EPS-ORA-00023

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-ORA-00023

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	180.8	4.9E-53	78	334	257

Status

Unreviewed

Ensembl Protein

ENSOANP00000013513

UniProt Accession

F6XL38;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1E

Gene Synonyms/Alias

PPM1E;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000008495	ENSOANP00000013513	ENSOANT00000013516

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

606

Protein Sequence
(FASTA)

NCPSFLAAAL ARATSDEVLQ SDLSVHYIPK ETDGAEGTVE IETVKLARSV FSKLHEICCS 60

WVKDFPLRRK PQLYYETSIH AIKNMRRKME DKHVCIPDFN MLFNLEDQEE QAYFAVFDGH 120

GGVDAAIYAS IHLHVNMVRQ EMFPHDPAEA LCRAFRVTDE RFVQKAARES LRCGTTGVVT 180

FIRGNMLHVA WLGDSQVMLV RKGQAVELMK PHKPDREDEK QRIEALGGCV VWFGAWRVNG 240

SLSVSRAIAR PGDAEHKPYI CGDADSASTV LDGSEDYLIL ACDGFYDTVN PDEAVKVVAD 300

HLKENNGDSS MVAHKLVASA RDAGSSDNIT VIVVFLRDMN TAVHVSQESD WTENSFRGGQ 360

EDGGDDKENH GDCKRPWPQH QCSAPADLGY DGRVDSFTDR TSLSSGSEIS ALQDPGYLDL 420

AGANPGRPPS AGWGPAVEAS GPGGPEGAVW ADAATMAEEP GRPAADGRGD GRERPAYFGL 480

DPAGRGGLRP EILFPVWPGP EGGRFEPGER RGSRDAHLRH YDYARRRHGF RVKPKFHSFL 540

FAREPPRRAG TGRSPLVLAG RRSRLLPRPC LVGRPDGCQS YSGNVLMMLR KNDCIPYPNW 600

PWSCQI 606

Nucleotide Sequence
(FASTA)

