EPS-ORA-00024

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-ORA-00024

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	178.6	2.2E-52	779	1025	247

Status

Unreviewed

Ensembl Protein

ENSOANP00000013005

UniProt Accession

F6RG36;

Protein Name

Protein Synonyms/Alias

Gene Name

PHLPP2

Gene Synonyms/Alias

PHLPP2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000008185	ENSOANP00000013005	ENSOANT00000013007

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

1324

Protein Sequence
(FASTA)

MKRSGSRNCL NRRSRFGSRE RDWLKEDVKR GCVYLYGADS ASTMATAAAT SSADLHLVLC 60

TVETPTSEIC TGEGRESLFL QLHGDLVRRL EPTERPLQIV YEYLARLGFE DPVRIQEEAT 120

NPDLSCMIRF YNEKPCQVDQ LDRILLSGIY NVRKGKTQLH KWAERVVVLC GTCLIVSSVK 180

DCQTGKMHIL PLVGGKVEEV KRRQHSLAFS SAGAQAQTYH ICFESLAEYQ RWHRQASKVV 240

SQRISTVDLS CYSLEEVPEH LFYSQDITYL NLRHNFMQLE RPGGLDCLHR FSQLKGLNLS 300

HNRLGQFPVL LCEISTLLEL NLSCNGLYEL PAQIGNLLNL QTLCLDGNFL TTLPDELGNL 360

QQLSSLGLSF NNFSQVPGVY EKLTTLDKLA LAGNQLESLD LGILNRLSHL KHVDLRMNHL 420

RRIVADNLEG NKHITHVDLR DNQLTDLDLS SLGSLDQLHC ERNQLRELTL SGYSLRALYA 480

SSNRLTAVNV YPVPSLLTCL ELSRNLLECV PDWACEAKKI EILDVSYNLL TEIPVRLLTS 540

LSLRKLMVGH NHIQNLPALL EHIPLEVLDL QHNLLTRLPE ALFTKALNLR FLNASANSLE 600

FLPSACSGEE SLSMLQLLYL TNNNLTDQCI PALVGHPHLR ILHLANNQLQ TFPASKLNKL 660

EQLEELNLSG NKLKTIPTTI ANCKQLHTLV AHSNNISIFP EILHLPQIQQ FVDLSCNDLT 720

EILIPEALPA TLQDLDLTGN TNLVLEHKTL DIFSHITTLK IDQKPLPTAD SSVGSTFWSH 780

GLAEMAGQRN KLCVSALAVD NFAEGVEAVY AMFDGDRNEE LPRLLQCTMA DVLLEEVQQS 840

TTDTVFMTNT FLVSHRKLGM AGQKLGSSAL LCYIRHDATD PASGFTLTLA NVGSCQAVLC 900

RNGQPLPLSK VFSLEQCPEE ARRVKDQKAI ITEDNKVNGV TCCTRMLGCT YLYPWILPKP 960

HIYSIPLTVQ DELLVLGNRA LWEHLSFAEA VAAVRHVHDP LAAAKKVCTL AQSYGCQDNV 1020

GAMVICLNIG EDGCTCEANG LPLPGPGGFA PTPAAVKDPP KPTTPSSSSG IASEFSSEMS 1080

ASEVSSEVGS TASDEHNATG LEAGLLMRPE RRCSLHPVPT SGLFQRQPSC ATFSSNQSDN 1140

GLDSDDDQPV EGVITNGSKV EVEVDIHCCK GKGLEPSSPT VEEGSPALGP GLEEDSGGGG 1200

RLLGIRRQNS VNSASHLLPV TKEKTELQKS PSTSCLYGKK LSNGSIVPLE DSLNLIEVAT 1260

EAPKKRTGYF AAPSQLEPED QFVVPHDLEE EVKEQMKHHP ENRPETEPHE EDRTDRREEF 1320

DTAL 1324

Nucleotide Sequence
(FASTA)

