EKS-ORA-00002
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORA-00002
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph518.62.5E-156621878258
StatusUnreviewed
Ensembl ProteinENSOANP00000006279
UniProt AccessionF6SA04;
Protein Name
Protein Synonyms/Alias
Gene NameEPHA5
Gene Synonyms/Alias EPHA5;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOANG00000003966ENSOANP00000006279ENSOANT00000006281
OrganismOrnithorhynchus anatinus
Functional Description
Protein Length983
Protein Sequence
(FASTA)
VNLLDSRTVM GDLGWIAYPK NGWEEIGEVD ENYAPIHTYQ VCKVMEQNQN NWLLTSWVSN 60
EGASRIFIEL KFTLRDCNSL PGGLGTCKET FNVYYFESDD EDGRNIKENQ YVKIDTIAAD 120
ESFTELDLGD RVMKLNTEVR DVGPLSKKGF YLAFQDVGAC IALVSVRVYY KKCPSVVRNL 180
ALFPDTITGA DSSQLLEVSG SCVNHSVTDE PPKMHCSAEG EWLVPIGKCM CKAGFEEKNS 240
TCQVCRPGFF KASHQSQSCS KCPPHSYTHD EASTSCLCEK DYFRRESDPP TMACTRPPSA 300
PRNAISNVNE TSVFLEWIPP ADTGGRKDVS YSIACKRCNS HAGVCAEECG SHVRYLPRQT 360
GLSNTSVMMV DLLAHTNYTF EIEAVNGVSD PNPEARQYVS VNVTTNQAAP SPVTNVKKGK 420
IAKNSISLSW QEPDRPNGII LEYEIKYFEK VGIKDQETSY TIIKSKETTI TADGLKPAST 480
YVFQIRARTA AGYGVFSRRF EFETIPVSVA ASSDQSQIPI IAVSVTVGVI LLAVVIGFLL 540
SGSCCECGCG RASSLCAVAH PSLIWRCGYS KAKQDPEEEK MHFHNGHIKL PGVRTYIDPH 600
TYEDPNQAVH EFAKEIEASC ITIERVIGAG EFGEVCSGRL KLPGKREFPV AIKTLKVGYT 660
EKQRRDFLGE ASIMGQFDHP NIIHLEGVVT KSKPVMIVTE YMENGSLDTF LKKNDGQFTV 720
IQLVGMLRGI ASGMKYLSDM GYVHRDLAAR NILINSNLVC KVSDFGLSRV LEDDPEAAYT 780
TRGGKIPIRW TAPEAIAFRK FTSASDVWSY GIVMWEVVSY GERPYWEMTN QDVIKAVEEG 840
YRLPSPMDCP AALYQLMLDC WQKDRNSRPK FEEIVSMLDK LIRNPSSLKT LVNASSRVSN 900
LLVEHGPLGT GAYRSVGEWL EAIKMGRYTE IFMENGYSSM DAVAQVTLED LRRLGVTLVG 960
HQKKIMNSLQ EMKVQMVNGM QTV 983
Nucleotide Sequence
(FASTA)
GTGAATTTAC TAGACTCGCG TACTGTAATG GGGGATCTTG GATGGATCGC CTACCCTAAA 60
AATGGGTGGG AAGAGATCGG AGAGGTTGAC GAAAACTATG CTCCGATCCA CACCTATCAA 120
GTGTGCAAGG TGATGGAACA GAATCAGAAC AACTGGCTCC TGACAAGTTG GGTCTCCAAC 180
GAAGGAGCCT CCCGGATCTT CATAGAACTC AAATTTACCT TGAGAGACTG TAACAGCCTC 240
CCTGGGGGCC TGGGGACCTG CAAGGAGACG TTCAACGTGT ACTACTTTGA ATCGGACGAC 300
GAGGATGGGC GGAATATCAA AGAGAACCAG TACGTCAAGA TAGACACCAT CGCAGCGGAC 360
GAGAGCTTCA CCGAGTTGGA CCTGGGAGAC CGAGTCATGA AACTGAACAC CGAGGTGAGA 420
GACGTCGGAC CTTTGAGCAA AAAGGGCTTT TACCTGGCTT TCCAAGATGT GGGAGCCTGC 480
ATCGCCCTGG TGTCGGTGCG TGTGTACTAC AAAAAGTGCC CATCGGTGGT ACGAAATCTT 540
GCCCTCTTCC CCGACACGAT CACGGGAGCC GATTCTTCCC AGTTGCTGGA AGTGTCAGGC 600
TCCTGCGTCA ACCATTCCGT GACAGACGAA CCTCCCAAGA TGCACTGTAG CGCCGAAGGA 660
GAGTGGCTCG TTCCGATTGG GAAATGCATG TGCAAGGCCG GCTTCGAGGA GAAGAACAGC 720
