EKS-ORA-00249
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORA-00249
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/STKR225.41.1E-66216381166
StatusUnreviewed
Ensembl ProteinENSOANP00000013320
UniProt AccessionF6XMR2;
Protein Name
Protein Synonyms/Alias
Gene NameACVR2A
Gene Synonyms/Alias ACVR2A;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOANG00000008384ENSOANP00000013320ENSOANT00000013323
OrganismOrnithorhynchus anatinus
Functional Description
Protein Length385
Protein Sequence
(FASTA)
WRRGYVTWGF ICRGLAYVEK SETQECIFYN ANWEKDKTNH SGLEPCYGDK DKRRHCFATW 60
KNISGSIEKV KQGCWLDDVN CYDRTDCVEK KDSPEVFFCC CEGNMCNERF FYFPEMEVTQ 120
PTSNPVPPKP ALFSTLLYAL VPLMGIAVAI LFAFWIYRHH KLAYPPVLVP TQSECVCGWA 180
GRGGGTMALF FPLPAQIQGP DPGPPPPSPL LGLKPLQLLE IKARGRFGCV WKAQLLNEYV 240
AVKIFPIQDK QSWQNEYEVY SLPGMKHENI LQFIGAEKRG TSIDVDLWLI TAFHEKGSLT 300
DFLKANVVSW NELCHIAETM ARGLAYLHED IPGLKDGHKP AISHRRDIKS KNVLLKNNLT 360
ACIADFGLAL KFEAGKSAGD THGQV 385
Nucleotide Sequence
(FASTA)
TGGAGGAGGG GATATGTAAC CTGGGGGTTT ATTTGTAGGG GACTGGCTTA TGTTGAAAAA 60
TCAGAAACCC AAGAGTGCAT CTTCTACAAT GCTAATTGGG AGAAAGATAA AACCAATCAC 120
AGTGGCCTGG AGCCATGCTA CGGTGATAAA GATAAAAGAC GACACTGTTT TGCTACCTGG 180
AAGAATATTT CCGGTTCAAT TGAAAAAGTG AAGCAAGGTT GTTGGCTGGA TGACGTTAAC 240
TGCTATGACA GAACTGACTG TGTAGAGAAA AAGGACAGCC CTGAAGTGTT TTTCTGCTGC 300
TGCGAAGGCA ACATGTGTAA CGAAAGGTTC TTCTATTTTC CAGAAATGGA AGTCACACAA 360
CCTACTTCCA ATCCAGTCCC CCCCAAGCCC GCCCTGTTCA GTACCTTGCT TTACGCGCTG 420
GTGCCCCTGA TGGGAATCGC TGTGGCTATC CTCTTTGCCT TTTGGATATA TAGGCATCAC 480
AAGCTGGCCT ATCCTCCGGT GCTTGTCCCC ACCCAAAGTG AGTGTGTGTG TGGGTGGGCG 540
GGAAGGGGAG GTGGCACAAT GGCCTTATTC TTCCCACTGC CAGCACAAAT TCAGGGTCCC 600
GACCCGGGAC CCCCTCCTCC TTCCCCCTTG CTGGGTTTGA AGCCGCTGCA GCTGCTCGAG 660
ATCAAGGCTC GGGGGAGATT CGGTTGTGTC TGGAAAGCGC AGCTGCTTAA TGAATACGTA 720
GCGGTCAAAA TCTTTCCCAT CCAGGACAAA CAGTCGTGGC AGAACGAGTA TGAGGTCTAC 780
AGCCTGCCCG GGATGAAACA CGAGAACATC TTGCAGTTTA TCGGTGCCGA GAAAAGGGGC 840
ACCAGCATCG ACGTGGATCT GTGGCTGATC ACGGCCTTTC ACGAAAAGGG TTCGCTGACG 900
GATTTCCTCA AAGCTAATGT GGTTTCCTGG AATGAACTGT GTCACATTGC AGAAACTATG 960
GCCCGAGGCT TGGCCTACCT TCACGAGGAC ATACCGGGTC TCAAAGATGG ACACAAACCT 1020
GCCATATCCC ACAGAAGGGA TATCAAAAGT AAAAACGTGC TGCTGAAAAA CAACCTGACA 1080
GCCTGCATCG CCGACTTCGG GCTGGCGCTC AAGTTTGAGG CCGGGAAGTC TGCGGGCGAC 1140
ACCCACGGAC AGGTA 1155
Domain Profile
S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60
         l+lle+ ++Gr+g+Vwka+l +e+vAvKif+ +d++sw++E e+y+++ ++henilqfi+
Q: 216   LQLLEIKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIG  275
         6899********************************************************
S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120
