EKS-ORA-00146

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORA-00146

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKG	510.2	1.1E-153	190	448	259

Status

Unreviewed

Ensembl Protein

ENSOANP00000011192

UniProt Accession

F7G5B2;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKG1

Gene Synonyms/Alias

PRKG1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000007026	ENSOANP00000011192	ENSOANT00000011194
ENSOANG00000007026	ENSOANP00000011190	ENSOANT00000011192

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

500

Protein Sequence
(FASTA)

MKFYLSFPPA LVNVKLWAID RQCFQTIMMR TGLIKHTEYM EFLKSVPTFQ SLPEEILSKL 60

ADVLEELHRE NGYFRLRKAS LKGTSKMGSE CSPSVSQNES ILSFHVWTSS LEAHFKFSFL 120

LCFLCREDVR TANVIAAEAV TCLVIDRDSF KHLIGGLDDV SNKAYEDAEA KAKYEAEAAF 180

FANLKLSDFN IIDTLGVGGF GRVELVQLKS EESKTFAMKI LKKRHIVDTR QQEHIRSEKQ 240

IMQGAHSDFI VRLYRTFKDS KYLYMLMEAC LGGELWTILR DRGSFEDSTT RFYTACVVEA 300

FAYLHSKGII YRDLKPENLI LDHRGYAKLV DFGFAKKIGF GKKTWTFCGT PEYVAPEIIL 360

NKGHDISADY WSLGILMYEL LTGSPPFSGP DPMKTYNIIL RGIDMIEFPK KIAKNAANLI 420

KKLCRDNPSE RLGNLKNGVK DIQKHKWFEG FNWEGLRKGT LTPPIIPSVA SPTDTSNFDS 480

FPEDNDEPPP DDNSGWDIDF 500

Nucleotide Sequence
(FASTA)