ACCTGCCAAG TGTGCAGACC CGGATTCTTT AAAGCCTCCC ATCAGAGTCA GAGCTGCAGT 780
AAGTGCCCTC CTCACAGTTA CACCCACGAT GAAGCCTCCA CCTCTTGTCT GTGTGAAAAG 840
GATTATTTCA GGAGGGAGTC TGATCCCCCC ACAATGGCTT GTACAAGACC CCCCTCGGCT 900
CCCCGGAATG CCATCTCAAA TGTTAACGAG ACTAGTGTCT TTCTGGAATG GATTCCTCCT 960
GCTGACACGG GCGGAAGGAA AGATGTGTCA TATTCTATTG CATGCAAGAG GTGCAACTCG 1020
CATGCAGGTG TGTGTGCGGA GGAATGTGGC AGTCATGTCA GGTATCTCCC CCGGCAAACC 1080
GGCCTGAGCA ACACCTCGGT CATGATGGTG GACTTGCTAG CTCACACAAA CTATACCTTT 1140
GAGATCGAGG CCGTGAACGG AGTGTCCGAT CCGAACCCGG AAGCCCGGCA ATATGTCTCT 1200
GTAAATGTAA CCACAAATCA AGCAGCACCT TCTCCAGTGA CCAATGTGAA AAAGGGGAAA 1260
ATAGCCAAAA ATAGCATCTC TCTGTCTTGG CAAGAGCCAG ATCGTCCCAA CGGCATCATC 1320
CTGGAGTATG AAATCAAATA TTTTGAAAAG GTGGGAATCA AGGATCAGGA GACCAGCTAT 1380
ACGATTATCA AATCTAAAGA GACAACCATC ACTGCCGATG GCTTGAAACC GGCGTCAACC 1440
TACGTCTTCC AAATCCGAGC GCGCACAGCG GCAGGCTACG GTGTCTTCAG CCGAAGATTT 1500
GAGTTTGAAA CCATCCCAGT GTCAGTAGCA GCCTCCAGCG ATCAGAGCCA AATTCCAATC 1560
ATCGCCGTGT CTGTCACCGT GGGAGTGATT CTTCTGGCCG TGGTGATCGG TTTCCTCCTC 1620
AGTGGAAGTT GCTGCGAATG TGGCTGTGGC AGGGCCTCTT CCCTCTGTGC CGTTGCCCAT 1680
CCAAGCCTAA TATGGCGGTG TGGCTACAGC AAAGCAAAAC AAGATCCTGA AGAAGAAAAG 1740
ATGCATTTTC ATAATGGGCA CATTAAACTA CCGGGAGTTA GAACCTATAT CGATCCGCAC 1800
ACCTATGAAG ACCCCAATCA AGCCGTCCAT GAATTTGCCA AGGAAATAGA AGCATCGTGC 1860
ATAACCATCG AAAGAGTTAT CGGAGCAGGT GAATTTGGAG AGGTCTGTAG CGGACGTTTA 1920
AAACTGCCTG GAAAACGAGA ATTCCCGGTG GCCATCAAAA CCCTCAAAGT TGGCTACACT 1980
GAGAAGCAAA GACGAGATTT CCTGGGTGAA GCCAGTATCA TGGGACAATT TGATCACCCC 2040
AACATCATTC ACTTGGAAGG TGTTGTCACG AAAAGCAAAC CAGTGATGAT AGTGACAGAG 2100
TACATGGAGA ACGGTTCCCT GGATACATTT TTAAAGAAGA ATGATGGACA GTTCACTGTG 2160
ATTCAGCTCG TTGGGATGCT GAGAGGTATC GCCTCTGGAA TGAAATACCT TTCGGACATG 2220
GGTTATGTGC ACAGAGACCT CGCAGCCAGG AATATCCTTA TCAACAGTAA CCTCGTGTGC 2280
AAAGTGTCTG ATTTTGGGCT TTCCAGAGTT CTGGAAGATG ATCCTGAAGC TGCGTACACC 2340
ACGAGGGGAG GCAAGATTCC CATCCGATGG ACGGCTCCCG AAGCTATCGC CTTTCGCAAG 2400
TTCACCTCGG CCAGTGATGT CTGGAGTTAT GGAATAGTGA TGTGGGAAGT GGTGTCTTAT 2460
GGGGAGAGGC CATACTGGGA GATGACCAAT CAAGATGTGA TTAAAGCTGT GGAAGAAGGC 2520
TATCGTCTGC CAAGCCCCAT GGACTGCCCC GCTGCTCTCT ACCAGCTAAT GCTGGATTGC 2580
TGGCAGAAGG ACCGAAACAG CAGGCCCAAG TTTGAGGAAA TAGTCAGCAT GTTGGACAAG 2640
CTCATCCGTA ATCCGAGCAG CTTGAAGACA CTGGTTAATG CCTCGAGCAG AGTGTCCAAT 2700
TTATTAGTAG AACATGGACC CCTTGGAACC GGAGCCTACA GATCAGTAGG TGAATGGCTG 2760
GAAGCAATCA AAATGGGACG ATATACCGAG ATTTTCATGG AAAATGGATA CAGTTCAATG 2820
GACGCTGTGG CTCAGGTGAC CTTGGAGGAT TTGAGGCGCC TTGGAGTGAC TCTTGTCGGT 2880
