EKS-ORA-00217

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORA-00217

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	288.0	6.4E-86	9	265	257

Status

Unreviewed

Ensembl Protein

ENSOANP00000010076

UniProt Accession

F6UR87;

Protein Name

Protein Synonyms/Alias

Gene Name

CHEK1

Gene Synonyms/Alias

CHEK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000006301	ENSOANP00000010076	ENSOANT00000010078

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

476

Protein Sequence
(FASTA)

MAVPFVEDWD LVQTLGEGAY GEVQLAVNRR TEEAVAVKIV DMKRAADCPE NIKKEICINK 60

MLNHENIVKF YGHRREGNIQ YLFLEYCSGG ELFDRIEPDV GMPEPEAQKF FHQLMAGVVY 120

LHGIGITHRD IKPENLLLDE RDNLKISDFG LATVFRHNNR ERLLNKMCGT LPYVAPELLK 180

RKEFRAEPVD VWSCGIVLTA MLAGELPWDQ PSDSCQEYCD WKEKKTYLPP WKKIDSAPLA 240

LLHKILTESP TARLTIPDIK KDRWYTKPLK KVAKRSRASS GGLADSPGGF GKHIRSSLDF 300

SPVSSALSED KVKYSSSQPE PRTGLSLGDS GPADIDKLVQ GISFSQPACP DHMLLNSQLL 360

ATPGSSQNPW QRLVKRMTRF FTKLDADRSY HCLKETCEKL GYQWKKSCVN QVTVSTTDRR 420

NNKLIFKVNL VEMGEKILVD FRLSKGDGLE FKRHFLKIKG KLSDVVSSQK LWLPAT 476

Nucleotide Sequence
(FASTA)

