EKS-ORA-00138

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORA-00138

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TLK	615.5	1.2E-185	421	699	279

Status

Unreviewed

Ensembl Protein

ENSOANP00000013646

UniProt Accession

F6PIG0;

Protein Name

Protein Synonyms/Alias

Gene Name

TLK1

Gene Synonyms/Alias

TLK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000008569	ENSOANP00000013646	ENSOANT00000013649

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

731

Protein Sequence
(FASTA)

NSPPPRGLPR LSAMDELHSL DPRRQELLEA RFTGVVSGST GSTGSCSVGA KASTNNESSN 60

HSFGSLGSLS DKESETPEKK QSEPSRGRKR KAESQSESSQ GKSIGGRGHK ISDYFEYQGG 120

NGSSPVRGIP PAIRSPQNSH SHSTPSSSVR PNSPSPTALA FGDHPVTQPK QLSFRITQTD 180

LTMLKLAALE SNKNQDLEKK EGRIDDLLRA NCDLRRQIDE QQKLLEKYKE RLNKCISMSK 240

KLLIEKSTQE KLASREKSMQ DRLRLGHFTT VRHGASFTEQ WTDGFAFQNL VKQQEWVNQQ 300

REDIERQRKL LAKRKPPSTN NSQAPSTNSE PKQRKNKAVN GAENDPFVRP NLPQLLTLAE 360

YHEQEEIFKL RLGHLKKEEA EIQAELERLE RVRNLHIREL KRINNEDNSQ FKDHPTLNER 420

YLLLHLLGRG GFSEVYKAFD LYEQRYAAVK IHQLNKSWRD EKKENYHKHA CREYRIHKEL 480

DHPRIVKLYD YFSLDTDTFC TVLEYCEGND LDFYLKQHKL MSEKEARSIV MQIVNALRYL 540

NEIKPPIIHY DLKPGNILLV DGTACGEIKI TDFGLSKIMD DDSYGVDGMD LTSQGAGTYW 600

YLPPECFVVG KEPPKISNKV DVWSVGVIFF QCLYGRKPFG HNQSQQDILQ ENTILKATEV 660

QFPVKPVVSN EAKAFIRRCL AYRKEDRFDV HQLANDPYLL PHMRRSNSSG NLHMAGLAAS 720

PTPPTSSVIS Y 731

Nucleotide Sequence
(FASTA)

