EKS-ORA-00242

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORA-00242

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	450.3	3.0E-135	228	515	288

Status

Unreviewed

Ensembl Protein

ENSOANP00000009796

UniProt Accession

F6VZX5;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR1

Gene Synonyms/Alias

ACVR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000006134	ENSOANP00000009796	ENSOANT00000009798

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

529

Protein Sequence
(FASTA)

MEELAGSRLH LQATSYTMLD GVMILPVLMM IAFPSPSVED EEPKLNAVLY TCVCEGLSCG 60

SQHHCQGQQC FVSLSINDGI KIHQKGCFQV YEQSKMTCRT PPTPDQAVEC CQGNWCNKNI 120

TAQLPTKGKS FQGASSSYYS LETIAIVSLC SIVVVCILGF LTVLMIRKFQ RYSEERLNPR 180

DVEYGTIEGL ITTNVGDSTL ADLLDHTCTS GSGSGLPFLV QRTVARQITL MECVGKGRYG 240

EVWRGQWQGE NIAVKIFSSR DEKSWFRETE LYNTVLLRHE NILGFIASDM TSRHSSTQLW 300

LITHYHEMGS LYDYLQLTTL DTVNCLRIVL SIASGLAHLH IEIFGTQGKP AISHRDLKSK 360

NILVKKNGQC CIADLGLAVM HSQSTNQLDV GNNPRVGTKR YMAPEVLDET IQVDCFDSYK 420

RVDIWAFGLV LWEVARRMVS NGIVEDYKPP FYDVVPNDPS FEDMRKVVCV DQQRPNIPNR 480

WFSDPTLTSL AKLMKECWYH NPSARLTALR IKKTLTKIDN SLDKLKADC 529

Nucleotide Sequence
(FASTA)

