EKS-ORA-00281

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORA-00281

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	308.0	6.0E-92	21	290	270

Status

Unreviewed

Ensembl Protein

ENSOANP00000009588

UniProt Accession

F6V5J6;

Protein Name

Protein Synonyms/Alias

Gene Name

MYO3A

Gene Synonyms/Alias

MYO3A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000006026	ENSOANP00000009587	ENSOANT00000009589
ENSOANG00000006026	ENSOANP00000009588	ENSOANT00000009590

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

1564

Protein Sequence
(FASTA)

MLSVTGKTII FDSFPDPSDT WEIIETIGKG TYGKVFKVLN KKNGQKAAVK ILDPVHDIDE 60

EIEAEYNILK GLSDHPNVVK FYGMYFKKDK KNGDQLWLVL ELCSGGSVTD LVKGLLKRGE 120

SMKEVLIAYI LREALLGLQH LHNNKTIHRD VKGNNILLTT DGGVKLVDFG VSAQLTSTRL 180

HRNTSVGTPF WMAPEVIACE QQLDTNYDAR CDAWSLGITA IELGDGDPPL ADVHPMRALF 240

KIPRSPPPTL QQPDLWSAEF NDFINNQCRC LTKDFEKRPT VSDLLQHEFI SQVEGRETLL 300

QKQLMEFIDV HQQTGVSEKS RHERIHTKKI NVTKFPVTNL KEVDDLATME VMDENLVAEQ 360

LQKCYARDQI YIYVGDILIA INPFQNLDLY SSQHTKQYIG AKRTDNPPHI FAIADLGYES 420

MVTYSSDQCI VISGESGSGK TESAHLLVQQ LTVLGKANNR TLQEKILQVN KLVEAFGNAS 480

TIINDNSSRF GKYLEMKFTS AGVVIGAQIS EYLLEKSRVV HQAIGEKNFH IFYYIYAGLA 540

EKKKLAHYKL PESKPPRYLQ NEHLRMVQDL MNSSFYRSQF ELIEQCFKVI GFTMDELGSV 600

YSILASILNI GNIEFSSVAT EHQIDKSNVS NPTALGNSAS LLYIQAEELH EALTSHCVVT 660

RGETIIRPNT VEKATDVRDA MAKALYGRLF SWIVNRINSL LKHDDTLRLD DELNIGILDI 720

FGFENFKRNS FEQLCINIAN EQIQFYFNQH VFAWEQNEYL NEDVDARVIE YEDNRPLLDM 780

FLQKPMGLLS LLDEESQFPR ATDQTLIEKF EDNLKSTYFW RPKRMDLTFG IHHYAGKVLY 840

NASGFLAKNR DTLPADIVLL LRSSENSLIR HLVSHPLTKT GNLAHSKTKS AINYQIRTPH 900

RSIHPSKGET GDSTYLPRET TNMKTQTVAS YFRYSLMDLL SKMVVGQPHF VRCIKPNSER 960

RAKKFDRDKV LVQLRYTGIL ETARIRRCGY SHRILFASFI ERYYILCYRS NEKPPVSSET 1020

CANILEKVGL DNWALGKTKV FLKYYHVEQL NLMRKEKVDK IVLIQAYVRG FLGSKRYQKL 1080

QKKREESARI IESGVMPVRN HLIFGFLSET YSFPNCCISG VLSSSTNLPH CQRCQTQKSL 1140

EKKENTDNVI SGSEIVGHCP HCKENTPVSS CKTAVGVTII IQTNSGGPQT QEEVSNPDET 1200

DATQELRGAD VPTSEMSPEC REGKRPEAIT EAERKDQVAM MIQKKYRGHM DKKKFEEEKK 1260

MSSVSNRASE EPDLLRHQIE KGNTNKSSPL MVPETCSNHQ KQILSQIGSK DRHDQSLLKH 1320

EETSLQGLEE EDKAAVVIQS RYRGFRSRQQ LRNCDQSLCL HHQEACVLGR LAVEHTQNVD 1380

SHSTRSNGSP TLRATKVGAP KAILEKEICG VTAFSKQVPH LSGDYIAVQQ KRNEMTWLHQ 1440

LKPVDLSVCA IEKPNNKQVS PSACPSGVSR EEEPRTLRVP RRAQKPKVLN NPEDSTYYIL 1500

LHKAIRQEKR RPRKESPGKV LDLEDFYYHE ISSSHVGLKE SNSKSRDTML QSELQNSSPI 1560

PGER 1564

Nucleotide Sequence
(FASTA)

