EKS-ORA-00087
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORA-00087
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec479.42.5E-144400650251
StatusUnreviewed
Ensembl ProteinENSOANP00000006710
UniProt AccessionF7BKT0;
Protein Name
Protein Synonyms/Alias
Gene NameBTK
Gene Synonyms/Alias BTK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOANG00000004224ENSOANP00000006710ENSOANT00000006712
OrganismOrnithorhynchus anatinus
Functional Description
Protein Length657
Protein Sequence
(FASTA)
MAGVILESIF LKRSQQKKKT SPLNFKKRLF LLTTNKLSYY EYDFERGRRG SKKGSVDIEK 60
ITCVETVVPE NNPPPERQIP RKGEEYGEME QISIIERFPY PFQVVYDEGP LYVFSPTEEL 120
RKRWIHQLKN VTRYNSDLVQ KYHPCFWIDG QYLCCSQTAK NAMGCQILEN RNGSLKSGSS 180
HRKTKKPLPP TPEDEQILKK PLPPEPSAAP VGELKKVVAL YDYTPMKPHD LQLQKGEEYF 240
ILEESNLPWW RARDKNGQEG YIPNNYVTEA EDSIEMYEWY SKHMTRSQAE QLLKQEGKEG 300
GFIVRDSSRA GKYTVSVFAK SAGDPQGVIR HYVVCSTPQN QFYLAEKHLF GTIPELINYH 360
QHNSAGLISR LKYPVCQRNK NAPSTAGLGY GSWEIDPKDL TFLKELGTGQ FGVVKYGKWR 420
GQYDVAIKMI REGSMSEDEF IEEAKVMMNL SHDKLVQLYG VCTKQRPIFI ITEYMANGCL 480
LSYLRETRHR FQSLQLLEMC KDVCEAMEYL ESKQFLHRDL AARNCLVNDQ GVVKVSDFGL 540
SRYVLDDEYT SSVGSKFPVR WSPPEVLMYS KFSSKSDIWA FGVLMWEVYS LGKMPYERFS 600
NSETAEHIAK GLRLYRPQLA SERVYAVMYS CWHEKADERP TFKLVLSNIL DVMDEES 657
Nucleotide Sequence
(FASTA)
ATGGCCGGTG TGATCCTGGA GAGCATCTTT CTGAAGCGGT CCCAGCAGAA GAAGAAGACT 60
TCCCCTCTGA ACTTCAAGAA GCGACTCTTC CTCCTGACCA CGAACAAACT GTCCTACTAT 120
GAGTACGACT TTGAGCGTGG GCGGCGCGGT AGTAAGAAGG GCTCGGTGGA CATCGAGAAG 180
ATCACCTGCG TGGAGACGGT GGTTCCCGAA AACAACCCTC CCCCTGAGCG GCAGATTCCG 240
AGAAAGGGAG AAGAGTACGG GGAGATGGAA CAGATCTCCA TCATCGAGAG GTTCCCCTAC 300
CCCTTCCAGG TGGTGTACGA CGAGGGGCCC CTCTATGTCT TCTCCCCCAC GGAAGAACTA 360
CGCAAGCGCT GGATCCACCA GCTCAAGAAC GTGACACGGT ACAACAGTGA CCTGGTACAG 420
AAATACCACC CCTGCTTCTG GATCGATGGG CAGTACCTCT GCTGTTCGCA GACCGCCAAA 480
AACGCCATGG GCTGCCAGAT TCTGGAGAAC AGAAACGGGA GCTTGAAATC TGGGAGCTCT 540
CATCGGAAGA CCAAAAAGCC TCTTCCCCCC ACTCCCGAGG ATGAACAGAT ACTGAAGAAG 600
CCGCTGCCCC CCGAGCCCTC AGCAGCCCCC GTGGGCGAGC TGAAGAAGGT GGTAGCCCTC 660
TACGACTACA CTCCGATGAA GCCTCATGAC CTGCAGCTGC AGAAAGGGGA GGAGTATTTC 720
ATCCTGGAGG AGAGCAACTT GCCCTGGTGG AGAGCCCGAG ACAAGAACGG GCAGGAAGGG 780
TACATCCCCA ACAATTACGT CACCGAGGCG GAAGACTCCA TAGAGATGTA TGAGTGGTAT 840
TCCAAGCACA TGACCCGAAG CCAAGCCGAG CAGTTGCTCA AACAGGAGGG GAAAGAGGGA 900
GGCTTTATCG TCAGAGACTC CAGCAGAGCG GGAAAATACA CCGTGTCTGT GTTTGCCAAA 960
TCTGCCGGGG ACCCGCAGGG GGTGATCCGC CACTACGTGG TCTGCTCCAC GCCCCAGAAC 1020
CAGTTCTACC TGGCTGAGAA GCACCTCTTC GGCACCATCC CCGAGCTCAT CAACTACCAC 1080
CAGCACAACT CCGCCGGCCT CATATCCAGG CTCAAGTATC CAGTGTGTCA GCGAAACAAG 1140
AACGCACCCT CCACGGCAGG GCTGGGCTAC GGGTCCTGGG AGATCGACCC GAAGGACCTG 1200
ACGTTCTTGA AGGAGCTGGG GACCGGGCAG TTCGGGGTGG TGAAGTATGG CAAGTGGCGG 1260
GGCCAGTACG ACGTGGCCAT CAAGATGATC AGGGAAGGCT CCATGTCCGA GGACGAGTTC 1320
ATCGAGGAGG CCAAAGTCAT GATGAACCTG TCCCACGACA AGCTGGTGCA GCTGTACGGC 1380
GTGTGCACCA AACAGCGGCC CATCTTCATC ATCACCGAAT ACATGGCCAA CGGCTGCCTG 1440
CTGAGCTACC TGCGTGAGAC ACGCCACCGC TTCCAGTCCC TGCAGCTCCT GGAGATGTGC 1500
AAGGACGTCT GCGAGGCCAT GGAATACCTG GAATCCAAAC AGTTCCTGCA CCGGGACCTG 1560
GCTGCTCGGA ACTGTCTGGT AAATGACCAA GGGGTAGTCA AAGTGTCCGA CTTTGGGCTG 1620
TCCAGGTACG TCCTGGACGA CGAATACACC AGCTCTGTCG GGTCCAAGTT TCCCGTCCGG 1680
