EKS-ORA-00149

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORA-00149

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKC	479.2	3.9E-144	245	503	259

Status

Unreviewed

Ensembl Protein

ENSOANP00000012815

UniProt Accession

F7CUS9;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKCA

Gene Synonyms/Alias

PRKCA;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000008060	ENSOANP00000012813	ENSOANT00000012815
ENSOANG00000008060	ENSOANP00000012814	ENSOANT00000012816
ENSOANG00000008060	ENSOANP00000012815	ENSOANT00000012817

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

578

Protein Sequence
(FASTA)

DPRSKHKFKI HTYGSPTFCD HCGSLLYGLI HQGMKCDTCD MNVHKQCVIN VPSLCGMDHT 60

EKRGRIYLKA EVTGEKLQVT VRDAKNLIPM DPNGLSDPYV KLKLIPDPKN ESKQKTKTIR 120

STLNPQWNES FTFKLKPTDK DRRLSVEIWD WDRTTRNDFM GSLSFGVSEL MKMPASGWYK 180

LLNQEEGEYY NVPIPEGDEE GNVELRQKFE KAKLGPAGNK VIGPSEDRKS SVPSNNLDRV 240

KLTDFNFLMV LGKGSFGKVM LADRKGTEEL YAIKILKKDV VIQDDDVECT MVEKRVLALL 300

DKPPFLTQLH SCFQTIDRLY FVMEYVNGGD LMYHIQQVGK FKEPQAVFYA AEISIGLFFL 360

HKRGIIYRDL KLDNVMLDSE GHIKIADFGM CKEHMMDGVT TRTFCGTPDY IAPEIIAYQP 420

YGKSVDWWAY GVLLYEMLAG QPPFDGEDED ELFQSIMEHN VSYPKSLSKE AVSICKGLMT 480

KHPAKRLGCG PEGEQDVREH AFFRRIDWEK LENREIQPPF KPKVCGKGAE NFDKFFTRGQ 540

PVLTPPDQLV ISNIDQADFE GFSYVNPQFV HPILQSVV 578

Nucleotide Sequence
(FASTA)

