EKS-ORA-00192

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORA-00192

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKN	499.0	3.1E-150	554	813	260

Status

Unreviewed

Ensembl Protein

ENSOANP00000012866

UniProt Accession

F7G3N5;

Protein Name

Protein Synonyms/Alias

Gene Name

PKN3

Gene Synonyms/Alias

PKN3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000008094	ENSOANP00000012866	ENSOANT00000012868
ENSOANG00000008094	ENSOANP00000012867	ENSOANT00000012869

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

884

Protein Sequence
(FASTA)

ERLLDPGFQQ RLEDEKELIR RAIQKELKIK EGAENLRKAA TDRHHLGHVE RLLRSSNRKL 60

EQLHWSLREL NARILLPDRA ESPAVSPDPC RWEEKPVARR VEALRKQLQV ELKVKQGAEN 120

MIQMYANGTP KERKLVATAQ QMLGDSKLKV ELLRMQIGKL GAGEATEPAA RAGRGELRVE 180

ELRHRLRIEA AVAEGAKNVV KLLGGRRLQD RKALAEAQAR LRESSQKLDL LRLSLERLAA 240

ELPAAHPTRS LVSRELREGT LGSLCSPSAL GKPTALTGTL EVRLIGCQEL LRAVPGRSRV 300

ATVLGSPGES RPWSRGAKPP RNEELANEVL AVLKVDNRVV GQTGWGPVSK QGWDQNFLIP 360

LERILEFQIG KIEYRYISHV TFMRLEDFLD NERHGLNLRL EPQGMFLAEV TFCDPVIQRR 420

PRLQRQKRIF FSKQRGEDFL RASQMNINIV TWGRLVLGLL PPCGSPSSTL SPPSRTPAHA 480

PAARVASAPA SASPFPLTLE EEDPPPKPPR LFLPLEPVAG DSPCTKRPHM DWAPGLLTPF 540

SLPPIRTIPQ LQDFRFVAVL GRGHFGKVLL VQAKGTGRHY AIKALKKQEI LSRDELESLH 600

CEKRILEVVG LAGHPFLLPL LACFQTPSHA CFITEFAPGG DLMMRIHADV FPEPHARFYS 660

ACVVLGLQFL HEKRIVYRDL KLDNLLLDAQ GFVKIADFGL CKEGMGFGDR TSTFCGTPEF 720

LAPEVLTDES YTRAVDWWGL GVLLYEMLVG ECPFPGDTEE EVFDSIVNEE APYPHFLSVE 780

GLGLICKLLQ KCPKQRLGAS ERDAEEVKVQ PFFRVTDWAA LLARRVQPPY VPPLRGPADV 840

RHFDREFTVL PPALTPPNPR CPLTPRQQAA FQGFDFVSDR FLEA 884

Nucleotide Sequence
(FASTA)

