EKS-ORA-00404

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORA-00404

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	333.1	1.4E-99	22	312	291

Status

Unreviewed

Ensembl Protein

ENSOANP00000012910

UniProt Accession

F7F430;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK4

Gene Synonyms/Alias

MAPK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000008123	ENSOANP00000012910	ENSOANT00000012912

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

579

Protein Sequence
(FASTA)

MAEKGDCIAS MYGYDLGCRF VDFQPLGFGV NGLVLSATDS QSCRKVAVKK IAVSDARSMK 60

HALREVKIIR RLDHDNIVKV YEVLGPKGVD LQGQLFKFNV VYVVQEYMET DLARLLEQGT 120

LTEDHAKLFM YQLLRGLKYI HSANVLHRDL KPANIFISTE DLVLKIGDFG LARIVDQHYS 180

HKGYLSEGLV TKWYRSPRLL LSPNNYTKAI DMWAAGCILA EMLTGRMLFA GGHELEQMQL 240

ILETIPVIRE EDKDELLKVM PSFINCTWEV KKPLRKLLPQ VNSEAIDFLE KILTFNPMDR 300

LTAELGLQHP YMSPYACPED EPISQHPFRI EDEIDDILLM AANQSQLSNW DRYHISLSSD 360

LEWRHDRYQA TSEVQRDPRA GSESIAEEAQ VDPRKYSQSS SERFLDQSHS SMDRAFEADY 420

GRSCDYKVGS PSYLDKLLWR DNKPHHYSEP KLILDLSHWK KASIAPAAEL ALEEEPSNLF 480

LEIAQWVKST QAGLECPGPL PEIQEQSLPS SPHHHRAPKE ANHSTDPQFD LDVFISRALK 540

LCSKPEDLPD SKLGEINGAC IGERPSDIVQ TEAYQKERW 579

Nucleotide Sequence
(FASTA)

