EKS-ORA-00322

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORA-00322

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	440.9	1.4E-132	249	499	251

Status

Unreviewed

Ensembl Protein

ENSOANP00000008740

UniProt Accession

F6X6I5;

Protein Name

Protein Synonyms/Alias

Gene Name

LYN

Gene Synonyms/Alias

LYN;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000005501	ENSOANP00000008740	ENSOANT00000008742

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

514

Protein Sequence
(FASTA)

MGCIKSKRKD NLNDDGIDLK SQPVRNTDRT IYVRDPTSNK QQRPVLCSDS HLLPGQRFQS 60

KDPEEQGVIV VALYPYDGIH QDDLSFKKGE KLKVLEEHGE WWKAKSLSTK REGFIPSNYV 120

AKVNTLETEE WFFKDITRKD AERQLLAPGN SAGAFLIRES ETQKGSFSLS IRDFDPQQGD 180

VIKHYKIRSL DNGGYYISPR ITFTCISDMI KHYQKQSDGL CRRLEKVCIS PKPQKPWDKD 240

AWEIARESIK LVKKLGAGQF GEVWMGYYNN TTKVAVKTLK PGTMSVQAFL EEANLMKTLQ 300

HDKLVRLYAV VTKEEPIYII TEYMAKGSLL DFLKSDEGGK VLLPKLIDFS AQIAEGMAYI 360

ERKNYIHRDL RAANVLVSEA LKCKIADFGL ARIIEDNEYT AREGAKFPIK WTAPEAINFG 420

SFTIKSDVWS FGILLYEIVT YGKIPYPGRT NADVMTALQQ GYRMPRMENC PDELYDIMKM 480

CWKEKAEERP TFDYLQSVLD DFYTATEGQY QQQP 514

Nucleotide Sequence
(FASTA)

