EKS-ORA-00321

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORA-00321

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	450.5	1.7E-135	198	447	250

Status

Unreviewed

Ensembl Protein

ENSOANP00000008375

UniProt Accession

F6VI70;

Protein Name

Protein Synonyms/Alias

Gene Name

YES1

Gene Synonyms/Alias

YES1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000005265	ENSOANP00000008375	ENSOANT00000008377

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

464

Protein Sequence
(FASTA)

MLCVVFFSPF SGGVTIFVAL YDYEARTTED LSFKKGERFQ IINNTEGDWW EARSIATGKT 60

GYIPSNYVAP ADSIQAEEWY FGKMGRKDAE RLLLSPGNQR GIFLVRESET TKGAYSLSIR 120

DWDEVRGDNV KHYKIRKLDN GGYYITTRAQ FESLQKLVKH YTEHADGLCH KLTTVCPTVK 180

PQTQGLAKDA WEIPRESLRL EVKLGQGCFG EVWMGTWNGT TKVAIKTLKP GTMMPEAFLQ 240

EAQIMKKLRH DKLVPLYAVV SEEPIYIVTE FMTKGSLLDF LKEGDGKYLK LPQLVDMAAQ 300

IADGMAYIER MNYIHRDLRA ANILVGDNLV CKIADFGLAR LIEDNEYTAR QGAKFPIKWT 360

APEAALYGRF TIKSDVWSFG ILLTELVTKG RVPYPGMVNR EVLEQVERGY RMPCPQGCPE 420

SLHELMKLCW KKDPDERPTF EYIQSFLEDY FTATEPQYQP GDNL 464

Nucleotide Sequence
(FASTA)

ATGCTTTGTG TGGTTTTTTT TTCCCCTTTC TCAGGTGGTG TTACTATATT TGTGGCCTTA 60

TATGATTATG AAGCTCGAAC TACAGAAGAT CTTTCGTTTA AGAAGGGTGA ACGGTTCCAG 120

ATCATTAACA ACACGGAAGG AGACTGGTGG GAAGCAAGAT CCATTGCTAC CGGAAAGACT 180

GGATATATCC CTAGCAATTA TGTAGCTCCT GCTGACTCCA TTCAGGCAGA AGAATGGTAT 240

TTTGGCAAAA TGGGCAGAAA GGATGCAGAG AGATTGCTAT TAAGCCCTGG GAACCAACGA 300

GGTATCTTTT TAGTAAGAGA AAGCGAAACC ACTAAAGGTG CTTATTCTCT CTCTATTCGT 360

GATTGGGATG AGGTAAGAGG GGACAATGTG AAACACTACA AAATCAGGAA GCTTGACAAT 420

GGTGGATACT ATATCACAAC AAGAGCACAA TTTGAATCGC TGCAGAAATT GGTCAAACAT 480

TACACAGAAC ACGCTGATGG CCTTTGCCAT AAGCTGACAA CTGTGTGTCC AACTGTGAAA 540

CCCCAGACTC AAGGCTTAGC GAAAGATGCT TGGGAAATTC CTCGAGAATC TCTGCGGCTA 600

GAGGTTAAGC TGGGACAGGG ATGTTTCGGT GAAGTGTGGA TGGGAACTTG GAATGGAACC 660

ACAAAAGTAG CAATCAAAAC ACTCAAGCCT GGTACAATGA TGCCAGAAGC TTTTCTTCAG 720

GAGGCCCAGA TCATGAAGAA GCTAAGGCAC GATAAACTCG TTCCTCTATA CGCTGTTGTT 780

TCTGAGGAAC CTATCTACAT TGTTACCGAA TTCATGACGA AAGGGAGCTT ACTAGATTTC 840

CTTAAAGAAG GAGATGGGAA ATATTTGAAA CTCCCACAGC TGGTTGACAT GGCCGCCCAG 900

ATTGCTGATG GAATGGCCTA CATCGAAAGA ATGAACTACA TCCACAGAGA TCTTCGGGCA 960

GCTAATATCC TTGTAGGCGA TAACCTTGTT TGTAAAATAG CAGATTTTGG GCTAGCGAGG 1020

TTAATTGAAG ACAACGAATA CACTGCAAGG CAAGGAGCCA AATTTCCAAT CAAATGGACG 1080

GCTCCTGAGG CTGCATTATA CGGCCGGTTT ACCATCAAAT CTGATGTCTG GTCATTTGGA 1140

ATTCTGCTGA CGGAGCTGGT AACAAAGGGA AGAGTGCCGT ATCCAGGGAT GGTGAACCGG 1200

GAAGTCCTAG AACAAGTAGA ACGTGGATAT AGGATGCCTT GTCCTCAGGG TTGTCCAGAG 1260

TCACTCCATG AATTGATGAA GCTTTGTTGG AAGAAGGACC CCGATGAGAG ACCAACATTT 1320

GAATATATTC AGTCCTTCTT AGAAGACTAC TTTACTGCTA CAGAACCACA GTATCAACCC 1380

GGAGACAATT TATAA 1395

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         l+l+ klG+G+fGevw+g+w+g++kva+ktlk+gt++peafl+eaqi+kklrh+klv ly

Q: 198   LRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLY  257

         68999*******************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avvse ePiyivte+m+kGslldflke +gk+lklp+lvd+aaq+a+Gmay+e++n+ihr

Q: 258   AVVSE-EPIYIVTEFMTKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHR  316

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+n+lvg++lv+k+adfGlarlied+eyta++gak+PikWtaPea+ +g+ftiksdv

Q: 317   DLRAANILVGDNLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV  376

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGillte+vtkG+vPypGm n+evleqvergyr+p+p+ cpe+l+el++ cwkkdp+e

Q: 377   WSFGILLTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMKLCWKKDPDE  436

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtfe++q++l

Q: 437   RPTFEYIQSFL  447

         *******9986

Domain Sequence
(FASTA)

LRLEVKLGQG CFGEVWMGTW NGTTKVAIKT LKPGTMMPEA FLQEAQIMKK LRHDKLVPLY 60

AVVSEEPIYI VTEFMTKGSL LDFLKEGDGK YLKLPQLVDM AAQIADGMAY IERMNYIHRD 120

LRAANILVGD NLVCKIADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW 180

SFGILLTELV TKGRVPYPGM VNREVLEQVE RGYRMPCPQG CPESLHELMK LCWKKDPDER 240

PTFEYIQSFL 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013