EKS-ORA-00232
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORA-00232
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/DYRK464.52.1E-139151464314
StatusUnreviewed
Ensembl ProteinENSOANP00000009442
UniProt AccessionF6PQX9;
Protein Name
Protein Synonyms/Alias
Gene NameDYRK2
Gene Synonyms/Alias DYRK2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOANG00000005931ENSOANP00000009442ENSOANT00000009444
OrganismOrnithorhynchus anatinus
Functional Description
Protein Length529
Protein Sequence
(FASTA)
MHAMTDHLHV GGHGQIQVQQ LFEDGSNKRA VLTAQPNGLT PVGKPGPPTA PADRQPDGAH 60
RRQGSAGSLK SLEGGGRPKP AALTPEQAVK QYLQKLTAFE QHEIAAYPEI YFLGPNAKKR 120
LGAAGGPNNG GYDDDQGSYV QVPHDHVAYR YEVLKVIGKG SFGQVVKAFD HKAQHHVALK 180
MVRNEKRFHR QAAEEIRILE HLRKQDRDNS MNVIHMLESF TFRNHICMTF ELLSMNLYEL 240
IKKNKFQGFS LPLVRKFAHS ILQCLEALHR NRIIHCDLKP ENILLKQQGR SGIKVIDFGS 300
SCYEHQRVYT YIQSRFYRAP EVILGARYGM PIDMWSLGCI LAELLTGYPL LPGEDEGDQL 360
ACMIELLGMP APKLLDASKR AKNFVSSKGY PRYCAVTTLS DGSVVLNGGR SRRGKLRGPP 420
ESRDWAKALK GCDDPLFLDF LKQCLEWDPA LRLSPGQALR HPWLRRRLPK PPTADKPVAR 480
RAPETTGAIT SISKLPPPSG SAKLRTSLAQ MTDANGNIQQ RTVLPKLVS 529
Nucleotide Sequence
(FASTA)
ATGCACGCGA TGACCGACCA CCTGCACGTC GGCGGTCACG GACAGATCCA GGTCCAGCAG 60
CTCTTCGAAG ACGGCAGTAA CAAGCGGGCG GTCCTGACGG CCCAACCCAA CGGGCTGACG 120
CCCGTCGGGA AGCCCGGCCC GCCCACGGCG CCCGCGGACC GGCAGCCGGA CGGTGCCCAC 180
AGGCGGCAGG GGAGCGCCGG GTCCCTCAAG TCGCTGGAGG GCGGCGGGCG GCCCAAGCCC 240
GCGGCCCTGA CCCCGGAGCA GGCCGTGAAG CAGTACCTGC AGAAGTTGAC GGCCTTCGAG 300
CAGCACGAGA TCGCCGCCTA CCCCGAGATC TACTTCCTGG GGCCCAACGC CAAGAAGAGG 360
CTGGGCGCGG CGGGGGGCCC CAACAACGGG GGCTACGACG ACGACCAGGG CTCCTACGTG 420
CAGGTCCCCC ACGACCACGT GGCCTACCGC TACGAGGTCC TCAAGGTGAT CGGCAAAGGC 480
AGCTTCGGCC AGGTGGTGAA GGCCTTCGAC CACAAGGCCC AGCACCACGT GGCCCTGAAG 540
ATGGTGCGGA ACGAGAAGCG GTTCCACCGG CAGGCCGCCG AGGAGATCCG CATCCTGGAG 600
CACCTCCGCA AGCAGGACCG GGACAACAGC ATGAACGTCA TCCACATGCT GGAGAGCTTC 660
ACCTTCCGCA ACCACATCTG CATGACCTTC GAGCTGCTGA GCATGAACCT CTACGAGCTG 720
ATCAAGAAGA ACAAGTTCCA AGGGTTCAGC CTGCCGCTGG TCCGCAAGTT CGCCCACTCG 780
ATCCTCCAGT GCCTGGAGGC CCTGCACCGC AACCGGATCA TCCACTGCGA CCTGAAGCCG 840
GAGAACATCC TGCTCAAGCA GCAGGGCCGC AGCGGCATCA AGGTGATCGA CTTCGGCTCC 900
AGTTGCTACG AGCACCAGCG CGTCTACACC TACATCCAGT CGCGGTTCTA CCGGGCCCCG 960
GAGGTCATCC TGGGGGCCCG CTACGGGATG CCCATCGACA TGTGGAGCCT GGGCTGCATC 1020
CTGGCCGAGC TCCTCACCGG CTACCCGCTC CTGCCGGGCG AGGACGAGGG GGACCAGCTG 1080
GCCTGCATGA TCGAGCTGCT GGGGATGCCC GCCCCCAAGC TGCTGGACGC CTCCAAGCGG 1140
GCCAAGAACT TCGTCAGCTC CAAGGGCTAC CCCCGCTACT GCGCCGTGAC CACCCTGTCC 1200
GACGGGTCGG TGGTCCTCAA CGGGGGCCGG TCGCGCAGGG GGAAGCTCCG GGGGCCCCCG 1260
GAGAGCCGGG ACTGGGCCAA GGCGCTCAAG GGCTGCGACG ACCCCCTCTT CCTCGACTTC 1320
TTGAAACAGT GTCTGGAGTG GGACCCTGCC TTGCGTCTGA GCCCGGGGCA GGCCCTGCGC 1380
CACCCCTGGC TGAGGCGGCG CCTGCCCAAG CCCCCCACGG CGGACAAGCC CGTGGCCCGG 1440
CGGGCCCCCG AGACCACCGG TGCTATCACT TCCATTTCCA AGTTACCTCC CCCCTCCGGC 1500
TCCGCCAAGC TGAGGACTAG CCTGGCGCAG ATGACCGACG CCAACGGCAA CATTCAGCAG 1560
AGGACGGTCT TGCCCAAACT GGTCAGCTGA 1590
Domain Profile
S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60
         yevl+vigkGsfgqVvka d+k++++va+k+++n+krf+rqa+eE++iLe+l+k+d++++