ATGGGATGTA TAAAATCAAA AAGGAAAGAC AATCTGAATG ACGATGGGAT AGATTTGAAG 60

AGCCAACCAG TACGTAATAC TGACCGAACT ATTTATGTGA GAGATCCAAC GTCCAATAAA 120

CAGCAAAGGC CAGTTCTCTG TTCAGACTCG CACCTTCTCC CAGGACAGAG GTTCCAAAGC 180

AAAGATCCAG AGGAACAAGG GGTCATTGTA GTAGCCTTGT ATCCCTACGA TGGCATTCAC 240

CAAGATGACT TATCTTTCAA GAAAGGAGAA AAATTGAAAG TCCTAGAGGA GCATGGAGAA 300

TGGTGGAAGG CTAAATCTCT CTCAACAAAA AGAGAAGGCT TCATTCCAAG CAATTACGTA 360

GCTAAAGTAA ACACCTTGGA AACCGAAGAG TGGTTCTTCA AGGATATAAC CAGGAAAGAT 420

GCAGAGAGAC AGCTTCTAGC TCCAGGAAAC AGTGCTGGAG CATTTCTTAT CAGAGAAAGT 480

GAAACACAAA AAGGCAGTTT CTCTCTCTCC ATCAGAGATT TTGACCCCCA GCAAGGTGAT 540

GTTATTAAGC ACTACAAAAT TAGAAGTCTG GACAATGGTG GCTATTATAT CTCTCCAAGA 600

ATTACTTTCA CCTGTATCAG CGACATGATC AAACATTACC AGAAGCAGTC AGATGGCTTA 660

TGCCGGCGGC TCGAAAAAGT GTGCATCAGT CCCAAACCAC AAAAACCGTG GGATAAAGAT 720

GCCTGGGAGA TTGCCCGTGA ATCCATTAAG CTAGTGAAGA AGCTTGGAGC TGGACAGTTT 780

GGAGAAGTCT GGATGGGTTA CTACAACAAT ACTACAAAAG TGGCCGTGAA AACCCTGAAG 840

CCCGGCACCA TGTCTGTTCA GGCTTTTCTG GAGGAAGCCA ACCTCATGAA GACCCTTCAG 900

CACGACAAGT TAGTCCGGCT GTACGCTGTG GTGACCAAAG AAGAGCCCAT TTACATCATC 960

ACAGAATACA TGGCAAAAGG CAGCCTGTTG GATTTTCTCA AGAGTGACGA AGGTGGCAAG 1020

GTTCTTCTGC CAAAGCTAAT CGACTTCTCT GCCCAGATCG CGGAGGGAAT GGCGTATATC 1080

GAAAGGAAGA ACTACATTCA CCGGGACCTG AGGGCGGCTA ACGTTTTGGT GTCGGAGGCA 1140

TTGAAGTGCA AAATAGCAGA TTTTGGCCTC GCTCGAATCA TCGAGGATAA TGAATACACG 1200

GCAAGAGAAG GTGCAAAGTT CCCCATTAAG TGGACGGCCC CAGAGGCGAT CAACTTTGGA 1260

TCCTTCACCA TCAAGTCGGA TGTCTGGTCC TTTGGAATTC TCCTGTATGA GATCGTAACC 1320

TACGGGAAAA TCCCCTACCC AGGGAGGACC AATGCTGACG TGATGACAGC TCTGCAGCAG 1380

GGCTACAGGA TGCCACGCAT GGAGAACTGT CCAGATGAGC TCTATGACAT CATGAAAATG 1440

TGCTGGAAGG AGAAAGCCGA AGAGAGGCCA ACATTTGATT ATTTACAGAG CGTGCTGGAC 1500

GACTTCTACA CGGCAACAGA AGGGCAGTAT CAACAACAGC CTTAG 1545

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         +klvkklG+GqfGevw+g++++++kvavktlk+gt+s +afleea+++k+l+h+klv+ly

Q: 249   IKLVKKLGAGQFGEVWMGYYNNTTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLY  308

         689*********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avv++eePiyi+te+makGslldflk++eg k+ lpkl+d++aq+aeGmay+e+kn+ihr

Q: 309   AVVTKEEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHR  368

         ************************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+nvlv+e l +k+adfGlar+ied+eyta+egak+PikWtaPeai++g+ftiksdv

Q: 369   DLRAANVLVSEALKCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDV  428

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGill+eivt+Gk+PypG tn++v++++++gyr+pr+e+cp+ely+++++cwk+++ee

Q: 429   WSFGILLYEIVTYGKIPYPGRTNADVMTALQQGYRMPRMENCPDELYDIMKMCWKEKAEE  488

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtf++lq+vl

Q: 489   RPTFDYLQSVL  499

         ********986

Domain Sequence
(FASTA)

IKLVKKLGAG QFGEVWMGYY NNTTKVAVKT LKPGTMSVQA FLEEANLMKT LQHDKLVRLY 60

AVVTKEEPIY IITEYMAKGS LLDFLKSDEG GKVLLPKLID FSAQIAEGMA YIERKNYIHR 120

DLRAANVLVS EALKCKIADF GLARIIEDNE YTAREGAKFP IKWTAPEAIN FGSFTIKSDV 180

WSFGILLYEI VTYGKIPYPG RTNADVMTAL QQGYRMPRME NCPDELYDIM KMCWKEKAEE 240

RPTFDYLQSV L 251

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005794	; C:Golgi apparatus
GO:0048471	; C:perinuclear region of cytoplasm
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0001782	; P:B cell homeostasis
GO:0050853	; P:B cell receptor signaling pathway
GO:0071300	; P:cellular response to retinoic acid
GO:0002774	; P:Fc receptor mediated inhibitory signaling pathway
GO:0002431	; P:Fc receptor mediated stimulatory signaling pathway
GO:0035556	; P:intracellular signal transduction
GO:0030889	; P:negative regulation of B cell proliferation
GO:0070373	; P:negative regulation of ERK1 and ERK2 cascade
GO:0043407	; P:negative regulation of MAP kinase activity
GO:0070667	; P:negative regulation of mast cell proliferation
GO:0002762	; P:negative regulation of myeloid leukocyte differentiation
GO:0034136	; P:negative regulation of toll-like receptor 2 signaling pathway
GO:0034144	; P:negative regulation of toll-like receptor 4 signaling pathway
GO:0018108	; P:peptidyl-tyrosine phosphorylation
GO:0002576	; P:platelet degranulation
GO:0030335	; P:positive regulation of cell migration
GO:2000670	; P:positive regulation of dendritic cell apoptotic process
GO:0070668	; P:positive regulation of mast cell proliferation
GO:0043552	; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0070304	; P:positive regulation of stress-activated protein kinase signaling cascade
GO:0042531	; P:positive regulation of tyrosine phosphorylation of STAT protein
GO:0002902	; P:regulation of B cell apoptotic process
GO:0050855	; P:regulation of B cell receptor signaling pathway
GO:0033628	; P:regulation of cell adhesion mediated by integrin
GO:0050707	; P:regulation of cytokine secretion
GO:0045646	; P:regulation of erythrocyte differentiation
GO:0050727	; P:regulation of inflammatory response
GO:0043304	; P:regulation of mast cell degranulation
GO:0090025	; P:regulation of monocyte chemotaxis
GO:0090330	; P:regulation of platelet aggregation
GO:0006974	; P:response to DNA damage stimulus
GO:0009725	; P:response to hormone stimulus
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

oaa:100079507

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013