EKS-ORA-00296

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORA-00296

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PEK	355.7	2.1E-106	563	973	411

Status

Unreviewed

Ensembl Protein

ENSOANP00000013215

UniProt Accession

F6QHG6;

Protein Name

Protein Synonyms/Alias

Gene Name

EIF2AK4

Gene Synonyms/Alias

EIF2AK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000008313	ENSOANP00000013215	ENSOANT00000013218

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

1621

Protein Sequence
(FASTA)

GGLLGQPSVF HSQAKEPPEI NLVLRPQGLT GDNEIYVKVD LRVKCPQNYP DVVPEIELEN 60

TKGLSNESIN ALKSSLEELA KERCGEVMIF ELADHVQSFL SEHNKPPSKS FHDEMLKNQQ 120

KLQERQAWEE QQRMLEAERQ EEQRQREILD EIQRREEEKR EEKKRKEMAK QERLEVASST 180

HQDATTRKEP ARPRAGVNLN GGTKEQGGQV KHRANSTGRS RRDRHHSVCS SEDSPGCGEV 240

LYFNAGSPCQ LTVHKGKCIE NDAELEKQVY NALEVTTGNF VLVYEWVLRW PKTKGPFLTS 300

QEKEKVEKYR KQIQGAETEF SSLVKLSHPN LVRYLAMSLR EQADATVVAV LVEHGGGLPL 360

SAPLSRGTPV PGDRLRRYAA QLLAGLDYLH RNSVVHKALG PARVLVDPEG HVRMTDHSIS 420

KRLADICRDG APEPARVRFS EDPLPGRPGK KGDIWQLGLL LLSLSQGREA KEFPVTVPRD 480

LPADFRDFLK KCVCSEDKER WSPQQLLTHR FLNPPPPNTP AVEDSDDSAE VDCIDTVIPR 540

SLLPSAACLS ETQRQFSRYF TEFEELQLLG KGAFGAVIKV QNKLDGCCYA VKRVSISPAS 600

KQFRRIKGEV TLLSRLNHEN IVRYYNAWIE RHERPLPGSP GPAPAEGKPA RPGPHLDGMG 660

LPAGDVETSA PPPVLTSSVE WSTSCERSPG AFAGTGPESS DEDEDDDDED GRDGVFSQSF 720

LPATDSDSDI IFDNEDENSK SASPEEEGAE KNGVHKGSVS SVTQTVHYLY IQMEYCEKST 780

LRDTIDQGLY QDPVRLWRLF REILDGLTYI HEKGMIHRDL KPVNIFLDSD DHVKIGDFGL 840

ATDHPFSTAE AKGEDGAGDR LIKSDPSGNL TGMVGTALYV SPEVQGSTRS AYNQKVDLFS 900

LGIIFFEMCY RPMATASERI FVLGRLREPT SPKFPEDFDD GKHAKQKAVV SWLLNHDPAK 960

RPTAMELLKS ELLPPPQLEE SELHEVLHHT LANPDGKAYR TVLARLFAQR VSPAIDYTYD 1020

SDVLKGSFSI RAAKIQQHVC ETVARIFKRH GAVELPTPLL LPRNRQIYEH NEAALFMDPS 1080

GTLVMLPYDL RIPFARYVAR NNISNLKRYC IERVFRPRKL DRCHPKELLE CAFDVVTCTA 1140

SSFLPVTEVI YTIYEIIQEF PGLQERNYNV FLNHTALLRA ILLHCGVPED KLGQVYVILN 1200

DAVTERLTRR EVEAKFCNLS LSPNSLRRLY TFIEQKGDLR DLSRTLNQVA TQKSGVAQLV 1260

KHGVKDLEEV VGLLKKLGVK LQVSVNLGLV YKVQQHHGVI FQFVAFIKRR QKTVPEILAA 1320

GGRYDHLIPQ FRGPQALGPV PSAIGVSVAI DRMAAVVASM EESVTVSSCD LLVVSAGQLS 1380

MPRAIGITQK LWTAGIAADI MYDWSQSQEE LQLHCRLHEI SFAALVSDKE GSYVKVKHFE 1440

KERQTEKRVL ESDLVDHVTQ RLRTRVCDER SLREAPDSLV GQNVKGPSSN TSGLFEIHGT 1500

TVVPSVSILA PEKLSASARR RCETQVQARL QSSLANLHQK SSEIEILAVD LPKETILQFL 1560

TLEWDADEQA FNTTVKQLLS RLPKQRYLKL VCDEIYSIKM EKKVSVLFLY SYRDDYYRIL 1620

F 1621

Nucleotide Sequence
(FASTA)