ATGGCGGTGC CCTTCGTGGA AGACTGGGAC CTGGTCCAGA CGCTAGGGGA AGGGGCCTAT 60

GGAGAAGTCC AGCTGGCAGT GAACAGGCGG ACGGAAGAAG CGGTCGCCGT CAAGATCGTG 120

GACATGAAGC GGGCCGCGGA CTGTCCCGAA AACATCAAGA AAGAGATCTG CATCAATAAA 180

ATGCTGAACC ACGAGAACAT AGTGAAATTC TACGGGCACC GGCGGGAGGG CAACATCCAG 240

TACCTGTTCC TGGAGTACTG CAGCGGGGGA GAGCTCTTTG ACCGCATAGA ACCCGATGTG 300

GGGATGCCTG AACCTGAGGC CCAAAAGTTC TTCCACCAGC TTATGGCCGG CGTGGTGTAC 360

CTGCATGGCA TCGGGATCAC CCACCGGGAT ATTAAGCCAG AAAACCTTCT GCTCGACGAG 420

AGAGATAACC TCAAGATCTC GGACTTCGGC CTGGCCACGG TGTTTCGGCA CAACAACCGC 480

GAGCGCCTGC TGAACAAGAT GTGCGGGACG CTGCCCTACG TGGCCCCGGA GCTGCTGAAG 540

CGCAAGGAGT TCCGGGCCGA GCCGGTGGAC GTCTGGTCGT GCGGCATCGT CTTGACCGCC 600

ATGCTGGCTG GAGAGCTGCC GTGGGATCAA CCTAGCGACA GTTGCCAGGA ATATTGTGAC 660

TGGAAGGAAA AGAAAACCTA CCTCCCACCT TGGAAAAAGA TTGATTCCGC CCCGTTAGCC 720

CTGCTGCATA AAATCCTGAC CGAGAGCCCG ACGGCACGGC TCACCATCCC AGACATTAAG 780

AAAGACCGAT GGTACACGAA ACCCCTGAAA AAAGTTGCGA AAAGGAGCCG GGCCTCTTCG 840

GGCGGCCTGG CGGACTCGCC CGGGGGCTTT GGCAAGCACA TTCGCTCCAG CTTGGACTTC 900

TCCCCCGTGA GCAGCGCCCT CAGCGAAGAT AAAGTGAAGT ATTCCAGCTC CCAGCCCGAG 960

CCTCGCACGG GGCTCTCCCT CGGCGACTCC GGCCCCGCTG ACATCGACAA GTTGGTTCAA 1020

GGCATCAGCT TCTCGCAGCC GGCCTGCCCG GACCACATGC TGCTGAACAG CCAGCTCCTT 1080

GCCACCCCGG GCTCCTCCCA GAACCCTTGG CAGCGGCTGG TTAAGAGAAT GACCCGGTTC 1140

TTCACGAAGC TGGACGCCGA CAGGTCCTAC CACTGCCTGA AGGAGACTTG CGAGAAGCTG 1200

GGCTACCAGT GGAAGAAGAG CTGTGTGAAC CAGGTCACGG TGTCGACGAC GGACCGGAGA 1260

AACAACAAGC TGATTTTCAA GGTGAACCTG GTGGAGATGG GCGAGAAGAT CCTGGTGGAT 1320

TTCCGGCTGT CCAAGGGTGA CGGGTTAGAA TTCAAGAGGC ACTTCCTGAA GATTAAAGGG 1380

AAGCTGAGTG ACGTGGTGAG CAGCCAGAAG CTCTGGCTTC CTGCCACTTG A 1431

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         ++l++tlGeg++g+V+la++++t+e+vavKi++ k++  +  e+ik+Ei i k+l+h+ni

Q: 9     WDLVQTLGEGAYGEVQLAVNRRTEEAVAVKIVDMKRAA-DCPENIKKEICINKMLNHENI  67

         7899******************************7765.5579*****************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         +k++   ++ +  yl+ley+sggeLfd+ie +  ++e ea+k+f+ql+++v Ylh  gi+

Q: 68    VKFYGHRREGNIQYLFLEYCSGGELFDRIEPDVGMPEPEAQKFFHQLMAGVVYLHGIGIT  127

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkeg...klletfcGsppYaaPellkgkkYegp  177

         HrD+KpeNllld+++n+ki+DFGla++f+++   +ll+++cG++pY+aPellk+k+++++

Q: 128   HRDIKPENLLLDERDNLKISDFGLATVFRHNnreRLLNKMCGTLPYVAPELLKRKEFRAE  187

         **************************9988877799************************

S: 178   kvDvWslGvvLyalvtgklPfdee..nlkellekilkgkleipkk.lskelesLlrklLv  234

         +vDvWs+G+vL a+++g+lP+d++  +++e+ ++ +k+++  p k +++    Ll+k+L+

Q: 188   PVDVWSCGIVLTAMLAGELPWDQPsdSCQEYCDWKEKKTYLPPWKkIDSAPLALLHKILT  247

         ***********************97568888877777777666658**************

S: 235   vdpekRatieeilkhewl  252

         ++p+ R+ti +i+k++w+

Q: 248   ESPTARLTIPDIKKDRWY  265

         *****************5

Domain Sequence
(FASTA)

WDLVQTLGEG AYGEVQLAVN RRTEEAVAVK IVDMKRAADC PENIKKEICI NKMLNHENIV 60

KFYGHRREGN IQYLFLEYCS GGELFDRIEP DVGMPEPEAQ KFFHQLMAGV VYLHGIGITH 120

RDIKPENLLL DERDNLKISD FGLATVFRHN NRERLLNKMC GTLPYVAPEL LKRKEFRAEP 180

VDVWSCGIVL TAMLAGELPW DQPSDSCQEY CDWKEKKTYL PPWKKIDSAP LALLHKILTE 240

SPTARLTIPD IKKDRWY 257

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005813	; C:centrosome
GO:0000785	; C:chromatin
GO:0000781	; C:chromosome, telomeric region
GO:0000794	; C:condensed nuclear chromosome
GO:0005657	; C:replication fork
GO:0005524	; F:ATP binding
GO:0035402	; F:histone kinase activity (H3-T11 specific)
GO:0071260	; P:cellular response to mechanical stimulus
GO:0048096	; P:chromatin-mediated maintenance of transcription
GO:0000077	; P:DNA damage checkpoint
GO:0006281	; P:DNA repair
GO:0000086	; P:G2/M transition of mitotic cell cycle
GO:0045839	; P:negative regulation of mitosis
GO:0010569	; P:regulation of double-strand break repair via homologous recombination
GO:2000615	; P:regulation of histone H3-K9 acetylation
GO:0046602	; P:regulation of mitotic centrosome separation
GO:0010767	; P:regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage

KEGG

oaa:100090345

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013