpt_N.
Pfam
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 2.
Prosites
PS50835; IG_LIKE; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
PR01832; VEGFRECEPTOR.
Created Date20-Feb-2013