EKS-ORA-00277

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORA-00277

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	325.3	3.2E-97	469	716	248

Status

Unreviewed

Ensembl Protein

ENSOANP00000013380

UniProt Accession

F6VUX4;

Protein Name

Protein Synonyms/Alias

Gene Name

PAK7

Gene Synonyms/Alias

PAK7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000008420	ENSOANP00000013380	ENSOANT00000013383

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

735

Protein Sequence
(FASTA)

MLLCVCIFPE FSIMFGKKKK RLEISGPSNF EHRVHTGFDP REQKFTGLPQ QWHSLLADTA 60

NRPKPMVDPS CITPIQLAPM KTIVRGNKPR KETSINGLLE EFDNISVTRS NSLRKESPPT 120

PHQGNSNHMR GHSEENGFIT FSQYSSESDT AADYVSDKYR DRSFYGEELD RCYKSSHGTR 180

HNGHVMKMKP DDTYYSDMRL FKSDISRFPS DYHAHMEALN KPSEYSGLPW DYQRVSSASP 240

LDYRDPFQYT PSRTAGTSEC SKESLQYGES EWGPSMDDYD KRPKSSYVNK TSPQPAMRQR 300

SRSGSGLQEP IIPYGAGAFK SNQQGHSYSS YTYPRLSEPA TCIPKVDYER TQMAVSPPLS 360

GSDTYPRGPT KLPQSHDKIN YSTSGYQYPS GYHKAAPYHH QPCLQSSSQY ISTASYPSSP 420

SISSSAYPPP SWGSSSDQQP SRVSHEQFRA ALQLVVSPGD PREYLDNFIK IGEGSTGIVC 480

IATEKHTGKQ VAVKKMDLRK QQRRELLFNE VVIMRDYHHD NVVDMYNSYL VGDELWVVME 540

FLEGGALTDI VTHTRMNEEQ IATVCLSVLR ALSYLHNQGV IHRDIKSDSI LLTSDGRIKL 600

SDFGFCAQVS KEVPKRKSLV GTPYWMAPEV ISRLPYGTEV DIWSLGIMVI EMIDGEPPYF 660

NEPPLQAMRR IRDNLPPRVK DLHKVSSVLR GFLDLMLVRE PTQRATAQEL IRHPFLKLAG 720

SPSCIVPLMR QFRHR 735

Nucleotide Sequence
(FASTA)

