EKS-ORA-00213

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORA-00213

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	333.6	7.7E-100	69	320	252

Status

Unreviewed

Ensembl Protein

ENSOANP00000008803

UniProt Accession

F6RTJ5;

Protein Name

Protein Synonyms/Alias

Gene Name

NUAK1

Gene Synonyms/Alias

NUAK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000005541	ENSOANP00000008803	ENSOANT00000008805

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

677

Protein Sequence
(FASTA)

MNTTTPPTPP TPRPPGMDGA AAPAGGPLGS GPPPDSTEAF PAAAAGGGEV RKQQGVKRHH 60

HKHNLKHRYE LQETLGKGTY GKVKRATERF SGRVVAIKSI RKDKIKDEQD MVHIRREIEI 120

MSSLNHPHII SIYEVFENKD KIVIIMEYAS KGELYDYISE RRRLSERETR HFFRQIVSAV 180

HYCHKSGVVH RDLKLENILL DDNCNIKIAD FGLSNLYQKD KFLQTFCGSP LYASPEIVNG 240

RPYRGPEVDS WALGVLLYTL VYGTMPFDGF DHKNLIRQIS SGEYREPTQP SDARGLIRWM 300

LMVNPERRAT IEDVANHWWV NWGYKNSVCD CDALRDSESP LLARIIDWHH RSTGLQAEAE 360

PKGKGLAKAG SSEAPLERQR SLKKSKKEND IVQSGQEGSA ESPSKSGSKR PKSILKKRSN 420

SEHRSHSAGF IEGVVSPGLL PTAFKLEQEL CSRTGGALPG KAEGDGPGPH GPKQAATMPK 480

KGILKKTQQR ESGYYSSPER SESSELLDSD AGPGAGDTSP GAGGPTRLGS PSLAYRRKGI 540

LKHSSKYAAD GMDSAPVSPD PPAPEAMEEA VGPGDGLSRS YSRPSSVISD DSILSSDSFD 600

LLDLQENRPT RQRIRSCVSA ENVLQIQDFE GLQNRPRPQY LKRYRNRLGD SSFSLLADMD 660

DVTQVYKKAL EICNKLN 677

Nucleotide Sequence
(FASTA)

