EKS-ORA-00399

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORA-00399

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/VPS15	494.0	1.4E-148	26	309	284

Status

Unreviewed

Ensembl Protein

ENSOANP00000010793

UniProt Accession

F7C3T3;

Protein Name

Protein Synonyms/Alias

Gene Name

PIK3R4

Gene Synonyms/Alias

PIK3R4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000006762	ENSOANP00000010793	ENSOANT00000010795

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

1362

Protein Sequence
(FASTA)

MGNQLAGIAP SQILSVDSYF SDIHDFEYDK SLGSTRFFKV ARAKHREGFV VVKVFAIQDP 60

TLPLTSYKQE LEELKIRLHS AQNCLPFQKA TMTEKAAMLF RQYVRDNLYD RISTRPFLNN 120

IEKRWIAFQI LTAVDQAHRS GVRHGDIKTE NVMVTSWNWV LLTDFASFKP TYLPEDNPAD 180

FNYFFDTSRR RTCYIAPERF VDGGMFATEL ESMRDPSTPL VDLASSNQRT RGELKRAMDI 240

FSAGCVIAEL FTEGVPLFDL SQLLAYRNGH FSPDQVLNKI EDHSIRELVT QMIRCEPDKR 300

LGAEDYLKQQ RGKAFPEIFY TFLQPYMAQF AKETFISADE RILVIRKDLD NIIHNLCGHD 360

RTEKAEGETK ENGLVILVSV ITSCLQTLKY CDSKLAALEL ILHLAPRLSV EILLDRMTPY 420

LLHFSNDSVP RVRAEAVRTL TKVLALVKEV PRNDVNIYPE YILPGIAHLA QDEATIVRLA 480

YAENIALLAE TALRFLELVQ LKNFNMENDP NSEELDEVTH PSENYDTDVG CHHVDLHDDY 540

ATAISQDDCP NSKRRMRTNL NRNSVCRCQF RASTTRLGHL LFTPFIHSSH VYSLLGGCFS 600

KPTCVAAYVG WQSSSILKPL LQQGLSDAEE FVIFKALNAL TCMCQLGLLQ KPHIYEFACD 660

IAPFLCHPNL WIRYGAVGFI TVVAQHLNIA DVYCKLMPFL HPFITQPIIQ IDKEIVLLSV 720

LKEPVTRSIF DYALRSKDIA SLFRHLQMRQ KKRIGTVSDC PPPEDPAIAQ LLKKLLSQGM 780

TEEEEDKLLA LKDFMMKSNK AKANIVDQSH LHDTQKGVID LATLGLTGRQ VDLVKTKQEP 840

DDKRARKHVK QDSNVNEEWK SMFGSLEPAT IAQPLPKGHG PTSDQEAIQT GKSFRSESSV 900

GVGIPLSSSP QATEIAAVQA RKPQIQVLSS TILPSSYQIR ITTCKTELQQ LVQQKREQCN 960

AERIAKQMME NAEWESKPPP PGWRPKGLLV AHLHEHKSAV NRIRVSDEHS LFATCSNDGT 1020

VKIWNSQKME GKTTTTRSII TYSRIGGRVK TLTFCQGSHY LAIASDNGAV QLLGIEASKL 1080

PKSPKIHPLQ SRLLDQKEDG CVVDIHHFNS GAQSVLAYAT VNGSLVGWDL RSSSNAWTLK 1140

HDLKSGLITS FAVDIHQCWL CIGTSNGTMA CWDMRFQLPI SSHCHPSRAR IRRLLMHPLY 1200

QSWVIAAVQG NNEVSMWDME TGDRRFTLWA SGAPPLSELQ PSPHSVHGIY CSPADGNPIL 1260

LTAGSDMKIR FWDLAYPERS YVVAGNTGSP TVSYYRKIIE GTEVVQEIQN KQKVGPSDDT 1320

PRRGPESLPV GHHDIITDVA TFQTTQGFIV TASRDGIVKV WK 1362

Nucleotide Sequence
(FASTA)

