EKS-ORA-00347
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORA-00347
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR571.77.0E-172588924337
StatusUnreviewed
Ensembl ProteinENSOANP00000006034
UniProt AccessionF6U370;
Protein Name
Protein Synonyms/Alias
Gene NameKIT
Gene Synonyms/Alias KIT;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOANG00000003803ENSOANP00000006034ENSOANT00000006036
OrganismOrnithorhynchus anatinus
Functional Description
Protein Length977
Protein Sequence
(FASTA)
EGNNHSIAYI CIALFIFSKV TERASPPPGL GDSGWSARPG PPPLTSTLVV EAGDSLNLSC 60
DLNSPVWWSF QNWPPEKKVL GDKLYKKQAT AHDTGRYTCT DRDLNTSSIY VFVKDPDILF 120
LVDSLLYGKE DSDILVKCSV TNPDLSNLTL RGCDGNPLPP DLKFVSNIEE GIIIKSVQRS 180
YNKVCFQCAA YEGTHLRLSE KMTLKVRSVR KAPPVVILPR THQLLREGEK FEVTCTIRDV 240
DSSVVSEWIT TNNRTSRHAP RSRNFGDYEY EQKSTLSIES VCVGDSGVFT CLANNSFGPA 300
SASMTLQVID KGFIHFLTGT NSTLSVNAGE NVDLVVEYEA YPKPSRQGWV CLNGTSTGRW 360
THRPGSEDEG NIRYVSELPL TRLKGTEGGT YTFFVANSDV NTSTVFHVYV NTKPEILTTD 420
RLVNGTLQCT ASGFPAPTID WYFCPGAEQR CLASIPPVDV RVRSPARFGK VVVESTVDPS 480
ALRNNGTVEC KASNGVGRTS AYFSFAIKGN SQEQISTHSL FTPLFIGLVS TATLLSLIIS 540
VLLYKYFKKP MYEVQWKVVE EINGNSYVYI DPTQLPYDHK WEFPRNRLSF GKTLGAGAFG 600
KVVEATAYGL FKSDAAMTVA VKMLKPSAHL TEREALMSEL KVLSYLGNHV NIVNLLGACT 660
VGGPTLVITE YCCYGDLLNF LRRKRDSFIC SKHEAQGDLT LYKNLLRSAE VLGCSDGADE 720
YMDMKPGVPY VVPTKAGKRR SAGAGSYAER EDGAAIMEDD ELALDIEDLL SFSYQVAKGM 780
SFLASKNCIH RDLAARNILL THGRITKICD FGLARDIKND SNYVVKGNAR LPVKWMAPES 840
IFGCVYTFES DVWSYGILLW ELFSLGSSPY PGMPVDSKFY RMIKEGYRML SPEWAPVEMY 900
DIMKSCWDAD PLQRPTFKQI VQLLEQQLSD SAINLYCNLC PSAPPSQSLA PVDHSVRINS 960
VGSSASSTQP LLVHDEA 977
Nucleotide Sequence
(FASTA)
GAGGGCAATA ATCATTCAAT AGCATATATT TGTATAGCAC TCTTCATTTT CTCCAAAGTC 60
ACAGAGCGTG CATCGCCACC ACCGGGTTTG GGGGATTCAG GATGGTCTGC ACGACCGGGC 120
CCGCCCCCTC TGACCTCGAC TTTGGTCGTG GAGGCCGGCG ACTCGCTCAA CCTGTCGTGC 180
GACCTCAACA GCCCGGTCTG GTGGAGCTTC CAGAACTGGC CCCCTGAGAA GAAGGTCCTT 240
GGTGACAAGT TGTACAAGAA GCAGGCGACC GCCCACGACA CGGGCCGGTA CACTTGCACC 300
GACAGAGACC TGAATACCAG CTCCATCTAT GTCTTCGTCA AAGATCCCGA CATCCTCTTC 360
CTGGTGGATT CCCTCCTGTA TGGGAAAGAG GACAGCGACA TCCTGGTCAA GTGTTCCGTG 420
ACCAACCCGG ATTTATCCAA CCTCACTCTG CGTGGCTGCG ATGGGAATCC TCTGCCTCCA 480
GACCTGAAGT TTGTCTCCAA CATCGAGGAG GGCATCATCA TAAAGAGCGT CCAGCGGTCC 540
TACAACAAAG TATGCTTCCA GTGCGCGGCC TACGAGGGGA CTCACCTCAG GCTGTCCGAA 600