ATGAAATTTT ACCTTTCTTT TCCCCCAGCT CTTGTAAATG TGAAACTTTG GGCCATCGAT 60

CGACAATGTT TTCAAACGAT AATGATGAGG ACAGGACTCA TCAAGCACAC CGAGTATATG 120

GAATTTTTAA AAAGTGTTCC AACATTCCAG AGCCTTCCTG AAGAGATTCT CAGTAAGCTC 180

GCTGACGTCC TTGAGGAGCT ACATAGAGAG AATGGGTATT TCCGTTTGAG AAAGGCTTCC 240

CTGAAGGGAA CTTCCAAAAT GGGCTCTGAA TGTTCCCCAT CTGTTTCACA GAATGAAAGT 300

ATTCTGAGTT TTCATGTATG GACCTCTTCA TTAGAAGCTC ATTTCAAATT TTCATTTCTA 360

TTATGTTTTC TTTGTAGGGA AGATGTGAGA ACGGCCAATG TAATTGCTGC AGAAGCGGTA 420

ACCTGCCTTG TGATTGACAG AGACTCTTTC AAGCACTTAA TTGGAGGGTT GGACGATGTT 480

TCTAATAAGG CTTATGAGGA TGCAGAAGCT AAAGCAAAAT ATGAAGCTGA AGCTGCCTTC 540

TTCGCCAACC TGAAACTTTC TGATTTCAAC ATCATTGACA CCCTTGGAGT TGGAGGTTTC 600

GGACGAGTTG AACTGGTCCA GCTGAAAAGT GAAGAATCCA AAACATTTGC AATGAAGATT 660

CTCAAGAAAC GCCACATAGT GGATACAAGA CAGCAAGAGC ACATCCGTTC TGAAAAGCAG 720

ATAATGCAAG GGGCTCACTC AGACTTCATT GTGAGACTTT ACCGAACCTT CAAGGACAGC 780

AAATATTTGT ATATGTTGAT GGAAGCATGC CTGGGTGGAG AGCTTTGGAC TATTCTCAGG 840

GATAGAGGTT CATTTGAAGA TTCTACAACT AGATTTTATA CAGCGTGTGT GGTAGAAGCC 900

TTTGCCTATC TGCATTCCAA AGGAATCATC TATAGGGACC TCAAGCCAGA AAACCTGATT 960

CTAGATCATC GAGGTTATGC CAAACTGGTT GATTTTGGCT TTGCAAAGAA AATAGGATTT 1020

GGAAAGAAAA CATGGACTTT TTGTGGGACT CCTGAATATG TAGCCCCGGA GATCATCCTG 1080

AATAAAGGTC ATGATATTTC AGCAGACTAC TGGTCACTGG GAATCTTAAT GTATGAACTC 1140

CTGACTGGCA GCCCACCTTT CTCAGGCCCA GATCCCATGA AGACCTATAA CATTATACTG 1200

AGAGGAATTG ACATGATAGA ATTTCCAAAG AAGATTGCAA AAAATGCTGC TAATTTAATC 1260

AAAAAACTAT GCAGGGATAA TCCATCAGAA AGATTAGGTA ACTTGAAAAA CGGCGTGAAA 1320

GACATCCAAA AGCACAAATG GTTTGAAGGC TTCAACTGGG AAGGCTTGAG AAAAGGCACC 1380

CTGACACCTC CAATAATACC CAGTGTTGCA TCTCCTACAG ACACAAGCAA TTTTGACAGT 1440

TTCCCTGAGG ACAACGACGA ACCACCACCT GACGACAACT CGGGCTGGGA TATAGACTTT 1500

TAA 1503

Domain Profile

S: 2     kviatlgvggfgrvelvkvksdeskafalkilkkkhivdtkqqehvlsekrileeaksdf  61

         ++i+tlgvggfgrvelv++ks+esk+fa+kilkk+hivdt+qqeh++sek+i++ a+sdf

Q: 190   NIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDF  249

         79**********************************************************

S: 62    ivklyrtfkdekyvyllleaclggelwtilrdrgsfddktakfivacvvealeylhskni  121

         iv+lyrtfkd+ky+y+l+eaclggelwtilrdrgsf+d+t++f++acvvea++ylhsk+i

Q: 250   IVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGI  309

         ************************************************************

S: 122   iyrdlkpenllldeegylklvdfgfakklksgkktwtfcgtpeyvapeiilnkghdlsvd  181

         iyrdlkpenl+ld++gy+klvdfgfakk++ gkktwtfcgtpeyvapeiilnkghd+s+d

Q: 310   IYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISAD  369

         ************************************************************

S: 182   ywalgilvyelltgkppfsgvdplktynlilkgidklelprkitkeaedlikklcrdnpa  241

         yw+lgil+yelltg+ppfsg+dp+ktyn+il+gid++e+p+ki+k+a++likklcrdnp+

Q: 370   YWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPS  429

         ************************************************************

S: 242   erlgylkggikdikkhkwf  260

         erlg+lk+g+kdi+khkwf

Q: 430   ERLGNLKNGVKDIQKHKWF  448

         ******************9

Domain Sequence
(FASTA)

NIIDTLGVGG FGRVELVQLK SEESKTFAMK ILKKRHIVDT RQQEHIRSEK QIMQGAHSDF 60

IVRLYRTFKD SKYLYMLMEA CLGGELWTIL RDRGSFEDST TRFYTACVVE AFAYLHSKGI 120

IYRDLKPENL ILDHRGYAKL VDFGFAKKIG FGKKTWTFCG TPEYVAPEII LNKGHDISAD 180

YWSLGILMYE LLTGSPPFSG PDPMKTYNII LRGIDMIEFP KKIAKNAANL IKKLCRDNPS 240

ERLGNLKNGV KDIQKHKWF 259

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005794	; C:Golgi apparatus
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0005246	; F:calcium channel regulator activity
GO:0030553	; F:cGMP binding
GO:0004692	; F:cGMP-dependent protein kinase activity
GO:0090331	; P:negative regulation of platelet aggregation
GO:0043087	; P:regulation of GTPase activity
GO:0007165	; P:signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR002374	; cGMP_dep_kinase.
IPR018490	; cNMP-bd-like.
IPR000595	; cNMP-bd_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR014710	; RmlC-like_jellyroll.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00100	; cNMP; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50042	; CNMP_BINDING_3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00104

; CGMPKINASE.

Created Date

20-Feb-2013