ATGGGAAATC AGCTAGCTGG CATCGCCCCC TCCCAGATCC TTTCGGTGGA CAGTTACTTT 60

TCGGACATCC ACGACTTTGA ATATGACAAG AGCCTGGGAA GTACTCGTTT TTTTAAAGTT 120

GCTCGGGCCA AGCACCGAGA AGGCTTTGTG GTTGTGAAGG TCTTTGCCAT TCAGGATCCG 180

ACCCTACCTT TAACGAGCTA CAAACAAGAG CTGGAGGAGC TGAAGATACG GCTTCATTCG 240

GCCCAGAACT GCCTGCCCTT TCAGAAGGCC ACTATGACGG AAAAGGCGGC CATGCTCTTC 300

AGACAGTACG TGCGAGACAA TCTCTACGAC CGAATCAGCA CCCGTCCGTT CTTAAACAAC 360

ATCGAGAAGC GGTGGATCGC GTTCCAGATC CTGACCGCGG TGGATCAAGC GCACAGATCG 420

GGGGTCCGTC ACGGGGACAT CAAGACTGAA AATGTCATGG TCACCAGTTG GAATTGGGTC 480

CTCCTCACCG ACTTTGCCAG TTTTAAGCCA ACTTATCTTC CGGAGGACAA CCCGGCGGAC 540

TTCAACTACT TCTTTGACAC TTCACGGAGG AGGACTTGTT ATATCGCTCC CGAGCGCTTC 600

GTCGACGGCG GCATGTTTGC CACAGAGTTA GAATCTATGA GAGATCCTTC AACCCCACTG 660

GTAGATTTGG CAAGCAGCAA TCAGAGAACG AGAGGAGAAT TGAAACGTGC GATGGATATA 720

TTTTCCGCAG GATGTGTAAT TGCTGAGTTG TTTACAGAAG GTGTACCACT GTTTGACCTG 780

TCACAGCTTT TGGCCTATAG GAACGGACAC TTTTCCCCCG ACCAGGTACT GAATAAAATC 840

GAAGATCACA GCATCAGAGA ACTGGTCACT CAGATGATTC GCTGCGAACC AGATAAACGT 900

TTAGGGGCAG AAGATTATTT AAAGCAGCAA CGTGGCAAGG CCTTTCCCGA AATATTTTAC 960

ACTTTCCTTC AGCCTTATAT GGCCCAGTTT GCCAAGGAAA CGTTTATCTC GGCGGATGAG 1020

CGTATTCTGG TCATCCGGAA AGATCTGGAC AACATCATCC ACAATCTCTG TGGGCACGAC 1080

CGCACCGAAA AAGCCGAGGG CGAGACCAAG GAGAATGGGC TGGTCATTTT GGTGTCCGTG 1140

ATAACTTCCT GTTTACAGAC CCTCAAGTAC TGTGATTCGA AACTTGCCGC TCTGGAGCTC 1200

ATTCTTCATT TGGCCCCCAG ACTAAGTGTC GAAATCTTGC TGGACCGCAT GACGCCCTAC 1260

CTTCTGCATT TCAGTAACGA CTCTGTGCCC AGGGTGAGGG CAGAAGCCGT GAGGACACTG 1320

ACCAAAGTTC TCGCCCTTGT CAAAGAAGTG CCACGGAACG ATGTCAATAT TTATCCGGAA 1380

TACATTTTGC CGGGCATCGC GCATTTGGCT CAGGATGAGG CCACGATTGT CAGGCTCGCT 1440

TATGCTGAAA ATATAGCATT GTTAGCAGAA ACAGCTCTCA GATTCCTGGA ATTGGTGCAA 1500

CTGAAAAATT TTAATATGGA AAATGACCCA AATAGTGAAG AATTAGATGA AGTAACACAC 1560

CCAAGTGAAA ATTATGACAC AGATGTAGGA TGTCATCATG TGGATCTTCA TGATGATTAT 1620

GCCACAGCCA TCTCCCAGGA CGACTGTCCA AACAGCAAAA GAAGGATGCG GACAAACCTG 1680

AACAGAAATT CAGTTTGTCG CTGTCAGTTC CGAGCTAGTA CTACCAGATT GGGTCACCTC 1740

TTGTTCACTC CATTCATTCA TTCAAGTCAT GTGTATTCTC TGTTGGGTGG TTGTTTTTCT 1800

AAACCAACAT GTGTCGCTGC CTACGTTGGC TGGCAGAGCT CATCCATCCT GAAGCCTCTG 1860

TTGCAGCAGG GCCTTAGTGA TGCTGAGGAA TTTGTTATCT TCAAGGCTCT CAATGCCCTT 1920

ACCTGCATGT GTCAGTTAGG GCTGTTGCAG AAACCCCATA TCTATGAATT TGCCTGTGAT 1980

ATTGCACCCT TTCTATGCCA TCCCAATCTT TGGATACGCT ACGGTGCGGT AGGATTCATC 2040

