EKS-ORA-00355
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORA-00355
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/IRAK351.83.2E-105164442279
StatusUnreviewed
Ensembl ProteinENSOANP00000009429
UniProt AccessionF6QM19;
Protein Name
Protein Synonyms/Alias
Gene NameIRAK3
Gene Synonyms/Alias IRAK3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOANG00000005923ENSOANP00000009429ENSOANT00000009431
OrganismOrnithorhynchus anatinus
Functional Description
Protein Length615
Protein Sequence
(FASTA)
MGSSGPVPAG TALLDLPPLL LGRLCALLDG AHGPLGWRDL AERLSSNWLE VRHFEKYVQQ 60
GRSGTRELLW SWAQKNKTVG DLLQVLEDMG HQRAIDCLTN PGESLNISPS QTCQRDGFQS 120
RASKKTADSA VGNEVLSPPK YQHQGIRPKA SIDFKSIIEG TGNFHGDLLI GEGEFFQVYR 180
MEFENQTYAI KLFKQEKTMQ SKKYWKPFFS ELEVLLLFHH PNILELTAYF IEAERFCLVY 240
PFMRHGSLFD RLQCLGNTAP LSWKVRLGVL IGVARAIQVL HSAKPCSVIS GSITSTNILL 300
DDQFQPKLTD FATVHLQPQT DCRSFTVSTK SNAAKHLWYM PEEYLRQSRL STKTDVYSFG 360
IIIMEVLTGC KVVMEEPKHI QLRDLLMEMM EKRGLDSCFS LLDKKVEACP RNFSAKLLTL 420
AGQCATSRAK SRPSMDEVLE TLETTRPALY FTEDPPASLR SFRPPSPLFL DLLPSVPVED 480
DENLPLSGEE PNRHGVDRKT PLECSQSEVT FLGCVQRVAT DDASHGASGE GGGPSKSDAY 540
LWPFTAGCVE PGSLAEAAGF PHEIRSGDGY RPPVGYRGDS EEDTKGGLRM ILPEEKEKER 600
CLNSKPLTSE GSNTL 615
Nucleotide Sequence
(FASTA)
ATGGGGTCCT CGGGCCCCGT CCCGGCGGGC ACCGCCCTGC TCGACCTGCC CCCGCTACTG 60
TTGGGACGCC TCTGCGCCCT GCTGGACGGC GCCCACGGCC CCCTCGGGTG GAGGGACCTC 120
GCCGAGAGAC TGTCAAGCAA CTGGCTGGAA GTTCGACATT TTGAAAAATA CGTTCAACAG 180
GGGAGGAGCG GGACGAGAGA ATTACTATGG TCCTGGGCGC AGAAAAACAA GACCGTCGGT 240
GACCTTCTGC AGGTCCTGGA GGACATGGGC CATCAGCGAG CCATCGACTG CCTCACCAAC 300
CCAGGAGAAT CGCTAAATAT TTCGCCAAGT CAGACCTGTC AAAGAGATGG ATTTCAAAGT 360
CGGGCTTCCA AGAAAACAGC TGACTCCGCA GTTGGTAATG AAGTTCTTTC TCCTCCTAAG 420
TACCAGCATC AAGGAATACG CCCTAAAGCC TCAATCGATT TTAAAAGCAT CATAGAAGGA 480
ACGGGAAACT TCCACGGTGA CTTGCTAATT GGAGAAGGGG AATTTTTCCA AGTCTACAGA 540
ATGGAGTTTG AAAATCAAAC ATATGCCATT AAATTATTTA AACAGGAGAA AACTATGCAG 600
AGTAAGAAAT ACTGGAAGCC ATTTTTCTCA GAACTGGAAG TTTTACTCCT GTTTCATCAT 660
CCAAACATCT TGGAACTGAC CGCATACTTT ATAGAGGCGG AAAGATTCTG TTTGGTGTAT 720
CCGTTCATGA GACATGGTTC GCTTTTTGAC AGATTACAGT GTTTGGGTAA CACGGCCCCA 780
CTTTCTTGGA AAGTTCGCCT CGGTGTATTG ATCGGGGTTG CCCGAGCCAT CCAGGTCTTA 840
CACAGTGCTA AACCGTGTTC CGTCATCAGT GGCAGCATAA CCAGCACAAA CATCCTTTTG 900
GACGATCAGT TTCAACCCAA ATTAACCGAT TTTGCTACGG TGCATCTGCA ACCCCAGACT 960
GACTGCCGCA GTTTTACCGT AAGCACCAAG AGCAATGCAG CAAAGCACTT GTGGTACATG 1020
CCCGAAGAGT ATTTAAGACA GAGCAGACTT TCCACTAAGA CAGACGTCTA CAGCTTTGGA 1080
ATTATTATTA TGGAAGTTCT GACGGGTTGC AAGGTGGTGA TGGAGGAGCC GAAACACATC 1140
CAGCTGAGGG ATCTCCTCAT GGAGATGATG GAGAAAAGAG GCCTTGATTC CTGCTTCTCA 1200
TTATTGGACA AGAAAGTGGA GGCGTGTCCT CGGAATTTCT CTGCGAAACT GCTCACGCTA 1260
GCTGGCCAGT GTGCCACGTC CCGTGCCAAG TCTAGACCTT CCATGGATGA AGTCCTGGAA 1320
ACCCTGGAGA CCACTCGTCC GGCTCTGTAT TTTACCGAAG ATCCCCCCGC GTCATTGCGG 1380
TCCTTCAGGC CTCCTTCCCC TCTTTTCCTA GACCTCTTAC CGAGCGTCCC AGTGGAAGAC 1440
GATGAAAATC TCCCTCTTTC CGGGGAAGAA CCGAACCGAC ATGGGGTGGA CCGGAAAACC 1500
CCACTCGAAT GCAGTCAGTC CGAAGTCACG TTTCTGGGCT GCGTCCAAAG AGTAGCCACT 1560
GATGATGCTT CCCACGGGGC CAGTGGGGAA GGTGGAGGAC CGTCCAAATC TGACGCTTAC 1620
CTCTGGCCCT TCACAGCCGG CTGTGTGGAA CCCGGCTCCC TGGCCGAGGC TGCCGGTTTT 1680
CCTCATGAGA TCCGGTCGGG AGATGGCTAC CGTCCACCCG TGGGCTATAG GGGGGACTCT 1740
GAAGAGGACA CGAAGGGTGG TTTAAGAATG ATTCTCCCTG AAGAGAAAGA AAAAGAGAGG 1800
