EKS-ORA-00243

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORA-00243

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	450.1	3.5E-135	196	483	288

Status

Unreviewed

Ensembl Protein

ENSOANP00000009791

UniProt Accession

F6W004;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR1C

Gene Synonyms/Alias

ACVR1C;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000006133	ENSOANP00000009791	ENSOANT00000009793

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

494

Protein Sequence
(FASTA)

MPGALLSALR QALLLVAACA SLSAGLKCVC LLCEHTNFTC QTEGACWGSV MLANGKEEVT 60

KSCISLPELK AQVFCHSSNL TKTECCFTDF CNNITLRLPT AATSSSSSKL GPVELTIIVT 120

VPVCLMSVAA MLAIYTCQGR HCSYKKKKRQ NIEEPLSECN LVNAGKTLKD LIYDMTTSGS 180

GSGLPLLVQR TIARTIVLQE IVGKGRFGEV WHGRWCGEDV AVKIFSSRDE RSWFREAEIY 240

QTVMLRHENI LGFIAADNKD NGTWTQLWLV SEYHEQGSLF DYLSRNTVTV DGMIKLALSV 300

ASGLAHLHME IVGTQGKPAI AHRDLKSKNI LVKKCETCAI ADLGLAVKHD SILNSIDIPQ 360

NPRVGTKRYM APEILDETMN TSIFESFKRA DIYSVGLVYW EIARRCSVGG NIEEYQLPFY 420

DMVPSDPSIE EMRKVVCEQK FRPNIPNQWQ SCEALRVMGR IMRECWFANG AARLTALRIK 480

KTISQLGVQE DSKV 494

Nucleotide Sequence
(FASTA)

ATGCCCGGCG CGCTCCTCTC CGCGCTGCGC CAGGCTCTGC TGCTGGTGGC CGCCTGCGCC 60

TCCCTCTCGG CAGGCCTGAA GTGTGTGTGT CTTCTATGTG AGCATACGAA CTTCACCTGC 120

CAAACGGAAG GGGCGTGCTG GGGCTCGGTC ATGCTGGCCA ATGGCAAAGA AGAGGTGACA 180

AAGTCCTGCA TCTCACTTCC CGAGTTGAAA GCCCAGGTTT TTTGCCACAG CTCCAACCTC 240

ACGAAGACAG AATGCTGCTT CACAGATTTT TGCAACAACA TAACACTCCG CCTCCCTACA 300

GCGGCAACAT CTTCTAGCTC ATCTAAGCTA GGACCAGTGG AATTGACCAT AATAGTTACT 360

GTTCCAGTTT GCCTCATGTC TGTAGCTGCA ATGCTCGCCA TATACACATG CCAAGGCCGC 420

CACTGCTCCT ATAAGAAGAA AAAGAGGCAA AATATTGAGG AACCCCTTTC TGAATGCAAC 480

TTAGTAAATG CCGGGAAAAC TCTTAAAGAT CTAATCTATG ATATGACAAC ATCTGGATCT 540

GGTTCTGGTT TACCACTCTT GGTCCAGAGA ACAATTGCAC GCACAATTGT CCTTCAAGAG 600

ATAGTGGGAA AAGGCCGGTT TGGTGAAGTG TGGCATGGGA GATGGTGTGG GGAAGATGTG 660

GCTGTGAAAA TCTTTTCTTC AAGAGATGAA AGGTCTTGGT TTCGGGAGGC AGAAATCTAT 720

CAGACAGTTA TGCTGCGACA TGAAAACATC CTTGGCTTTA TTGCAGCTGA TAACAAAGAT 780

AATGGAACTT GGACTCAACT GTGGCTCGTA TCTGAATACC ATGAACAGGG CTCACTGTTT 840

GACTACTTAA GCAGAAACAC GGTGACCGTA GATGGGATGA TTAAATTGGC GCTCTCTGTA 900

GCCAGTGGCC TTGCCCACCT ACATATGGAG ATAGTCGGTA CACAAGGTAA ACCGGCAATT 960

GCACACCGTG ATCTAAAATC AAAAAACATA CTTGTGAAGA AATGTGAAAC CTGTGCCATA 1020

GCAGACTTGG GCTTGGCTGT GAAGCACGAT TCAATACTGA ACAGTATCGA TATCCCTCAG 1080

AACCCAAGAG TAGGGACCAA AAGGTATATG GCTCCGGAAA TACTTGATGA AACGATGAAC 1140

ACTAGCATCT TCGAATCCTT CAAGCGTGCA GACATATACT CTGTTGGACT GGTGTACTGG 1200

GAGATAGCCC GGCGATGTTC AGTTGGAGGG AACATTGAGG AGTACCAGTT GCCATTTTAC 1260

GATATGGTGC CTTCAGACCC CTCAATAGAG GAAATGAGGA AAGTTGTTTG TGAACAGAAA 1320

TTTAGACCAA ATATTCCCAA CCAATGGCAA AGCTGTGAGG CACTCCGAGT AATGGGCAGG 1380

ATAATGCGGG AGTGCTGGTT TGCAAATGGA GCAGCTCGCC TGACAGCCCT GCGTATAAAG 1440

AAAACCATTT CTCAGCTTGG TGTACAGGAA GACTCCAAAG TCTGA 1485

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e++gkGr+geVw++++ ge+vAvKifs++de+sw+rE+eiyqtv+lrhenil+fia

Q: 196   IVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIA  255

         5789********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv+eyhe+gsL+dyL+r+t++v+ +++lals+asGlahLH+eivgt+

Q: 256   ADNKDNGTWTQLWLVSEYHEQGSLFDYLSRNTVTVDGMIKLALSVASGLAHLHMEIVGTQ  315

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk +tc+iaDlGLa+k+++  +++d+ +n +vGtkRYmaPE

Q: 316   G--KPAIAHRDLKSKNILVKKCETCAIADLGLAVKHDSILNSIDIPQNPRVGTKRYMAPE  373

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         +l+e++n++ fe+fkraD+Ys+gLv+WE+a+Rc+  ++++eey+lpf+++v+sdPs+eem

Q: 374   ILDETMNTSIFESFKRADIYSVGLVYWEIARRCSV-GGNIEEYQLPFYDMVPSDPSIEEM  432

         **********************************9.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+e+k rP+ip++w+++eal+++ ++++ecW a+++aRltalr+kk++

Q: 433   RKVVCEQKFRPNIPNQWQSCEALRVMGRIMRECWFANGAARLTALRIKKTI  483

         ************************************************986

Domain Sequence
(FASTA)

IVLQEIVGKG RFGEVWHGRW CGEDVAVKIF SSRDERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSEYHE QGSLFDYLSR NTVTVDGMIK LALSVASGLA HLHMEIVGTQ 120

GKPAIAHRDL KSKNILVKKC ETCAIADLGL AVKHDSILNS IDIPQNPRVG TKRYMAPEIL 180

DETMNTSIFE SFKRADIYSV GLVYWEIARR CSVGGNIEEY QLPFYDMVPS DPSIEEMRKV 240

VCEQKFRPNI PNQWQSCEAL RVMGRIMREC WFANGAARLT ALRIKKTI 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0048179	; C:activin receptor complex
GO:0016361	; F:activin receptor activity, type I
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0030154	; P:cell differentiation
GO:0019915	; P:lipid storage
GO:0008285	; P:negative regulation of cell proliferation
GO:0046676	; P:negative regulation of insulin secretion
GO:0038092	; P:nodal signaling pathway
GO:0043280	; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0009749	; P:response to glucose stimulus
GO:0032868	; P:response to insulin stimulus

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013