ATGCTTTCAG TAACGGGGAA AACGATCATC TTTGATAGTT TTCCGGATCC TTCCGACACA 60

TGGGAGATAA TTGAAACCAT CGGGAAAGGA ACTTATGGCA AAGTTTTCAA AGTGTTGAAC 120

AAGAAAAATG GCCAAAAAGC AGCAGTCAAA ATCCTGGATC CAGTTCATGA TATCGATGAA 180

GAAATTGAAG CTGAGTATAA CATCTTGAAA GGCCTTTCTG ACCATCCTAA TGTAGTCAAG 240

TTCTATGGGA TGTACTTCAA GAAGGACAAG AAGAACGGTG ACCAGCTGTG GTTGGTTCTT 300

GAGCTATGTA GTGGAGGATC AGTGACTGAT CTTGTGAAGG GACTTTTGAA AAGAGGTGAA 360

AGCATGAAAG AAGTTCTCAT TGCCTATATT TTACGAGAGG CTCTTCTGGG GCTTCAACAT 420

TTGCACAACA ACAAGACGAT TCATCGAGAT GTGAAAGGAA ACAACATCCT CCTGACCACT 480

GATGGTGGAG TTAAGCTAGT AGATTTTGGT GTGTCCGCCC AGCTCACCAG CACGCGACTT 540

CATCGGAATA CGTCTGTGGG GACGCCATTT TGGATGGCCC CAGAGGTGAT TGCTTGTGAA 600

CAACAGCTGG ACACCAACTA TGATGCCAGG TGCGATGCTT GGTCTCTTGG AATCACAGCT 660

ATAGAGCTCG GAGATGGAGA TCCACCCCTT GCTGATGTGC ATCCTATGAG AGCCCTCTTC 720

AAAATACCGA GAAGCCCTCC TCCAACTCTC CAACAACCAG ACCTGTGGTC CGCTGAATTC 780

AATGACTTTA TTAACAACCA GTGCAGGTGC TTGACTAAGG ACTTTGAGAA GCGTCCCACA 840

GTGTCTGATC TCTTGCAGCA TGAATTTATT AGTCAAGTCG AGGGCAGAGA AACTTTATTA 900

CAGAAACAAC TCATGGAGTT CATTGATGTT CATCAACAGA CGGGAGTCTC AGAGAAGTCC 960

AGACATGAGC GTATTCACAC AAAGAAAATT AATGTCACCA AGTTCCCTGT TACAAACCTG 1020

AAGGAGGTAG ATGACTTAGC CACCATGGAA GTTATGGATG AGAATTTAGT GGCGGAACAG 1080

CTGCAGAAAT GCTACGCTCG AGATCAGATC TACATCTATG TTGGAGATAT CCTTATTGCT 1140

ATCAACCCCT TTCAGAATTT GGACCTGTAC TCCTCCCAGC ATACTAAACA ATACATTGGG 1200

GCGAAGAGGA CTGACAATCC TCCACACATC TTTGCCATTG CTGATTTGGG ATATGAATCC 1260

ATGGTCACTT ACAGTTCAGA TCAGTGCATT GTCATTTCTG GAGAAAGTGG TTCCGGGAAG 1320

ACCGAAAGTG CCCATCTCCT TGTCCAACAG TTGACTGTCC TGGGAAAGGC TAATAACCGA 1380

ACCCTGCAAG AGAAGATTTT GCAAGTGAAC AAGCTAGTGG AAGCTTTCGG TAATGCCAGC 1440

ACCATTATAA ATGATAATTC CAGCCGATTT GGAAAATATT TGGAAATGAA ATTCACCTCT 1500

GCTGGGGTCG TAATAGGAGC CCAGATTTCA GAGTACCTCC TTGAAAAATC AAGAGTGGTC 1560

CACCAAGCAA TCGGAGAGAA AAATTTTCAT ATTTTTTATT ACATCTACGC TGGTTTGGCG 1620

GAAAAGAAAA AACTGGCCCA TTATAAGTTG CCAGAAAGCA AGCCTCCCAG ATACCTACAA 1680

AATGAGCATC TCAGAATGGT GCAGGACTTA ATGAATAGCA GTTTCTACCG GTCCCAGTTT 1740