TGTCTTAATT CTAAACCCTT AACTTCGGAG GGAAGCAACA CACTATAA 1848
Domain Profile
S: 1     fsednrigeGgfgevyrgelkntavavkklkeeadlslkelkqsfltElkvlarfrHdni  60
         f+ d  igeG+f++vyr e++n+++a+k +k+e+ ++ k+ ++ f +El+vl+ f+H+ni
Q: 164   FHGDLLIGEGEFFQVYRMEFENQTYAIKLFKQEKTMQSKKYWKPFFSELEVLLLFHHPNI  223
         78999*******************************************************
S: 61    lellgysaeseklcLvYqymknGsLedrLqcqkgsepLsWpqRlsillGtaraiefLHea  120
         lel +y++e e++cLvY++m+ GsL+drLqc ++++pLsW++Rl +l+G+arai+ LH+a
Q: 224   LELTAYFIEAERFCLVYPFMRHGSLFDRLQCLGNTAPLSWKVRLGVLIGVARAIQVLHSA  283
         ************************************************************
S: 121   sp.slihgdiksaNiLLDekltpKlgDfglarfapesekqsstvlrtskvrgtlaYlpee  179
         +p s+i g+i s+NiLLD++++pKl+Df+ ++++p+++  s tv + s+  ++l+Y+pee
Q: 284   KPcSVISGSITSTNILLDDQFQPKLTDFATVHLQPQTDCRSFTVSTKSNAAKHLWYMPEE  343
         ************************************************************
S: 180   firvgqltvkvDvySfGiVllEvltGlravdedrktkyLkdllkeeieeekveilekfld  239
         ++r+ +l++k+DvySfGi+++EvltG+++v e++k+ +L+dll+e +e+++++++ + ld
Q: 344   YLRQSRLSTKTDVYSFGIIIMEVLTGCKVVMEEPKHIQLRDLLMEMMEKRGLDSCFSLLD  403
         ************************************************************
S: 240   kkagkleeellealielalaclaekakkrPtmsqvlell  278
         kk+  ++++++++l++la++c+ ++ak rP+m++vle+l
Q: 404   KKVEACPRNFSAKLLTLAGQCATSRAKSRPSMDEVLETL  442
         ************************************987
Domain Sequence
(FASTA)
FHGDLLIGEG EFFQVYRMEF ENQTYAIKLF KQEKTMQSKK YWKPFFSELE VLLLFHHPNI 60
LELTAYFIEA ERFCLVYPFM RHGSLFDRLQ CLGNTAPLSW KVRLGVLIGV ARAIQVLHSA 120
KPCSVISGSI TSTNILLDDQ FQPKLTDFAT VHLQPQTDCR SFTVSTKSNA AKHLWYMPEE 180
YLRQSRLSTK TDVYSFGIII MEVLTGCKVV MEEPKHIQLR DLLMEMMEKR GLDSCFSLLD 240
KKVEACPRNF SAKLLTLAGQ CATSRAKSRP SMDEVLETL 279
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>
EKS-AIM-00378
EKS-BOT-00407
EKS-CAJ-00410
EKS-CAF-00407
EKS-CAP-00435
EKS-DAR-00794
EKS-ECT-00006
EKS-EQC-00399
EKS-FEC-00390
EKS-GAA-00494
EKS-HOS-00413
EKS-ICT-00386
EKS-LAC-00422
EKS-LOA-00416
EKS-MAM-00405
EKS-MOD-00398
EKS-MUM-00439
EKS-MUP-00401
EKS-MYL-00402
EKS-NOL-00370
EKS-OCP-00086
EKS-ORC-00382
EKS-OTG-00409
EKS-PAT-00385
EKS-PEM-00222
EKS-POA-00397
EKS-RAN-00421
EKS-SAH-00378
EKS-SUS-00359
EKS-TUT-00121
EKS-VIP-00063
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0070498; P:interleukin-1-mediated signaling pathway
GO:0045824; P:negative regulation of innate immune response
GO:0010936; P:negative regulation of macrophage cytokine production
GO:0043407; P:negative regulation of MAP kinase activity
GO:0032088; P:negative regulation of NF-kappaB transcription factor activity
GO:0042177; P:negative regulation of protein catabolic process
GO:0043242; P:negative regulation of protein complex disassembly
GO:0034122; P:negative regulation of toll-like receptor signaling pathway
GO:0032720; P:negative regulation of tumor necrosis factor production
GO:0010933; P:positive regulation of macrophage tolerance induction
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity
GO:0046777; P:protein autophosphorylation
GO:0043330; P:response to exogenous dsRNA
KEGG
InterPros
IPR000488; Death.
IPR011029; DEATH-like.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
Pfam
PF00531; Death; 1.
PF00069; Pkinase; 1.
SMARTs
Prosites
PS50017; DEATH_DOMAIN; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
Created Date20-Feb-2013