GGTGGCCTTT TAGGACAACC TTCTGTTTTT CACTCCCAGG CGAAGGAGCC GCCCGAAATC 60

AATTTAGTGC TCCGCCCTCA AGGGCTGACC GGCGACAACG AAATCTACGT GAAAGTGGAC 120

CTGAGGGTCA AGTGTCCGCA GAACTATCCA GATGTAGTCC CCGAAATCGA GCTGGAGAAC 180

ACAAAGGGTC TTTCCAATGA AAGCATCAAT GCATTAAAAT CCAGCTTGGA AGAACTGGCC 240

AAGGAGCGCT GTGGAGAGGT GATGATATTT GAGTTGGCCG ATCACGTGCA GTCGTTCCTC 300

AGCGAGCACA ACAAGCCGCC TTCCAAGTCT TTCCATGATG AGATGCTGAA GAATCAACAA 360

AAGCTGCAGG AGAGACAGGC CTGGGAGGAG CAACAGAGGA TGCTGGAAGC CGAGCGGCAA 420

GAGGAGCAGA GGCAACGGGA AATCCTTGAT GAAATTCAGA GAAGGGAAGA GGAGAAAAGA 480

GAAGAAAAAA AAAGGAAGGA AATGGCAAAG CAGGAGCGTC TGGAGGTGGC CAGTTCCACG 540

CACCAAGATG CCACTACCAG GAAAGAGCCG GCAAGGCCCA GAGCAGGCGT GAACCTGAAT 600

GGCGGAACTA AGGAGCAGGG AGGACAGGTC AAACACCGGG CCAACTCCAC CGGGCGATCC 660

AGGCGAGACC GGCATCATTC GGTGTGTAGC AGTGAAGATT CCCCGGGCTG CGGTGAAGTC 720

CTGTATTTCA ACGCGGGCTC CCCCTGCCAG CTCACCGTGC ACAAAGGGAA ATGTATCGAG 780

AACGACGCGG AGTTGGAGAA GCAGGTCTAC AACGCCTTGG AAGTGACCAC GGGGAACTTC 840

GTCCTGGTCT ACGAGTGGGT CCTGCGGTGG CCCAAAACCA AGGGACCGTT CCTCACGAGC 900

CAAGAGAAGG AGAAAGTGGA GAAATACCGG AAGCAGATCC AGGGAGCGGA GACGGAGTTC 960

AGTTCGCTGG TGAAGCTGAG CCACCCGAAC CTCGTGCGCT ACCTGGCGAT GTCGCTGCGG 1020

GAGCAGGCCG ACGCGACGGT GGTGGCCGTC CTGGTGGAGC ACGGCGGCGG CCTCCCCTTG 1080

TCTGCCCCCC TGAGCCGCGG GACCCCGGTA CCCGGCGACC GGCTGCGCCG TTACGCCGCC 1140

CAGCTCCTGG CCGGCTTGGA CTACCTGCAT CGCAACTCGG TGGTGCACAA GGCCCTGGGC 1200

CCCGCGCGGG TCCTGGTGGA CCCCGAGGGC CACGTCAGGA TGACGGACCA CAGCATCTCC 1260

AAGCGCCTGG CGGACATCTG CAGGGACGGG GCGCCGGAGC CGGCCCGGGT GCGCTTCAGC 1320

GAGGACCCGC TGCCCGGCCG GCCCGGGAAG AAGGGTGACA TCTGGCAGCT GGGCCTCCTG 1380

CTGCTCTCGC TCAGCCAGGG CCGGGAAGCC AAGGAGTTCC CAGTCACCGT GCCCCGAGAC 1440

CTGCCGGCCG ACTTCCGGGA TTTCCTGAAA AAGTGCGTCT GCTCGGAGGA CAAGGAGCGG 1500

TGGAGTCCCC AGCAGCTGTT GACACATCGC TTCCTCAACC CCCCTCCGCC GAACACACCC 1560

GCGGTGGAAG ACAGCGACGA TTCGGCAGAG GTCGACTGCA TCGACACCGT CATCCCCAGG 1620

AGCCTTCTCC CCAGCGCGGC CTGCCTCAGC GAGACGCAGC GCCAGTTTTC TCGCTACTTC 1680

ACCGAGTTCG AAGAGCTGCA GCTCCTCGGG AAGGGAGCGT TCGGCGCCGT GATCAAGGTC 1740

CAGAACAAGC TGGACGGCTG CTGCTACGCG GTGAAGCGCG TCTCCATCAG CCCCGCCAGC 1800

AAGCAGTTCC GGCGCATCAA GGGGGAGGTG ACGCTGCTCT CCCGCCTGAA CCATGAGAAC 1860