GAGCGCCTCC TGGATCCGGG CTTCCAACAG CGTCTGGAGG ACGAGAAGGA GCTGATCCGC 60

AGGGCCATCC AGAAGGAGCT GAAGATCAAG GAGGGAGCCG AGAACCTGCG GAAGGCCGCC 120

ACCGACCGGC ACCACCTGGG CCACGTGGAG CGACTCCTCC GCTCCTCCAA CCGCAAGCTG 180

GAGCAGCTGC ACTGGAGCCT ACGGGAGCTC AACGCCCGCA TCCTGCTGCC CGACCGGGCC 240

GAGAGTCCTG CCGTCTCTCC AGATCCCTGC CGCTGGGAGG AGAAGCCGGT GGCCCGGAGG 300

GTGGAGGCGC TGAGGAAGCA GCTGCAGGTG GAACTGAAGG TGAAGCAGGG TGCAGAGAAC 360

ATGATCCAGA TGTACGCCAA CGGCACCCCT AAGGAACGCA AGCTCGTGGC CACGGCCCAG 420

CAGATGCTCG GGGACAGCAA GCTGAAGGTG GAGCTGCTGC GCATGCAGAT TGGGAAGCTG 480

GGAGCCGGGG AGGCCACCGA GCCAGCGGCT AGGGCCGGGC GCGGGGAGCT GCGTGTGGAG 540

GAGCTGAGAC ACCGGCTGCG CATCGAGGCG GCTGTAGCCG AGGGTGCCAA GAACGTGGTG 600

AAGTTGCTGG GAGGGCGGAG GCTGCAGGAC CGCAAGGCGC TGGCCGAGGC CCAGGCTCGG 660

CTGCGCGAAT CCTCCCAGAA GCTGGACCTC CTGCGGCTGT CCCTGGAGCG GCTGGCCGCC 720

GAACTGCCGG CCGCCCACCC CACGCGGAGT CTCGTGTCCC GGGAGTTGCG GGAAGGGACT 780

CTCGGGAGCC TCTGCTCCCC CTCGGCGCTC GGCAAGCCCA CAGCCCTTAC GGGGACCCTG 840

GAGGTGCGAC TGATCGGGTG CCAGGAGCTG CTGAGGGCGG TGCCAGGCCG GTCCCGCGTG 900

GCCACGGTGC TGGGGAGCCC AGGAGAGAGT CGGCCCTGGA GCCGAGGAGC CAAGCCACCG 960

CGGAATGAGG AGCTGGCCAA CGAGGTCCTG GCGGTGCTCA AGGTAGACAA CCGTGTGGTC 1020

GGACAGACGG GCTGGGGGCC GGTCAGCAAG CAGGGGTGGG ACCAGAACTT CCTGATCCCC 1080

TTGGAGAGGA TTTTAGAATT TCAGATAGGG AAAATAGAGT ATAGATACAT AAGTCACGTC 1140

ACCTTCATGC GGTTGGAAGA TTTCCTAGAC AACGAACGCC ACGGACTGAA CCTGCGGCTA 1200

GAGCCCCAGG GCATGTTCTT AGCTGAGGTG ACGTTCTGTG ACCCCGTCAT CCAGCGGAGG 1260

CCCCGGCTAC AGAGGCAGAA GCGCATCTTC TTCTCCAAGC AGCGGGGTGA GGACTTCCTT 1320

CGTGCCTCCC AGATGAACAT AAACATTGTC ACGTGGGGGC GACTGGTGTT GGGCTTGTTG 1380

CCCCCCTGTG GCTCTCCAAG CAGCACTCTC AGCCCCCCCA GTCGGACCCC CGCCCACGCT 1440

CCCGCAGCCC GGGTCGCCTC TGCCCCTGCC TCTGCTAGCC CCTTCCCGCT GACGCTGGAG 1500

GAGGAGGACC CCCCGCCCAA GCCCCCACGC CTCTTCCTGC CTCTGGAGCC GGTCGCCGGG 1560

GACTCTCCGT GCACCAAACG CCCGCACATG GACTGGGCAC CTGGGCTCCT GACACCATTT 1620

TCTCTCCCCC CCATCAGGAC AATCCCCCAG CTCCAGGACT TCCGCTTTGT GGCTGTGTTG 1680

GGCCGGGGCC ATTTTGGGAA GGTGCTCCTG GTTCAGGCCA AGGGGACGGG ACGACACTAT 1740

GCCATTAAGG CCCTGAAGAA GCAAGAGATC CTGAGCCGGG ATGAGCTGGA GAGCCTGCAC 1800

TGTGAGAAGC GGATCCTGGA GGTGGTGGGC CTCGCCGGGC ACCCTTTCCT CCTGCCTCTA 1860

CTGGCCTGCT TCCAGACGCC CAGCCACGCC TGCTTCATCA CAGAGTTTGC ACCTGGCGGG 1920

GACCTGATGA TGCGCATCCA CGCCGATGTC TTCCCTGAGC CCCATGCCCG GTTTTACTCA 1980

GCCTGTGTGG TGTTAGGGCT ACAGTTCCTG CATGAGAAGC GGATTGTGTA CAGGGATCTG 2040

AAGCTGGATA ACCTGCTGCT GGATGCCCAG GGCTTTGTCA AAATCGCCGA CTTTGGGCTG 2100

TGCAAGGAGG GAATGGGCTT CGGCGATCGA ACCAGCACTT TCTGTGGCAC CCCGGAGTTC 2160

