EKS-ORA-00324

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORA-00324

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	383.6	4.3E-115	248	497	250

Status

Unreviewed

Ensembl Protein

ENSOANP00000025299

UniProt Accession

F7FMT3;

Protein Name

Protein Synonyms/Alias

Gene Name

SRMS

Gene Synonyms/Alias

SRMS;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000004911	ENSOANP00000007778	ENSOANT00000007780
ENSOANG00000004911	ENSOANP00000025299	ENSOANT00000029103

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

509

Protein Sequence
(FASTA)

KEFKPTPAVV EMEPFLRKRL TFLSFFWNKL WPTEIPDDCI PRYPGPDPVT MDLDPDPDPV 60

SSQPGSPSST VLFTALYDFT ARCADELSVN RGDKLFAIKE EGDYIFARRL SGRPSTGLVP 120

INYVAKATHE SFSTQPWFFG GISRSEAQQL LLSPSNQHGA FLVRPSESSR GDYSLSVRTK 180

AKVCHYRISK APDGGLYIQK GQVFPSLEEL LAFYKANWKI IQNPLLKPCI PERPPERDEW 240

ERPRSEFALR RKLGEGYFGE VWEGLWLNMV PVAIKIIKQA DMRLDDFTKE IQNLKSLKHE 300

KLIRLHAVCS IGEPVYIVTE LMRKGNLQNY LNSPEGKTLS LIHLMSIACQ VVEGMTYLEE 360

KHIVHRDLAA RNILVGDDLT CKIADFGLAR LLKDDIYSTS SSTKIPVKWT APEAANYRIY 420

SQKSDVWSFG ILLYEVFTFG QCPYEGMTNQ ETIHQITRGY RLPRPNTCSP EVYVIMLECW 480

KANAEERPTF FTLREKLNSI YRRVYHSFT 509

Nucleotide Sequence
(FASTA)