ATCGTGCGCT ACTACAACGC CTGGATCGAG AGACACGAGA GGCCGCTGCC CGGCTCGCCG 1920

GGGCCCGCCC CGGCGGAGGG GAAGCCGGCC CGCCCCGGGC CCCACCTGGA TGGGATGGGG 1980

CTCCCGGCGG GCGACGTGGA AACCAGCGCC CCGCCCCCGG TGCTGACCAG CTCGGTGGAG 2040

TGGAGCACCT CGTGCGAGCG GTCCCCCGGG GCCTTCGCGG GGACCGGCCC GGAGTCCAGC 2100

GACGAGGACG AGGACGATGA CGATGAAGAC GGCCGGGACG GCGTCTTCTC CCAGTCGTTT 2160

CTCCCCGCCA CAGATTCTGA TAGCGACATC ATCTTCGACA ACGAAGATGA GAACAGTAAA 2220

AGCGCCAGCC CGGAAGAAGA GGGTGCCGAA AAGAACGGCG TCCACAAAGG CAGTGTGTCC 2280

TCAGTGACGC AGACTGTCCA CTACCTTTAC ATCCAGATGG AGTATTGTGA GAAGAGCACC 2340

CTCCGGGACA CCATCGACCA GGGCCTGTAC CAAGATCCTG TCCGACTCTG GAGGCTTTTC 2400

CGGGAAATCC TGGACGGATT AACGTACATC CATGAGAAAG GGATGATTCA CAGGGATTTG 2460

AAGCCGGTGA ACATTTTTTT GGATAGCGAC GACCATGTGA AAATCGGGGA CTTTGGCTTG 2520

GCCACGGACC ACCCGTTCTC CACGGCAGAA GCCAAAGGGG AAGATGGGGC GGGCGATCGA 2580

CTGATCAAGT CGGACCCTTC AGGCAACCTG ACGGGGATGG TGGGCACGGC GCTCTATGTG 2640

AGCCCGGAGG TTCAGGGCAG CACCAGGTCG GCGTACAACC AGAAAGTGGA TCTGTTCAGC 2700

CTCGGCATCA TCTTCTTTGA GATGTGCTAT CGGCCCATGG CCACGGCGTC GGAGCGGATC 2760

TTCGTCCTCG GCCGACTCAG AGAGCCTACT TCTCCCAAGT TTCCAGAAGA TTTTGACGAC 2820

GGGAAGCACG CGAAGCAGAA AGCGGTCGTC TCCTGGCTCC TGAACCACGA CCCGGCCAAG 2880

CGGCCGACGG CCATGGAGCT GCTGAAGAGC GAGCTGCTGC CCCCGCCTCA GCTGGAGGAG 2940

TCGGAGCTGC ACGAGGTCCT GCACCACACG CTGGCCAACC CCGACGGCAA GGCCTACCGG 3000

ACCGTGCTGG CGCGCCTCTT CGCCCAGCGC GTCTCGCCCG CCATCGACTA CACCTACGAC 3060

AGCGACGTCC TTAAGGGCAG CTTCTCAATC CGCGCAGCTA AGATCCAGCA GCATGTGTGC 3120

GAGACCGTCG CTCGCATCTT TAAGAGACAC GGAGCGGTGG AGCTGCCCAC GCCCCTGCTG 3180

TTGCCCCGCA ACAGGCAGAT CTACGAGCAT AACGAGGCGG CCTTGTTCAT GGACCCCAGC 3240

GGCACGCTGG TGATGCTCCC CTATGACCTC AGGATCCCTT TTGCCAGATA TGTGGCAAGA 3300

AATAACATCT CAAACCTGAA ACGGTACTGC ATAGAGCGGG TCTTCCGACC CCGCAAGCTA 3360

GATCGATGCC ACCCCAAGGA GTTACTGGAA TGCGCGTTCG ACGTCGTCAC TTGCACGGCC 3420

AGCAGCTTCT TGCCCGTCAC TGAAGTCATC TACACCATCT ATGAGATCAT CCAAGAGTTT 3480

CCAGGGCTGC AGGAGAGAAA CTACAATGTC TTCCTGAACC ACACAGCCCT GCTCAGGGCC 3540

ATCCTCCTGC ACTGCGGGGT CCCGGAGGAC AAGCTCGGTC AAGTCTACGT CATCCTGAAC 3600

GACGCGGTGA CGGAGAGGCT GACCCGGCGA GAAGTGGAAG CCAAGTTCTG CAACCTCTCC 3660

CTGTCTCCCA ACAGCCTGCG TCGGCTGTAC ACGTTCATCG AGCAGAAGGG AGACTTGCGG 3720

