EKS-ORA-00065
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORA-00065
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Musk600.74.9E-181601881281
StatusUnreviewed
Ensembl ProteinENSOANP00000011101
UniProt AccessionF7D8N0;
Protein Name
Protein Synonyms/Alias
Gene NameMUSK
Gene Synonyms/Alias MUSK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOANG00000006972ENSOANP00000011101ENSOANT00000011103
OrganismOrnithorhynchus anatinus
Functional Description
Protein Length895
Protein Sequence
(FASTA)
MKDLINIPLL HILLAALSLA EKLPQAPVIT TPLETMDASV EGTATFICAV DSYPQPEIAW 60
TRNKILIKMF DTRYSIRENG QLLTILSVED SDDGIYCCTA NNGVGEAAES CGALQVKMKP 120
KITRPPINVK ITEGLKVVLP CTTMGNPKPS VSWIKGETTL KENARIAVLE SGNLRIHNVQ 180
REDAGHYRCL AKNSLGTAYS KPVMLEVEAI EESEPERDTK VFARILRAPE SHNVTFGSIV 240
KLRCTATGIP VPTVTWLENG NVVSTGSILE SVKDRVIDSQ LQLFITRPGL FTCIATNKHG 300
EKLSTAKAAA TISVSEAPAS WEHKIQSCVW INFSSKLYKG DTGYCSTYKG EVCSAVLVKD 360
ALVFFNSSYA DSEKIQEMLA QAVWSELKTV SLLCRQAAES LLCNHVFQEC HPTAVIPTPK 420
PICREHCLAV RDQYCSNDWL TMEAKSHKGL YQSGLHQLIL PECSKLPSMH VDPTACTKIP 480
YFEYRKENIT TAPSPVTAKS SAEIPNLPSS SSSFSPTYSM TVIISIMSSF AVIGLFTITT 540
LVCCRRRKQW KNKSKESATP TLTTLPSELL LDRLHPNPMY QRMPLLLNPK LLSLEYPRNN 600
IEYVRDIGEG AFGRVFQARA PGLLSYEPFT MVAVKMLKEE ASADMQADFQ REAALMAEFD 660
DPNIVKLLGV CAVGKPMCLL FEYMAFGDLN EFLRNMSPRT VCSLSHGNLV PRMRISSPGP 720
PPLCCAEQLC IARQVAAGMA YLSERKFVHR DLATRNCLVG ENMVVKIADF GLSRNIYSAD 780
YYKANENDAI PIRWMPPESI FYNRYTTESD IWAYGVVLWE IFSYGLQPYY GMAHEEVIYY 840
VRDGNILSCP ENCPLELYNL MRLCWSKLPA DRPSFTSIHR ILARMCERAE AAMHA 895
Nucleotide Sequence
(FASTA)
ATGAAAGACC TAATCAACAT TCCACTTTTA CACATCCTCC TAGCAGCTCT CAGCCTGGCC 60
GAGAAACTTC CACAAGCCCC TGTCATCACC ACTCCTCTTG AAACAATGGA TGCATCAGTA 120
GAAGGGACAG CCACTTTCAT CTGTGCGGTG GATTCTTATC CACAGCCTGA GATTGCCTGG 180
ACACGTAACA AGATTCTCAT CAAGATGTTT GATACACGGT ATAGCATTCG GGAGAATGGG 240
CAGCTATTGA CCATCCTGAG TGTGGAAGAT AGTGATGATG GCATTTACTG CTGCACCGCA 300
AACAATGGAG TAGGAGAAGC TGCTGAGAGT TGTGGGGCTT TGCAAGTGAA AATGAAACCT 360
AAAATAACCC GTCCTCCCAT TAATGTAAAA ATAACTGAAG GATTGAAGGT GGTTCTGCCA 420
TGCACGACAA TGGGCAATCC CAAACCTTCT GTATCATGGA TCAAGGGAGA AACTACACTA 480
AAGGAAAATG CTCGAATTGC AGTTCTTGAA TCTGGAAATT TAAGGATTCA CAATGTTCAA 540
AGGGAAGATG CGGGACATTA TCGATGTTTA GCCAAAAACA GTCTCGGAAC AGCATATTCC 600
AAACCGGTAA TGCTGGAAGT GGAAGCAATA GAAGAAAGTG AACCTGAACG AGATACTAAA 660
GTTTTCGCCA GAATACTGAG AGCACCTGAA TCCCACAATG TCACTTTTGG CTCCATAGTG 720
AAGCTGCGCT GCACTGCTAC CGGCATTCCA GTCCCCACTG TCACATGGCT TGAAAATGGA 780
AATGTTGTTT CCACTGGGTC CATTCTAGAA AGTGTAAAAG ACAGAGTGAT TGATTCCCAA 840
CTGCAGCTGT TTATCACCAG ACCGGGACTG TTCACTTGCA TAGCCACTAA CAAACATGGG 900