CTGGCCCCCG AGGTGCTGAC GGACGAGTCC TACACAAGGG CGGTGGACTG GTGGGGGCTG 2220

GGGGTCCTGC TCTACGAGAT GCTGGTGGGA GAGTGCCCGT TTCCCGGAGA CACGGAGGAG 2280

GAGGTGTTTG ACAGCATCGT CAACGAGGAG GCACCCTACC CCCACTTCCT GTCGGTGGAG 2340

GGACTTGGAC TCATCTGCAA GCTTCTCCAA AAGTGCCCGA AGCAGCGCCT GGGTGCAAGC 2400

GAGCGTGACG CGGAGGAGGT CAAGGTTCAG CCCTTCTTCA GGGTGACAGA CTGGGCCGCC 2460

TTGCTGGCCC GCCGGGTCCA GCCTCCCTAC GTGCCCCCGC TCCGGGGCCC GGCCGACGTG 2520

CGCCACTTCG ACCGAGAGTT CACCGTGCTT CCCCCGGCGC TGACTCCCCC CAACCCCCGC 2580

TGCCCCCTGA CCCCCCGCCA GCAGGCGGCC TTCCAGGGCT TCGACTTCGT CTCCGACCGC 2640

TTCCTGGAGG CCTGA 2655

Domain Profile

S: 1     frllavlgrghfgkvllseykstgelyaikalkkgdilardevesllcekrileavssvr  60

         fr++avlgrghfgkvll++ k+tg+ yaikalkk++il+rde+esl cekrile+v+ ++

Q: 554   FRFVAVLGRGHFGKVLLVQAKGTGRHYAIKALKKQEILSRDELESLHCEKRILEVVGLAG  613

         9***********************************************************

S: 61    hpflvnllacfqtkehvcfvmeyaaggdlmlhihedvfsepravfyaacvvlglqflhek  120

         hpfl+ llacfqt +h+cf++e+a+ggdlm++ih dvf+ep+a fy+acvvlglqflhek

Q: 614   HPFLLPLLACFQTPSHACFITEFAPGGDLMMRIHADVFPEPHARFYSACVVLGLQFLHEK  673

         ************************************************************

S: 121   kivyrdlkldnllldtegyvkiadfglckeglgygdrtstfcgtpeflapevltetsytr  180

         +ivyrdlkldnllld++g+vkiadfglckeg+g+gdrtstfcgtpeflapevlt++sytr

Q: 674   RIVYRDLKLDNLLLDAQGFVKIADFGLCKEGMGFGDRTSTFCGTPEFLAPEVLTDESYTR  733

         ************************************************************

S: 181   avdwwglgvllyemlvgespfpgddeeevfdsivndevryprflsveaieilrrllrknp  240

         avdwwglgvllyemlvge+pfpgd+eeevfdsivn+e++yp+flsve+++++ +ll+k+p

Q: 734   AVDWWGLGVLLYEMLVGECPFPGDTEEEVFDSIVNEEAPYPHFLSVEGLGLICKLLQKCP  793

         ************************************************************

S: 241   ekrlgaserdaedvkkqpff  260

         ++rlgaserdae+vk+qpff

Q: 794   KQRLGASERDAEEVKVQPFF  813

         *******************9

Domain Sequence
(FASTA)

FRFVAVLGRG HFGKVLLVQA KGTGRHYAIK ALKKQEILSR DELESLHCEK RILEVVGLAG 60

HPFLLPLLAC FQTPSHACFI TEFAPGGDLM MRIHADVFPE PHARFYSACV VLGLQFLHEK 120

RIVYRDLKLD NLLLDAQGFV KIADFGLCKE GMGFGDRTST FCGTPEFLAP EVLTDESYTR 180

AVDWWGLGVL LYEMLVGECP FPGDTEEEVF DSIVNEEAPY PHFLSVEGLG LICKLLQKCP 240

KQRLGASERD AEEVKVQPFF 260

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007165	; P:signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011072	; HR1_rho-bd.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF02185	; HR1; 3.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00742	; Hr1; 3.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013