EKS-ORA-00263
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORA-00263
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR496.22.1E-149713970258
StatusUnreviewed
Ensembl ProteinENSOANP00000011184
UniProt AccessionF7GAV2;
Protein Name
Protein Synonyms/Alias
Gene NameERBB4
Gene Synonyms/Alias ERBB4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOANG00000007021ENSOANP00000011184ENSOANT00000011186
OrganismOrnithorhynchus anatinus
Functional Description
Protein Length1220
Protein Sequence
(FASTA)
GLWVWLSLLL AAGTPQPSAG QAVCAGTENK LSSLSDLEQQ YRALRKYYEN CEVVMGNLEI 60
TSIEHNRDLS FLRSIREVTG YVLVALNQFR YLPLENLRII RGTKLYEDRY ALAIFLNYRK 120
DGNFGLQELG LKNLTEILNG GVYVDQNKFL CYADTIHWQD IVRNPWPSNL TLVATNGSSG 180
CGRCHKSCTG RCWGPTETHC QSLTKTVCAE QCDGRCYGPY VSDCCHRECA GGCSGPKDTD 240
CFACMNFNDS GACVTQCPQT FVYNPTTFQL EHNFNAKYTY GAFCVKKCPH NFVVDSSSCV 300
RACPSSKMEV EENGIKMCKP CTDICPKACD GIGTGTLTSA QTVDSSNIDK FINCTKINGN 360
LIFLVTGIHG DPYNAIKAMD PEKLNIFRTV REITGFLNIQ SWPPNMTDFS VFSNLVTIGG 420
RVLYSGLSLL ILKQQSITSL QFQSLKEISA GNIYITDNTN LCYYHTVNWT TLFSTLNQRI 480
VIRDNRKAEN CTAEGMVCNP LCSTDGCWGP GADQCLSCRR FSRGRTCIES CNLYDGEFRE 540
YANGSICVEC DPQCEKMEDG LRTCHGQGPD NCTKCSHFKD GPNCVEKCPD GLQGANSFIF 600
KYADQDRECH PCHPNCTQGC RGPTSHDCIY YPWMGHSTLP QHARTPLIAA GVIGGLFILV 660
ITALTFAVYV RRKSIKKKRA LRRFLETELV EPLTPSGTAP NQAQLRILKE TELKRVKVLG 720
SGAFGTVYKG IWVPEGETVK IPVAIKILNE TTGPKANVEF MDEALIMATM DHPHLVRLLG 780
VSLSPTIQLV TQLMPHGCLL DYVHEHKDNI GSQLLLNWCV QIAKGMMYLE ERRLVHRDLA 840
ARNVLVKSPN HVKITDFGLA RLLEGDEKEY NADGGKMPIK WMALECIHYR KFTHQSDVWS 900
YGVTIWELMT FGGKPYDGIP TREIPDLLEK GERLPQPPIC TIDVYMVMVK CWMIDADSRP 960
KFKELAAEFS RMARDPQRYL VIQGDDRMKL PSPNDSKFFQ NLLDEEDLED MMDAEEYLVP 1020
QAFNIPPPIY TSRTRIDSNR SEIGHSPPPA YTPMSGNQFV YRDGGFGAEQ GVSMPYRATT 1080
CILPEAPATQ GAAAEICEDP CCNGTLRKPV APATQDDSST QRYSADPTVF VAERAPRGEL 1140
DEDGYMTPMR DKVKSDYLNP VEENPFVSRR KNGELQALDN PEYHNTPNEQ AKAEDEYVNE 1200
PLYLNTFANT LGNPEYLKSN 1220
Nucleotide Sequence
(FASTA)
GGGCTGTGGG TCTGGCTGAG CCTCCTGCTG GCCGCCGGGA CCCCCCAGCC CAGCGCCGGA 60
CAGGCAGTGT GTGCTGGCAC GGAGAACAAG CTGAGCTCTC TCTCTGACCT GGAACAGCAA 120
TATCGTGCCT TGAGGAAATA CTATGAAAAC TGTGAGGTAG TCATGGGCAA CCTGGAGATA 180
ACCAGCATTG AGCACAACCG AGATCTCTCC TTCCTACGGT CCATCCGAGA AGTCACAGGG 240
TATGTCTTAG TGGCCCTGAA TCAATTTCGT TACCTCCCTC TGGAGAATCT CCGTATCATT 300
CGAGGAACAA AGCTCTATGA GGATCGATAT GCTCTGGCAA TCTTTCTCAA CTACAGGAAA 360