Q: 151   YEVLKVIGKGSFGQVVKAFDHKAQHHVALKMVRNEKRFHRQAAEEIRILEHLRKQDRDNS  210
         9***********************************************************
S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120
         +nv+++le+f+frnh+c++fells+nLyel+kknkf+g+sl lvrk+a++il++L++L++
Q: 211   MNVIHMLESFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLEALHR  270
         ************************************************************
S: 121   lkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglkyd  180
         ++iiH+DlKPeNill++++rs +kviDFGss++++q+ +ytyiqsrfYraPE+ilg++y 
Q: 271   NRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQR-VYTYIQSRFYRAPEVILGARYG  329
         *************************************.**********************
S: 181   eaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftkke  240
         + iDmWSlGc+laEl+tG+pL+pGe+e dqla+++e+lg+p++kll+++k+ak+f+++k+
Q: 330   MPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPAPKLLDASKRAKNFVSSKG  389
         ************************************************************
S: 241   apkyilktkksdrkkklvlnvkkaakkrkaplskelgealkekedklfkdllkrmleldp  300
         +p+y+ +t+ sd +++l+ ++++++k r +p+s+++++alk ++d lf d+lk++le+dp
Q: 390   YPRYCAVTTLSDGSVVLNGGRSRRGKLRGPPESRDWAKALKGCDDPLFLDFLKQCLEWDP  449
         ************************************************************
S: 301   akRitpkealkhpfv  315
         a R++p +al+hp++
Q: 450   ALRLSPGQALRHPWL  464
         **************6
Domain Sequence
(FASTA)
YEVLKVIGKG SFGQVVKAFD HKAQHHVALK MVRNEKRFHR QAAEEIRILE HLRKQDRDNS 60
MNVIHMLESF TFRNHICMTF ELLSMNLYEL IKKNKFQGFS LPLVRKFAHS ILQCLEALHR 120
NRIIHCDLKP ENILLKQQGR SGIKVIDFGS SCYEHQRVYT YIQSRFYRAP EVILGARYGM 180
PIDMWSLGCI LAELLTGYPL LPGEDEGDQL ACMIELLGMP APKLLDASKR AKNFVSSKGY 240
PRYCAVTTLS DGSVVLNGGR SRRGKLRGPP ESRDWAKALK GCDDPLFLDF LKQCLEWDPA 300
LRLSPGQALR HPWL 314
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00248
EKS-ANC-00254
EKS-BOT-00265
EKS-CAE-00237
EKS-CAJ-00271
EKS-CAF-00272
EKS-CAP-00300
EKS-CHH-00017
EKS-CII-00159
EKS-CIS-00039
EKS-DAR-00600
EKS-DAN-00013
EKS-DRM-00136
EKS-ECT-00027
EKS-EQC-00257
EKS-ERE-00019
EKS-FEC-00251
EKS-GAM-00163
EKS-GAG-00222
EKS-GAA-00325
EKS-GOG-00265
EKS-HOS-00271
EKS-ICT-00250
EKS-LAC-00277
EKS-LOA-00275
EKS-MAM-00267
EKS-MAE-00016
EKS-MEG-00210
EKS-MOD-00263
EKS-MUM-00296
EKS-MUP-00262
EKS-MYL-00267
EKS-NOL-00243
EKS-OCP-00023
EKS-ORN-00342
EKS-ORC-00250
EKS-ORL-00319
EKS-OTG-00271
EKS-PAT-00250
EKS-PES-00235
EKS-PEM-00140
EKS-POA-00258
EKS-PRC-00021
EKS-PTV-00034
EKS-RAN-00280
EKS-SAH-00249
EKS-SOA-00021
EKS-SUS-00230
EKS-TAG-00280
EKS-TAR-00338
EKS-TEN-00333
EKS-TUB-00020
EKS-TUT-00030
EKS-XET-00340
EKS-XIM-00334
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0030529; C:ribonucleoprotein complex
GO:0000151; C:ubiquitin ligase complex
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0030145; F:manganese ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0004713; F:protein tyrosine kinase activity
GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0045725; P:positive regulation of glycogen biosynthetic process
GO:0007224; P:smoothened signaling pathway
KEGG
oaa:100080193;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013