AACTGCCCTT CATTTCTGGC CGCCGCCTTG GCCAGAGCGA CATCAGATGA AGTCCTTCAG 60

AGTGATCTTT CGGTGCACTA CATACCAAAG GAAACAGACG GGGCCGAAGG GACCGTTGAG 120

ATCGAGACCG TGAAACTGGC CCGTTCCGTC TTCAGCAAAC TCCACGAGAT CTGTTGCAGC 180

TGGGTGAAAG ACTTCCCTCT CCGCAGGAAA CCCCAGCTCT ACTACGAGAC GTCCATTCAT 240

GCCATCAAGA ACATGCGCCG GAAAATGGAG GACAAGCACG TCTGCATTCC GGACTTTAAC 300

ATGCTCTTCA ACTTAGAGGA CCAAGAGGAA CAGGCCTACT TCGCGGTGTT TGATGGGCAC 360

GGAGGGGTGG ACGCTGCCAT CTACGCCTCC ATCCACTTGC ACGTGAACAT GGTGCGCCAA 420

GAGATGTTCC CTCACGACCC GGCCGAGGCC CTCTGCCGCG CCTTCCGGGT GACAGACGAG 480

CGGTTTGTGC AGAAGGCCGC CAGGGAGAGC CTGCGCTGCG GAACCACGGG GGTGGTGACC 540

TTCATCCGCG GCAATATGCT CCACGTCGCC TGGTTGGGCG ATTCCCAGGT CATGCTCGTG 600

AGGAAAGGCC AAGCGGTGGA GCTCATGAAG CCTCACAAGC CTGACAGAGA GGACGAGAAG 660

CAGCGGATCG AGGCCCTGGG CGGCTGTGTG GTCTGGTTCG GGGCCTGGCG CGTTAACGGA 720

AGCCTGTCGG TCTCCAGAGC GATTGCCCGG CCAGGGGACG CCGAGCACAA GCCATACATC 780

TGTGGAGATG CGGACTCCGC CTCCACGGTC CTGGACGGGT CCGAAGACTA CCTCATCCTG 840

GCCTGCGACG GCTTCTACGA CACCGTGAAC CCCGATGAGG CGGTGAAGGT GGTGGCGGAC 900

CACCTGAAGG AAAACAACGG CGACAGCAGC ATGGTGGCCC ACAAACTGGT GGCCTCGGCG 960

CGGGACGCCG GCTCGAGCGA CAACATCACG GTGATCGTGG TCTTCCTGAG GGACATGAAC 1020

ACCGCCGTCC ACGTCAGCCA GGAGTCCGAC TGGACAGAGA ACTCGTTCCG AGGAGGGCAA 1080

GAAGACGGCG GGGACGACAA GGAGAACCAC GGAGACTGCA AGCGCCCTTG GCCTCAGCAC 1140

CAGTGCTCGG CCCCGGCGGA CCTTGGCTAC GACGGGCGGG TGGACTCTTT CACCGATCGA 1200

ACTAGCCTGA GCTCGGGTTC CGAGATCAGC GCCCTCCAGG ACCCGGGCTA CCTCGACCTC 1260

GCCGGAGCCA ACCCCGGCCG ACCTCCGAGT GCCGGCTGGG GACCGGCTGT GGAGGCGTCT 1320

GGGCCCGGAG GGCCCGAGGG GGCGGTCTGG GCCGACGCCG CGACGATGGC GGAAGAACCC 1380

GGAAGGCCGG CGGCGGACGG ACGGGGTGAC GGCCGAGAGC GTCCGGCTTA TTTTGGCTTG 1440

GATCCCGCGG GGCGGGGCGG CCTCCGCCCA GAGATTCTGT TTCCGGTCTG GCCGGGGCCG 1500

GAAGGTGGAC GCTTCGAGCC CGGGGAGAGG AGAGGGTCTC GCGATGCTCA CTTGCGTCAC 1560

TACGATTATG CCAGGAGGCG GCACGGTTTC AGGGTCAAGC CAAAGTTTCA TTCCTTCCTC 1620

TTTGCTCGAG AGCCTCCCCG CCGGGCGGGC ACCGGCCGAT CTCCACTGGT CCTAGCCGGG 1680

CGGAGAAGCA GGCTGCTGCC GAGACCGTGT CTGGTGGGGA GGCCCGATGG CTGCCAGAGT 1740

TACAGTGGGA ATGTGCTGAT GATGCTGAGG AAGAATGACT GTATACCTTA CCCCAACTGG 1800

CCCTGGAGCT GTCAAATCTA G 1821

Domain Profile

S: 4     gvvsvngrrnemedavtsspnflkspekkdr..laffgvyDGhggsevakfcseklheil  61

         ++ +++++r++med++   p+f    + +d+   a+f+v+DGhgg ++a ++s +lh  +

Q: 78    SIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQeeQAYFAVFDGHGGVDAAIYASIHLHVNM  137

         567899**************99766555544459***********************988

S: 62    aeelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikdsklyvan  121

          ++         +  +al +aF  tde++  ++++  ++ ++G+t vv  i+++ l+va

Q: 138   VRQEM----FPHDPAEALCRAFRVTDERF--VQKAARESLRCGTTGVVTFIRGNMLHVAW  191

         88855....6788888999**********..7777788888*******************

S: 122   vGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdga.RvlGvLavsRal..  178

         +GdS+++L r+g+avel + Hkp+redE++Rie+ gg v+ + ga Rv+G+L vsRa+

Q: 192   LGDSQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVV-WFGAwRVNGSLSVSRAIar  250

         *************************************999.55899************99

S: 179   .GdlylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvle.kkeaeq  236

          Gd + kpy+  + +  s+ l+ ++++liLa+DG +d+v++ eav++v d+l+ ++ + +

Q: 251   pGDAEHKPYICGDADSASTVLDGSEDYLILACDGFYDTVNPDEAVKVVADHLKeNNGDSS  310

         99*************************************************996677889

S: 237   eaakkLvklalargskdnvsaivv  260

          +a+kLv+ a++ gs+dn+++ivv

Q: 311   MVAHKLVASARDAGSSDNITVIVV  334

         9*******************9997

Domain Sequence
(FASTA)

SIHAIKNMRR KMEDKHVCIP DFNMLFNLED QEEQAYFAVF DGHGGVDAAI YASIHLHVNM 60

VRQEMFPHDP AEALCRAFRV TDERFVQKAA RESLRCGTTG VVTFIRGNML HVAWLGDSQV 120

MLVRKGQAVE LMKPHKPDRE DEKQRIEALG GCVVWFGAWR VNGSLSVSRA IARPGDAEHK 180

PYICGDADSA STVLDGSEDY LILACDGFYD TVNPDEAVKV VADHLKENNG DSSMVAHKLV 240

ASARDAGSSD NITVIVV 257

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005730	; C:nucleolus
GO:0043234	; C:protein complex
GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0035690	; P:cellular response to drug
GO:0006469	; P:negative regulation of protein kinase activity
GO:0035970	; P:peptidyl-threonine dephosphorylation
GO:0051496	; P:positive regulation of stress fiber assembly

KEGG

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013