GACGGGAACT TTGGCCTCCA AGAACTCGGC CTCAAGAACT TAACTGAAAT CCTAAACGGA 420
GGTGTGTACG TGGACCAGAA CAAATTCCTG TGCTATGCAG ACACCATTCA CTGGCAGGAT 480
ATTGTACGCA ACCCTTGGCC TTCCAACCTG ACCCTGGTCG CCACAAATGG CAGCTCAGGA 540
TGTGGACGCT GCCACAAATC CTGCACTGGA CGCTGCTGGG GTCCTACTGA GACGCATTGC 600
CAGAGCTTAA CGAAGACGGT GTGCGCGGAA CAATGCGATG GGAGATGCTA CGGCCCATAC 660
GTCAGCGACT GCTGCCACCG TGAGTGTGCT GGAGGCTGCT CAGGACCTAA AGACACCGAT 720
TGCTTTGCCT GCATGAATTT CAATGACAGT GGGGCATGTG TAACTCAGTG CCCACAAACC 780
TTTGTCTACA ATCCAACCAC CTTCCAACTG GAGCACAACT TCAATGCAAA GTACACCTAT 840
GGAGCATTCT GTGTCAAGAA GTGTCCACAC AACTTTGTGG TGGATTCCAG CTCCTGTGTC 900
CGTGCCTGTC CCAGTTCCAA GATGGAAGTT GAAGAAAATG GAATTAAAAT GTGTAAACCC 960
TGCACTGATA TTTGTCCAAA AGCATGCGAT GGTATTGGCA CCGGGACCTT GACTTCAGCT 1020
CAAACAGTGG ACTCGAGTAA CATTGATAAA TTCATAAACT GCACCAAGAT CAATGGAAAC 1080
CTTATCTTCC TGGTCACTGG AATTCATGGA GACCCCTACA ATGCAATCAA AGCAATGGAT 1140
CCAGAGAAAT TGAACATCTT TCGAACTGTC AGAGAGATTA CAGGTTTCTT GAATATCCAA 1200
TCATGGCCCC CAAATATGAC TGATTTCAGT GTCTTTTCCA ACCTAGTCAC TATTGGTGGA 1260
AGAGTTCTTT ACAGCGGCCT CTCCTTGCTT ATCCTTAAGC AACAGAGTAT CACCTCTCTG 1320
CAGTTCCAGT CACTGAAAGA AATCAGCGCA GGCAATATCT ACATAACAGA CAACACGAAC 1380
TTGTGCTATT ACCACACTGT TAACTGGACG ACCCTCTTCA GCACACTCAA CCAAAGAATA 1440
GTGATCCGTG ACAATAGGAA GGCGGAGAAC TGCACCGCAG AAGGCATGGT GTGCAATCCT 1500
TTGTGTTCGA CTGACGGCTG CTGGGGACCA GGAGCAGATC AGTGTCTCTC TTGCAGACGT 1560
TTCAGCAGGG GCAGGACCTG TATAGAATCC TGTAATCTCT ATGACGGTGA ATTTCGGGAG 1620
TATGCAAATG GCTCCATCTG CGTGGAATGT GATCCCCAAT GTGAGAAGAT GGAGGACGGA 1680
CTCCGGACTT GCCATGGGCA GGGGCCAGAC AACTGTACCA AGTGCTCCCA CTTCAAGGAT 1740
GGGCCAAATT GTGTGGAAAA ATGCCCAGAT GGTCTTCAGG GGGCGAACAG CTTCATTTTC 1800
AAGTATGCAG ACCAGGATCG GGAATGCCAC CCATGCCATC CAAACTGCAC CCAGGGGTGT 1860
AGAGGCCCCA CTAGCCATGA CTGCATTTAC TACCCTTGGA TGGGCCATTC CACGTTACCT 1920
CAGCATGCTA GGACGCCCCT GATTGCAGCT GGTGTGATTG GCGGACTATT CATCCTGGTC 1980
ATCACGGCAC TGACTTTTGC AGTTTATGTT CGGCGGAAGA GTATTAAGAA GAAGAGAGCT 2040
CTGAGGAGAT TCCTGGAGAC TGAGTTGGTG GAACCCTTGA CCCCAAGTGG TACTGCTCCC 2100
AACCAGGCCC AGCTGCGCAT CTTGAAAGAA ACGGAGCTGA AGAGAGTCAA GGTGCTGGGC 2160
TCAGGGGCCT TCGGAACTGT GTATAAAGGG ATTTGGGTAC CAGAGGGAGA GACAGTAAAG 2220
ATTCCTGTGG CTATAAAGAT CCTTAATGAA ACAACTGGAC CCAAAGCGAA TGTGGAGTTC 2280
ATGGATGAAG CTCTGATAAT GGCAACTATG GACCACCCAC ACTTGGTGAG ATTACTGGGA 2340
