EKS-ORA-00089
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORA-00089
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec462.05.0E-139370619250
StatusUnreviewed
Ensembl ProteinENSOANP00000008068
UniProt AccessionF6PFT9;
Protein Name
Protein Synonyms/Alias
Gene NameITK
Gene Synonyms/Alias ITK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOANG00000005082ENSOANP00000008068ENSOANT00000008070
OrganismOrnithorhynchus anatinus
Functional Description
Protein Length627
Protein Sequence
(FASTA)
MNNYILLEEQ LIKKSQQKRR TSPSNFKVRF FVLTKTSLAY FEDRQGKKRT LKGSIELSRI 60
KCVEIVKSDI SIPCHYKYPF QTECTLEIVV HDNYLLYVFA PDRESRQRWV LALKKETRNN 120
NSLVPKYHPN FWMDGRWRCC VQTEKLAPGC AEYDPTKNAS KKPLPPTPED NRKLLPESEE 180
NLVIAMYDYL TQDPQELMLQ RNEEYYVLDS SEIHWWRVQD KNGHEGYVPS SYLVEKSPNN 240
LETYEWYNKN INRNKAEKLL LDEGKEGAFM VRDSRTLGTY TVSVFTKAFV SDSCPSIKHY 300
HIKETNDTPK RYYVAEKFVF DSIPQLIKYH QHNGGGLVTR LRHPVCSWRQ KAPITAGLRY 360
GKWMINPSEL TFVQEIGSGQ FGLVHLGYWL EKNKVAIKTI QEGAMSEEEF IEEAEVMMKL 420
SHPKLVQLYG VCLEQTPICL VFEFMEHGCL SDYLRNQRGS FTTDTLLGMC QDVCEGMAYL 480
EKAFVIHRDL AARNCLVGES QVIKVSDFGM TRFVLDDQYT SSTGTKFPVK WASPEVFSFN 540
RYSSKSDVWS FGVLMWEVFS EGKIPYESRS NTEVVEDISA GLRLYKPRLA SQGIFKIMSH 600
CWKERPEDRP SFSHLLCQLI EIAECEL 627
Nucleotide Sequence
(FASTA)
ATGAATAACT ATATCCTCCT GGAAGAGCAG CTGATCAAGA AATCCCAACA AAAAAGAAGG 60
ACCTCTCCCT CCAACTTTAA AGTGCGCTTC TTTGTTTTAA CCAAAACCAG CCTTGCTTAC 120
TTTGAGGATC GCCAAGGGAA AAAACGAACA CTGAAGGGAT CCATTGAACT TTCCAGAATC 180
AAATGTGTTG AAATTGTGAA AAGTGACATT AGCATTCCAT GTCACTATAA ATACCCCTTC 240
CAGACTGAGT GTACATTGGA AATCGTTGTT CATGATAATT ATCTCCTCTA TGTCTTTGCT 300
CCTGACCGAG AGAGTCGGCA GAGATGGGTG CTGGCTCTTA AAAAAGAAAC CAGGAACAAC 360
AACAGTCTGG TGCCAAAGTA TCACCCCAAT TTCTGGATGG ATGGGAGGTG GAGATGCTGC 420
GTCCAGACAG AAAAGCTAGC ACCTGGTTGT GCAGAGTATG ATCCAACCAA GAACGCTTCA 480
AAGAAGCCTC TTCCTCCCAC TCCTGAAGAT AACCGGAAAC TACTGCCAGA GTCTGAAGAA 540
AACTTAGTCA TTGCTATGTA TGACTACCTT ACCCAGGATC CCCAGGAACT AATGCTTCAA 600
CGCAATGAAG AGTACTATGT GCTTGACAGC TCAGAGATTC ATTGGTGGAG AGTCCAAGAT 660
AAAAATGGGC ATGAAGGGTA TGTGCCAAGC AGTTACCTAG TGGAAAAGTC ACCAAATAAT 720
CTGGAAACAT ATGAGTGGTA CAATAAGAAC ATCAACCGAA ATAAAGCTGA GAAACTCCTT 780
TTAGATGAGG GTAAAGAAGG AGCCTTCATG GTGCGAGATT CTCGAACTCT AGGGACATAC 840
ACGGTCTCGG TTTTCACCAA GGCATTTGTA AGTGACAGTT GTCCAAGCAT AAAGCACTAT 900
CACATCAAAG AGACAAATGA CACCCCCAAG CGATATTATG TTGCAGAAAA GTTTGTGTTT 960
GATTCCATCC CACAACTCAT CAAATATCAC CAGCACAATG GAGGAGGTCT GGTCACACGT 1020
TTACGACACC CAGTTTGTTC CTGGAGACAA AAGGCCCCCA TCACAGCTGG GCTGAGATAC 1080
GGCAAATGGA TGATAAACCC TTCAGAGCTC ACTTTTGTGC AAGAGATTGG CAGTGGACAG 1140
TTTGGATTGG TGCATCTTGG CTACTGGCTT GAAAAGAATA AGGTAGCCAT TAAGACTATT 1200
CAAGAAGGGG CAATGTCAGA AGAGGAATTC ATAGAAGAGG CGGAAGTCAT GATGAAGCTC 1260
TCTCATCCCA AATTGGTTCA ACTCTATGGG GTGTGCCTGG AACAAACTCC CATCTGTCTA 1320
GTATTTGAGT TCATGGAACA TGGCTGCTTG TCTGATTATC TTCGGAATCA GCGGGGAAGC 1380
TTTACCACAG ACACTCTTCT AGGCATGTGC CAAGATGTGT GTGAAGGGAT GGCTTATCTG 1440
GAAAAAGCCT TTGTCATTCA CAGAGACCTG GCCGCCCGGA ACTGCTTGGT GGGAGAATCC 1500
CAAGTCATTA AAGTGTCAGA TTTTGGAATG ACAAGGTTTG TCCTTGATGA CCAATATACC 1560
