EKS-ORA-00272

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORA-00272

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	352.6	1.5E-105	22	272	251

Status

Unreviewed

Ensembl Protein

ENSOANP00000008684

UniProt Accession

F7BC69;

Protein Name

Protein Synonyms/Alias

Gene Name

STK24

Gene Synonyms/Alias

STK24;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000005462	ENSOANP00000008684	ENSOANT00000008686

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

429

Protein Sequence
(FASTA)

LFFSPFPHAF QQNLKADPEE LFTKLEKIGK GSFGEVFKGI DNRTQKVVAI KIIDLEEAED 60

EIEDIQQEIT VLSQCDSPYV TKYYGSYLKD TKLWIIMEYL GGGSALDLLE PGSLDEIQIA 120

TILREILKGL DYLHSEKKIH RDIKAANVLL SEQGEVKLAD FGVAGQLTDT QIKRNTFVGT 180

PFWMAPEVIK QSAYDSKADI WSLGITAIEL AKGEPPHSDL HPMKVLFLIP KNSPPTLEGN 240

YSRSLKEFVE ACLNKEPSFR PTAKELLKHK FIIRNAKKTS YLTELIDRYK RWKAEQSHDD 300

SGSEDSDTET EGQASGGSDS GSWIFTIREK NPKNLENGTA QPQELERNEV EDIPSRPLSQ 360

CLSTIISPVF AELKEKSQAY GGNPESIDDL RSAIYVAEEA CPGISDAMVA HLVQRLQRYS 420

LSGGDTSTH 429

Nucleotide Sequence
(FASTA)

CTATTTTTTT CCCCCTTTCC CCATGCTTTT CAACAGAATC TAAAAGCAGA TCCAGAAGAA 60

CTCTTTACAA AACTGGAGAA AATTGGCAAG GGATCTTTTG GTGAAGTGTT TAAAGGTATT 120

GACAATCGAA CTCAGAAAGT GGTTGCTATA AAAATTATTG ATCTGGAAGA AGCAGAAGAT 180

GAAATTGAGG ACATTCAGCA GGAAATCACA GTGCTGAGTC AGTGTGACAG TCCGTATGTA 240

ACCAAGTATT ATGGTTCCTA TCTGAAGGAT ACCAAACTCT GGATAATCAT GGAGTATCTC 300

GGTGGTGGTT CTGCCCTAGA TCTATTAGAA CCTGGCTCTC TAGACGAAAT TCAGATTGCT 360

ACAATATTAA GAGAAATTCT GAAAGGACTC GACTATTTGC ATTCAGAAAA GAAAATCCAC 420

AGAGATATTA AAGCGGCCAA TGTTTTGCTG TCTGAACAAG GAGAAGTGAA ACTTGCAGAT 480

TTTGGAGTAG CAGGGCAGCT GACAGATACC CAAATAAAAA GAAATACCTT TGTGGGCACA 540

CCTTTTTGGA TGGCCCCTGA AGTAATAAAG CAGTCAGCGT ATGACTCAAA GGCAGACATC 600

TGGTCTTTGG GCATAACAGC CATCGAGCTT GCCAAGGGCG AACCGCCTCA TTCAGACCTG 660

CATCCAATGA AGGTTTTATT CCTCATCCCA AAGAACAGCC CGCCAACGCT GGAAGGCAAC 720

TACAGCAGAT CCCTCAAAGA GTTTGTTGAG GCCTGTTTGA ACAAGGAGCC AAGCTTTAGA 780

CCCACAGCCA AGGAGCTGTT GAAACACAAA TTCATCATTC GAAATGCCAA GAAAACATCG 840

TACTTGACCG AGCTCATTGA CAGGTACAAA AGATGGAAGG CTGAACAGAG CCATGACGAC 900

TCTGGCTCTG AGGACTCTGA TACGGAAACA GAAGGCCAGG CATCCGGTGG CAGTGACTCA 960

GGGTCCTGGA TCTTCACAAT CCGAGAAAAA AATCCCAAGA ATCTTGAGAA TGGAACAGCT 1020

CAGCCACAAG AATTGGAAAG AAATGAGGTA GAAGATATTC CGAGCCGGCC TTTGTCTCAG 1080

TGCTTATCCA CAATCATTTC TCCCGTATTT GCAGAGTTGA AAGAGAAGAG TCAGGCGTAT 1140

GGTGGTAACC CAGAGTCCAT AGATGATCTG AGAAGCGCTA TTTATGTAGC AGAGGAGGCA 1200

TGTCCAGGGA TCTCAGATGC CATGGTAGCC CATCTTGTAC AGAGGCTTCA AAGGTATTCT 1260

CTGAGTGGAG GAGACACGTC AACCCACTGA 1290

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekq.ekleelqkeisvlkklkhpniv  59

         ++ le+igkG++g+v+++ +++t+++vaik+i+le+  +++e++q+ei+vl+++++p+++

Q: 22    FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAeDEIEDIQQEITVLSQCDSPYVT  81

         7889*******************************99899********************

S: 60    eylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkv  119

         +y++s+lk+++lw++meyl gGs+ dl++     +l+E qia+ilre+lk+L+ylHs+k+

Q: 82    KYYGSYLKDTKLWIIMEYLGGGSALDLLE---PGSLDEIQIATILREILKGLDYLHSEKK  138

         *****************************...****************************

S: 120   iHrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYde  179

         iHrdika+n+Ll+e+geVkL+dfgva ql++t+ kr+t+vgtp+wmAPEvi+  ++ Yd+

Q: 139   IHRDIKAANVLLSEQGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIK--QSAYDS  196

         ****************************************************..9*****

S: 180   kaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclq  239

         kaDiwslGItaiela+gepP++dl+p+k+l++i+kn+pp+l+ +  +s+++kefve+cl+

Q: 197   KADIWSLGITAIELAKGEPPHSDLHPMKVLFLIPKNSPPTLEGN--YSRSLKEFVEACLN  254

         *****************************************776..**************

S: 240   knpekRpsasellkhkFl  257

         k+p++Rp+a+ellkhkF+

Q: 255   KEPSFRPTAKELLKHKFI  272

         *****************7

Domain Sequence
(FASTA)

FTKLEKIGKG SFGEVFKGID NRTQKVVAIK IIDLEEAEDE IEDIQQEITV LSQCDSPYVT 60

KYYGSYLKDT KLWIIMEYLG GGSALDLLEP GSLDEIQIAT ILREILKGLD YLHSEKKIHR 120

DIKAANVLLS EQGEVKLADF GVAGQLTDTQ IKRNTFVGTP FWMAPEVIKQ SAYDSKADIW 180

SLGITAIELA KGEPPHSDLH PMKVLFLIPK NSPPTLEGNY SRSLKEFVEA CLNKEPSFRP 240

TAKELLKHKF I 251

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006917	; P:induction of apoptosis
GO:0008631	; P:intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0030336	; P:negative regulation of cell migration
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013