GTTTCCCTGA GCCCAACCAT CCAGCTGGTC ACTCAGCTTA TGCCTCATGG ATGTCTGCTG 2400
GATTATGTTC ATGAACATAA GGATAACATT GGTTCCCAAC TTCTACTAAA CTGGTGTGTC 2460
CAGATTGCTA AGGGTATGAT GTATCTGGAA GAAAGACGTC TGGTTCATCG AGACCTGGCA 2520
GCACGGAATG TCCTGGTAAA ATCTCCAAAC CATGTGAAGA TCACTGACTT TGGCTTGGCC 2580
AGGCTCTTAG AAGGGGATGA AAAAGAGTAT AATGCTGATG GGGGAAAGAT GCCAATTAAA 2640
TGGATGGCTC TAGAGTGCAT TCACTACAGG AAATTCACCC ATCAGAGTGA TGTTTGGAGC 2700
TATGGAGTCA CGATCTGGGA ACTCATGACT TTTGGAGGGA AGCCATATGA TGGAATTCCA 2760
ACTCGTGAAA TCCCAGATTT ACTGGAGAAG GGGGAGCGCT TGCCACAACC TCCCATCTGC 2820
ACCATCGATG TGTACATGGT AATGGTTAAA TGTTGGATGA TTGATGCTGA CAGTCGACCA 2880
AAATTCAAGG AACTCGCTGC GGAATTTTCC AGAATGGCTC GTGACCCTCA GCGGTACCTG 2940
GTCATTCAGG GTGACGATCG GATGAAGCTG CCGAGTCCCA ATGACAGCAA GTTCTTTCAG 3000
AACCTGCTGG ACGAAGAGGA CCTGGAAGAC ATGATGGATG CCGAGGAATA TCTGGTTCCA 3060
CAAGCTTTCA ACATCCCACC GCCGATCTAC ACCTCCAGAA CAAGAATTGA CTCCAATAGG 3120
AGTGAAATTG GACACAGCCC TCCTCCTGCC TACACCCCTA TGTCAGGAAA CCAGTTTGTG 3180
TATCGAGATG GAGGCTTTGG AGCAGAGCAA GGAGTGTCTA TGCCATACAG AGCTACCACC 3240
TGCATTCTTC CGGAAGCTCC GGCCACCCAG GGAGCTGCGG CCGAGATCTG TGAGGATCCC 3300
TGTTGCAACG GCACTCTGCG CAAACCAGTG GCTCCTGCCA CCCAAGATGA CAGCAGCACC 3360
CAGAGATACA GCGCAGACCC CACGGTGTTT GTGGCAGAAC GGGCCCCCAG GGGAGAGTTA 3420
GATGAAGATG GGTACATGAC TCCGATGCGG GACAAAGTGA AATCAGATTA CCTGAACCCC 3480
GTGGAAGAGA ATCCTTTTGT CTCCCGGAGA AAGAACGGAG AGCTCCAGGC CTTGGACAAC 3540
CCCGAGTATC ACAACACCCC CAACGAGCAA GCCAAGGCAG AGGATGAGTA CGTGAATGAG 3600
CCACTGTACC TCAACACCTT TGCCAACACC TTAGGGAACC CAGAGTACCT GAAAAGCAAC 3660
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         lk++kvlGsGafGtvykGiw+pege+vkipvaik+l+e+tg+kan e++deal++a++dh
Q: 713   LKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMATMDH  772
         699*********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         ++lvrllg+ ls t+qlvtql+p+Gclldyv+ehkd++Gsq llnwcvqiakGm+ylee+
Q: 773   PHLVRLLGVSLSPTIQLVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEER  832
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         rlvhrdlaarnvlvkspnhvkitdfGla+lle deke++a+ggk+pikw+ale+i++rk+
Q: 833   RLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKF  892
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvt+wel+tfG kpydgip++eipdllekGerl+qppictidvymv+vkcw
Q: 893   THQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCW  952