GAGTTGATTG AGCAGTGCTT CAAAGTAATA GGTTTCACAA TGGATGAACT TGGGAGCGTA 1800

TACAGTATTC TTGCCTCAAT TTTGAACATT GGGAATATTG AATTTTCTTC AGTGGCAACA 1860

GAGCACCAGA TTGACAAGAG CAACGTTTCC AATCCAACAG CTCTTGGGAA TTCGGCTTCT 1920

CTGCTCTACA TTCAGGCGGA AGAACTGCAT GAAGCTCTTA CCTCTCACTG TGTGGTGACT 1980

CGAGGGGAAA CCATCATTCG TCCCAATACT GTGGAAAAAG CCACCGATGT CAGAGACGCT 2040

ATGGCCAAAG CCTTGTATGG TCGACTCTTC AGCTGGATAG TCAATCGCAT CAACAGTTTG 2100

CTGAAGCATG ATGACACTCT ACGACTTGAC GATGAGCTGA ACATCGGCAT TCTGGATATC 2160

TTTGGCTTTG AAAATTTCAA AAGAAATTCC TTTGAGCAAC TATGCATCAA TATTGCAAAT 2220

GAACAAATCC AGTTCTACTT CAATCAGCAC GTGTTTGCAT GGGAGCAGAA TGAATACTTA 2280

AATGAAGATG TTGATGCTAG AGTTATTGAA TATGAAGACA ACCGGCCTCT CTTAGATATG 2340

TTTCTACAGA AACCAATGGG CTTGCTGTCT CTGCTTGATG AGGAGAGTCA ATTCCCCAGA 2400

GCTACTGATC AGACCCTCAT AGAAAAATTT GAAGACAATT TGAAATCGAC GTACTTCTGG 2460

AGACCCAAAA GAATGGACCT TACTTTTGGA ATTCACCATT ATGCAGGCAA GGTTCTTTAT 2520

AATGCAAGCG GGTTCTTGGC TAAAAATAGG GACACCCTCC CAGCTGACAT TGTGCTGCTT 2580

CTGCGGTCTT CAGAAAACAG CCTAATTCGA CATCTTGTGA GCCACCCACT AACCAAAACA 2640

GGCAATCTGG CCCATTCTAA AACTAAAAGT GCAATAAATT ATCAAATTAG GACCCCACAC 2700

AGATCAATCC ACCCATCCAA GGGTGAAACA GGAGATTCAA CATATTTACC AAGAGAGACT 2760

ACAAACATGA AAACCCAGAC AGTCGCATCT TATTTTAGGT ACTCACTGAT GGACTTGCTC 2820

TCGAAGATGG TAGTTGGCCA ACCTCACTTT GTACGTTGCA TAAAACCCAA CAGTGAGCGC 2880

CGGGCCAAGA AATTTGACAG AGATAAAGTG CTGGTTCAGC TGCGTTACAC GGGGATTCTG 2940

GAAACGGCTC GGATCCGGAG ATGTGGCTAT TCCCATCGCA TACTGTTTGC CAGCTTCATC 3000

GAGCGGTACT ATATCCTCTG CTATCGATCC AATGAGAAAC CTCCTGTGAG CTCTGAAACC 3060

TGTGCCAACA TCTTGGAAAA AGTTGGTCTC GACAACTGGG CTCTTGGAAA GACCAAAGTG 3120

TTCCTTAAAT ACTATCATGT GGAGCAGTTG AATTTAATGA GAAAGGAAAA GGTTGACAAG 3180

ATTGTATTGA TACAGGCCTA TGTCAGAGGA TTCCTGGGTT CAAAGAGGTA TCAAAAACTT 3240

CAAAAGAAGA GGGAGGAAAG TGCCCGAATA ATAGAGTCAG GTGTAATGCC TGTGAGAAAT 3300

CACCTTATAT TTGGGTTCCT CAGTGAAACA TATTCATTTC CTAATTGCTG CATCTCTGGA 3360

GTGCTGTCAT CATCAACCAA CCTGCCTCAC TGCCAGAGGT GTCAAACCCA AAAGAGTTTG 3420