AAGATGACGC TCAAAGTGCG ATCAGTTCGC AAGGCTCCGC CCGTGGTTAT CCTGCCTAGG 660
ACGCACCAGC TCCTCCGGGA AGGGGAGAAA TTTGAAGTGA CCTGCACCAT AAGGGATGTG 720
GACAGCTCAG TGGTATCGGA GTGGATAACC ACTAACAACC GGACCAGCCG CCATGCACCG 780
CGGAGCAGGA ACTTCGGTGA TTACGAGTAC GAACAGAAAT CCACGTTGAG CATCGAGTCT 840
GTGTGCGTTG GCGATTCTGG GGTGTTCACG TGCCTCGCCA ATAACTCATT TGGACCTGCA 900
AGTGCCAGCA TGACGCTCCA AGTGATCGAC AAGGGATTCA TCCACTTCCT CACGGGGACC 960
AACTCCACGC TGTCCGTAAA CGCCGGTGAA AACGTGGATC TGGTCGTGGA GTACGAGGCC 1020
TACCCGAAAC CGAGCCGCCA GGGCTGGGTG TGCCTGAACG GGACGTCGAC GGGCAGGTGG 1080
ACCCATCGCC CCGGCTCCGA GGACGAGGGC AACATCCGGT ACGTGAGTGA ACTGCCGCTC 1140
ACCAGGCTGA AGGGCACGGA GGGAGGCACC TACACATTTT TCGTGGCTAA CTCTGACGTC 1200
AACACCTCGA CCGTGTTTCA CGTCTATGTG AACACGAAGC CAGAGATCCT GACGACGGAC 1260
AGGCTAGTGA ACGGCACCCT GCAATGCACC GCCTCCGGCT TCCCCGCCCC CACCATCGAC 1320
TGGTATTTCT GCCCCGGGGC TGAACAGAGG TGCTTGGCGT CCATCCCCCC GGTGGACGTG 1380
CGCGTGAGGA GCCCGGCCCG CTTCGGGAAG GTGGTGGTGG AGAGCACGGT GGACCCCAGC 1440
GCCCTGAGGA ACAACGGCAC GGTGGAGTGT AAGGCGTCTA ACGGCGTCGG CCGGACCTCC 1500
GCCTATTTTA GCTTTGCTAT TAAAGGTAAC AGCCAAGAGC AAATCAGCAC CCACTCCCTG 1560
TTCACACCAC TATTCATCGG CCTCGTGTCC ACCGCTACGC TCTTGAGCCT CATCATCTCG 1620
GTTCTCCTCT ATAAGTACTT TAAGAAACCC ATGTATGAAG TCCAGTGGAA AGTGGTGGAG 1680
GAGATCAACG GAAACAGCTA CGTGTACATA GATCCTACAC AGCTTCCTTA CGACCACAAA 1740
TGGGAGTTCC CCAGAAACAG GCTGAGTTTT GGGAAGACCC TCGGAGCCGG TGCTTTCGGC 1800
AAAGTGGTGG AGGCGACGGC GTACGGCCTG TTCAAGTCGG ACGCGGCCAT GACCGTGGCG 1860
GTCAAGATGC TCAAACCCAG CGCTCATCTG ACGGAGAGGG AGGCCCTGAT GTCCGAACTC 1920
AAGGTCCTCA GCTATCTTGG GAACCACGTG AACATCGTCA ATCTCCTCGG GGCCTGCACG 1980
GTCGGAGGAC CCACCTTGGT CATTACGGAA TACTGTTGCT ATGGCGACCT TCTGAATTTT 2040
CTGAGAAGAA AGCGGGACTC ATTTATCTGC TCCAAGCACG AAGCTCAAGG GGACCTGACA 2100
CTCTATAAGA ATCTTCTCCG CTCAGCAGAG GTCCTGGGCT GCAGCGATGG CGCAGACGAG 2160
TACATGGACA TGAAGCCGGG TGTTCCGTAC GTCGTCCCGA CCAAGGCCGG CAAGAGACGG 2220
TCAGCGGGAG CCGGCTCCTA TGCTGAGAGG GAGGACGGCG CCGCCATCAT GGAGGATGAC 2280
GAGTTGGCAC TGGACATTGA GGACCTGCTG AGCTTCTCTT ACCAAGTGGC TAAGGGCATG 2340
AGCTTCCTCG CCTCAAAGAA TTGCATTCAC AGAGACTTGG CCGCCAGAAA CATTCTCCTC 2400
ACTCACGGCC GGATAACGAA AATCTGCGAC TTTGGCCTGG CCAGGGACAT CAAGAACGAC 2460
TCCAACTACG TCGTCAAAGG CAACGCCCGG CTCCCGGTCA AATGGATGGC TCCCGAGAGC 2520
ATCTTTGGCT GCGTGTACAC GTTCGAGAGC GACGTCTGGT CCTATGGCAT CCTGCTCTGG 2580