         ************************************************************
S: 241   midaesrpkfkelaeefs  258
         mida+srpkfkela+efs
Q: 953   MIDADSRPKFKELAAEFS  970
         ****************96
Domain Sequence
(FASTA)
LKRVKVLGSG AFGTVYKGIW VPEGETVKIP VAIKILNETT GPKANVEFMD EALIMATMDH 60
PHLVRLLGVS LSPTIQLVTQ LMPHGCLLDY VHEHKDNIGS QLLLNWCVQI AKGMMYLEER 120
RLVHRDLAAR NVLVKSPNHV KITDFGLARL LEGDEKEYNA DGGKMPIKWM ALECIHYRKF 180
THQSDVWSYG VTIWELMTFG GKPYDGIPTR EIPDLLEKGE RLPQPPICTI DVYMVMVKCW 240
MIDADSRPKF KELAAEFS 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00279
EKS-ANC-00288
EKS-BOT-00300
EKS-CAE-00255
EKS-CAJ-00303
EKS-CAF-00303
EKS-CAP-00332
EKS-DAR-00648
EKS-DRM-00152
EKS-EQC-00288
EKS-FEC-00285
EKS-GAM-00190
EKS-GAG-00250
EKS-GAA-00369
EKS-GOG-00294
EKS-HOS-00303
EKS-ICT-00282
EKS-LAC-00313
EKS-MAM-00300
EKS-MEG-00242
EKS-MOD-00291
EKS-MUM-00328
EKS-MUP-00294
EKS-MYL-00299
EKS-NOL-00273
EKS-OCP-00048
EKS-ORN-00385
EKS-ORC-00279
EKS-ORL-00356
EKS-OTG-00306
EKS-PAT-00282
EKS-PES-00266
EKS-PEM-00164
EKS-POA-00290
EKS-PTV-00063
EKS-RAN-00313
EKS-SAH-00281
EKS-SUS-00266
EKS-TAG-00313
EKS-TAR-00389
EKS-TEN-00384
EKS-TUT-00065
EKS-VIP-00031
EKS-XET-00370
EKS-XIM-00381
Gene Ontology
GO:0016323; C:basolateral plasma membrane
GO:0016021; C:integral to membrane
GO:0005739; C:mitochondrion
GO:0005524; F:ATP binding
GO:0004716; F:receptor signaling protein tyrosine kinase activity
GO:0044212; F:transcription regulatory region DNA binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0006915; P:apoptotic process
GO:0045165; P:cell fate commitment
GO:0016477; P:cell migration
GO:0043066; P:negative regulation of apoptotic process
GO:0008285; P:negative regulation of cell proliferation
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0060045; P:positive regulation of cardiac muscle cell proliferation
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:2000366; P:positive regulation of STAT protein import into nucleus
GO:0045893; P:positive regulation of transcription, DNA-dependent
GO:0042523; P:positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0046777; P:protein autophosphorylation
GO:0030334; P:regulation of cell migration
GO:0023014; P:signal transduction by phosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 5.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013