EKS-ORA-00026
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORA-00026
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Jak257.32.1E-76526781256
StatusUnreviewed
Ensembl ProteinENSOANP00000008510
UniProt AccessionF6X8E5;
Protein Name
Protein Synonyms/Alias
Gene NameJAK3
Gene Synonyms/Alias JAK3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOANG00000005345ENSOANP00000008510ENSOANT00000008512
OrganismOrnithorhynchus anatinus
Functional Description
Protein Length1103
Protein Sequence
(FASTA)
MAPLGEDTPL IGGRSCSLSS SEVGGLQLLL YHHTNAPRSV PDSSWILTFS FGEYSAEDLC 60
IAAAKACGIL PVCHSLFALA TEDLKCWFPP NHIFTVDDTS AQVLVYRLRF FFPNWFGLER 120
CYRFGLRKDR ASAILDFPVL DYLFAQARSD FVSGRMEFSL SLKEQEECLS LAVLDLTQLA 180
REKGQGPEEI FKSVSYKSCL PEKFRRQIQG LSFLTRKRIR KTVQQSLRQV AGCQADGRSL 240
KLKYLMDLER MDSAFPPETF PVKAPGTGHS EGACQFIHVS GENGISWNSS GNEGSQHFCD 300
FPEITDISIK QVSRDGNPRE TRLVTLTRTD NRTLEVEFPT LREALSFISL IDGYYRLTAD 360
AHHYFCKEVA PPQLLENIED QCHGPITWSE FAVNKLKVAG GIAGSYLLRR SPQDFDSFLL 420
TICIQVQSPA PLPHGPQATP SSQNNRVGNN NNHSGGPCYA LSAKCWSGRV GGRWVNYFLI 480
FLHPPPEKSN LIVVRRDCSQ LPSSPSPQPR LQLSHMMFHT IQPESLQWHE NLGHGSFTKI 540
YRGTRRDMAD EETRETEVLL KVMDSTHQNC SEEGLQLSSK LPRVSFISPL LWDPSPPGIM 600
VQEFVRFGAL DTHLKKHTPN ITASWKLQVA KQLAYALNYL EDRRIVHGNV SAKKVLLARE 660
GDGASGSPPF IKLSDPGVSP AVLAKELLTD RIPWVAPECL WDPKSLSLEA DKWSFGATVW 720
EIFSGGTMPL STLEPAEKLQ FYKKQHQLPA PKWTELANLI GQCMDYSPPR RPSFRAVIRD 780
LNSLITSDYE LLSDLSPSEL AVRDGFWPST NLSACQDPTL FEERHLKYIS LLGKVGHGRG 840
RSRLPKLLME GERASSSERT CSGGDEVGEW KRAAQSTQQQ GSSGLVERGR RNQEGRREGE 900
KSMGAPGGQE GKSLRGHRGW SALFRDPSLL SLQGMEYLGS QRYVHRDLAN RNILVESETH 960
VKIGDFGLAK ILPQDKEYYV VQEPGQSPIF WYAPESLSDN VFSRESDVWS FGVVLYELYT 1020
YSEKSRSPSA EFLRMMGCDR TMPILCHLLE LLKEGKRLPT PPGCPWEVSG CHLSRWPEGR 1080
EVGRMASGSK SRTATQLGVG RLE 1103
Nucleotide Sequence
(FASTA)
ATGGCGCCCC TAGGGGAAGA CACACCCCTG ATCGGGGGTC GCTCCTGCAG TCTGTCGTCC 60
AGTGAGGTGG GGGGGCTGCA GCTCCTCCTG TACCATCACA CCAACGCCCC TCGCTCGGTG 120
CCTGACTCAT CCTGGATCCT GACCTTCTCC TTCGGGGAGT ACTCTGCCGA AGATCTCTGC 180
ATCGCAGCTG CCAAAGCCTG TGGGATCCTG CCCGTGTGCC ACAGTCTCTT TGCCCTGGCT 240
ACAGAAGATC TGAAGTGCTG GTTTCCGCCC AACCACATCT TCACAGTGGA TGACACGAGT 300
GCGCAGGTCC TCGTCTACAG GCTGAGGTTC TTTTTCCCAA ACTGGTTTGG CCTGGAGAGA 360