GAAAAGAAGG AAAATACTGA CAACGTAATC TCTGGTAGTG AAATTGTCGG ACACTGTCCA 3480

CACTGTAAAG AAAACACCCC CGTATCCTCT TGTAAAACTG CAGTAGGGGT CACCATCATC 3540

ATTCAGACAA ACTCTGGAGG ACCCCAAACT CAGGAAGAAG TCAGCAATCC TGATGAAACA 3600

GATGCCACCC AAGAGTTACG GGGGGCAGAT GTCCCCACAT CAGAAATGAG CCCAGAATGC 3660

AGAGAGGGGA AGAGACCAGA AGCTATCACT GAAGCTGAGA GGAAAGACCA GGTTGCCATG 3720

ATGATCCAGA AGAAGTATCG GGGCCACATG GACAAGAAGA AGTTTGAGGA AGAAAAGAAA 3780

ATGTCCTCAG TCAGTAACAG AGCATCTGAA GAGCCAGATC TCCTAAGACA CCAAATAGAG 3840

AAGGGAAACA CTAACAAATC CTCACCTTTA ATGGTGCCAG AGACCTGTAG CAACCACCAA 3900

AAACAGATCC TGTCCCAGAT CGGGTCTAAA GATCGCCATG ATCAAAGCCT CCTGAAGCAT 3960

GAAGAAACTA GTCTTCAAGG CTTGGAAGAG GAAGACAAAG CAGCAGTGGT CATTCAGAGC 4020

AGATATCGAG GCTTTCGAAG TAGGCAGCAG TTAAGGAATT GTGACCAGTC TCTTTGTCTC 4080

CACCACCAGG AAGCCTGTGT GCTAGGGAGG CTAGCAGTGG AACACACTCA GAACGTTGAT 4140

TCCCACTCAA CAAGAAGTAA TGGAAGCCCA ACTCTAAGAG CGACGAAGGT TGGGGCTCCA 4200

AAAGCCATCT TAGAGAAAGA GATCTGTGGT GTGACTGCCT TTTCAAAGCA GGTACCACAT 4260

TTATCTGGAG ACTATATTGC AGTACAGCAA AAACGGAATG AAATGACTTG GTTGCATCAA 4320

TTGAAGCCTG TGGACCTGAG TGTCTGCGCC ATAGAGAAGC CAAACAATAA GCAAGTGTCT 4380

CCTTCTGCAT GCCCTTCAGG TGTCTCTAGA GAAGAGGAAC CAAGAACGCT GAGAGTTCCA 4440

AGGAGAGCAC AGAAACCCAA AGTTTTAAAC AACCCCGAGG ACTCCACCTA TTACATTCTG 4500

CTGCATAAGG CAATCCGGCA AGAAAAACGA AGACCAAGGA AAGAAAGTCC AGGAAAAGTG 4560

CTAGATTTAG AAGACTTTTA CTACCACGAA ATTTCATCTA GTCATGTTGG ACTGAAAGAA 4620

AGTAACTCTA AGTCAAGAGA TACAATGTTG CAATCTGAGC TCCAGAATTC AAGTCCCATA 4680

CCTGGCGAAA GGTAG 4695

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkh.pniv  59

         +e++e+igkG++gkv++  +kk+g+++a+k+++  + +  ee++ e+++lk l++ pn+v

Q: 21    WEIIETIGKGTYGKVFKVLNKKNGQKAAVKILDPVH-DIDEEIEAEYNILKGLSDhPNVV  79

         799******************************998.9999**********98755****

S: 60    eylesflk.....eeelwlvmeylagGslsdlvk..eelkselkEeqiayilrevlkaLe  112

         +++++++k      ++lwlv+e+++gGs++dlvk   ++ +++kE  iayilre+l +L+

Q: 80    KFYGMYFKkdkknGDQLWLVLELCSGGSVTDLVKglLKRGESMKEVLIAYILREALLGLQ  139