GAGCTTTTCT CTCTCGGAAG CAGCCCCTAC CCAGGAATGC CTGTGGATTC CAAGTTCTAC 2640
CGCATGATCA AGGAAGGCTA CCGGATGCTG AGTCCCGAAT GGGCGCCGGT GGAAATGTAC 2700
GACATCATGA AGAGTTGCTG GGACGCCGAT CCCCTGCAGA GACCAACGTT TAAGCAGATC 2760
GTTCAGCTTC TTGAACAGCA GCTGTCAGAC AGCGCCATCA ACCTTTACTG CAACCTGTGC 2820
CCGTCTGCGC CCCCGAGCCA GAGCCTGGCC CCGGTGGACC ACTCGGTGAG GATCAACTCC 2880
GTGGGCAGCA GCGCGTCATC CACCCAGCCG CTCCTGGTCC ACGACGAAGC GTGA 2934
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l++Gk+lG+GafGkvveatayGl ksda+++vavkmlk++a+ +e+ealmselk+ls+lG
Q: 588   LSFGKTLGAGAFGKVVEATAYGLFKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLG  647
         79**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h nivnllGact+gGp++viteyccyGdlln+lrrkr+sf+   ++k++ +   + +k+
Q: 648   NHVNIVNLLGACTVGGPTLVITEYCCYGDLLNFLRRKRDSFI---CSKHEAQGDLTLYKN  704
         ******************************************...666666666667777
S: 121   lladkslrs.ksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleee  179
         l     lrs ++  +s++ +ey+d+k++v +v ++ka k++s+   s+ ere  aa++e+
Q: 705   L-----LRSaEVLGCSDGADEYMDMKPGVPYVVPTKAGKRRSAGAGSYAEREDGAAIMED  759
         7.....4440556699********************************************
S: 180   dsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimk  239
         d+ +l++edllsfsyqvakGm flasknc+hrdlaarn+llt+G+++kicdfGlardi++
Q: 760   DELALDIEDLLSFSYQVAKGMSFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKN  819
         ************************************************************
S: 240   dsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskf  299
         dsnyvvkGnarlpvkwmapesif ++yt++sdvwsyGillwe+fslGs+pypg++vdskf
Q: 820   DSNYVVKGNARLPVKWMAPESIFGCVYTFESDVWSYGILLWELFSLGSSPYPGMPVDSKF  879
         ************************************************************
S: 300   yklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         y++ikeGyrm +p++a+ e+y+im++cw+a+p +rp+fkq+v+ll
Q: 880   YRMIKEGYRMLSPEWAPVEMYDIMKSCWDADPLQRPTFKQIVQLL  924
         ******************************************996
Domain Sequence
(FASTA)
LSFGKTLGAG AFGKVVEATA YGLFKSDAAM TVAVKMLKPS AHLTEREALM SELKVLSYLG 60
NHVNIVNLLG ACTVGGPTLV ITEYCCYGDL LNFLRRKRDS FICSKHEAQG DLTLYKNLLR 120
SAEVLGCSDG ADEYMDMKPG VPYVVPTKAG KRRSAGAGSY AEREDGAAIM EDDELALDIE 180
DLLSFSYQVA KGMSFLASKN CIHRDLAARN ILLTHGRITK ICDFGLARDI KNDSNYVVKG 240
NARLPVKWMA PESIFGCVYT FESDVWSYGI LLWELFSLGS SPYPGMPVDS KFYRMIKEGY 300
