EKS-ORA-00051

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORA-00051

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	371.2	3.6E-111	52	346	295

Status

Unreviewed

Ensembl Protein

ENSOANP00000006585

UniProt Accession

F6Z942;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK12

Gene Synonyms/Alias

CDK12;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000004149	ENSOANP00000006585	ENSOANT00000006587

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

588

Protein Sequence
(FASTA)

PPPLPPPPQT QIAPIALPPQ TRFLVRCRIC CPRYGERRQT ESDWGKRCVD KFDIIGIIGE 60

GTYGQVYKAK DKDTGELVAL KKVRLDNEKE GFPITAIREI KILRQLIHRS VVNMKEIVTD 120

KQDALDFKKD KGAFYLVFEY MDHDLMGLLE SGLVHFSEDH IKSFMKQLME GLDYCHKKNF 180

LHRDIKCSNI LLNNSGQIKL ADFGLARLYS SEESRPYTNK VITLWYRPPE LLLGEERYTP 240

AIDVWSCGCI LGELFTKKPI FQANLELAQL ELISRLCGSP CPAAVWPDVI KLPYFNTMKP 300

KKQYRRRLRE EFSFIPSAAL DLLDRMLTLD PNKRCTAEQA LQSDFLRDVE LSKMAPPERI 360

PYPQLARSPE GETDVDIGEA PGHRLRTVAG SGDAGCRGRP AWRRSRSGPG EPPPSPPVTV 420

PLPFSAGLGD ITQQLNQSEL AVLLNLLQSQ TDLSVPQMAQ LLNVHSNPEM QQQLEALNQS 480

INALTEATSQ QRDSERLALE EAAKEAPRAA TVAPPEQTVP DAPGTAGDVQ NVLAVLLSQL 540

MKSQEPAGGL EESNGEKSGP QGSRRSPAVP QEEAAGKESR PPAPPGAP 588

Nucleotide Sequence
(FASTA)