ACAGTGGTAG CTCAACATCT AAATATTGCC GACGTCTACT GCAAACTAAT GCCCTTTCTT 2100

CATCCTTTTA TAACTCAGCC AATAATACAG ATTGATAAGG AAATTGTTCT ACTGAGTGTT 2160

CTTAAGGAGC CAGTAACCCG CTCCATATTT GATTATGCCT TGAGGTCCAA AGACATCGCC 2220

AGTCTTTTCA GACACCTTCA GATGCGTCAG AAGAAACGCA TTGGAACCGT TTCTGACTGC 2280

CCTCCTCCAG AGGATCCTGC CATTGCACAG TTGCTCAAGA AATTGCTCTC ACAGGGAATG 2340

ACAGAGGAGG AGGAAGACAA GCTGTTAGCT TTGAAAGACT TCATGATGAA ATCCAATAAA 2400

GCGAAGGCCA ATATTGTGGA CCAGAGCCAC CTTCACGATA CTCAAAAAGG TGTGATCGAC 2460

TTGGCCACTC TAGGCCTAAC CGGAAGACAA GTTGACCTTG TTAAAACCAA GCAAGAGCCC 2520

GACGACAAAA GGGCTAGAAA ACACGTAAAG CAAGATTCAA ATGTGAATGA AGAATGGAAG 2580

AGTATGTTTG GGTCATTGGA ACCAGCTACC ATTGCTCAGC CACTACCAAA AGGCCATGGA 2640

CCAACTAGTG ATCAAGAAGC AATTCAGACA GGGAAATCTT TTCGTTCCGA GTCGTCGGTT 2700

GGCGTGGGCA TTCCTCTGTC GTCATCTCCT CAGGCCACTG AAATAGCAGC TGTCCAGGCT 2760

CGGAAACCTC AGATCCAAGT TTTGAGCAGT ACCATTTTGC CATCCAGCTA CCAAATCCGC 2820

ATCACAACTT GTAAAACTGA ACTTCAGCAG CTAGTGCAAC AGAAGCGCGA GCAGTGCAAC 2880

GCCGAGCGGA TAGCCAAGCA GATGATGGAG AATGCAGAAT GGGAGAGCAA GCCACCCCCG 2940

CCGGGTTGGC GACCTAAAGG ACTATTGGTC GCACATCTTC ACGAACACAA ATCTGCGGTA 3000

AATCGCATCA GAGTCTCCGA CGAACACTCC CTCTTTGCAA CATGCTCAAA TGATGGGACT 3060

GTGAAAATCT GGAACAGCCA GAAGATGGAA GGCAAGACCA CTACTACCAG GTCAATCATA 3120

ACATACTCTC GCATCGGAGG ACGTGTCAAG ACGCTTACGT TTTGCCAAGG CTCCCATTAT 3180

TTGGCCATAG CTTCTGATAA TGGAGCCGTT CAGCTCCTTG GGATCGAGGC TTCCAAGTTA 3240

CCTAAATCTC CAAAGATACA TCCGCTACAA AGCAGGCTTT TAGACCAGAA AGAGGATGGG 3300

TGTGTTGTAG ATATACATCA CTTCAATTCT GGAGCGCAGT CAGTGCTGGC CTATGCCACC 3360

GTGAATGGTT CCTTAGTTGG TTGGGACCTC AGGTCTTCGA GTAACGCGTG GACGCTAAAG 3420

CACGATTTGA AGTCAGGCCT CATAACGTCA TTTGCCGTGG ACATCCACCA GTGCTGGCTG 3480

TGTATTGGAA CCAGCAATGG TACTATGGCC TGTTGGGACA TGAGGTTCCA GTTGCCGATT 3540

TCCAGCCACT GCCATCCTTC GCGGGCTCGG ATCAGACGCC TCCTGATGCA TCCTCTCTAT 3600

CAGTCTTGGG TCATCGCAGC TGTTCAAGGC AACAATGAAG TGTCCATGTG GGACATGGAA 3660

ACGGGCGACA GACGGTTCAC GCTCTGGGCC AGCGGTGCCC CACCGCTTTC CGAATTACAG 3720

CCGTCCCCAC ACAGCGTTCA CGGGATATAT TGCAGTCCCG CAGATGGAAA TCCGATCCTG 3780

TTGACGGCAG GCTCGGACAT GAAAATAAGA TTTTGGGATT TAGCGTACCC CGAGCGATCC 3840

TACGTCGTTG CAGGAAATAC AGGCTCCCCA ACAGTGTCGT ACTACAGGAA GATCATCGAA 3900

GGCACCGAAG TAGTCCAGGA AATTCAGAAC AAGCAGAAGG TGGGGCCCTC GGACGACACC 3960

CCACGAAGGG GTCCGGAATC TCTCCCGGTG GGCCATCACG ATATCATCAC CGACGTTGCT 4020

ACGTTCCAGA CCACGCAAGG CTTTATCGTG ACTGCTTCCA GAGATGGGAT TGTTAAAGTA 4080

TGGAAATGA 4089