ATGAAACGCA GCGGAAGCAG AAACTGTTTG AACAGAAGAA GTAGGTTTGG CTCCCGAGAG 60

AGAGATTGGC TGAAAGAGGA CGTGAAAAGA GGCTGTGTCT ACCTTTATGG CGCGGACTCT 120

GCCTCTACGA TGGCCACGGC TGCGGCCACC TCATCTGCTG ACTTACATCT GGTCCTTTGC 180

ACGGTTGAAA CACCAACATC AGAGATCTGC ACTGGAGAGG GGAGGGAGAG CCTCTTCTTA 240

CAGCTTCACG GAGACCTGGT CAGGAGGCTG GAACCAACTG AAAGACCCCT ACAGATTGTT 300

TATGAGTATT TGGCCAGACT GGGATTTGAG GATCCTGTGC GCATTCAAGA GGAAGCAACA 360

AATCCTGACC TTAGTTGCAT GATTCGCTTT TACAATGAAA AGCCCTGTCA GGTGGATCAA 420

TTAGACAGAA TCCTGCTCTC TGGGATCTAT AATGTGCGCA AGGGGAAGAC CCAGCTGCAT 480

AAGTGGGCAG AACGTGTGGT TGTCCTCTGT GGCACCTGTC TGATCGTGTC CTCGGTGAAA 540

GACTGCCAGA CCGGAAAGAT GCATATTCTG CCTCTTGTTG GAGGAAAGGT AGAAGAAGTG 600

AAAAGGAGGC AGCATTCCCT GGCTTTCAGT TCAGCTGGAG CACAGGCCCA GACGTATCAC 660

ATCTGCTTTG AGTCATTGGC AGAATACCAG AGATGGCACC GGCAAGCATC AAAGGTGGTG 720

TCTCAGCGAA TTAGTACCGT CGATCTCTCG TGTTATAGCC TCGAGGAGGT TCCTGAGCAC 780

CTCTTCTATA GTCAAGACAT CACCTACCTC AATTTGCGAC ACAACTTCAT GCAGCTAGAA 840

AGACCAGGAG GCCTTGACTG TCTCCACAGG TTTTCTCAGC TCAAGGGCCT GAATCTGTCC 900

CACAATAGAC TCGGGCAGTT TCCCGTACTG CTGTGTGAGA TCTCCACTCT GCTGGAACTC 960

AATCTTTCCT GTAATGGACT TTACGAACTG CCAGCTCAGA TCGGCAATCT GCTCAATCTT 1020

CAGACTCTCT GTCTTGACGG CAACTTTCTC ACTACTTTAC CTGACGAATT GGGAAACCTG 1080

CAGCAACTTT CGTCCCTTGG GCTTTCCTTC AATAACTTCA GCCAAGTTCC TGGAGTCTAC 1140

GAGAAACTCA CTACATTAGA TAAACTGGCT CTGGCAGGGA ACCAACTGGA GAGCCTAGAT 1200

CTGGGGATAC TGAACAGGTT GAGCCATTTG AAACATGTTG ATCTAAGAAT GAACCATTTG 1260

AGAAGGATAG TTGCCGACAA CCTGGAGGGG AATAAGCATA TTACCCACGT GGACTTGCGT 1320

GACAATCAGT TAACTGACCT GGATCTCAGC TCCTTGGGCA GCTTGGACCA GCTGCATTGT 1380

GAACGGAACC AGCTGCGGGA GCTGACATTG AGTGGTTACT CCCTCCGGGC CCTCTATGCC 1440

AGTTCTAACA GGCTGACAGC AGTGAATGTT TATCCAGTTC CTAGCCTGCT GACCTGTCTA 1500

GAACTCTCTC GGAACCTCCT TGAGTGTGTC CCTGACTGGG CCTGTGAAGC AAAGAAGATT 1560

GAGATATTAG ATGTGAGCTA TAATCTCCTC ACCGAGATCC CTGTGAGACT CCTCACTAGC 1620

CTGAGTCTCA GGAAGCTGAT GGTGGGACAC AACCATATTC AGAACCTTCC AGCCCTGCTG 1680

GAGCACATTC CTCTAGAGGT GCTGGATCTT CAGCATAACT TGCTTACCCG GCTTCCAGAA 1740

GCCCTCTTCA CCAAGGCCCT AAATCTCAGG TTCTTGAATG CGTCTGCAAA TAGTCTAGAG 1800