CCTCCTCCTC TCCCCCCCCC CCCCCAAACC CAGATCGCCC CTATCGCCCT TCCTCCCCAA 60

ACCCGTTTTC TGGTCCGTTG CAGAATCTGC TGTCCTCGTT ACGGAGAGAG GAGACAGACG 120

GAAAGCGACT GGGGGAAGCG CTGCGTGGAC AAGTTTGACA TCATCGGGAT TATCGGCGAG 180

GGGACCTACG GGCAGGTGTA CAAAGCCAAG GACAAAGACA CCGGGGAGTT GGTGGCTCTG 240

AAGAAAGTGC GTCTGGACAA TGAGAAAGAG GGCTTCCCGA TCACGGCCAT TCGCGAGATC 300

AAAATCCTCC GGCAGTTGAT CCATCGCAGC GTCGTCAACA TGAAGGAGAT TGTCACAGAC 360

AAACAAGACG CGCTGGACTT TAAGAAAGAC AAAGGTGCCT TTTACCTTGT ATTTGAATAC 420

ATGGACCACG ACCTGATGGG GCTGCTCGAG TCCGGGCTGG TGCATTTTTC CGAGGACCAT 480

ATCAAGTCTT TCATGAAACA GCTGATGGAA GGATTGGATT ATTGCCACAA AAAGAACTTC 540

CTGCATCGGG ACATCAAGTG CTCCAACATT CTGCTCAACA ACAGCGGGCA GATCAAACTG 600

GCGGATTTCG GACTCGCCCG GCTCTATAGC TCCGAAGAGA GCCGACCGTA CACCAATAAG 660

GTCATTACGC TATGGTACCG ACCTCCAGAA CTGCTGCTGG GAGAGGAGCG TTACACGCCA 720

GCCATAGATG TCTGGAGCTG TGGCTGCATT CTCGGGGAAC TGTTTACAAA GAAGCCCATT 780

TTCCAAGCCA ATCTGGAACT GGCACAGCTA GAACTCATCA GCCGGCTGTG CGGCAGCCCC 840

TGCCCGGCCG CCGTGTGGCC CGACGTCATC AAGCTGCCCT ACTTCAACAC CATGAAACCC 900

AAGAAGCAGT ACCGGCGACG GCTGCGGGAG GAGTTCTCTT TCATTCCCTC GGCCGCCCTC 960

GACCTGCTGG ACCGCATGCT GACGCTGGAT CCCAACAAGC GGTGCACGGC CGAGCAGGCC 1020

CTGCAGAGCG ACTTCCTCAG AGACGTCGAG CTCAGCAAAA TGGCTCCCCC GGAACGCATT 1080

CCCTACCCAC AGCTAGCTCG CAGTCCGGAG GGGGAGACGG ACGTTGATAT AGGGGAGGCC 1140

CCGGGGCACC GGCTACGGAC GGTCGCGGGC TCTGGGGACG CGGGGTGCCG GGGGCGGCCG 1200

GCCTGGCGGC GGTCCCGCTC GGGGCCGGGT GAGCCCCCGC CCTCCCCTCC GGTGACGGTG 1260

CCGCTCCCCT TCTCCGCGGG CCTCGGGGAC ATCACGCAGC AGCTGAACCA GAGCGAGCTG 1320

GCCGTGTTGC TGAACCTGCT GCAGAGCCAG ACGGACCTGA GCGTCCCCCA GATGGCACAG 1380

CTGCTCAACG TCCACTCCAA CCCGGAGATG CAGCAGCAGC TGGAGGCCCT CAACCAGTCC 1440

ATCAACGCCC TGACGGAGGC CACCTCCCAG CAGCGGGACT CGGAGCGCCT CGCCCTGGAG 1500

GAGGCCGCCA AGGAGGCCCC CCGGGCCGCC ACGGTGGCGC CGCCCGAGCA GACGGTCCCC 1560

GACGCCCCGG GCACGGCGGG CGACGTCCAG AACGTCCTGG CGGTCCTGTT GAGCCAGCTG 1620

ATGAAGTCCC AGGAGCCGGC GGGAGGCCTG GAGGAGAGCA ACGGGGAGAA GAGTGGGCCG 1680

CAGGGGTCTC GGAGAAGTCC CGCGGTGCCG CAGGAGGAGG CCGCAGGTAA AGAGAGCCGG 1740

CCCCCGGCCC CTCCGGGAGC CCCGTAA 1767

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         ++ +  igeGtyg+vykakdk+tge+vAlKk+rl++ekeg+pita+rEi++l++l h+ +

Q: 52    FDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSV  111

         667889******************************************************

S: 61    vkLlevva.........kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlle  111

         v+++e+v+         kdk  +yLvfe++++dL+ ll++    ++s++++ks+++ql+e

Q: 112   VNMKEIVTdkqdaldfkKDKGAFYLVFEYMDHDLMGLLESGLV-HFSEDHIKSFMKQLME  170

         ****************8899********************999.****************

S: 112   glaylHsnkilHRDlKpqNlLiskegklklaDfGlarafssplk.tytkevvTlwYraPe  170

         gl+y+H++++lHRD+K++N+L++++g++klaDfGlar +ss+++  yt++v+TlwYr+Pe

Q: 171   GLDYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYSSEESrPYTNKVITLWYRPPE  230

         ***************************************7665527**************

S: 171   lLlgakeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpse.kvwpevs  229

         lLlg+++Y+ a+D+Ws+gcil el+t+kp+fq++ e  qle i++l+g+p   +vwp+v

Q: 231   LLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPaAVWPDVI  290

         **************************************************86269*****

S: 230   klpeykksfpkkkkk.klkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         klp +++  pkk+++ +l+e+++ + ++aldll+++l+ldp+kR++a++alq++++

Q: 291   KLPYFNTMKPKKQYRrRLREEFSFIPSAALDLLDRMLTLDPNKRCTAEQALQSDFL  346

         ******7777777777******9999**************************9985

Domain Sequence
(FASTA)

FDIIGIIGEG TYGQVYKAKD KDTGELVALK KVRLDNEKEG FPITAIREIK ILRQLIHRSV 60

VNMKEIVTDK QDALDFKKDK GAFYLVFEYM DHDLMGLLES GLVHFSEDHI KSFMKQLMEG 120

LDYCHKKNFL HRDIKCSNIL LNNSGQIKLA DFGLARLYSS EESRPYTNKV ITLWYRPPEL 180

LLGEERYTPA IDVWSCGCIL GELFTKKPIF QANLELAQLE LISRLCGSPC PAAVWPDVIK 240

LPYFNTMKPK KQYRRRLREE FSFIPSAALD LLDRMLTLDP NKRCTAEQAL QSDFL 295

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0016607	; C:nuclear speck
GO:0005730	; C:nucleolus
GO:0005524	; F:ATP binding
GO:0008353	; F:RNA polymerase II carboxy-terminal domain kinase activity
GO:0070816	; P:phosphorylation of RNA polymerase II C-terminal domain
GO:0046777	; P:protein autophosphorylation
GO:0043405	; P:regulation of MAP kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013