Domain Profile

S: 1     veyvknlgstrflkvakakteeGeivvkvfvkqdptlslesfkqrleelklklakaqncl  60

         +ey+k+lgstrf+kva+ak++eG +vvkvf++qdptl+l+s+kq+leelk++l++aqncl

Q: 26    FEYDKSLGSTRFFKVARAKHREGFVVVKVFAIQDPTLPLTSYKQELEELKIRLHSAQNCL  85

         68**********************************************************

S: 61    pfqkvlekekaavllrqyvkdnlydrlstrPflneiekkwiafqllkaldqihksgvvhG  120

         pfqk++++ekaa+l+rqyv+dnlydr+strPfln+iek+wiafq+l+a+dq+h+sgv+hG

Q: 86    PFQKATMTEKAAMLFRQYVRDNLYDRISTRPFLNNIEKRWIAFQILTAVDQAHRSGVRHG  145

         ************************************************************

S: 121   diktenvlvtswnWvlltdfasfkPtylpednPadftyffdtsrrrtcyiaPerfvsala  180

         diktenv+vtswnWvlltdfasfkPtylpednPadf+yffdtsrrrtcyiaPerfv++++

Q: 146   DIKTENVMVTSWNWVLLTDFASFKPTYLPEDNPADFNYFFDTSRRRTCYIAPERFVDGGM  205

         ************************************************************

S: 181   sdekl...rdgstelvdld.siqrlrgelkkamdifsaGcvilelftegrplfelsqlla  236

         ++++l   rd+st+lvdl  s+qr+rgelk+amdifsaGcvi+elfteg+plf+lsqlla

Q: 206   FATELesmRDPSTPLVDLAsSNQRTRGELKRAMDIFSAGCVIAELFTEGVPLFDLSQLLA  265

         ***99889*********86279**************************************

S: 237   yrsgeflvekvlekiededlrnlvlqliqlepekrksaedllkk  280

         yr+g+f +++vl+kied+++r+lv+q+i  ep+kr+ aed+lk+

Q: 266   YRNGHFSPDQVLNKIEDHSIRELVTQMIRCEPDKRLGAEDYLKQ  309

         ******************************************97

Domain Sequence
(FASTA)

FEYDKSLGST RFFKVARAKH REGFVVVKVF AIQDPTLPLT SYKQELEELK IRLHSAQNCL 60

PFQKATMTEK AAMLFRQYVR DNLYDRISTR PFLNNIEKRW IAFQILTAVD QAHRSGVRHG 120

DIKTENVMVT SWNWVLLTDF ASFKPTYLPE DNPADFNYFF DTSRRRTCYI APERFVDGGM 180

FATELESMRD PSTPLVDLAS SNQRTRGELK RAMDIFSAGC VIAELFTEGV PLFDLSQLLA 240

YRNGHFSPDQ VLNKIEDHSI RELVTQMIRC EPDKRLGAED YLKQ 284

Keyword

Complete proteome; Reference proteome; Repeat; WD repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005770	; C:late endosome
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR021133	; HEAT_type_2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015943	; WD40/YVTN_repeat-like_dom.
IPR001680	; WD40_repeat.
IPR019775	; WD40_repeat_CS.
IPR017986	; WD40_repeat_dom.

Pfam

PF00069	; Pkinase; 1.
PF00400	; WD40; 3.

SMARTs

SM00320

; WD40; 5.

Prosites

PS50077	; HEAT_REPEAT; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00678	; WD_REPEATS_1; 2.
PS50082	; WD_REPEATS_2; 2.
PS50294	; WD_REPEATS_REGION; 2.

Prints

Created Date

20-Feb-2013