         a+k+ ++  ++l+l+t++hekgsL+d+Lk+++++++el+++a+++a+Gla+LHe+i+g k
Q: 276   AEKRGTSIDVDLWLITAFHEKGSLTDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLK  335
         ************************************************************
S: 121   gkkKpaiaH.RDlkskNilvkkdltcciaDlGLalkleeekeeldl  165
         + +Kpai+H RD+kskN+l+k++lt+ciaD+GLalk+e+ k++ d+
Q: 336   DGHKPAISHrRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDT  381
         *********55***************************99998774
Domain Sequence
(FASTA)
LQLLEIKARG RFGCVWKAQL LNEYVAVKIF PIQDKQSWQN EYEVYSLPGM KHENILQFIG 60
AEKRGTSIDV DLWLITAFHE KGSLTDFLKA NVVSWNELCH IAETMARGLA YLHEDIPGLK 120
DGHKPAISHR RDIKSKNVLL KNNLTACIAD FGLALKFEAG KSAGDT 166
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00264
EKS-ANC-00270
EKS-BOT-00282
EKS-CAJ-00289
EKS-CAF-00288
EKS-CAP-00317
EKS-CHH-00018
EKS-CII-00166
EKS-CIS-00047
EKS-DAR-00622
EKS-EQC-00274
EKS-ERE-00021
EKS-FEC-00268
EKS-GAM-00176
EKS-GAG-00236
EKS-GAA-00345
EKS-GOG-00281
EKS-HOS-00289
EKS-ICT-00266
EKS-LAC-00293
EKS-LOA-00292
EKS-MAM-00284
EKS-MEG-00222
EKS-MIM-00021
EKS-MOD-00277
EKS-MUM-00313
EKS-MUP-00277
EKS-MYL-00285
EKS-NOL-00260
EKS-ORN-00363
EKS-ORC-00265
EKS-ORL-00339
EKS-OTG-00287
EKS-PAT-00266
EKS-PES-00251
EKS-PEM-00157
EKS-POA-00273
EKS-PTV-00040
EKS-RAN-00298
EKS-SAH-00264
EKS-SOA-00025
EKS-SUS-00248
EKS-TAG-00295
EKS-TAR-00365
EKS-TAS-00019
EKS-TEN-00364
EKS-TUB-00023
EKS-TUT-00039
EKS-VIP-00018
EKS-XET-00355
EKS-XIM-00356
Gene Ontology
GO:0009986; C:cell surface
GO:0005737; C:cytoplasm
GO:0034673; C:inhibin-betaglycan-ActRII complex
GO:0017002; F:activin-activated receptor activity
GO:0005524; F:ATP binding
GO:0015026; F:coreceptor activity
GO:0004702; F:receptor signaling protein serine/threonine kinase activity
GO:0005024; F:transforming growth factor beta-activated receptor activity
GO:0030509; P:BMP signaling pathway
GO:0032927; P:positive regulation of activin receptor signaling pathway
GO:0030501; P:positive regulation of bone mineralization
GO:0045648; P:positive regulation of erythrocyte differentiation
GO:0045669; P:positive regulation of osteoblast differentiation
GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0030510; P:regulation of BMP signaling pathway
GO:0050999; P:regulation of nitric-oxide synthase activity
GO:0023014; P:signal transduction by phosphorylation
KEGG
InterPros
IPR000333; Activin_II/TGFBeta-II_recpt.
IPR015768; Activin_II_recpt.
IPR000472; Activin_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
Pfam
PF01064; Activin_recp; 1.
PF00069; Pkinase; 1.
SMARTs
Prosites
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
PR00653; ACTIVIN2R.
Created Date20-Feb-2013