ATGCTTCTTT GTGTTTGCAT TTTTCCAGAA TTTTCCATCA TGTTTGGAAA GAAAAAGAAG 60

AGGCTTGAAA TTTCCGGGCC ATCCAATTTT GAGCACCGGG TCCACACTGG ATTTGATCCC 120

AGGGAGCAGA AGTTCACGGG ACTACCTCAA CAGTGGCACA GTTTGTTGGC GGATACAGCA 180

AACCGACCTA AACCCATGGT GGACCCTTCA TGTATCACAC CCATACAACT TGCTCCCATG 240

AAGACAATCG TTAGGGGGAA CAAGCCACGA AAAGAGACTT CAATCAACGG ACTGCTCGAA 300

GAGTTCGACA ATATCTCCGT CACCCGTTCC AACTCCCTCA GGAAGGAGAG CCCTCCCACC 360

CCTCATCAGG GAAACTCAAA CCATATGCGA GGCCATTCAG AGGAAAATGG CTTCATCACC 420

TTCTCTCAAT ATTCCAGTGA ATCAGATACC GCCGCGGACT ATGTGTCCGA TAAGTATAGA 480

GATAGAAGCT TCTATGGCGA AGAGTTAGAC CGATGCTATA AAAGCAGCCA CGGGACCAGG 540

CATAATGGGC ACGTCATGAA AATGAAGCCC GACGATACCT ACTATTCGGA TATGAGGTTG 600

TTCAAATCCG ATATTTCCAG GTTTCCTTCA GATTACCATG CACACATGGA AGCGCTAAAT 660

AAACCAAGTG AATATAGTGG CCTCCCCTGG GACTATCAAA GGGTCTCCAG TGCATCCCCT 720

CTAGATTACC GGGATCCTTT TCAGTACACG CCTTCTCGAA CTGCAGGCAC CAGCGAGTGC 780

TCCAAGGAAA GCCTGCAATA TGGTGAGAGT GAGTGGGGGC CGTCAATGGA TGATTACGAC 840

AAGAGGCCAA AGTCATCCTA CGTAAATAAG ACAAGCCCTC AGCCTGCCAT GAGACAGAGA 900

TCCAGGTCGG GTTCTGGGCT GCAGGAACCA ATCATCCCAT ACGGAGCAGG TGCATTCAAG 960

TCAAACCAAC AGGGACACTC ATACAGCTCC TACACTTACC CCCGCCTGTC AGAACCTGCA 1020

ACGTGTATTC CAAAGGTGGA TTATGAGCGA ACTCAGATGG CTGTTAGCCC TCCCCTGTCT 1080

GGATCAGACA CCTACCCCCG AGGCCCAACA AAACTACCTC AAAGTCATGA CAAAATTAAC 1140

TATTCCACCA GTGGCTACCA GTATCCCTCT GGGTATCACA AAGCGGCTCC CTACCACCAT 1200

CAGCCTTGTC TCCAGTCCAG TTCCCAGTAC ATCTCCACGG CTTCTTATCC AAGCTCTCCG 1260

AGTATCTCTT CAAGTGCTTA CCCCCCACCC AGTTGGGGAT CGTCCTCAGA CCAGCAGCCC 1320

TCCAGAGTGT CCCACGAACA ATTTCGAGCT GCGCTGCAGC TGGTCGTCAG CCCAGGGGAC 1380

CCCAGGGAGT ACTTGGACAA CTTCATCAAA ATTGGAGAAG GGTCAACTGG AATCGTCTGC 1440

ATTGCAACAG AGAAGCATAC AGGAAAACAA GTTGCTGTGA AGAAAATGGA CCTCAGGAAG 1500

CAACAAAGAA GAGAACTGCT CTTCAATGAG GTTGTAATAA TGAGGGACTA CCACCATGAC 1560

AACGTGGTTG ACATGTACAA CAGCTATCTT GTAGGTGATG AGTTATGGGT GGTCATGGAG 1620

TTTCTAGAAG GTGGTGCTTT GACAGACATA GTTACTCATA CCAGGATGAA TGAAGAACAG 1680

ATAGCTACAG TTTGCCTATC AGTTCTGAGA GCCCTGTCCT ACCTTCATAA TCAAGGGGTT 1740

ATTCACCGGG ACATAAAAAG CGACTCTATT CTTCTGACGA GTGATGGACG GATCAAATTA 1800

TCTGATTTTG GTTTCTGTGC CCAAGTATCA AAAGAGGTCC CAAAAAGAAA ATCACTGGTT 1860

GGAACACCAT ACTGGATGGC CCCTGAGGTC ATATCTAGAC TACCTTATGG AACTGAGGTG 1920

GATATCTGGT CCCTTGGCAT CATGGTAATA GAAATGATAG ATGGAGAACC TCCTTACTTC 1980

AATGAGCCTC CTCTCCAGGC GATGCGGAGA ATCCGTGATA ACTTACCTCC AAGAGTGAAG 2040

GACCTGCACA AGGTTTCCTC AGTGCTTCGG GGGTTCTTAG ACTTGATGTT GGTGAGGGAG 2100

CCTACCCAGA GAGCAACAGC ACAAGAACTT ATAAGGCATC CATTCTTGAA ACTGGCAGGC 2160

TCTCCTTCTT GCATTGTGCC ACTCATGAGG CAATTTAGGC ACCGTTGA 2208

Domain Profile

S: 5     eeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpniveyles  64

          +ig+G++g v++a+ek+tg++va+kk++l+kq++ e+l++e+ ++++++h n+v++++s

Q: 469   IKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYNS  528

         68**********************************************************

S: 65    flkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkviHrdi  124

         +l+ +elw+vme+l+gG+l+d+v+   +++++Eeqia+++ +vl+aL+ylH+++viHrdi

Q: 529   YLVGDELWVVMEFLEGGALTDIVT---HTRMNEEQIATVCLSVLRALSYLHNQGVIHRDI  585

         ************************...9********************************

S: 125   kakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdekaDiw  184

         k+++iLlt++g++kLsdfg++aq++k++ krk++vgtpywmAPEvi+  +  Y +++Diw

Q: 586   KSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVIS--RLPYGTEVDIW  643

         ***********************************************..9**********

S: 185   slGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqknpek  244

         slGI++ie+++gepP+++++pl+a+ +i +n pp++k+ +k+s+ ++ f++ +l ++p +

Q: 644   SLGIMVIEMIDGEPPYFNEPPLQAMRRIRDNLPPRVKDLHKVSSVLRGFLDLMLVREPTQ  703

         ************************************************************

S: 245   RpsasellkhkFl  257

         R++a+el++h+Fl

Q: 704   RATAQELIRHPFL  716

         ************7

Domain Sequence
(FASTA)

IKIGEGSTGI VCIATEKHTG KQVAVKKMDL RKQQRRELLF NEVVIMRDYH HDNVVDMYNS 60

YLVGDELWVV MEFLEGGALT DIVTHTRMNE EQIATVCLSV LRALSYLHNQ GVIHRDIKSD 120

SILLTSDGRI KLSDFGFCAQ VSKEVPKRKS LVGTPYWMAP EVISRLPYGT EVDIWSLGIM 180

VIEMIDGEPP YFNEPPLQAM RRIRDNLPPR VKDLHKVSSV LRGFLDLMLV REPTQRATAQ 240

ELIRHPFL 248

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005739	; C:mitochondrion
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000095	; PAK_box_Rho-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00786	; PBD; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00285	; PBD; 1.
SM00220	; S_TKc; 1.

Prosites

PS50108	; CRIB; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013