TTCTTGCCGT CGGCTTGCAG TGGGGAGGAA AGTCTGAGTA TGCTGCAACT TCTGTATCTG 1860

ACCAATAATA ACCTGACAGA TCAATGCATC CCTGCACTGG TGGGGCACCC ACACCTCCGC 1920

ATCTTGCACC TCGCTAACAA CCAATTACAG ACCTTCCCAG CAAGCAAACT CAATAAACTG 1980

GAGCAGTTGG AGGAGCTGAA CTTGAGTGGC AACAAGCTAA AAACTATTCC CACAACAATA 2040

GCAAACTGTA AACAGCTGCA CACACTTGTT GCACACTCCA ACAACATCAG CATATTCCCA 2100

GAGATCCTAC ATTTGCCCCA GATCCAGCAG TTTGTAGATT TGAGCTGCAA TGACTTGACT 2160

GAAATCCTGA TTCCTGAGGC TCTTCCTGCC ACTCTCCAGG ACCTAGATCT GACTGGAAAT 2220

ACCAATCTGG TTCTGGAACA CAAAACACTA GACATCTTCA GCCATATCAC AACTCTGAAA 2280

ATTGATCAGA AACCCTTGCC AACAGCTGAT TCTTCAGTCG GATCAACCTT CTGGAGTCAT 2340

GGACTGGCAG AGATGGCTGG TCAGAGGAAT AAGCTTTGTG TATCTGCCCT TGCTGTGGAT 2400

AACTTTGCAG AGGGTGTGGA GGCCGTGTAT GCCATGTTTG ATGGGGACCG AAATGAGGAA 2460

TTGCCCCGCC TCCTGCAGTG TACGATGGCG GATGTGCTCT TAGAAGAAGT GCAGCAGTCA 2520

ACAACTGATA CAGTTTTCAT GACGAATACG TTTTTGGTGT CTCACAGAAA ACTGGGTATG 2580

GCTGGCCAGA AGCTGGGCTC CTCTGCTCTC CTGTGTTACA TTCGACACGA CGCTACCGAT 2640

CCAGCAAGTG GCTTCACCCT GACGCTGGCC AACGTGGGCT CGTGTCAGGC AGTTCTGTGC 2700

CGCAATGGGC AACCGCTGCC CCTCTCCAAA GTCTTCAGTT TGGAACAGTG CCCAGAGGAG 2760

GCCAGAAGAG TTAAGGACCA AAAAGCCATC ATAACTGAGG ACAATAAAGT AAATGGAGTG 2820

ACCTGCTGTA CCCGGATGTT GGGTTGTACG TACCTGTACC CCTGGATCCT CCCCAAGCCC 2880

CACATCTATT CCATCCCCCT CACGGTGCAA GATGAGCTGT TGGTCTTGGG GAACAGAGCC 2940

CTGTGGGAGC ATCTGTCGTT CGCGGAAGCC GTCGCGGCCG TGCGCCACGT GCACGACCCG 3000

TTGGCGGCCG CCAAGAAGGT GTGCACCCTG GCCCAGAGTT ACGGTTGTCA GGATAACGTC 3060

GGGGCGATGG TGATCTGCTT GAACATCGGG GAGGATGGCT GCACCTGTGA AGCGAATGGA 3120

CTCCCCCTCC CGGGCCCCGG GGGGTTCGCC CCCACCCCCG CCGCCGTCAA GGACCCTCCC 3180

AAGCCGACCA CCCCTTCCTC CAGCAGCGGC ATCGCCTCGG AGTTTAGCAG TGAAATGTCC 3240

GCCTCCGAGG TGAGCAGCGA GGTGGGCTCC ACCGCCTCCG ACGAGCACAA CGCCACCGGC 3300

CTAGAGGCGG GCTTGCTGAT GAGGCCAGAG AGACGTTGCA GCCTCCATCC TGTGCCCACC 3360

TCTGGGCTCT TTCAGCGCCA GCCTTCTTGC GCCACTTTCT CGAGTAACCA GTCGGACAAC 3420

GGCTTGGACA GCGATGACGA CCAGCCGGTC GAAGGGGTCA TAACGAATGG CAGCAAGGTG 3480

GAGGTGGAAG TGGATATCCA TTGCTGTAAA GGAAAGGGTC TCGAACCGTC CTCGCCCACG 3540

GTTGAAGAGG GGTCTCCTGC TCTGGGCCCA GGCCTAGAGG AAGATTCTGG AGGTGGGGGG 3600

AGGCTGCTTG GGATCAGGAG GCAGAATAGC GTCAACAGTG CCAGTCACCT CCTGCCAGTC 3660

