EKS-ORA-00047

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORA-00047

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	416.0	7.8E-125	4	287	284

Status

Unreviewed

Ensembl Protein

ENSOANP00000006989

UniProt Accession

F7BI12;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK1

Gene Synonyms/Alias

CDK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000004413	ENSOANP00000006989	ENSOANT00000006991

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

303

Protein Sequence
(FASTA)

MEDYTKIEKI GEGTYGVVYK GRHKTTGQVV AMKKIRLESE EEGVPSTAIR EISLLKELRH 60

PNIVCLQDVL MQDARLYLIF EFLSMDLKKY LDSIPPGQYM DSSLVKSYLY QILQGIVFCH 120

SRRVLHRDLK PQNLLIDDKG VIKLADFGLA RAFGIPIRVY THEVVTLWYR SPEVLLGSAR 180

YSTPVDIWSI GTIFAELATK KPLFHGDSEI DQLFRIFRAL GTPNNEVWPE VESLQDYKNT 240

FPKWKPGSLA SHVKNLDENG IDLLSKMLVY DPAKRISGKM ALNHPYFNDL DKFNLPSSQI 300

KKF 303

Nucleotide Sequence
(FASTA)

ATGGAAGACT ATACAAAGAT AGAGAAAATT GGTGAAGGTA CCTACGGTGT GGTGTATAAA 60

GGCCGACACA AAACCACCGG TCAAGTGGTG GCTATGAAGA AAATCCGACT AGAGAGTGAG 120

GAGGAAGGGG TCCCCAGTAC TGCAATTCGA GAAATATCTC TTTTGAAAGA GCTTCGTCAT 180

CCAAATATAG TATGTCTTCA AGATGTGCTT ATGCAAGATG CCAGACTGTA CCTAATCTTT 240

GAATTCCTTT CCATGGATCT CAAGAAATAT TTGGATTCTA TCCCTCCTGG CCAGTATATG 300

GATTCTTCTC TGGTTAAGAG TTATTTGTAC CAAATCCTAC AAGGTATTGT GTTCTGTCAC 360

TCAAGAAGAG TTCTTCACAG AGATTTAAAA CCCCAGAACT TGTTAATAGA TGATAAAGGA 420

GTAATTAAAT TGGCAGACTT TGGACTTGCA CGAGCCTTTG GAATCCCCAT AAGAGTTTAC 480

ACACATGAGG TAGTTACCCT TTGGTACAGA TCTCCGGAAG TGTTACTAGG ATCTGCTCGC 540

TATTCGACTC CTGTAGATAT ATGGAGCATA GGCACAATAT TTGCTGAATT AGCAACCAAG 600

AAGCCACTCT TCCATGGGGA TTCTGAGATT GATCAGCTGT TCAGAATTTT CAGGGCTTTG 660

GGTACCCCCA ATAATGAAGT ATGGCCAGAG GTGGAATCCT TGCAAGATTA TAAGAACACA 720

TTTCCCAAGT GGAAACCAGG GAGCTTGGCA TCCCATGTCA AAAACTTGGA TGAAAATGGA 780

ATAGACTTGC TCTCGAAAAT GTTAGTTTAT GATCCTGCAA AGCGAATTTC TGGCAAAATG 840

GCATTGAATC ATCCATACTT TAATGATTTG GACAAATTTA ACCTTCCATC CAGTCAAATA 900

AAGAAGTTCT AG 912

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         y+k+ekigeGtyg+vyk+++k+tg+vvA+Kkirle+e+egvp+ta+rEisllkel+h+ni

Q: 4     YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI  63

         89**********************************************************

S: 61    vkLlevvakdkkklyLvfefleqdLkkllkkkkkk.klsleevkslllqlleglaylHsn  119

         v L++v++ ++++lyL+fefl++dLkk+l++ +   +++++ vks+l+q+l+g+ ++Hs+

Q: 64    VCLQDVLM-QDARLYLIFEFLSMDLKKYLDSIPPGqYMDSSLVKSYLYQILQGIVFCHSR  122

         ********.99********************9875599**********************

S: 120   kilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYs  179

         ++lHRDlKpqNlLi+++g++klaDfGlaraf+ p + yt+evvTlwYr+Pe+Llg+ +Ys

Q: 123   RVLHRDLKPQNLLIDDKGVIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYS  182

         ************************************************************

S: 180   tavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeykksfp  239

         t vDiWs+g i+ael+t+kplf+g+seidql+rif+ lgtp+++vwpev++l++yk++fp

Q: 183   TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFP  242

         ************************************************************

S: 240   kkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         k+k+ +l+++vk+l+e+++dll+k+l +dp+kRis k al+h+yf

Q: 243   KWKPGSLASHVKNLDENGIDLLSKMLVYDPAKRISGKMALNHPYF  287

         ********************************************9

Domain Sequence
(FASTA)

YTKIEKIGEG TYGVVYKGRH KTTGQVVAMK KIRLESEEEG VPSTAIREIS LLKELRHPNI 60

VCLQDVLMQD ARLYLIFEFL SMDLKKYLDS IPPGQYMDSS LVKSYLYQIL QGIVFCHSRR 120

VLHRDLKPQN LLIDDKGVIK LADFGLARAF GIPIRVYTHE VVTLWYRSPE VLLGSARYST 180

PVDIWSIGTI FAELATKKPL FHGDSEIDQL FRIFRALGTP NNEVWPEVES LQDYKNTFPK 240

WKPGSLASHV KNLDENGIDL LSKMLVYDPA KRISGKMALN HPYF 284

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0030496	; C:midbody
GO:0005634	; C:nucleus
GO:0005876	; C:spindle microtubule
GO:0005524	; F:ATP binding
GO:0004693	; F:cyclin-dependent protein kinase activity
GO:0008353	; F:RNA polymerase II carboxy-terminal domain kinase activity
GO:0007095	; P:mitotic cell cycle G2/M transition DNA damage checkpoint
GO:0034501	; P:protein localization to kinetochore

KEGG

oaa:100077655

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013