EKS-ORA-00401

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORA-00401

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	417.4	3.0E-125	49	344	296

Status

Unreviewed

Ensembl Protein

ENSOANP00000009964

UniProt Accession

F6VWB1;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK10

Gene Synonyms/Alias

MAPK10;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000006227	ENSOANP00000009964	ENSOANT00000009966

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

408

Protein Sequence
(FASTA)

MAMGSLIGFD KQVDVSYISK HYNMSKSKVD NQFYSVEVGD STFTVLKRYQ NLKPIGSGAQ 60

GIVCAAYDAV LDRNVAIKKL SRPFQNQTHA KRAYRELVLM KCVNHKNIIS LLNVFTPQKS 120

LEEFQDVYLV MELMDANLCQ VIQMELDHER MSYLLYQMLC GIKHLHSAGI IHRDLKPSNI 180

VVKSDCTLKI LDFGLARTAG TSFMMTPYVV TRYYRAPEVI LGMGYKENVD IWSVGCIMGE 240

MVRHKILFPG RDYIDQWNKV IEQLGTPCPE FMKKLQPTVR NYVENRPKYA GLTFPKLFPD 300

SLFPADSEHN KLKASQARDL LSKMLVIDPA KRISVDEALQ HPYINVWYDP AEVEAPPPQI 360

YDKQLDEREH TIEEWKELIY KEVMNSEEKT KNGVVKGQPS PSGAAATM 408

Nucleotide Sequence
(FASTA)

ATGGCGATGG GGTCTCTCAT TGGATTTGAT AAACAAGTGG ATGTGTCATA TATCTCCAAG 60

CATTACAACA TGAGCAAAAG CAAAGTTGAC AACCAGTTCT ACAGTGTGGA AGTGGGAGAT 120

TCGACTTTCA CAGTTCTTAA GCGCTACCAG AACCTAAAGC CTATTGGCTC TGGGGCACAG 180

GGCATAGTTT GCGCTGCCTA TGACGCTGTC CTTGACCGAA ATGTGGCCAT TAAGAAGCTC 240

AGCCGACCGT TCCAGAATCA AACCCACGCC AAGAGGGCTT ACCGGGAGCT GGTCCTCATG 300

AAATGCGTCA ATCATAAAAA CATTATCAGT TTATTAAATG TCTTCACACC CCAGAAGTCA 360

CTTGAGGAGT TCCAAGATGT GTATCTGGTA ATGGAGTTGA TGGACGCCAA CTTGTGTCAA 420

GTCATTCAGA TGGAACTGGA CCATGAGAGA ATGTCTTACC TTCTCTACCA AATGCTATGT 480

GGTATCAAGC ACCTTCACTC TGCCGGGATC ATTCACAGGG ATTTAAAGCC CAGCAACATC 540

GTGGTCAAGT CAGACTGCAC GCTGAAGATT CTGGACTTCG GACTGGCCAG AACTGCAGGC 600

ACGAGCTTCA TGATGACTCC TTACGTGGTG ACCCGCTATT ACAGAGCACC GGAGGTCATC 660

TTGGGAATGG GCTACAAGGA AAACGTGGAT ATATGGTCTG TGGGATGCAT TATGGGAGAA 720

ATGGTTCGTC ACAAAATCCT CTTTCCAGGA AGGGACTATA TCGACCAGTG GAACAAAGTC 780

ATTGAACAAC TAGGAACACC TTGCCCAGAG TTTATGAAGA AATTGCAACC CACAGTGAGA 840

AATTATGTTG AGAACAGGCC TAAGTATGCA GGTCTGACTT TCCCCAAGCT CTTTCCAGAC 900

TCTCTCTTCC CAGCTGATTC AGAGCACAAT AAACTCAAAG CCAGCCAAGC GCGGGATCTT 960

CTGTCCAAGA TGCTGGTGAT TGACCCAGCC AAAAGGATAT CGGTGGATGA AGCTCTGCAA 1020

CACCCGTACA TCAATGTCTG GTACGACCCT GCGGAAGTGG AAGCGCCTCC TCCACAGATA 1080

TACGATAAAC AGCTGGATGA AAGAGAACAC ACCATCGAGG AGTGGAAAGA ACTTATCTAC 1140

AAGGAAGTAA TGAATTCTGA AGAAAAGACT AAAAATGGCG TAGTTAAAGG ACAGCCTTCT 1200

CCTTCAGGTG CAGCAGCAAC GATGTGA 1227

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++lkp+g+Ga+g+v++a+d+  +++vaikklsrpfq++t+akr++REl l+k+++h+Ni

Q: 49    YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI  108

         899*********************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i+ll+vftp+++lee++dvYlv+elm+++L++vi+++ l++e++++llyq+l+g+k+lHs

Q: 109   ISLLNVFTPQKSLEEFQDVYLVMELMDANLCQVIQME-LDHERMSYLLYQMLCGIKHLHS  167

         ************************************9.**********************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180

         a++iHrDlKPsN++v++dc+lkildFGlar+a ++ +  +t+yv+tr+YraPe++l  +

Q: 168   AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFM--MTPYVVTRYYRAPEVILG-MG  224

         **********************************976..*****************9.99

S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240

         y+++vDiWsvGCI++E++++k+lfpg+d+idq++k++e+lgtp  ef+kk++  ++rny+

Q: 225   YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQP-TVRNYV  283

         *****************************************************.5*****

S: 241   kslpkkkkkdfeelfpk............aseealdLleklLvldpdkRisveeaLehpY  288

         +++pk++  +f +lfp+            + ++a+dLl+k+Lv+dp kRisv+eaL+hpY

Q: 284   ENRPKYAGLTFPKLFPDslfpadsehnklKASQARDLLSKMLVIDPAKRISVDEALQHPY  343

         *****************************99*****************************

S: 289   l  289

Q: 344   I  344

Domain Sequence
(FASTA)

YQNLKPIGSG AQGIVCAAYD AVLDRNVAIK KLSRPFQNQT HAKRAYRELV LMKCVNHKNI 60

ISLLNVFTPQ KSLEEFQDVY LVMELMDANL CQVIQMELDH ERMSYLLYQM LCGIKHLHSA 120

GIIHRDLKPS NIVVKSDCTL KILDFGLART AGTSFMMTPY VVTRYYRAPE VILGMGYKEN 180

VDIWSVGCIM GEMVRHKILF PGRDYIDQWN KVIEQLGTPC PEFMKKLQPT VRNYVENRPK 240

YAGLTFPKLF PDSLFPADSE HNKLKASQAR DLLSKMLVID PAKRISVDEA LQHPYI 296

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008351	; MAPK_JNK.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01772

; JNKMAPKINASE.

Created Date

20-Feb-2013