TGTTACCGCT TCGGGCTGAG GAAAGATCGA GCCAGCGCCA TCCTAGACTT CCCCGTCCTT 420
GACTACCTGT TTGCCCAGGC CCGCAGTGAC TTTGTCAGTG GGAGGATGGA GTTCAGCTTG 480
AGTCTGAAGG AGCAAGAGGA GTGTCTGAGC TTGGCTGTGC TGGACCTGAC CCAGCTGGCC 540
CGGGAGAAGG GCCAGGGCCC AGAGGAGATC TTCAAGAGTG TCAGCTATAA GTCCTGCCTC 600
CCGGAAAAAT TCCGACGGCA GATCCAGGGA CTCAGCTTCC TGACCCGGAA GAGGATCCGA 660
AAGACCGTGC AGCAGTCCCT GCGGCAGGTG GCTGGGTGCC AGGCCGACGG GCGGTCACTG 720
AAGCTCAAGT ACCTGATGGA CCTGGAGCGG ATGGACTCGG CCTTCCCGCC CGAGACCTTC 780
CCCGTGAAGG CCCCTGGGAC TGGGCACAGT GAGGGCGCCT GCCAGTTTAT CCACGTGTCT 840
GGGGAGAATG GCATCTCCTG GAACTCCAGT GGCAATGAGG GCTCTCAGCA TTTCTGCGAC 900
TTTCCCGAAA TCACCGACAT CAGCATCAAG CAAGTGAGTC GGGACGGCAA CCCCAGGGAG 960
ACCCGGCTCG TTACTCTCAC CAGGACAGAT AACAGGACCC TGGAGGTGGA GTTCCCCACT 1020
CTGCGGGAGG CCCTGTCCTT CATCTCCCTC ATCGATGGCT ACTACCGCCT CACGGCCGAT 1080
GCTCACCACT ATTTCTGCAA GGAGGTTGCC CCACCGCAGC TCTTGGAAAA CATAGAGGAC 1140
CAGTGCCACG GCCCCATCAC GTGGTCCGAG TTTGCAGTGA ACAAGCTGAA AGTGGCGGGA 1200
GGAATTGCAG GCTCCTACCT GCTGCGTCGC AGCCCCCAGG ACTTTGACAG CTTCCTGCTC 1260
ACCATATGCA TCCAGGTCCA GAGCCCAGCT CCCCTCCCCC ACGGACCCCA GGCAACCCCC 1320
AGCAGCCAAA ACAATAGAGT TGGTAATAAT AATAATCATA GTGGTGGTCC TTGTTATGCA 1380
CTTAGCGCTA AGTGCTGGAG TGGGAGGGTC GGTGGGCGGT GGGTAAATTA TTTTCTCATC 1440
TTCCTCCATC CTCCCCCAGA GAAGTCCAAT TTGATTGTGG TGCGGAGGGA CTGCAGTCAG 1500
CTACCCTCGT CCCCTTCGCC GCAGCCCCGG CTTCAGCTCA GTCACATGAT GTTTCACACC 1560
ATTCAACCCG AGAGTCTGCA GTGGCACGAA AACCTGGGCC ACGGCTCTTT CACCAAGATC 1620
TATCGGGGCA CCCGGCGGGA CATGGCAGAT GAGGAAACGC GGGAGACTGA AGTGCTTCTC 1680
AAAGTCATGG ACAGCACCCA CCAAAATTGC TCTGAGGAGG GATTGCAGCT TTCCTCAAAG 1740
CTCCCCAGGG TTTCTTTCAT CTCCCCACTT CTGTGGGACC CCTCCCCCCC GGGTATCATG 1800
GTGCAGGAGT TTGTCCGGTT CGGGGCGCTG GACACGCACC TGAAGAAGCA CACCCCCAAC 1860
ATCACTGCCA GCTGGAAGCT GCAGGTAGCC AAGCAGTTGG CCTATGCCCT CAACTACCTG 1920
GAGGACAGAC GCATCGTCCA CGGCAACGTC TCTGCCAAGA AAGTGCTGCT GGCCAGGGAA 1980
GGAGATGGGG CCAGTGGGAG CCCCCCTTTC ATCAAACTCA GCGACCCCGG GGTCAGCCCT 2040
GCAGTGCTGG CCAAGGAGCT CCTTACTGAC CGCATCCCGT GGGTGGCCCC CGAGTGCCTG 2100
TGGGATCCCA AGAGCTTGAG CCTGGAAGCT GACAAGTGGA GCTTCGGCGC AACAGTCTGG 2160
GAGATCTTCA GTGGGGGCAC CATGCCCCTG AGCACCCTGG AACCTGCAGA GAAACTCCAG 2220
TTCTACAAGA AGCAGCACCA GCTGCCTGCA CCCAAGTGGA CGGAACTGGC CAACCTGATC 2280
