EKS-ORA-00248
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORA-00248
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/STKR232.85.8E-69248408161
StatusUnreviewed
Ensembl ProteinENSOANP00000006283
UniProt AccessionF6S9E3;
Protein Name
Protein Synonyms/Alias
Gene NameACVRL1
Gene Synonyms/Alias ACVRL1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOANG00000003970ENSOANP00000006283ENSOANT00000006285
ENSOANG00000003970ENSOANP00000006281ENSOANT00000006283
OrganismOrnithorhynchus anatinus
Functional Description
Protein Length411
Protein Sequence
(FASTA)
GQSRRALRMP LTSRAGPGVL PAGNVTCVCE GSHCLQSTCR GAWCLVAAVR PRDDPPYVTK 60
NCGRSNYQET CLGFPKEVIA LRCCHSHMCN QNISLDLPQE PRPSGEPPPS DQLPLILGPG 120
LALVALLVLG ALACWRLGWR RHRREKRLLQ SRELGESSLV LKTSDSGDSL LGGPQDLLDS 180
DCTTGSGSGL PFLVQRTVAR QITLAECVGE QGRIQQNWDH QWHPPTPQIR PPNWCEGGHS 240
LKPTIPRVPR VQSFIASDMT SRSSSTQLWL ITHFHEHGSL FDFLQRSALE PAMALQLALS 300
AACGLVHLHM EIFGTQGKPA IAHRDLKSRN VLVKSNLQCC IADLGLAVMH SQTSDYLDLG 360
HNPRVGTKRY MAPEVLDEQI RTDCFESYKR TDVWAFGLVL WEIARRTMVN G 411
Nucleotide Sequence
(FASTA)
GGGCAGAGCC GGAGGGCTCT CAGGATGCCG CTGACCAGCC GGGCCGGGCC GGGGGTCCTT 60
CCTGCAGGAA ACGTGACGTG CGTGTGTGAG GGGTCTCATT GCCTCCAGAG CACGTGCCGG 120
GGGGCCTGGT GCCTAGTGGC GGCCGTGAGA CCCCGGGACG ACCCCCCGTA CGTCACCAAG 180
AACTGCGGGC GGAGCAACTA CCAGGAGACC TGCCTGGGCT TCCCGAAGGA GGTGATCGCC 240
CTGCGCTGCT GCCACAGCCA CATGTGCAAC CAGAACATCA GCCTGGACCT GCCTCAGGAG 300
CCGAGGCCTT CAGGGGAACC ACCGCCGAGC GACCAGCTGC CGCTGATCCT GGGCCCGGGG 360
CTGGCGCTGG TCGCGCTGCT GGTGCTGGGG GCTCTGGCCT GCTGGCGGCT GGGCTGGCGC 420
CGCCATCGGA GGGAGAAGCG GCTGCTGCAG AGCCGGGAGC TCGGAGAGTC CAGCCTCGTC 480
CTCAAGACCT CCGACAGCGG GGACAGCCTG CTGGGGGGGC CCCAGGACCT ACTGGACAGT 540
GACTGCACCA CGGGCAGTGG CTCGGGCTTG CCATTTCTGG TGCAGCGGAC GGTGGCTCGC 600
CAGATCACAC TGGCAGAATG TGTGGGTGAG CAGGGCCGGA TTCAGCAGAA TTGGGACCAC 660
CAGTGGCATC CCCCGACCCC CCAGATCAGA CCTCCAAACT GGTGTGAGGG AGGTCACTCC 720
CTAAAACCCA CAATCCCCAG AGTCCCCAGG GTCCAGAGCT TCATCGCCTC GGACATGACG 780
TCTCGGAGCT CGAGCACCCA ACTCTGGCTG ATCACGCACT TCCACGAGCA CGGCTCGCTG 840
TTCGACTTCT TGCAGCGCTC GGCCCTGGAG CCCGCCATGG CCCTGCAGCT GGCGCTGTCG 900
GCGGCCTGCG GCCTGGTGCA CCTGCACATG GAGATCTTCG GCACGCAGGG CAAGCCGGCC 960
ATCGCCCACC GTGACCTCAA GAGCCGCAAC GTGCTCGTCA AGAGCAACCT GCAGTGCTGC 1020
ATCGCCGACC TGGGCCTGGC GGTGATGCAC TCCCAGACCA GCGACTACCT GGACCTCGGC 1080
CACAACCCCC GGGTGGGCAC CAAGCGCTAC ATGGCGCCCG AGGTGCTGGA CGAGCAGATC 1140
CGCACGGACT GCTTTGAGTC TTACAAGCGG ACGGACGTCT GGGCCTTTGG CCTGGTGCTG 1200
TGGGAGATCG CCCGCCGGAC CATGGTCAAC GGT 1233
Domain Profile
S: 52    henilqfiaadkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlah  111
          + + +fia+d+++++s+t+l+l+t++he+gsL+d+L+r+ l+   +l+lals+a+Gl h
Q: 248   VPRVQSFIASDMTSRSSSTQLWLITHFHEHGSLFDFLQRSALEPAMALQLALSAACGLVH  307
         567889******************************************************
S: 112   LHeeivgtkgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqv  171
         LH+ei+gt+g  KpaiaHRDlks+N+lvk++l+cciaDlGLa++++++++ ldl +n +v
Q: 308   LHMEIFGTQG--KPAIAHRDLKSRNVLVKSNLQCCIADLGLAVMHSQTSDYLDLGHNPRV  365
         **********..************************************************
S: 172   GtkRYmaPEvleealnlkdfeafkraDvYslgLvlWEvasRce  214
         GtkRYmaPEvl+e++ +++fe++kr+Dv+++gLvlWE+a+R+ 
Q: 366   GTKRYMAPEVLDEQIRTDCFESYKRTDVWAFGLVLWEIARRTM  408
         *****************************************86
Domain Sequence
(FASTA)
VPRVQSFIAS DMTSRSSSTQ LWLITHFHEH GSLFDFLQRS ALEPAMALQL ALSAACGLVH 60
LHMEIFGTQG KPAIAHRDLK SRNVLVKSNL QCCIADLGLA VMHSQTSDYL DLGHNPRVGT 120
KRYMAPEVLD EQIRTDCFES YKRTDVWAFG LVLWEIARRT M 161
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ochotona princeps"; ?>
EKS-OCP-00028
Gene Ontology
GO:0009986; C:cell surface
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005024; F:transforming growth factor beta-activated receptor activity
GO:0030509; P:BMP signaling pathway
GO:0071773; P:cellular response to BMP stimulus
GO:0071560; P:cellular response to transforming growth factor beta stimulus
GO:0043537; P:negative regulation of blood vessel endothelial cell migration
GO:0030308; P:negative regulation of cell growth
GO:2000279; P:negative regulation of DNA biosynthetic process
GO:0045602; P:negative regulation of endothelial cell differentiation
GO:0001937; P:negative regulation of endothelial cell proliferation
GO:0051895; P:negative regulation of focal adhesion assembly
GO:0045603; P:positive regulation of endothelial cell differentiation
GO:0001938; P:positive regulation of endothelial cell proliferation
GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0007179; P:transforming growth factor beta receptor signaling pathway
GO:0035313; P:wound healing, spreading of epidermal cells
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.
IPR003605; TGF_beta_rcpt_GS.
Pfam
PF00069; Pkinase; 1.
PF08515; TGF_beta_GS; 1.
SMARTs
SM00467; GS; 1.
Prosites
PS51256; GS; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013