CACCAGAAGA AGATAATGAA CAGTCTTCAA GAAATGAAGG TCCAGATGGT AAATGGGATG 2940
CAAACCGTGT AA 2952
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         ++ie+viGaGefGevcsGrlklpgkre +vaiktlk g+tekqrrdfl easi+Gqfdhp
Q: 621   ITIERVIGAGEFGEVCSGRLKLPGKREFPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHP  680
         78**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         nii+leGvvtkskpvmivteymeng+ld+fl+k+dgqftviqlvgmlrGiasgmkylsdm
Q: 681   NIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGIASGMKYLSDM  740
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180
         gyvhrdlaarnil+nsnlvckvsdfGlsrvledd+eaaytt+ggkipirwtapeaia+rk
Q: 741   GYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRK  800
         ************************************************************
S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240
         ftsasdvwsyGiv+wev+syGerpyw+m+nqdvika+eegyrlp+pmdcpaalyqlmldc
Q: 801   FTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDC  860
         ************************************************************
S: 241   wqkdraerpkfeqivsil  258
         wqkdr++rpkfe+ivs+l
Q: 861   WQKDRNSRPKFEEIVSML  878
         ***************986
Domain Sequence
(FASTA)
ITIERVIGAG EFGEVCSGRL KLPGKREFPV AIKTLKVGYT EKQRRDFLGE ASIMGQFDHP 60
NIIHLEGVVT KSKPVMIVTE YMENGSLDTF LKKNDGQFTV IQLVGMLRGI ASGMKYLSDM 120
GYVHRDLAAR NILINSNLVC KVSDFGLSRV LEDDPEAAYT TRGGKIPIRW TAPEAIAFRK 180
FTSASDVWSY GIVMWEVVSY GERPYWEMTN QDVIKAVEEG YRLPSPMDCP AALYQLMLDC 240
WQKDRNSRPK FEEIVSML 258
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00005
EKS-BOT-00003
EKS-CAJ-00003
EKS-CAF-00002
EKS-CAP-00002
EKS-DAR-00003
EKS-EQC-00002
EKS-GAG-00002
EKS-GAA-00010
EKS-GOG-00011
EKS-ICT-00003
EKS-LOA-00003
EKS-MAM-00003
EKS-MOD-00003
EKS-MUP-00005
EKS-MYL-00007
EKS-NOL-00003
EKS-ORN-00010
EKS-ORL-00011
EKS-OTG-00008
EKS-PAT-00004
EKS-PES-00002
EKS-PEM-00004
EKS-POA-00003
EKS-PTV-00002
EKS-SAH-00003
EKS-SOA-00001
EKS-SUS-00010
EKS-TAG-00002
EKS-TEN-00010
EKS-XIM-00009
Gene Ontology
GO:0030425; C:dendrite
GO:0009897; C:external side of plasma membrane
GO:0005887; C:integral to plasma membrane
GO:0043025; C:neuronal cell body
GO:0048471; C:perinuclear region of cytoplasm
GO:0005791; C:rough endoplasmic reticulum
GO:0005524; F:ATP binding
GO:0005004; F:GPI-linked ephrin receptor activity
GO:0032956; P:regulation of actin cytoskeleton organization
GO:0061178; P:regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0032314; P:regulation of Rac GTPase activity
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013