GAGAAACTCA GCACTGCAAA AGCCGCTGCC ACCATCAGTG TATCAGAGGC TCCAGCTAGT 960
TGGGAGCACA AAATTCAGTC ATGTGTTTGG ATCAATTTCT CAAGTAAACT ATACAAAGGT 1020
GATACAGGCT ACTGCAGCAC ATACAAGGGT GAGGTATGTA GTGCTGTCTT GGTGAAGGAT 1080
GCTCTTGTTT TCTTCAACTC CTCCTATGCT GACTCAGAGA AGATCCAAGA AATGCTTGCC 1140
CAAGCCGTCT GGAGTGAACT GAAAACAGTG AGTTTACTCT GCCGGCAGGC GGCTGAATCT 1200
TTGCTGTGTA ACCACGTCTT CCAGGAGTGC CACCCAACTG CAGTTATACC AACACCCAAA 1260
CCGATCTGCA GAGAGCACTG CCTGGCTGTA AGGGATCAAT ACTGCTCCAA TGATTGGCTT 1320
ACAATGGAAG CAAAGTCACA CAAGGGACTC TATCAATCTG GACTACACCA GTTGATTCTA 1380
CCAGAATGCA GCAAACTTCC CAGCATGCAT GTGGACCCCA CGGCCTGCAC AAAAATACCC 1440
TATTTTGAGT ATAGAAAGGA AAACATAACA ACAGCACCTT CACCAGTAAC AGCGAAGTCA 1500
AGTGCAGAGA TTCCAAATCT CCCATCCTCT TCCTCTTCTT TTTCACCCAC ATATTCCATG 1560
ACTGTAATCA TTTCCATCAT GTCCAGCTTT GCTGTGATTG GGTTGTTCAC CATCACTACC 1620
CTTGTATGCT GCAGAAGGCG AAAGCAATGG AAAAACAAGA GTAAGGAATC AGCAACCCCC 1680
ACCCTAACCA CCCTTCCTTC AGAATTACTG TTGGACAGGC TTCATCCCAA CCCTATGTAC 1740
CAGAGAATGC CACTGCTGCT GAACCCTAAA CTACTCAGCT TGGAGTATCC AAGAAACAAT 1800
ATTGAATACG TGAGAGACAT CGGAGAAGGA GCCTTTGGAA GGGTCTTTCA AGCCAGGGCT 1860
CCTGGTTTGC TTTCCTATGA ACCTTTCACC ATGGTGGCAG TCAAGATGCT CAAAGAAGAA 1920
GCCTCAGCAG ACATGCAAGC TGATTTCCAG AGAGAGGCGG CCCTCATGGC AGAATTTGAC 1980
GACCCTAACA TCGTCAAACT CCTTGGAGTC TGTGCTGTGG GGAAGCCGAT GTGCCTGCTG 2040
TTTGAATACA TGGCCTTCGG GGATCTAAAC GAGTTTCTCC GCAATATGTC TCCTCGCACC 2100
GTGTGCAGCC TTAGCCACGG TAACCTGGTC CCGAGGATGA GAATCTCCAG CCCAGGCCCA 2160
CCTCCCCTCT GCTGTGCTGA GCAGCTCTGC ATTGCCAGGC AGGTCGCAGC CGGCATGGCT 2220
TACCTCTCAG AGCGCAAGTT TGTGCACCGC GACTTGGCCA CCAGGAACTG TCTGGTTGGG 2280
GAGAACATGG TGGTGAAAAT TGCTGACTTT GGCCTCTCCA GGAACATCTA TTCAGCAGAC 2340
TACTACAAAG CCAACGAGAA TGATGCCATC CCTATCCGCT GGATGCCCCC GGAGTCTATT 2400
TTCTACAACC GCTACACGAC TGAGTCTGAC ATCTGGGCCT ATGGTGTGGT CCTTTGGGAG 2460
ATCTTTTCCT ACGGCCTTCA GCCCTACTAC GGGATGGCTC ATGAAGAAGT CATTTACTAT 2520
GTGAGAGATG GCAATATTCT CTCCTGCCCA GAGAACTGCC CCCTGGAGCT GTACAATCTG 2580
ATGCGTCTCT GTTGGAGCAA GCTACCTGCC GACCGCCCCA GCTTCACCAG CATCCATCGC 2640
ATCCTGGCGC GCATGTGTGA GCGGGCGGAG GCAGCGATGC ATGCCTGA 2688
Domain Profile
S: 1     ieyvrdlgegafgrvfqarapgllpyeefllvavkmlkeeasadmqadfereaallaefd  60
         ieyvrd+gegafgrvfqarapgll ye+f++vavkmlkeeasadmqadf+reaal+aefd
Q: 601   IEYVRDIGEGAFGRVFQARAPGLLSYEPFTMVAVKMLKEEASADMQADFQREAALMAEFD  660
         89**********************************************************
S: 61    npnivkllgvcavgkpmcllfeymaygdlneflrslspytvcslshsdlslraqvsspdr  120
         +pnivkllgvcavgkpmcllfeyma+gdlneflr +sp tvcslsh +l  r ++ssp++