GACCTGAGCC GGACCCTTAA CCAGGTGGCC ACCCAGAAAA GCGGGGTGGC CCAGCTGGTG 3780

AAGCATGGCG TGAAGGATCT GGAGGAGGTC GTGGGGCTCC TGAAGAAGCT CGGAGTAAAA 3840

CTGCAGGTGT CTGTGAACCT GGGCCTGGTG TACAAGGTCC AGCAACACCA CGGCGTGATC 3900

TTCCAGTTCG TGGCGTTCAT CAAGCGCCGA CAGAAGACGG TGCCCGAGAT CCTGGCGGCC 3960

GGCGGCAGAT ACGACCACCT GATCCCCCAG TTCCGAGGCC CCCAGGCCCT GGGACCGGTC 4020

CCCTCCGCCA TCGGGGTCAG CGTGGCCATC GATCGGATGG CCGCTGTCGT CGCCAGCATG 4080

GAGGAGTCGG TCACCGTGAG CTCCTGCGAC CTCCTGGTCG TGAGTGCCGG CCAGCTGTCC 4140

ATGCCGAGGG CCATCGGCAT CACCCAGAAA CTTTGGACGG CGGGCATCGC GGCCGACATC 4200

ATGTACGACT GGTCCCAGTC CCAGGAGGAG CTGCAGCTGC ACTGCAGGCT CCACGAGATC 4260

TCCTTCGCGG CCCTGGTCTC CGACAAGGAG GGGAGCTACG TGAAGGTGAA GCACTTCGAG 4320

AAGGAGCGGC AGACGGAGAA GCGGGTGCTG GAGTCCGACC TCGTCGACCA CGTGACCCAG 4380

AGGCTGAGGA CAAGAGTGTG CGATGAAAGA AGTCTCAGGG AAGCACCCGA CAGCCTGGTG 4440

GGACAGAATG TGAAGGGACC GTCTTCGAAC ACCTCAGGTC TATTTGAGAT CCACGGCACC 4500

ACGGTCGTGC CCAGCGTGAG CATCCTGGCG CCCGAGAAGC TGTCGGCCAG CGCCAGGCGC 4560

CGCTGCGAGA CTCAGGTACA AGCCAGGCTC CAGTCCTCAC TGGCCAACCT GCACCAGAAA 4620

AGCAGTGAGA TCGAAATTCT GGCCGTGGAC CTGCCAAAGG AAACCATCTT ACAGTTTTTA 4680

ACTCTGGAGT GGGACGCGGA CGAACAGGCC TTCAACACCA CCGTGAAGCA GCTGCTGTCC 4740

CGCCTGCCCA AACAACGCTA CCTCAAGCTC GTCTGTGACG AAATCTACAG CATCAAGATG 4800

GAAAAAAAGG TTTCGGTGCT GTTCCTGTAT AGCTACCGAG ACGATTATTA CCGCATCTTG 4860

TTTTAG 4866

Domain Profile

S: 1     feeikvlGkGgfgvVlkaknkldkkeyaikriklnkakkelekverevkaLaklehpniv  60

         fee+++lGkG+fg+V+k++nkld+++ya+kr+ ++ a+k++++++ ev++L++l+h+niv

Q: 563   FEELQLLGKGAFGAVIKVQNKLDGCCYAVKRVSISPASKQFRRIKGEVTLLSRLNHENIV  622

         89**********************************************************

S: 61    rYfaawleekeesl..............................................  74

         rY++aw+e++e++l

Q: 623   RYYNAWIERHERPLpgspgpapaegkparpgphldgmglpagdvetsapppvltssvews  682

         *************************************99998888888888888888888

S: 75    ...........................................tdsseveaeaeleeses  91

                                                    +ds+ ++ +++ +++++

Q: 683   tscerspgafagtgpessdededdddedgrdgvfsqsflpatdSDSDIIFDNEDENSKSA  742

         888888888888888888888888888888888888888886422333333333333333

