EKS-ORA-00197

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORA-00197

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE7	382.4	1.2E-114	64	325	262

Status

Unreviewed

Ensembl Protein

ENSOANP00000012319

UniProt Accession

F6PXH5;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP2K3

Gene Synonyms/Alias

MAP2K3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000007732	ENSOANP00000012319	ENSOANT00000012321

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

347

Protein Sequence
(FASTA)

KDPSVPAQSP ACSSLSGKPK KRKDLKIVTI KPPVSNPTPP RNLDSRTFIT IGDKENFEVE 60

ADDLVTISEL GRGAYGVVEK VRHAQSGTIM AVKRIRATVN TQEQKRLLMD LDISMRTVDC 120

FYTVTFYGAL FREGDVWICM ELMDTSLDKF YKKVLEKNMT IPEDILGEIA VSIVRALEHL 180

HSKLSVIHRD VKPSNVLINK EGHVKMCDFG ISGYLVDSVA KTMDAGCKPY MAPERINPEL 240

NQKGYNVKSD VWSLGITMIE MAILRFPYES WGTPFQQLKQ VVEEPSPQLP ADRFSPEFVD 300

FTAQCLRKNP AERMSYLELM EHPFFNLHKT KETDIAAFVI EILGEDS 347

Nucleotide Sequence
(FASTA)

AAAGATCCTT CAGTTCCTGC ACAAAGCCCT GCATGTTCTT CTCTTTCAGG AAAACCCAAG 60

AAAAGGAAGG ATTTAAAAAT AGTCACCATC AAGCCACCAG TTTCCAACCC CACGCCTCCC 120

CGGAACCTGG ACTCCAGGAC CTTCATTACC ATCGGGGATA AGGAGAATTT TGAAGTGGAG 180

GCCGATGACT TGGTGACCAT CTCGGAACTG GGTCGGGGGG CGTACGGAGT CGTGGAGAAA 240

GTGCGGCACG CGCAGAGTGG GACCATCATG GCTGTCAAGA GGATCCGTGC AACTGTGAAC 300

ACTCAGGAAC AGAAGAGGCT GCTCATGGAC CTGGACATTT CAATGAGGAC AGTGGATTGC 360

TTCTACACTG TCACGTTCTA TGGAGCCCTG TTCAGAGAGG GTGATGTGTG GATATGCATG 420

GAGCTGATGG ACACTTCCCT GGACAAATTC TATAAGAAGG TTCTTGAGAA GAATATGACA 480

ATCCCGGAAG ACATTTTGGG AGAGATCGCA GTGTCCATTG TGAGAGCGCT GGAGCATTTG 540

CACAGTAAAT TGTCGGTTAT TCACAGAGAT GTGAAACCAT CTAATGTTCT CATCAACAAG 600

GAAGGTCATG TGAAAATGTG TGACTTCGGG ATCAGTGGCT ACTTGGTGGA CTCAGTTGCC 660

AAGACCATGG ATGCCGGTTG CAAGCCCTAC ATGGCGCCCG AGAGAATAAA CCCCGAGCTG 720

AACCAGAAAG GTTACAACGT CAAGTCAGAT GTCTGGAGTC TGGGAATTAC CATGATCGAG 780

ATGGCCATCC TCCGGTTCCC GTACGAGTCC TGGGGAACCC CCTTCCAGCA ACTGAAGCAG 840

GTGGTGGAGG AGCCCTCGCC CCAACTCCCA GCAGACCGTT TCTCCCCCGA GTTTGTGGAC 900

TTCACAGCCC AGTGCTTACG GAAGAACCCT GCAGAGCGGA TGAGCTACCT GGAACTTATG 960

GAACACCCCT TCTTTAACTT GCACAAAACC AAAGAGACTG ACATCGCTGC CTTCGTGATA 1020

GAGATCCTGG GGGAGGACTC GTAG 1044

Domain Profile

S: 1     lekleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyi  60

         l +++elG+G++gvVekv+h +sg+i+avK+ir++++++eqk++l++l++ +++ ++ y+

Q: 64    LVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNTQEQKRLLMDLDISMRTVDCFYT  123

         56899*******************************************************

S: 61    vkfyGafvsegdvsicmelmdgtsldkvlkkvlekkkripekvlgkiavavvkaleylke  120

         v+fyGa+++egdv+icmelmd tsldk++kkvlek+ +ipe++lg+iav++v+ale+l++

Q: 124   VTFYGALFREGDVWICMELMD-TSLDKFYKKVLEKNMTIPEDILGEIAVSIVRALEHLHS  182

         *********************.**************************************

S: 121   klkiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksa.vGtksYmaPErieg...k  176

         kl++iHRDvKPsN+L+n++G+vK+CDFG+sg+lvds+Ak++ +G+k+YmaPEri++   +

Q: 183   KLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMdAGCKPYMAPERINPelnQ  242

         ********************************************************9999

S: 177   kkYsvksdvWslGltlvelatgrypyeklkeilellkaivneeppklpeeefseefqefv  236

         k Y+vksdvWslG+t++e+a+ r+pye++ +++++lk++v+e++p+lp+++fs+ef++f

Q: 243   KGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFT  302

         9***********************************************************

S: 237   skClkkdekeRpklkellkhafi  259

         ++Cl+k+++eR+++ el++h+f+

Q: 303   AQCLRKNPAERMSYLELMEHPFF  325

         *********************96

Domain Sequence
(FASTA)

LVTISELGRG AYGVVEKVRH AQSGTIMAVK RIRATVNTQE QKRLLMDLDI SMRTVDCFYT 60

VTFYGALFRE GDVWICMELM DTSLDKFYKK VLEKNMTIPE DILGEIAVSI VRALEHLHSK 120

LSVIHRDVKP SNVLINKEGH VKMCDFGISG YLVDSVAKTM DAGCKPYMAP ERINPELNQK 180

GYNVKSDVWS LGITMIEMAI LRFPYESWGT PFQQLKQVVE EPSPQLPADR FSPEFVDFTA 240

QCLRKNPAER MSYLELMEHP FF 262

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004708	; F:MAP kinase kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006954	; P:inflammatory response
GO:0045893	; P:positive regulation of transcription, DNA-dependent
GO:0042035	; P:regulation of cytokine biosynthetic process

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013