EKS-ORA-00077

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORA-00077

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PIKK	396.5	1.2E-118	420	730	311

Status

Unreviewed

Ensembl Protein

ENSOANP00000009992

UniProt Accession

F6V0M0;

Protein Name

Protein Synonyms/Alias

Gene Name

ATM

Gene Synonyms/Alias

ATM;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000006244	ENSOANP00000009993	ENSOANT00000009995
ENSOANG00000006244	ENSOANP00000009992	ENSOANT00000009994

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

731

Protein Sequence
(FASTA)

QLPERAMYQI KQYNSARSEA SAWQLEEAQV FWAKKEQSLA LNILKQMIKK LDSNWSEVKN 60

DSRLQLIHTE CLRVCGNWLA ETCLESPTVI LKKYLEKAVE IAGHRDGGSS DEFKSGKRKA 120

FLSLARFSDT QYQRIENYMN SSEFENKQAL LKKAKEEVGL IKEHRVQSSN TRYTVKVQRE 180

LELDECAIRA LKEDRKRFLC KAVENYISCL LSGEEHDMWI FRLCSLWLEN SGVSEVNVMM 240

KKSGSKIPSY KFLPLMYQLA ARMGTKMTGG LGFHEVLNNL IARISLDHPH HTLFIILALA 300

NANKDDLLQS AEGAKRSKIS KNVPKQISQL DMNRMEAANN IINIIRSSRA HMVRGVETLC 360

DAYITLANLD ATPWKAQRKG IRISADQPIT RLKNLKDVVV PTMEIKVDPT GKYENLVTIS 420

SFKPEFRLAG GLNLPKIIDC VGSDGKERRQ LVKGQDDLRQ DAVMQQVFQM CNTLLQRNTE 480

TRKRKLTICT YKVVPLSQRS GVLEWCTGTV PIGEFLVNSE NGAHKRYRPK DFSALQCQQK 540

MMDIQKKSFE EKYETFLEVC NNFQPVFRYF CMEKFLDPAV WFERRLAYTR SVATSSIVGY 600

ILGLGDRHVQ NILINEQSAE LVHIDLGVAF EQGKILPTPE TVPFRLTRDI VDGMGITGVE 660

GVFRRCCEKT MEVMRNSQET LLTIVEVLLY DPLFDWTMNP LKALYLQQRP EDETELNSTL 720

NAEDQECNRK L 731

Nucleotide Sequence
(FASTA)