TGGTCGCCCC CGGAAGTCCT CATGTACAGC AAGTTCAGCA GCAAGTCCGA CATCTGGGCT 1740
TTTGGAGTTT TGATGTGGGA GGTTTACTCG CTGGGGAAGA TGCCGTACGA GAGGTTTAGT 1800
AACAGTGAGA CGGCAGAGCA CATCGCCAAG GGCCTGCGTC TCTACCGGCC TCAGCTGGCT 1860
TCCGAGAGGG TGTATGCCGT CATGTACAGC TGCTGGCATG AGAAAGCAGA TGAACGTCCC 1920
ACCTTCAAGT TGGTTCTCAG CAATATTTTG GACGTCATGG ACGAAGAATC CTGA 1974
Domain Profile
S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60
         lt+lkelg+gqfgvvk+gkwr+++dvaik+i+eg+mse++fieeakvmm+lsh+klvqly
Q: 400   LTFLKELGTGQFGVVKYGKWRGQYDVAIKMIREGSMSEDEFIEEAKVMMNLSHDKLVQLY  459
         79**********************************************************
S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120
         gvc+kq+pi+i+tey++ngcll ylre+++++++ +llemckdvce+meyle+k+f+hrd
Q: 460   GVCTKQRPIFIITEYMANGCLLSYLRETRHRFQSLQLLEMCKDVCEAMEYLESKQFLHRD  519
         ************************************************************
S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180
         laarnclv+++ vvkvsdfgl+ryvldd+y+ssvg+kfpv+wsppevl+ysk+ssksd+w
Q: 520   LAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIW  579
         ************************************************************
S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240
         afgvlmwev+s+gk+pye++snse++e++++glrlyrp+las++vy vm+scw+ek++er
Q: 580   AFGVLMWEVYSLGKMPYERFSNSETAEHIAKGLRLYRPQLASERVYAVMYSCWHEKADER  639
         ************************************************************
S: 241   ptfkellsale  251
         ptfk +ls++ 
Q: 640   PTFKLVLSNIL  650
         *******9986
Domain Sequence
(FASTA)
LTFLKELGTG QFGVVKYGKW RGQYDVAIKM IREGSMSEDE FIEEAKVMMN LSHDKLVQLY 60
GVCTKQRPIF IITEYMANGC LLSYLRETRH RFQSLQLLEM CKDVCEAMEY LESKQFLHRD 120
LAARNCLVND QGVVKVSDFG LSRYVLDDEY TSSVGSKFPV RWSPPEVLMY SKFSSKSDIW 180
AFGVLMWEVY SLGKMPYERF SNSETAEHIA KGLRLYRPQL ASERVYAVMY SCWHEKADER 240
PTFKLVLSNI L 251
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00098
EKS-ANC-00100
EKS-BOT-00108
EKS-CAJ-00109
EKS-CAF-00109
EKS-CAP-00103
EKS-CIS-00119
EKS-DAR-00355
EKS-EQC-00104
EKS-FEC-00102
EKS-GAM-00052
EKS-GAG-00088
EKS-GAA-00127
EKS-GOG-00108
EKS-HOS-00110
EKS-ICT-00102
EKS-LAC-00112
EKS-LOA-00102
EKS-MAM-00103
EKS-MEG-00083
EKS-MOD-00109
EKS-MUM-00109
EKS-MUP-00110
EKS-MYL-00121
EKS-NOL-00100
EKS-ORN-00132
EKS-ORC-00099
EKS-ORL-00124
EKS-OTG-00109
EKS-PAT-00098
EKS-PES-00092
EKS-PEM-00054
EKS-POA-00100
EKS-PTV-00097
EKS-RAN-00109
EKS-SAH-00100
EKS-SOA-00057
EKS-SUS-00094
EKS-TAR-00136
EKS-TEN-00126
EKS-XET-00090
EKS-XIM-00130
Gene Ontology
GO:0031410; C:cytoplasmic vesicle
GO:0005829; C:cytosol
GO:0045121; C:membrane raft
GO:0005634; C:nucleus
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding
GO:0004713; F:protein tyrosine kinase activity
GO:0007249; P:I-kappaB kinase/NF-kappaB cascade
GO:0018108; P:peptidyl-tyrosine phosphorylation
KEGG
oaa:100080912;
InterPros
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001562; Znf_Btk_motif.
Pfam
PF00779; BTK; 1.
PF00169; PH; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00107; BTK; 1.
SM00233; PH; 1.
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
PS51113; ZF_BTK; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00402; TECBTKDOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013