EKS-ORA-00373

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORA-00373

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/WEE	369.0	1.4E-110	144	414	271

Status

Unreviewed

Ensembl Protein

ENSOANP00000009321

UniProt Accession

F6XVD1;

Protein Name

Protein Synonyms/Alias

Gene Name

WEE1

Gene Synonyms/Alias

WEE1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000005854	ENSOANP00000009321	ENSOANT00000009323

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

491

Protein Sequence
(FASTA)

RSAGTASASP VPDYPGTPPH KTFRKLRLFD TPHTPKSLLS KARGLDSSSV KLRGGSLFMS 60

SGRSEKQGFD MRQTPQVNIN PFTPDSMLLH SSGQCRRRKR THWNDSCGED MEASDGELED 120

EATRPAKRIT ITESNMTSRY ASEFHELEKI GSGEFGSVFK CVKRLDGCIY AIKRSKKPLA 180

GSVDEQNALR EVYAHAVLGQ HAHVVRYFSA WAEDDHMLIQ NEYCNGGSLA DAISENYRSM 240

NYYTQAELKD LLLQVGRGLR YIHSMSLVHM DIKPSNIFIS RTSVPGNTSE EGDEDEWSSN 300

RVIFKIGDLG HVTRMSSPQV EEGDSRFLAN EVLQENYTHL PKADIFALAL TVICAAGAEP 360

LPTNGDQWHE IRQGKLPRMP QVLSQELTDL LKLMIHPDPE RRPSAVALVK HSVLLSASRK 420

SAEQLRIELN AEKFKNSLLQ KELKKAQLAK AAAEERALFT DRMATRSATQ SNRTSRLIGK 480

KMNRSLSLTI Y 491

Nucleotide Sequence
(FASTA)