ATGGAGGAGT TGGCTGGGTC TCGGCTCCAT CTTCAAGCTA CGAGCTATAC AATGTTAGAT 60

GGAGTTATGA TTCTTCCTGT ACTGATGATG ATAGCTTTCC CCTCCCCAAG TGTGGAAGAT 120

GAGGAGCCAA AGTTGAACGC TGTCCTCTAC ACCTGTGTGT GTGAAGGGCT GTCCTGTGGG 180

AGCCAGCATC ACTGCCAGGG CCAGCAGTGC TTTGTCTCCC TGAGCATAAA CGATGGCATC 240

AAAATCCATC AGAAAGGCTG CTTCCAAGTC TACGAGCAGA GCAAGATGAC CTGCAGAACG 300

CCGCCCACTC CCGACCAGGC TGTGGAGTGC TGCCAGGGTA ACTGGTGCAA CAAGAACATC 360

ACGGCCCAGC TGCCCACCAA AGGAAAATCC TTCCAAGGGG CCTCTTCATC ATACTACAGC 420

CTGGAAACCA TCGCCATCGT GTCACTCTGT TCGATTGTCG TAGTATGCAT TCTAGGTTTC 480

CTCACCGTGC TGATGATTAG AAAATTCCAG AGGTACAGTG AAGAGCGACT CAACCCCAGA 540

GATGTGGAGT ATGGCACCAT CGAAGGGCTC ATCACCACAA ATGTCGGCGA CAGCACCTTA 600

GCAGATTTAT TGGACCATAC CTGCACATCG GGGAGTGGCT CCGGCCTTCC TTTCTTGGTT 660

CAAAGAACCG TGGCGCGACA GATCACGCTC ATGGAGTGTG TAGGAAAGGG CAGATATGGA 720

GAGGTTTGGC GGGGCCAATG GCAAGGAGAG AACATCGCAG TGAAAATATT TTCTTCCCGC 780

GATGAAAAAT CCTGGTTCAG AGAAACAGAG TTGTATAATA CTGTGTTGCT AAGACATGAG 840

AATATCTTGG GTTTCATTGC CTCAGATATG ACATCGAGAC ATTCAAGCAC CCAGCTCTGG 900

CTGATTACGC ATTATCACGA GATGGGATCC TTGTATGACT ACCTACAGCT CACGACACTG 960

GACACAGTGA ACTGCCTCCG AATAGTGCTG TCCATAGCTA GCGGCCTCGC GCATCTGCAC 1020

ATAGAAATAT TTGGTACCCA GGGGAAGCCA GCTATCTCCC ACCGGGACTT AAAGAGCAAA 1080

AACATCCTTG TGAAGAAGAA TGGGCAGTGC TGCATAGCCG ACTTAGGCCT CGCCGTCATG 1140

CACTCCCAGA GCACCAATCA GCTGGATGTG GGTAACAACC CCCGCGTGGG AACCAAGCGC 1200

TACATGGCCC CCGAAGTTCT GGACGAAACC ATCCAGGTGG ACTGTTTCGA CTCCTACAAG 1260

AGGGTGGATA TCTGGGCCTT TGGACTGGTC CTGTGGGAGG TGGCCCGGCG GATGGTGAGC 1320

AATGGAATTG TAGAAGATTA CAAGCCTCCT TTCTACGATG TGGTCCCAAA TGACCCGAGC 1380

TTTGAAGATA TGAGAAAAGT GGTCTGCGTG GATCAGCAGA GGCCAAACAT TCCCAACAGA 1440

TGGTTCTCAG ATCCAACGTT AACCTCTCTG GCCAAGCTGA TGAAAGAGTG CTGGTATCAC 1500

AATCCATCTG CAAGACTAAC AGCCCTGCGA ATCAAAAAGA CTTTGACCAA AATTGATAAT 1560

TCCTTAGATA AACTGAAAGC TGACTGTTGA 1590

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         ++l+e++gkGrygeVw+++++ge++AvKifs++de+sw+rE+e+y+tvllrhenil+fia

Q: 228   ITLMECVGKGRYGEVWRGQWQGENIAVKIFSSRDEKSWFRETELYNTVLLRHENILGFIA  287

         789*********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         +d+++++s+t+l+l+t+yhe+gsL+dyL+ +tld+ ++lr++ls+asGlahLH ei+gt+

Q: 288   SDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVNCLRIVLSIASGLAHLHIEIFGTQ  347

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  Kpai+HRDlkskNilvkk+++cciaDlGLa+++++++++ld+ +n +vGtkRYmaPE

Q: 348   G--KPAISHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPE  405

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e++++++f+++kr+D++++gLvlWEva+R+ + +++ve+yk+pf++vv++dPs+e+m

Q: 406   VLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVS-NGIVEDYKPPFYDVVPNDPSFEDM  464

         **********************************9.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+++++rP+ip++w ++++l++l+kl++ecW+++p+aRltalr+kk+l

Q: 465   RKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYHNPSARLTALRIKKTL  515

         *************************************************97

Domain Sequence
(FASTA)

ITLMECVGKG RYGEVWRGQW QGENIAVKIF SSRDEKSWFR ETELYNTVLL RHENILGFIA 60

SDMTSRHSST QLWLITHYHE MGSLYDYLQL TTLDTVNCLR IVLSIASGLA HLHIEIFGTQ 120

GKPAISHRDL KSKNILVKKN GQCCIADLGL AVMHSQSTNQ LDVGNNPRVG TKRYMAPEVL 180

DETIQVDCFD SYKRVDIWAF GLVLWEVARR MVSNGIVEDY KPPFYDVVPN DPSFEDMRKV 240

VCVDQQRPNI PNRWFSDPTL TSLAKLMKEC WYHNPSARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0045177	; C:apical part of cell
GO:0005887	; C:integral to plasma membrane
GO:0016361	; F:activin receptor activity, type I
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005025	; F:transforming growth factor beta receptor activity, type I
GO:0002526	; P:acute inflammatory response
GO:0030509	; P:BMP signaling pathway
GO:0000082	; P:G1/S transition of mitotic cell cycle
GO:0032926	; P:negative regulation of activin receptor signaling pathway
GO:0043066	; P:negative regulation of apoptotic process
GO:0060389	; P:pathway-restricted SMAD protein phosphorylation
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0030501	; P:positive regulation of bone mineralization
GO:2000017	; P:positive regulation of determination of dorsal identity
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0010862	; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter
GO:0023014	; P:signal transduction by phosphorylation
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

oaa:100077006

;

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013