         ********9998889*******************77778899******************

S: 113   ylHskkviHrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaq  172

         +lH++k+iHrd+k++niLlt++g VkL+dfgv+aql++tr +r+t vgtp+wmAPEvia+

Q: 140   HLHNNKTIHRDVKGNNILLTTDGGVKLVDFGVSAQLTSTRLHRNTSVGTPFWMAPEVIAC  199

         ************************************************************

S: 173   e...ekgYdekaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfske  229

         e   +++Yd+++D wslGItaiel +g+pP++d++p++al+ki++++pp+l++++ +s e

Q: 200   EqqlDTNYDARCDAWSLGITAIELGDGDPPLADVHPMRALFKIPRSPPPTLQQPDLWSAE  259

         9888899*****************************************************

S: 230   fkefvek...clqknpekRpsasellkhkFl  257

         f++f+++   cl+k++ekRp++s+ll+h+F+

Q: 260   FNDFINNqcrCLTKDFEKRPTVSDLLQHEFI  290

         *****955559*******************7

Domain Sequence
(FASTA)

WEIIETIGKG TYGKVFKVLN KKNGQKAAVK ILDPVHDIDE EIEAEYNILK GLSDHPNVVK 60

FYGMYFKKDK KNGDQLWLVL ELCSGGSVTD LVKGLLKRGE SMKEVLIAYI LREALLGLQH 120

LHNNKTIHRD VKGNNILLTT DGGVKLVDFG VSAQLTSTRL HRNTSVGTPF WMAPEVIACE 180

QQLDTNYDAR CDAWSLGITA IELGDGDPPL ADVHPMRALF KIPRSPPPTL QQPDLWSAEF 240

NDFINNQCRC LTKDFEKRPT VSDLLQHEFI 270

Keyword

ATP-binding; Complete proteome; Motor protein; Myosin; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0031941	; C:filamentous actin
GO:0030175	; C:filopodium
GO:0016459	; C:myosin complex
GO:0030898	; F:actin-dependent ATPase activity
GO:0043531	; F:ADP binding
GO:0005524	; F:ATP binding
GO:0060002	; F:plus-end directed microfilament motor activity
GO:0004672	; F:protein kinase activity
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR000048	; IQ_motif_EF-hand-BS.
IPR011009	; Kinase-like_dom.
IPR001609	; Myosin_head_motor_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00612	; IQ; 2.
PF00063	; Myosin_head; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00015	; IQ; 3.
SM00242	; MYSc; 1.
SM00220	; S_TKc; 1.

Prosites

PS50096	; IQ; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

PR00193

; MYOSINHEAVY.

Created Date

20-Feb-2013