CGCTCGGCGG GGACCGCCTC CGCCTCCCCG GTGCCCGACT ACCCCGGGAC CCCGCCGCAC 60

AAGACCTTCC GAAAGCTGAG GCTCTTCGAC ACCCCGCACA CCCCCAAGAG TTTGCTCTCC 120

AAAGCTCGAG GACTAGATTC CAGCTCTGTT AAACTGCGAG GTGGCTCTCT GTTTATGAGT 180

TCAGGAAGAT CAGAGAAGCA AGGATTTGAC ATGAGACAGA CGCCACAAGT GAATATTAAC 240

CCTTTCACAC CAGATTCCAT GTTACTTCAC TCTTCTGGGC AGTGTCGGCG CAGAAAGAGA 300

ACACACTGGA ACGATTCATG TGGTGAGGAC ATGGAAGCTA GTGATGGAGA GCTTGAAGAT 360

GAAGCAACCA GGCCTGCCAA GAGAATTACA ATTACAGAAA GTAACATGAC TTCAAGATAC 420

GCATCTGAAT TTCATGAGCT GGAGAAAATC GGGTCTGGAG AATTTGGTTC AGTCTTTAAG 480

TGTGTGAAGA GGCTAGATGG ATGTATCTAT GCCATAAAAC GATCTAAGAA GCCTTTGGCC 540

GGTTCTGTTG ATGAGCAGAA TGCTTTAAGA GAAGTTTATG CACATGCAGT GCTGGGGCAG 600

CATGCTCACG TGGTTCGATA CTTCTCAGCC TGGGCAGAAG ACGATCATAT GCTCATACAG 660

AACGAATATT GTAATGGTGG AAGTTTAGCT GATGCCATAA GCGAGAACTA CAGGAGTATG 720

AACTATTATA CTCAAGCAGA ACTGAAAGAT CTCCTCCTGC AGGTTGGCCG GGGCTTGCGA 780

TATATCCATT CAATGTCTTT GGTGCATATG GATATAAAAC CTAGTAATAT CTTCATATCG 840

AGGACATCAG TCCCAGGTAA TACTTCTGAA GAAGGAGATG AAGATGAATG GTCATCTAAC 900

AGAGTTATTT TTAAAATAGG TGACCTTGGA CATGTAACTA GAATGTCTAG TCCACAGGTA 960

GAAGAGGGTG ATAGTCGTTT TCTGGCAAAT GAAGTTTTAC AAGAGAATTA CACTCACTTG 1020

CCAAAAGCCG ACATCTTTGC TCTTGCTCTT ACTGTGATAT GTGCTGCTGG AGCTGAACCG 1080

CTTCCCACCA ATGGAGACCA GTGGCATGAA ATTCGACAGG GAAAACTGCC CAGGATGCCA 1140

CAAGTGCTTT CCCAAGAATT AACAGATTTG TTAAAACTTA TGATTCACCC AGATCCGGAG 1200

AGAAGACCAT CAGCAGTGGC ATTAGTCAAA CACTCAGTGC TGCTGTCAGC ATCCAGGAAG 1260

AGTGCAGAAC AGTTGCGAAT AGAATTGAAT GCTGAAAAGT TCAAAAATTC ACTCTTGCAG 1320

AAAGAACTGA AGAAGGCACA GCTGGCAAAA GCAGCAGCAG AGGAAAGAGC ACTATTCACA 1380

GATAGAATGG CAACCAGGTC TGCAACGCAG AGTAACAGAA CGTCTCGACT CATCGGAAAG 1440

AAAATGAATC GCTCTCTTAG CCTTACTATA TATTGA 1476

Domain Profile

S: 1     FeevekiGkGefgevfkvvkredgklyAikkskkplkglskekkalrEvtahavlgqhen  60

         F+e+ekiG+Gefg+vfk+vkr+dg++yAik+skkpl+g+++e++alrEv+ahavlgqh +

Q: 144   FHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHAH  203

         99**********************************************************

S: 61    vvryisaWeeddslyiqtElCeggsLeaalqeceakkkaleeaelkkilldlllglrylH  120

         vvry+saW+edd+++iq+E+C+ggsL++a++e+++++++ ++aelk++ll++ +glry+H

Q: 204   VVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRSMNYYTQAELKDLLLQVGRGLRYIH  263

         ************************************************************

S: 121   ssslvHlDikpenifi...................tkevtlklgDlGlvtelnsedkskv  161

         s+slvH+Dikp+nifi                   +++v++k+gDlG+vt++   ++++v

Q: 264   SMSLVHMDIKPSNIFIsrtsvpgntseegdedewsSNRVIFKIGDLGHVTRM---SSPQV  320

         ****************************************************...9****

S: 162   eEGDsrylakEilqeeyskl.kaDiFslgltilevaanvelPsnGeaWhklRkgklpdei  220

         eEGDsr+la+E+lqe+y++l kaDiF+l+lt++++a++++lP+nG++Wh++R+gklp ++

Q: 321   EEGDSRFLANEVLQENYTHLpKADIFALALTVICAAGAEPLPTNGDQWHEIRQGKLP-RM  379

         *********************************************************.**

S: 221   lkelsedlrellklmlepdperRptaeellkhevl  255

          ++ls++l++llklm++pdperRp+a +l+kh+vl

Q: 380   PQVLSQELTDLLKLMIHPDPERRPSAVALVKHSVL  414

         ********************************986

Domain Sequence
(FASTA)

FHELEKIGSG EFGSVFKCVK RLDGCIYAIK RSKKPLAGSV DEQNALREVY AHAVLGQHAH 60

VVRYFSAWAE DDHMLIQNEY CNGGSLADAI SENYRSMNYY TQAELKDLLL QVGRGLRYIH 120

SMSLVHMDIK PSNIFISRTS VPGNTSEEGD EDEWSSNRVI FKIGDLGHVT RMSSPQVEEG 180

DSRFLANEVL QENYTHLPKA DIFALALTVI CAAGAEPLPT NGDQWHEIRQ GKLPRMPQVL 240

SQELTDLLKL MIHPDPERRP SAVALVKHSV L 271

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0030010	; P:establishment of cell polarity
GO:0000226	; P:microtubule cytoskeleton organization
GO:0007067	; P:mitosis
GO:0018108	; P:peptidyl-tyrosine phosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR017164	; Wee1-like_protein_kinase.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013