RMLSPEWAPV EMYDIMKSCW DADPLQRPTF KQIVQLL 337
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00374
EKS-ANC-00389
EKS-BOT-00402
EKS-CAJ-00407
EKS-CAF-00402
EKS-CAP-00432
EKS-CII-00236
EKS-DAR-00787
EKS-EQC-00394
EKS-FEC-00386
EKS-GAG-00341
EKS-GAA-00515
EKS-GOG-00394
EKS-HOS-00409
EKS-ICT-00381
EKS-LAC-00419
EKS-LOA-00412
EKS-MAM-00402
EKS-MEG-00335
EKS-MOD-00391
EKS-MUM-00435
EKS-MUP-00399
EKS-MYL-00397
EKS-NOL-00368
EKS-ORN-00514
EKS-ORC-00378
EKS-ORL-00472
EKS-OTG-00405
EKS-PAT-00381
EKS-PES-00357
EKS-POA-00394
EKS-PTV-00114
EKS-RAN-00418
EKS-SAH-00372
EKS-SUS-00353
EKS-TAG-00473
EKS-TAR-00510
EKS-TEN-00511
EKS-TUT-00118
EKS-XET-00515
EKS-XIM-00506
Gene Ontology
GO:0005737; C:cytoplasm
GO:0009897; C:external side of plasma membrane
GO:0005615; C:extracellular space
GO:0005887; C:integral to plasma membrane
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0005020; F:stem cell factor receptor activity
GO:0005021; F:vascular endothelial growth factor-activated receptor activity
GO:0031532; P:actin cytoskeleton reorganization
GO:0000187; P:activation of MAPK activity
GO:0097067; P:cellular response to thyroid hormone stimulus
GO:0048066; P:developmental pigmentation
GO:0038093; P:Fc receptor signaling pathway
GO:0006687; P:glycosphingolipid metabolic process
GO:0007243; P:intracellular protein kinase cascade
GO:0002551; P:mast cell chemotaxis
GO:0043303; P:mast cell degranulation
GO:0043069; P:negative regulation of programmed cell death
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0008284; P:positive regulation of cell proliferation
GO:0010628; P:positive regulation of gene expression
GO:0043410; P:positive regulation of MAPK cascade
GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0042511; P:positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042523; P:positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0046777; P:protein autophosphorylation
GO:0048070; P:regulation of developmental pigmentation
GO:0009314; P:response to radiation
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
GO:0038084; P:vascular endothelial growth factor signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
IPR009134; Tyr_kinase_VEGFR_rcpt_N.
Pfam
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 2.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
PR01832; VEGFRECEPTOR.
Created Date20-Feb-2013