CAGCTTCCCG AAAGAGCAAT GTATCAAATC AAACAGTACA ATTCAGCTAG AAGCGAAGCC 60

TCTGCGTGGC AGCTAGAGGA AGCTCAAGTT TTCTGGGCTA AAAAAGAGCA GAGTCTTGCT 120

CTGAATATTC TAAAACAGAT GATCAAGAAG CTGGATTCAA ATTGGTCAGA GGTCAAGAAT 180

GATTCACGCC TACAGTTAAT ACACACAGAG TGTTTGAGAG TCTGTGGAAA CTGGTTAGCG 240

GAAACATGCT TGGAAAGCCC GACAGTTATC TTGAAGAAAT ATTTAGAAAA GGCAGTGGAA 300

ATCGCTGGGC ATCGGGACGG AGGCAGCAGC GATGAGTTTA AGAGTGGAAA GCGGAAGGCT 360

TTTCTCTCGT TGGCCCGTTT CTCTGATACT CAGTACCAGA GGATTGAGAA CTACATGAAC 420

TCATCAGAAT TTGAGAACAA ACAAGCTCTG TTGAAGAAAG CCAAAGAAGA GGTGGGCCTC 480

ATAAAGGAGC ACAGGGTCCA GTCCTCCAAC ACCAGATACA CCGTGAAGGT TCAGCGGGAG 540

CTGGAGCTGG ATGAATGTGC AATCCGGGCC CTGAAGGAGG ATCGGAAACG TTTCCTATGT 600

AAAGCAGTTG AGAACTACAT TAGCTGTTTG TTAAGTGGAG AAGAACATGA CATGTGGATA 660

TTCCGACTCT GTTCCCTCTG GCTGGAAAAC TCTGGAGTGT CTGAAGTCAA CGTCATGATG 720

AAGAAAAGCG GCTCAAAGAT TCCTTCATAC AAGTTTCTGC CTCTTATGTA CCAGTTGGCT 780

GCTAGAATGG GAACCAAGAT GACGGGAGGA CTTGGGTTCC ATGAAGTTCT GAATAACCTC 840

ATTGCTCGAA TTTCCCTAGA TCATCCTCAT CATACTTTGT TTATTATACT GGCCCTGGCA 900

AACGCAAACA AAGACGACCT TTTGCAAAGT GCAGAGGGAG CAAAGAGAAG CAAAATATCT 960

AAAAATGTGC CGAAACAAAT CTCCCAACTT GACATGAATC GAATGGAGGC CGCCAACAAC 1020

ATCATAAATA TCATAAGGAG TAGTCGCGCT CACATGGTCA GAGGTGTTGA GACCCTGTGC 1080

GATGCTTATA TTACATTAGC AAACTTGGAT GCCACTCCGT GGAAAGCTCA GAGAAAAGGC 1140

ATCCGTATCT CGGCTGACCA ACCAATCACA AGACTAAAGA ATCTGAAAGA TGTGGTTGTC 1200

CCCACCATGG AAATTAAGGT GGACCCAACC GGGAAGTATG AAAATCTGGT GACTATTTCC 1260

TCATTTAAGC CAGAATTCCG TTTGGCAGGA GGCCTCAATC TGCCGAAAAT AATAGATTGC 1320

GTGGGCTCAG ATGGCAAGGA AAGGAGGCAG CTTGTCAAGG GTCAAGATGA CCTGAGACAA 1380

GATGCTGTAA TGCAGCAGGT TTTCCAGATG TGTAACACGC TACTCCAACG AAACACTGAA 1440

ACCAGAAAGA GAAAACTGAC TATCTGTACT TATAAGGTGG TTCCCCTGTC TCAACGAAGC 1500

GGGGTCCTGG AGTGGTGCAC GGGGACCGTG CCCATCGGCG AATTCCTGGT CAACAGTGAA 1560

AATGGAGCCC ATAAGAGGTA TAGGCCAAAG GACTTCAGTG CTCTACAGTG CCAGCAGAAA 1620

ATGATGGATA TACAGAAGAA ATCCTTTGAA GAAAAATACG AAACCTTCCT GGAGGTCTGC 1680

AATAATTTTC AGCCGGTGTT CCGCTATTTC TGCATGGAGA AGTTCCTGGA TCCAGCAGTT 1740

TGGTTCGAGA GGCGGCTGGC GTACACTCGC AGCGTGGCGA CTTCATCCAT CGTTGGCTAC 1800

ATACTTGGAC TTGGCGATCG TCACGTACAG AACATCCTGA TAAATGAGCA GTCAGCAGAG 1860

CTTGTTCACA TAGATTTAGG AGTGGCTTTT GAGCAGGGTA AAATCCTTCC CACTCCAGAA 1920

ACGGTGCCTT TCAGGCTAAC CAGGGACATA GTAGACGGGA TGGGTATCAC AGGTGTGGAA 1980

GGGGTCTTCA GAAGATGCTG TGAGAAAACG ATGGAGGTCA TGAGAAACTC CCAGGAAACT 2040

CTGTTAACCA TTGTGGAGGT CCTGCTCTAC GATCCTCTCT TCGACTGGAC CATGAACCCC 2100

TTGAAAGCTT TATATTTACA ACAGAGGCCA GAAGATGAGA CTGAGCTGAA CTCCACTCTG 2160

AATGCCGAGG ACCAGGAATG TAATCGAAAA CTC 2193

Domain Profile

S: 2     agfderveilaskqkpkklllrGsdgkeypyLvkgkeDlrqdervlqlfslvNtlLakdk  61

          +f+++  +   ++ pk +   Gsdgke+++Lvkg++Dlrqd++++q+f+++NtlL++++

Q: 420   SSFKPEFRLAGGLNLPKIIDCVGSDGKERRQLVKGQDDLRQDAVMQQVFQMCNTLLQRNT  479

         66777777777788999*******************************************

S: 62    etsrrkLkirtykVvplstrsgliewventvsLkellkklvekkavlldqpisyrykdls  121

         et++rkL+i+tykVvpls+rsg++ew+++tv+++e+l   v++++++++   +yr+kd+s

Q: 480   ETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEFL---VNSENGAHK---RYRPKDFS  533

         *************************************...799999**9...********

S: 122   tvqarkpklkhlkls....levfkevlenlvpkdllkklllekfpspeewfelrkaytrs  177

         + q+++++++ +k+s    +e f ev++n++p  +++++++ekf++p++wfe+r aytrs

Q: 534   ALQCQQKMMDIQKKSfeekYETFLEVCNNFQP--VFRYFCMEKFLDPAVWFERRLAYTRS  591

         ********************************..9*************************

S: 178   lAvislvgyiLgLgdrhlenllidqetgevvhidfgvafekaktqlkvpekvPFRLTrni  237

         +A++s+vgyiLgLgdrh++n+li+++++e+vhid+gvafe++k+ l++pe+vPFRLTr+i

Q: 592   VATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKI-LPTPETVPFRLTRDI  650

         ********************************************.***************

S: 238   vnalgvtgveGvfrasceavlrvlreskeklltiLevflydplvdwkk......kkktsk  291

         v+++g+tgveGvfr++ce++++v+r+s+e+llti+ev+lydpl+dw++      + ++++

Q: 651   VDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTMnplkalYLQQRP  710

         ******************************************************9*****

S: 292   eteeelaekakaealkikkl  311

         e+e+el+++ +ae+++++++

Q: 711   EDETELNSTLNAEDQECNRK  730

         ****************9876

Domain Sequence
(FASTA)

SSFKPEFRLA GGLNLPKIID CVGSDGKERR QLVKGQDDLR QDAVMQQVFQ MCNTLLQRNT 60

ETRKRKLTIC TYKVVPLSQR SGVLEWCTGT VPIGEFLVNS ENGAHKRYRP KDFSALQCQQ 120

KMMDIQKKSF EEKYETFLEV CNNFQPVFRY FCMEKFLDPA VWFERRLAYT RSVATSSIVG 180

YILGLGDRHV QNILINEQSA ELVHIDLGVA FEQGKILPTP ETVPFRLTRD IVDGMGITGV 240

EGVFRRCCEK TMEVMRNSQE TLLTIVEVLL YDPLFDWTMN PLKALYLQQR PEDETELNST 300

LNAEDQECNR K 311

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0004674	; F:protein serine/threonine kinase activity
GO:0000077	; P:DNA damage checkpoint
GO:0006281	; P:DNA repair
GO:0016572	; P:histone phosphorylation
GO:0090399	; P:replicative senescence
GO:0010212	; P:response to ionizing radiation
GO:0000723	; P:telomere maintenance

KEGG

InterPros

IPR015519	; ATM/Tel1.
IPR003151	; PIK-rel_kinase_FAT.
IPR014009	; PIK_FAT.

Pfam

PF02259

; FAT; 1.

SMARTs

Prosites

PS51189

; FAT; 1.

Prints

Created Date

20-Feb-2013