S: 92    seesdtk..................llyiqmelceketLkdwiderkllesrselvmrlf  133

         s+e++                    +lyiqme+cek+tL+d+id+  l+++  +l+ rlf

Q: 743   SPEEEGAekngvhkgsvssvtqtvhYLYIQMEYCEKSTLRDTIDQG-LYQDPVRLW-RLF  800

         3333333677888888999999999*********************.9********.***

S: 134   kqllegleylHskgliHrdLkpsniFldsddqvKigDFgLatalaealkedvkqdaqske  193

         +++l+gl y+H+kg+iHrdLkp+niFldsdd+vKigDFgLat+    +++++k ++ +++

Q: 801   REILDGLTYIHEKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHP-FSTAEAKGEDGAGD  859

         ******************************************955.44556777777777

S: 194   ........akhtgqvgtklymsPeql..eksqYnkkvDifsLGlilfeLly.pfstemer  242

                 ++ tg+vgt+ly+sPe++  ++s+Yn+kvD+fsLG+i+fe++y p+ t++er

Q: 860   rliksdpsGNLTGMVGTALYVSPEVQgsTRSAYNQKVDLFSLGIIFFEMCYrPMATASER  919

         667777767*****************999*******************************

S: 243   vetltelrd...gkipedfdd.kvpkekkllqkllsrdpkeRpsasellksell  292

         + +l  lr+    k+pedfdd k+ k+k ++++ll++dp++Rp+a+ellksell

Q: 920   IFVLGRLREptsPKFPEDFDDgKHAKQKAVVSWLLNHDPAKRPTAMELLKSELL  973

         ********99999**************************************986

Domain Sequence
(FASTA)

FEELQLLGKG AFGAVIKVQN KLDGCCYAVK RVSISPASKQ FRRIKGEVTL LSRLNHENIV 60

RYYNAWIERH ERPLPGSPGP APAEGKPARP GPHLDGMGLP AGDVETSAPP PVLTSSVEWS 120

TSCERSPGAF AGTGPESSDE DEDDDDEDGR DGVFSQSFLP ATDSDSDIIF DNEDENSKSA 180

SPEEEGAEKN GVHKGSVSSV TQTVHYLYIQ MEYCEKSTLR DTIDQGLYQD PVRLWRLFRE 240

ILDGLTYIHE KGMIHRDLKP VNIFLDSDDH VKIGDFGLAT DHPFSTAEAK GEDGAGDRLI 300

KSDPSGNLTG MVGTALYVSP EVQGSTRSAY NQKVDLFSLG IIFFEMCYRP MATASERIFV 360

LGRLREPTSP KFPEDFDDGK HAKQKAVVSW LLNHDPAKRP TAMELLKSEL L 411

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004694	; F:eukaryotic translation initiation factor 2alpha kinase activity
GO:0000049	; F:tRNA binding

KEGG

InterPros

IPR026920	; EIF2AK4.
IPR024435	; GCN2_anticodon-bd_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR006575	; RWD-domain.
IPR008271	; Ser/Thr_kinase_AS.
IPR016135	; UBQ-conjugating_enzyme/RWD.

Pfam

PF12745	; HGTP_anticodon2; 1.
PF00069	; Pkinase; 3.
PF05773	; RWD; 1.

SMARTs

SM00591

; RWD; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50908	; RWD; 1.

Prints

Created Date

20-Feb-2013