GACCCTAGAA GCAAGCACAA ATTTAAAATC CACACATATG GAAGCCCCAC GTTCTGTGAT 60

CACTGTGGGT CACTGCTCTA CGGACTTATC CATCAGGGGA TGAAATGTGA CACCTGTGAC 120

ATGAATGTTC ACAAGCAATG TGTAATAAAC GTCCCAAGCC TCTGTGGAAT GGACCATACG 180

GAGAAAAGAG GGCGAATTTA TCTGAAAGCT GAAGTTACCG GTGAAAAATT GCAGGTCACA 240

GTACGAGATG CGAAGAATTT AATCCCTATG GATCCAAACG GCCTCTCAGA TCCCTATGTG 300

AAGCTGAAAC TTATTCCTGA CCCAAAGAAT GAAAGTAAAC AGAAAACCAA AACCATCCGT 360

TCCACACTGA ACCCTCAATG GAATGAATCG TTTACATTCA AATTAAAACC AACAGACAAA 420

GATCGACGGC TATCTGTGGA GATCTGGGAC TGGGATCGGA CAACTAGAAA TGATTTCATG 480

GGGTCCCTCT CATTTGGTGT GTCAGAGCTG ATGAAAATGC CTGCAAGTGG ATGGTACAAG 540

TTGCTTAACC AAGAAGAAGG GGAATACTAC AATGTGCCCA TTCCAGAAGG AGATGAAGAA 600

GGAAATGTGG AGCTCAGGCA GAAATTTGAG AAAGCCAAGC TTGGGCCTGC CGGTAACAAA 660

GTGATCGGTC CATCTGAAGA CAGGAAATCC AGTGTGCCGT CCAATAACCT CGACAGGGTC 720

AAGCTCACAG ATTTTAACTT CCTTATGGTG CTGGGAAAAG GAAGTTTTGG AAAGGTGATG 780

CTGGCAGACA GAAAGGGAAC AGAAGAGCTC TATGCCATCA AGATTTTGAA AAAAGACGTG 840

GTGATCCAAG ATGATGATGT GGAGTGTACA ATGGTGGAGA AGAGGGTGCT AGCCCTACTA 900

GACAAGCCAC CTTTCCTAAC ACAGCTGCAT TCCTGCTTCC AGACCATTGA TCGTCTGTAT 960

TTTGTCATGG AATACGTCAA TGGCGGTGAC CTCATGTACC ACATTCAGCA AGTAGGAAAA 1020

TTTAAGGAAC CGCAAGCAGT GTTTTATGCT GCAGAGATTT CCATCGGATT ATTCTTTCTC 1080

CATAAAAGAG GAATAATTTA CAGAGATCTG AAATTAGATA ATGTCATGTT GGATTCAGAA 1140

GGACACATCA AGATCGCTGA TTTTGGGATG TGCAAGGAGC ACATGATGGA CGGAGTCACA 1200

ACCAGGACAT TTTGTGGGAC TCCAGATTAC ATTGCCCCTG AGATTATCGC TTATCAGCCG 1260

TATGGAAAAT CCGTGGATTG GTGGGCTTAC GGCGTCCTGT TGTATGAAAT GCTAGCTGGG 1320

CAGCCTCCAT TTGATGGTGA AGATGAGGAT GAGCTCTTCC AGTCAATAAT GGAACATAAT 1380

GTTTCGTATC CAAAATCGCT GTCCAAAGAA GCAGTTTCCA TTTGTAAAGG GTTAATGACC 1440

AAGCACCCCG CCAAACGGCT CGGCTGTGGG CCTGAGGGAG AACAGGATGT CAGAGAGCAT 1500

GCGTTCTTCA GGAGAATCGA CTGGGAGAAA CTGGAGAACA GGGAGATCCA GCCACCATTC 1560

AAACCGAAAG TGTGCGGTAA AGGAGCTGAA AACTTCGACA AGTTTTTCAC TCGAGGACAA 1620

CCAGTCTTAA CACCTCCTGA TCAGTTGGTC ATTTCTAACA TAGACCAAGC CGACTTTGAA 1680

GGGTTCTCCT ATGTCAACCC ACAGTTTGTG CACCCCATTT TACAGAGTGT TGTATGA 1737

Domain Profile

S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60

         f++l+vlGkGsfgkv+la++k+t+elyaik+lkkdvv+qdddve+t+vekrvlal +k+p

Q: 245   FNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPP  304

         99**********************************************************

S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120

         fl+ql+scfqt drl+fv+eyvnGGdlm+hiq+++k+ke++a+fyaaei+++l+flh++g

Q: 305   FLTQLHSCFQTIDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRG  364

         ************************************************************

S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180

         iiyrdlkldnv+ld+eGhik+adfG+cke++++g tt+tfcGtPdyiaPei+++++ygks

Q: 365   IIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKS  424

         ************************************************************

S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240

         vdwwa+Gvllyemlagq+Pf+gededelf+si+e++v+yPkslskeav+i+kgl+tk+p+

Q: 425   VDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPA  484

         ************************************************************

S: 241   krlGvkeegeedikehaff  259

         krlG+ +ege+d++ehaff

Q: 485   KRLGCGPEGEQDVREHAFF  503

         ******************9

Domain Sequence
(FASTA)

FNFLMVLGKG SFGKVMLADR KGTEELYAIK ILKKDVVIQD DDVECTMVEK RVLALLDKPP 60

FLTQLHSCFQ TIDRLYFVME YVNGGDLMYH IQQVGKFKEP QAVFYAAEIS IGLFFLHKRG 120

IIYRDLKLDN VMLDSEGHIK IADFGMCKEH MMDGVTTRTF CGTPDYIAPE IIAYQPYGKS 180

VDWWAYGVLL YEMLAGQPPF DGEDEDELFQ SIMEHNVSYP KSLSKEAVSI CKGLMTKHPA 240

KRLGCGPEGE QDVREHAFF 259

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004697	; F:protein kinase C activity
GO:0008270	; F:zinc ion binding
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR000008	; C2_Ca-dep.
IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR020477	; C2_dom.
IPR018029	; C2_membr_targeting.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR014375	; Protein_kinase_C_a/b/g.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00130	; C1_1; 1.
PF00168	; C2; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00239	; C2; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50004	; C2; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

PR00360	; C2DOMAIN.
PR00008	; DAGPEDOMAIN.

Created Date

20-Feb-2013