Q: 661   DPNIVKLLGVCAVGKPMCLLFEYMAFGDLNEFLRNMSPRTVCSLSHGNLVPRMRISSPGP  720
         ************************************************************
S: 121   lplseaellciarqvaagmaylserkfvhrdlatrnclvgetmvvkiadfglsrkiysad  180
         +pl +ae+lciarqvaagmaylserkfvhrdlatrnclvge+mvvkiadfglsr+iysad
Q: 721   PPLCCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSAD  780
         ************************************************************
S: 181   yykadendaipirwmplesilynrytlesdvwaygvvlweifsyalqpyyglaheeviky  240
         yyka+endaipirwmp+esi+ynryt+esd+waygvvlweifsy+lqpyyg+aheevi+y
Q: 781   YYKANENDAIPIRWMPPESIFYNRYTTESDIWAYGVVLWEIFSYGLQPYYGMAHEEVIYY  840
         ************************************************************
S: 241   vrdgnilacpentplelyalmrlcwsklpadrpsfasihri  281
         vrdgnil+cpen+plely+lmrlcwsklpadrpsf+sihri
Q: 841   VRDGNILSCPENCPLELYNLMRLCWSKLPADRPSFTSIHRI  881
         ***************************************98
Domain Sequence
(FASTA)
IEYVRDIGEG AFGRVFQARA PGLLSYEPFT MVAVKMLKEE ASADMQADFQ REAALMAEFD 60
DPNIVKLLGV CAVGKPMCLL FEYMAFGDLN EFLRNMSPRT VCSLSHGNLV PRMRISSPGP 120
PPLCCAEQLC IARQVAAGMA YLSERKFVHR DLATRNCLVG ENMVVKIADF GLSRNIYSAD 180
YYKANENDAI PIRWMPPESI FYNRYTTESD IWAYGVVLWE IFSYGLQPYY GMAHEEVIYY 240
VRDGNILSCP ENCPLELYNL MRLCWSKLPA DRPSFTSIHR I 281
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00073
EKS-ANC-00070
EKS-BOT-00079
EKS-CAJ-00080
EKS-CAP-00079
EKS-DAR-00333
EKS-DRM-00037
EKS-EQC-00077
EKS-FEC-00076
EKS-GAG-00063
EKS-GAA-00097
EKS-GOG-00078
EKS-HOS-00081
EKS-ICT-00074
EKS-LAC-00084
EKS-LOA-00078
EKS-MAM-00078
EKS-MEG-00059
EKS-MOD-00079
EKS-MUM-00082
EKS-MUP-00082
EKS-MYL-00087
EKS-NOL-00075
EKS-ORN-00106
EKS-ORC-00074
EKS-ORL-00098
EKS-OTG-00083
EKS-PAT-00071
EKS-PES-00069
EKS-PEM-00043
EKS-POA-00076
EKS-RAN-00075
EKS-SAH-00075
EKS-TAG-00114
EKS-TAR-00112
EKS-TEN-00104
EKS-XET-00074
EKS-XIM-00101
Gene Ontology
GO:0016021; C:integral to membrane
GO:0031594; C:neuromuscular junction
GO:0005886; C:plasma membrane
GO:0045211; C:postsynaptic membrane
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0043525; P:positive regulation of neuron apoptotic process
GO:2000541; P:positive regulation of protein geranylgeranylation
GO:0001934; P:positive regulation of protein phosphorylation
GO:0043113; P:receptor clustering
GO:0006355; P:regulation of transcription, DNA-dependent
KEGG
InterPros
IPR020067; Frizzled_dom.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF01392; Fz; 1.
PF07679; I-set; 3.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 1.
SM00408; IGc2; 2.
SM00219; TyrKc; 1.
Prosites
PS50038; FZ; 1.
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013