ATGAATACTA CTACCCCCCC GACCCCCCCG ACCCCCCGAC CCCCGGGGAT GGACGGGGCT 60

GCGGCGCCCG CCGGCGGCCC GCTCGGCTCG GGGCCCCCGC CCGACAGCAC GGAGGCCTTC 120

CCGGCGGCGG CGGCGGGCGG CGGGGAGGTG CGGAAGCAGC AGGGGGTGAA GCGCCATCAC 180

CACAAGCACA ACCTGAAGCA TCGCTACGAG CTGCAGGAGA CCCTGGGCAA GGGCACCTAC 240

GGAAAAGTCA AGCGGGCCAC CGAGAGGTTT TCCGGCAGAG TGGTTGCAAT AAAATCCATT 300

CGCAAGGACA AAATTAAGGA TGAACAAGAC ATGGTTCACA TCCGACGGGA GATTGAGATC 360

ATGTCATCCC TCAACCATCC TCATATCATC AGTATATATG AAGTGTTTGA AAACAAGGAT 420

AAGATTGTGA TTATCATGGA ATATGCCAGT AAAGGCGAGC TATATGATTA CATCAGCGAG 480

AGGCGAAGGC TCAGCGAAAG AGAAACAAGA CATTTCTTCC GGCAAATAGT CTCTGCCGTC 540

CACTACTGTC ACAAGAGCGG TGTCGTCCAT CGGGACTTAA AGCTGGAAAA CATCTTGCTC 600

GATGACAACT GCAACATCAA GATTGCTGAC TTTGGCCTCT CCAATCTGTA CCAAAAGGAT 660

AAATTTCTTC AGACGTTCTG TGGCAGCCCA CTATACGCGT CCCCCGAAAT TGTCAACGGG 720

AGACCTTACC GAGGCCCAGA GGTTGACAGC TGGGCTTTGG GTGTGTTGCT TTACACTCTG 780

GTTTATGGAA CGATGCCTTT CGACGGCTTT GATCACAAAA ATCTAATCCG GCAGATCAGC 840

AGTGGAGAGT ACCGTGAGCC AACGCAGCCT TCAGATGCCC GAGGCTTGAT CCGCTGGATG 900

CTGATGGTGA ATCCTGAACG GCGGGCCACC ATCGAGGACG TTGCCAATCA CTGGTGGGTC 960

AACTGGGGCT ATAAGAACAG CGTCTGCGAC TGCGATGCCC TGAGAGACTC CGAGTCCCCG 1020

CTGCTGGCCC GGATCATCGA CTGGCATCAC CGGTCCACGG GCCTGCAGGC CGAGGCCGAG 1080

CCGAAGGGCA AGGGCCTGGC CAAAGCCGGG AGCTCAGAAG CACCCCTGGA ACGGCAGCGG 1140

TCGCTGAAGA AATCCAAGAA GGAGAATGAC ATCGTGCAGT CCGGCCAGGA GGGCTCGGCG 1200

GAAAGCCCGT CCAAGTCTGG CTCCAAGAGG CCCAAGAGCA TCTTGAAGAA GAGGAGCAAC 1260

AGCGAGCACC GATCCCACAG TGCCGGGTTC ATCGAGGGGG TGGTCAGCCC CGGGCTCCTC 1320

CCCACTGCCT TCAAGCTGGA ACAGGAGTTG TGCAGTAGGA CCGGGGGCGC CCTGCCGGGG 1380

AAGGCCGAGG GGGATGGCCC AGGCCCACAC GGACCCAAGC AGGCAGCCAC CATGCCCAAG 1440

AAAGGGATCT TAAAAAAGAC CCAGCAACGA GAATCCGGCT ACTACTCCTC TCCGGAGCGC 1500

AGCGAGTCAT CCGAGCTGCT GGACAGCGAT GCCGGACCGG GGGCCGGCGA CACCTCCCCT 1560

GGGGCGGGAG GCCCCACGAG GTTAGGCTCC CCCAGCCTCG CTTACCGCAG GAAGGGCATC 1620

CTGAAGCACA GCAGCAAGTA TGCCGCCGAC GGCATGGACT CGGCCCCGGT CAGCCCCGAC 1680

CCGCCCGCGC CGGAAGCGAT GGAGGAGGCG GTCGGGCCGG GGGACGGCCT CTCCCGAAGT 1740

TACAGTCGCC CTTCCAGCGT GATCAGCGAC GACAGCATCC TGTCCAGTGA CTCCTTTGAC 1800

TTGCTGGACT TGCAGGAGAA CCGGCCCACC CGGCAGAGGA TCCGGAGCTG TGTTTCTGCC 1860

GAGAACGTCC TCCAGATCCA GGATTTCGAG GGGCTCCAGA ACCGCCCCCG CCCCCAGTAC 1920

CTGAAACGCT ACCGGAACCG ACTGGGAGAC AGCAGCTTTT CCCTGCTTGC GGACATGGAC 1980

GATGTGACTC AGGTCTACAA AAAAGCTCTA GAGATCTGCA ACAAGCTCAA CTAG 2034

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkkl.seeslekikrEieilkklkhpn  59

         y+l++tlG+g++gkVk a+++  ++ va+K i+k+k+ +e+ + +i+rEiei+++l+hp+

Q: 69    YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIkDEQDMVHIRREIEIMSSLNHPH  128

         99**********************************95667788****************

S: 60    iikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgi  119

         ii+++ev+e+k+k+++++eyas+geL+dyi+e++rl+e+e+r++f+q+vsav+Y+h++g+

Q: 129   IISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKSGV  188

         ************************************************************

S: 120   vHrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkv  179

         vHrDlK+eN+lld++ nikiaDFGl+nl++++k l+tfcGsp Ya+Pe+++g++Y+gp+v

Q: 189   VHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEV  248

         ************************************************************

S: 180   DvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpek  239

         D W+lGv+Ly+lv+g++Pfd+ + k+l ++i++g+++ p++  ++++ L+r +L+v+pe+

Q: 249   DSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQ-PSDARGLIRWMLMVNPER  307

         ***************************************99.7789**************

S: 240   Ratieeilkhewl  252

         Ratie++ +h w+

Q: 308   RATIEDVANHWWV  320

         ************6

Domain Sequence
(FASTA)

YELQETLGKG TYGKVKRATE RFSGRVVAIK SIRKDKIKDE QDMVHIRREI EIMSSLNHPH 60

IISIYEVFEN KDKIVIIMEY ASKGELYDYI SERRRLSERE TRHFFRQIVS AVHYCHKSGV 120

VHRDLKLENI LLDDNCNIKI ADFGLSNLYQ KDKFLQTFCG SPLYASPEIV NGRPYRGPEV 180

DSWALGVLLY TLVYGTMPFD GFDHKNLIRQ ISSGEYREPT QPSDARGLIR WMLMVNPERR 240

ATIEDVANHW WV 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0030155	; P:regulation of cell adhesion
GO:2000772	; P:regulation of cellular senescence
GO:0035507	; P:regulation of myosin-light-chain-phosphatase activity

KEGG

oaa:100076959

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013