AAAGAATTTA AGCCAACTCC AGCTGTGGTT GAGATGGAGC CTTTCTTAAG AAAGAGGCTG 60

ACCTTCCTCT CCTTCTTTTG GAATAAGCTT TGGCCTACAG AAATCCCTGA TGACTGTATT 120

CCCAGGTATC CGGGGCCTGA TCCAGTCACG ATGGACCTCG ATCCGGACCC CGATCCTGTC 180

TCCTCCCAGC CTGGCAGCCC CTCGTCCACT GTTCTCTTTA CAGCTCTATA TGACTTCACG 240

GCCAGGTGTG CGGATGAGCT GAGTGTGAAT CGGGGAGACA AGCTCTTTGC CATTAAGGAA 300

GAGGGGGACT ATATCTTCGC CAGGAGACTC TCAGGGAGGC CCAGCACTGG ACTGGTCCCC 360

ATTAATTATG TAGCCAAGGC AACTCATGAG TCCTTCTCCA CCCAACCCTG GTTCTTCGGC 420

GGGATCAGCC GCAGTGAGGC CCAGCAGCTC CTGCTTTCTC CCTCCAATCA GCATGGCGCC 480

TTCCTGGTGC GGCCCAGCGA GAGCAGCAGA GGGGACTACT CGTTGTCAGT CCGCACCAAA 540

GCCAAAGTCT GTCACTACCG CATCTCCAAG GCTCCTGATG GGGGTCTCTA CATCCAGAAA 600

GGGCAGGTCT TTCCCAGCCT GGAGGAGCTG CTTGCCTTCT ACAAAGCAAA TTGGAAAATC 660

ATTCAGAATC CCTTGCTTAA ACCCTGCATC CCAGAGAGGC CTCCCGAACG GGATGAATGG 720

GAACGACCTC GATCCGAGTT TGCCCTCCGG AGAAAACTTG GAGAAGGATA TTTTGGAGAG 780

GTGTGGGAAG GACTGTGGCT GAACATGGTG CCGGTAGCCA TCAAGATCAT AAAGCAAGCG 840

GACATGAGGC TCGATGACTT CACCAAAGAG ATTCAGAACC TAAAGAGCCT GAAACACGAG 900

AAGCTCATCA GGCTGCATGC AGTCTGCTCC ATCGGGGAGC CTGTGTACAT CGTCACAGAA 960

CTCATGAGGA AAGGAAACCT CCAGAACTAC CTCAACAGTC CAGAAGGGAA AACCCTGAGT 1020

CTGATTCACT TGATGAGTAT TGCCTGCCAA GTGGTGGAGG GTATGACGTA CCTGGAGGAG 1080

AAACACATCG TGCACCGCGA TCTGGCAGCC AGAAACATCC TGGTGGGAGA CGATCTTACT 1140

TGCAAGATTG CAGACTTCGG CCTGGCGAGG CTTCTCAAGG ATGATATTTA CTCTACAAGC 1200

AGCAGCACCA AAATCCCAGT GAAATGGACA GCCCCCGAGG CAGCAAACTA CCGGATTTAC 1260

TCCCAGAAAT CAGATGTCTG GTCCTTTGGG ATTCTCCTCT ATGAAGTTTT CACTTTTGGG 1320

CAGTGCCCAT ATGAAGGGAT GACAAACCAA GAGACTATCC ATCAGATAAC AAGGGGCTAC 1380

CGCCTACCCC GCCCCAACAC CTGCTCTCCC GAAGTCTACG TCATCATGCT GGAGTGCTGG 1440

AAGGCCAATG CCGAAGAACG GCCCACCTTC TTCACCCTGA GAGAGAAGCT CAACTCCATC 1500

TACAGACGAG TGTATCACTC GTTCACATGA 1530

Domain Profile

S: 2     klvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvklya  61

          l +klGeG+fGevw+g+w + v+va+k +k+++++ ++f++e+q lk+l+hekl++l+a

Q: 248   ALRRKLGEGYFGEVWEGLWLNMVPVAIKIIKQADMRLDDFTKEIQNLKSLKHEKLIRLHA  307

         688*********************************************************

S: 62    vvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihrd  121

         v+s +eP+yivtelm+kG+l+++l++ egk+l+l +l+ +a+qv eGm+yleek+++hrd

Q: 308   VCSIGEPVYIVTELMRKGNLQNYLNSPEGKTLSLIHLMSIACQVVEGMTYLEEKHIVHRD  367

         ************************************************************

S: 122   laarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdvW  181

         laarn+lvg++l++k+adfGlarl++dd+y++++++k+P+kWtaPea++++ +++ksdvW

Q: 368   LAARNILVGDDLTCKIADFGLARLLKDDIYSTSSSTKIPVKWTAPEAANYRIYSQKSDVW  427

         ************************************************************

S: 182   sfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpeer  241

         sfGill+e++t G++Py+Gmtn+e+++q++rgyrlprp++c  e+y ++lecwk+++eer

Q: 428   SFGILLYEVFTFGQCPYEGMTNQETIHQITRGYRLPRPNTCSPEVYVIMLECWKANAEER  487

         ************************************************************

S: 242   Ptfetlqevl  251

         Ptf tl+e+l

Q: 488   PTFFTLREKL  497

         *****99875

Domain Sequence
(FASTA)

ALRRKLGEGY FGEVWEGLWL NMVPVAIKII KQADMRLDDF TKEIQNLKSL KHEKLIRLHA 60

VCSIGEPVYI VTELMRKGNL QNYLNSPEGK TLSLIHLMSI ACQVVEGMTY LEEKHIVHRD 120

LAARNILVGD DLTCKIADFG LARLLKDDIY STSSSTKIPV KWTAPEAANY RIYSQKSDVW 180

SFGILLYEVF TFGQCPYEGM TNQETIHQIT RGYRLPRPNT CSPEVYVIML ECWKANAEER 240

PTFFTLREKL 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013