ATGGCGGAAA AGGGGGACTG TATCGCCAGC ATGTACGGCT ACGACCTGGG CTGTCGCTTT 60

GTTGACTTCC AGCCCCTGGG CTTTGGGGTC AACGGGCTGG TCCTCTCGGC CACGGACAGC 120

CAGAGCTGCC GGAAGGTGGC CGTGAAGAAG ATCGCCGTGA GCGACGCCCG GAGCATGAAG 180

CACGCGCTGC GGGAGGTCAA GATCATTCGC CGGCTGGACC ACGACAACAT CGTCAAGGTG 240

TACGAGGTGT TGGGGCCCAA GGGGGTGGAC CTGCAGGGGC AGCTGTTCAA GTTCAACGTG 300

GTGTACGTGG TCCAGGAGTA CATGGAGACG GATCTGGCCC GGCTCCTGGA GCAGGGCACT 360

CTGACCGAGG ACCACGCCAA GCTCTTCATG TACCAGCTTC TCCGCGGGCT GAAGTACATT 420

CACTCGGCCA ACGTCCTGCA CAGGGACCTG AAGCCGGCCA ACATTTTCAT CAGCACCGAG 480

GACCTCGTCC TGAAGATTGG GGACTTCGGC TTGGCCCGGA TCGTCGATCA GCATTACTCC 540

CACAAGGGTT ATCTGTCAGA AGGGTTGGTA ACGAAATGGT ATCGATCTCC TCGCCTGCTC 600

CTCTCACCCA ACAACTACAC CAAAGCCATC GATATGTGGG CGGCAGGGTG CATCCTGGCA 660

GAAATGCTCA CTGGGAGAAT GCTGTTTGCT GGAGGCCACG AGCTGGAACA GATGCAACTC 720

ATCCTGGAGA CAATCCCTGT GATCCGGGAA GAGGACAAAG ATGAACTCCT CAAAGTGATG 780

CCTTCCTTCA TCAACTGCAC CTGGGAAGTG AAGAAACCAC TGCGGAAACT GCTTCCTCAA 840

GTGAACAGCG AAGCTATTGA TTTCCTAGAG AAGATCCTAA CCTTTAACCC CATGGACCGC 900

TTAACAGCTG AGCTGGGGCT GCAGCACCCT TATATGAGCC CTTACGCCTG CCCCGAGGAT 960

GAGCCCATCT CCCAGCACCC ATTCCGCATC GAGGACGAGA TTGACGATAT CCTGCTGATG 1020

GCGGCCAACC AGAGCCAGCT GTCCAACTGG GACAGATATC ACATCAGTCT GTCTTCGGAC 1080

CTAGAATGGA GACACGATCG ATACCAGGCC ACCAGTGAGG TTCAGCGGGA TCCCCGCGCG 1140

GGTTCCGAAT CCATCGCGGA AGAGGCCCAG GTGGATCCGC GGAAGTATTC CCAGAGCAGT 1200

TCGGAACGGT TCCTGGACCA GTCCCACTCC TCCATGGACC GAGCATTCGA AGCGGACTAC 1260

GGGCGGTCCT GCGACTACAA GGTCGGCTCT CCCTCCTACC TGGACAAGCT GCTGTGGAGG 1320

GACAACAAGC CCCATCACTA CTCTGAGCCC AAGCTCATCT TAGACTTGTC CCACTGGAAA 1380

AAAGCATCCA TCGCCCCTGC CGCCGAGCTG GCCCTGGAAG AGGAGCCGTC CAATCTCTTC 1440

CTGGAGATCG CCCAGTGGGT GAAAAGCACC CAGGCGGGGC TGGAGTGCCC CGGACCCCTC 1500

CCCGAGATCC AGGAACAGAG CCTGCCCTCC TCCCCCCACC ACCACCGGGC CCCCAAGGAG 1560

GCGAACCACA GCACTGACCC TCAGTTCGAC TTGGACGTCT TCATCTCCCG GGCCCTTAAA 1620

CTCTGCTCCA AACCCGAGGA CCTGCCCGAC AGCAAGCTGG GAGAGATCAA CGGGGCCTGC 1680

ATCGGAGAGC GCCCCAGTGA TATCGTGCAG ACCGAAGCCT ATCAGAAGGA GAGGTGGTGA 1740

Domain Profile

S: 3     slkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNiik  62

         + +plg G +g+v+sa+d+++ ++va+kk++   +++ s+k++lRE+k++++l+h+Ni+k

Q: 22    DFQPLGFGVNGLVLSATDSQSCRKVAVKKIA--VSDARSMKHALREVKIIRRLDHDNIVK  79

         6799**************************9..99*************************

S: 63    lldvftpee.....eleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglky  117

         +++v+ p+      +l +++ vY+v+e+metdL++++++ +l+++h+kl++yq+lrglky

Q: 80    VYEVLGPKGvdlqgQLFKFNVVYVVQEYMETDLARLLEQGTLTEDHAKLFMYQLLRGLKY  139

         *******9988888999*******************************************

S: 118   lHsanviHrDlKPsNllvnedc.elkildFGlarsadkekekk..lteyvatrwYraPei  174

         +Hsanv+HrDlKP+N++++++   lki dFGlar+ d+++++k  l+e ++t+wYr+P++

Q: 140   IHSANVLHRDLKPANIFISTEDlVLKIGDFGLARIVDQHYSHKgyLSEGLVTKWYRSPRL  199

         ******************8765169**************999999***************

S: 175   llslkeytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkiese  234

         lls ++ytka+D+W++GCIlaE+ltg++lf+g +e++q+++ile+++  +ee+ +++ +

Q: 200   LLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGGHELEQMQLILETIPVIREEDKDELLKV  259

         **********************************************************95

S: 235   earnyikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

          + ++i+ +++ kk ++++l+p+ ++ea+d+lek+L+++p++R+++e  L+hpY+

Q: 260   -MPSFINCTWEVKK-PLRKLLPQVNSEAIDFLEKILTFNPMDRLTAELGLQHPYM  312

         .9999998888776.***************************************7

Domain Sequence
(FASTA)

DFQPLGFGVN GLVLSATDSQ SCRKVAVKKI AVSDARSMKH ALREVKIIRR LDHDNIVKVY 60

EVLGPKGVDL QGQLFKFNVV YVVQEYMETD LARLLEQGTL TEDHAKLFMY QLLRGLKYIH 120

SANVLHRDLK PANIFISTED LVLKIGDFGL ARIVDQHYSH KGYLSEGLVT KWYRSPRLLL 180

SPNNYTKAID MWAAGCILAE MLTGRMLFAG GHELEQMQLI LETIPVIREE DKDELLKVMP 240

SFINCTWEVK KPLRKLLPQV NSEAIDFLEK ILTFNPMDRL TAELGLQHPY M 291

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

oaa:100077098

;

InterPros

IPR011009	; Kinase-like_dom.
IPR008350	; MAPK_ERK3/4.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01771

; ERK3ERK4MAPK.

Created Date

20-Feb-2013