GGGCAGTGCA TGGATTACTC TCCTCCCCGC AGACCCTCCT TCCGCGCGGT CATCCGGGAC 2340
CTCAACAGCC TCATCACCTC AGATTACGAA CTCCTCTCGG ACCTGTCCCC CAGTGAGTTG 2400
GCTGTCCGAG ACGGGTTCTG GCCCAGCACC AATCTGTCTG CCTGCCAAGA CCCCACGCTG 2460
TTTGAGGAGC GCCATCTCAA ATACATCTCC CTGTTGGGCA AGGTAGGGCA TGGGAGGGGA 2520
AGGAGCAGGT TACCCAAGCT GTTGATGGAG GGAGAAAGGG CATCATCTTC GGAGAGGACC 2580
TGCTCCGGGG GTGACGAGGT TGGAGAGTGG AAAAGGGCCG CCCAGAGCAC GCAGCAGCAA 2640
GGCAGCAGTG GGCTAGTGGA GAGGGGGAGG CGAAACCAGG AGGGAAGGAG GGAGGGAGAG 2700
AAGAGTATGG GTGCCCCCGG AGGACAAGAA GGCAAAAGCC TCAGAGGTCA CCGGGGGTGG 2760
TCTGCTCTGT TCCGTGACCC TTCCCTCCTC TCCTTACAGG GGATGGAGTA CCTGGGTTCT 2820
CAGCGCTACG TCCACAGGGA CCTGGCCAAC AGGAACATCC TGGTGGAGAG CGAGACTCAT 2880
GTTAAGATCG GGGACTTTGG CCTGGCCAAG ATCCTGCCCC AGGACAAGGA GTACTATGTG 2940
GTTCAGGAGC CCGGCCAGAG CCCCATCTTC TGGTATGCCC CAGAGTCCCT GTCTGACAAT 3000
GTCTTCTCCC GGGAATCTGA TGTCTGGAGC TTTGGGGTCG TGCTATATGA GCTTTACACC 3060
TACAGCGAGA AGAGCAGGAG TCCTTCAGCG GAGTTTCTGC GCATGATGGG ATGTGACAGG 3120
ACGATGCCCA TCCTTTGCCA CTTGCTGGAG CTTCTCAAGG AAGGCAAAAG GCTACCCACT 3180
CCCCCTGGCT GCCCATGGGA GGTAAGCGGG TGTCACCTCT CCAGGTGGCC AGAGGGCAGG 3240
GAGGTTGGGA GAATGGCCTC TGGAAGTAAA TCAAGGACAG CGACTCAACT TGGGGTGGGA 3300
AGACTGGAG 3309
Domain Profile
S: 1     lkqiesLgkgtftkvfevred..aegdsteeevalkvLkesgedisrdfkreaeilsqls  58
         l+++e+Lg+g+ftk+++++++  a+++++e+ev+lkv+++ ++++s++  + ++ l  +s
Q: 526   LQWHENLGHGSFTKIYRGTRRdmADEETRETEVLLKVMDSTHQNCSEEGLQLSSKLPRVS  585
         689***************9966899999999******************99999999888
S: 59    hehivklkgvcvaegen.rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYL  117
             +      ++++   ++V+e+v+ G+Ld+ L+k+ +++++s++l+vakqla+a++YL
Q: 586   FISPL-----LWDPSPPgIMVQEFVRFGALDTHLKKHTPNITASWKLQVAKQLAYALNYL  640
         65444.....455555569*****************************************
S: 118   edkklvhrdvaarnvLveresn..egtppfvklsdpglakavnqdeYylvreerdsripw  175
         ed+++vh++v+a++vL++re++  +g+ppf+klsdpg++ av      l++e  ++ripw
Q: 641   EDRRIVHGNVSAKKVLLAREGDgaSGSPPFIKLSDPGVSPAV------LAKELLTDRIPW  694
         *********************99999****************......************
S: 176   lapeclseaknlstasdvWsFgvtlyelltcskgesplrseslerklelleekerlpkpk  235
         +apecl + k+ls+++d+WsFg+t++e+  +s g++pl++ ++++kl++++++++lp+pk