ACCAAGGAGA AGACTGAATT ACAGAAATCG CCCTCCACTT CCTGTCTGTA CGGGAAGAAG 3720

CTCTCCAACG GCTCCATAGT GCCCCTGGAA GATAGCCTCA ACCTAATCGA GGTGGCTACA 3780

GAAGCTCCTA AAAAGAGAAC TGGCTACTTT GCCGCTCCCT CCCAGCTGGA GCCCGAAGAT 3840

CAATTCGTGG TCCCCCATGA CCTGGAGGAG GAAGTGAAGG AACAAATGAA ACATCACCCG 3900

GAAAACAGAC CCGAGACAGA ACCCCACGAA GAGGATCGGA CTGACCGTCG TGAAGAATTT 3960

GACACCGCTT TATAA 3975

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g++++ g+rn+++ ++ +++nf++  e+     +++++DG++++e  + +++++ ++l

Q: 779   SHGLAEMAGQRNKLCVSALAVDNFAEGVEA-----VYAMFDGDRNEELPRLLQCTMADVL  833

         6899**********************9875.....9************************

S: 62    aeelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikds......  115

          ee++    +++  + +++++Fl  +++l       ++ +k Gs+a++++i+++

Q: 834   LEEVQ----QSTTDTVFMTNTFLVSHRKL------GMAGQKLGSSALLCYIRHDatdpas  883

         ***99....66667778************......89***********************

S: 116   ..klyvanvGdSravLcrngkavelssdHkpsr.edEleRieeaggsvilkdgaRvlGvL  172

           +l+ anvG ++avLcrng++++ls+ ++ ++ ++E +R++++++ +++++  +v+Gv+

Q: 884   gfTLTLANVGSCQAVLCRNGQPLPLSKVFSLEQcPEEARRVKDQKAIITEDN--KVNGVT  941

         ******************************87527**********9999998..******

S: 173   avsRalGdlylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvlekk  232

         +++R+lG++yl+p++ p+P+++s++lt +de l+L+   lw+++s  eav++vr+v++

Q: 942   CCTRMLGCTYLYPWILPKPHIYSIPLTVQDELLVLGNRALWEHLSFAEAVAAVRHVHD--  999

         **********************************************************..

S: 233   eaeqeaakkLvklalargskdnvsaivv  260

           + +aakk+++la+++g++dnv a+v+

Q: 1000  --PLAAAKKVCTLAQSYGCQDNVGAMVI  1025

         ..************************97

Domain Sequence
(FASTA)

SHGLAEMAGQ RNKLCVSALA VDNFAEGVEA VYAMFDGDRN EELPRLLQCT MADVLLEEVQ 60

QSTTDTVFMT NTFLVSHRKL GMAGQKLGSS ALLCYIRHDA TDPASGFTLT LANVGSCQAV 120

LCRNGQPLPL SKVFSLEQCP EEARRVKDQK AIITEDNKVN GVTCCTRMLG CTYLYPWILP 180

KPHIYSIPLT VQDELLVLGN RALWEHLSFA EAVAAVRHVH DPLAAAKKVC TLAQSYGCQD 240

NVGAMVI 247

Keyword

Complete proteome; Leucine-rich repeat; Reference proteome; Repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>