AGCTCCACTG GCACCAAATT CCCTGTGAAA TGGGCATCAC CCGAGGTTTT CTCTTTCAAT 1620
CGTTACAGCA GCAAGTCTGA TGTCTGGTCA TTTGGAGTGC TGATGTGGGA GGTCTTCAGT 1680
GAGGGCAAGA TACCATATGA GAGCCGCAGC AACACAGAGG TGGTTGAAGA CATCAGTGCC 1740
GGATTACGTT TATACAAACC CAGATTGGCC TCCCAAGGCA TCTTTAAGAT CATGAGTCAT 1800
TGTTGGAAAG AGAGACCAGA AGACCGGCCA TCCTTCTCCC ACCTGCTGTG TCAGCTGATC 1860
GAGATAGCGG AATGTGAACT TTAA 1884
Domain Profile
S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60
         lt+++e+gsgqfg+v+lg+w +k +vaik+i+egamsee+fieea+vmmklshpklvqly
Q: 370   LTFVQEIGSGQFGLVHLGYWLEKNKVAIKTIQEGAMSEEEFIEEAEVMMKLSHPKLVQLY  429
         79**********************************************************
S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120
         gvcl+q+pi++v+e++e+gcl++ylr++++++++++ll mc+dvcegm+yle++ +ihrd
Q: 430   GVCLEQTPICLVFEFMEHGCLSDYLRNQRGSFTTDTLLGMCQDVCEGMAYLEKAFVIHRD  489
         ************************************************************
S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180
         laarnclv+e++v+kvsdfg++r+vlddqy+ss+g+kfpvkw++pev+s+++yssksdvw
Q: 490   LAARNCLVGESQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFNRYSSKSDVW  549
         ************************************************************
S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240
         +fgvlmwevfsegk+pye +sn+evve++s glrly+p+las+ ++++m +cwke+pe+r
Q: 550   SFGVLMWEVFSEGKIPYESRSNTEVVEDISAGLRLYKPRLASQGIFKIMSHCWKERPEDR  609
         ************************************************************
S: 241   ptfkellsal  250
         p+f++ll +l
Q: 610   PSFSHLLCQL  619
         *******987
Domain Sequence
(FASTA)
LTFVQEIGSG QFGLVHLGYW LEKNKVAIKT IQEGAMSEEE FIEEAEVMMK LSHPKLVQLY 60
GVCLEQTPIC LVFEFMEHGC LSDYLRNQRG SFTTDTLLGM CQDVCEGMAY LEKAFVIHRD 120
LAARNCLVGE SQVIKVSDFG MTRFVLDDQY TSSTGTKFPV KWASPEVFSF NRYSSKSDVW 180
SFGVLMWEVF SEGKIPYESR SNTEVVEDIS AGLRLYKPRL ASQGIFKIMS HCWKERPEDR 240
PSFSHLLCQL 250
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00101
EKS-ANC-00099
EKS-BOT-00110
EKS-CAJ-00111
EKS-CAF-00112
EKS-CAP-00105
EKS-DAR-00357
EKS-EQC-00108
EKS-FEC-00105
EKS-GAG-00090
EKS-GAA-00128
EKS-GOG-00111
EKS-HOS-00113
EKS-ICT-00105
EKS-LAC-00114
EKS-LOA-00106
EKS-MAM-00105
EKS-MEG-00085
EKS-MOD-00106
EKS-MUM-00112
EKS-MUP-00113
EKS-MYL-00124
EKS-NOL-00103
EKS-OCP-00072
EKS-ORC-00102
EKS-ORL-00125
EKS-OTG-00112
EKS-PAT-00100
EKS-PES-00093
EKS-POA-00103
EKS-RAN-00108
EKS-SAH-00102
EKS-TAG-00138
EKS-TAR-00137
EKS-TEN-00127
EKS-XET-00091
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0005543; F:phospholipid binding
GO:0007202; P:activation of phospholipase C activity
GO:0002250; P:adaptive immune response
GO:0035556; P:intracellular signal transduction
GO:0050852; P:T cell receptor signaling pathway
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001562; Znf_Btk_motif.
Pfam
PF00779; BTK; 1.
PF00169; PH; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00107; BTK; 1.
SM00233; PH; 1.
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
PS51113; ZF_BTK; 1.
Prints
PR00401; SH2DOMAIN.
PR00402; TECBTKDOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013