Q: 695   VAPECLWDPKSLSLEADKWSFGATVWEI--FSGGTMPLSTLEPAEKLQFYKKQHQLPAPK  752
         ****************************..******************************
S: 236   cpaelaelmtnclsyepsqrpsFrailedl  265
         ++ ela+l+ +c++y+p +rpsFra+++dl
Q: 753   WT-ELANLIGQCMDYSPPRRPSFRAVIRDL  781
         **.*************************98
Domain Sequence
(FASTA)
LQWHENLGHG SFTKIYRGTR RDMADEETRE TEVLLKVMDS THQNCSEEGL QLSSKLPRVS 60
FISPLLWDPS PPGIMVQEFV RFGALDTHLK KHTPNITASW KLQVAKQLAY ALNYLEDRRI 120
VHGNVSAKKV LLAREGDGAS GSPPFIKLSD PGVSPAVLAK ELLTDRIPWV APECLWDPKS 180
LSLEADKWSF GATVWEIFSG GTMPLSTLEP AEKLQFYKKQ HQLPAPKWTE LANLIGQCMD 240
YSPPRRPSFR AVIRDL 256
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>
EKS-AIM-00027
EKS-BOT-00033
EKS-CAF-00032
EKS-CAP-00034
EKS-EQC-00030
EKS-FEC-00029
EKS-GOG-00029
EKS-HOS-00030
EKS-ICT-00030
EKS-LAC-00034
EKS-LOA-00032
EKS-MEG-00028
EKS-MOD-00032
EKS-MUM-00033
EKS-MUP-00033
EKS-MYL-00033
EKS-NOL-00031
EKS-OTG-00032
EKS-PAT-00027
EKS-PTV-00031
EKS-RAN-00034
EKS-SAH-00030
EKS-SUS-00027
Gene Ontology
GO:0005856; C:cytoskeleton
GO:0016020; C:membrane
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0007167; P:enzyme linked receptor protein signaling pathway
GO:0035771; P:interleukin-4-mediated signaling pathway
GO:0007243; P:intracellular protein kinase cascade
GO:0002731; P:negative regulation of dendritic cell cytokine production
GO:0045221; P:negative regulation of FasL biosynthetic process
GO:0032693; P:negative regulation of interleukin-10 production
GO:0032695; P:negative regulation of interleukin-12 production
GO:0045626; P:negative regulation of T-helper 1 cell differentiation
GO:0070244; P:negative regulation of thymocyte apoptotic process
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0043029; P:T cell homeostasis
KEGG
InterPros
IPR019749; Band_41_domain.
IPR019748; FERM_central.
IPR000299; FERM_domain.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR008266; Tyr_kinase_AS.
IPR016251; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020775; Tyr_kinase_non-rcpt_Jak3.
Pfam
PF07714; Pkinase_Tyr; 2.
SMARTs
SM00295; B41; 1.
SM00252; SH2; 1.
Prosites
PS50057; FERM_3; 1.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR01823; JANUSKINASE.
PR01826; JANUSKINASE3.
PR00109; TYRKINASE.
Created Date20-Feb-2013