AACTCACCTC CTCCAAGAGG CCTTCCCAGA CTGAGTGCAA TGGATGAGCT TCATAGTCTG 60

GACCCAAGAA GGCAAGAATT GCTAGAGGCC AGATTTACAG GAGTTGTGAG TGGTAGCACT 120

GGGAGTACTG GAAGCTGCAG TGTTGGAGCA AAAGCCTCAA CAAACAATGA AAGTTCAAAT 180

CACAGCTTTG GAAGCTTGGG ATCTCTAAGT GACAAAGAAT CAGAGACTCC AGAGAAAAAA 240

CAGTCAGAGC CATCCAGAGG AAGAAAGAGA AAAGCCGAAA GCCAGAGTGA AAGCAGTCAA 300

GGAAAAAGTA TTGGGGGACG AGGTCACAAA ATTAGTGATT ATTTTGAATA CCAAGGGGGG 360

AATGGTTCAA GTCCAGTAAG AGGCATACCT CCTGCAATCC GTTCACCTCA GAACTCACAT 420

TCACATTCCA CCCCTTCCTC TTCTGTACGT CCAAATAGCC CTTCTCCTAC TGCATTAGCC 480

TTTGGGGACC ATCCTGTCAC ACAACCAAAG CAGTTATCAT TTAGAATTAC TCAGACTGAT 540

CTCACAATGT TGAAATTAGC TGCACTAGAA AGTAATAAAA ATCAAGACCT GGAAAAGAAG 600

GAAGGTCGAA TAGATGACTT GCTCAGGGCT AACTGTGATC TTAGAAGACA AATAGATGAA 660

CAACAAAAGC TACTTGAAAA ATATAAAGAA AGGTTAAACA AATGCATTTC AATGAGCAAG 720

AAGCTTCTGA TTGAAAAGAG CACACAAGAA AAACTGGCAA GCAGGGAGAA GAGCATGCAA 780

GATCGACTCC GCCTTGGGCA TTTTACAACT GTCCGGCATG GTGCTTCATT TACTGAACAG 840

TGGACGGATG GCTTTGCCTT TCAAAATCTT GTGAAGCAGC AAGAGTGGGT GAATCAGCAA 900

AGGGAGGATA TTGAAAGGCA AAGAAAACTC CTAGCCAAGC GAAAACCTCC ATCTACAAAT 960

AATTCTCAGG CACCCTCGAC CAATTCTGAA CCAAAACAAA GGAAAAACAA AGCTGTCAAT 1020

GGAGCAGAAA ACGATCCTTT TGTCAGACCT AATTTGCCCC AGCTGTTGAC TTTAGCCGAA 1080

TATCATGAAC AGGAAGAAAT TTTCAAGCTT AGATTAGGAC ATCTCAAAAA GGAAGAAGCA 1140

GAAATTCAGG CAGAACTTGA GCGTTTGGAA AGAGTCCGAA ATCTTCATAT AAGGGAACTC 1200

AAAAGAATAA ACAATGAAGA TAATTCTCAG TTCAAAGATC ATCCTACGTT AAATGAGCGA 1260

TATTTGTTAC TACATCTACT TGGTAGAGGT GGCTTTAGTG AAGTATATAA GGCTTTTGAC 1320

CTTTATGAAC AAAGATATGC TGCTGTGAAG ATCCATCAGC TTAATAAAAG CTGGAGAGAT 1380

GAGAAGAAAG AAAATTACCA CAAACATGCA TGCAGAGAAT ATAGAATACA CAAAGAACTG 1440

GACCACCCCA GAATAGTTAA ACTCTATGAC TATTTCTCTC TGGACACGGA TACGTTTTGT 1500

ACAGTGTTAG AATACTGTGA AGGCAATGAC TTGGATTTCT ATCTGAAACA ACATAAATTA 1560

ATGTCAGAAA AGGAAGCTAG GTCCATTGTA ATGCAAATTG TAAATGCACT AAGATATCTC 1620

AATGAGATCA AACCCCCCAT TATACATTAT GATCTTAAGC CAGGAAACAT CCTTCTTGTA 1680

GATGGCACAG CGTGTGGAGA AATTAAAATC ACTGATTTTG GTCTGTCCAA AATTATGGAT 1740

GATGATAGTT ATGGTGTGGA TGGAATGGAC CTTACTTCCC AAGGAGCAGG GACATACTGG 1800

TACTTACCAC CCGAATGTTT TGTAGTTGGT AAAGAGCCAC CAAAGATTTC TAACAAAGTT 1860

GATGTGTGGT CAGTTGGAGT CATCTTTTTT CAGTGTCTTT ATGGTCGCAA GCCATTTGGT 1920

CATAACCAAT CTCAACAAGA CATCCTTCAA GAAAATACCA TATTAAAAGC CACTGAAGTC 1980

CAGTTCCCTG TAAAACCTGT TGTAAGCAAT GAAGCCAAGG CATTCATAAG GCGCTGTTTA 2040

GCATATCGCA AAGAGGATCG ATTTGATGTG CACCAGCTGG CTAATGATCC TTACCTTCTT 2100

CCCCACATGA GAAGATCAAA TTCTTCAGGA AACTTACATA TGGCTGGGCT GGCAGCATCC 2160

CCTACACCAC CTACTTCAAG TGTAATTTCT TATTGA 2196

Domain Profile

S: 1     ylllkllgkggfsevykafdlkeqryvavkihqlnkdwkdekkenyvkhalreyrihkel  60

         ylll+llg+ggfsevykafdl+eqry+avkihqlnk+w+dekkeny+kha+reyrihkel

Q: 421   YLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKEL  480

         9***********************************************************

S: 61    dhprivklydllsldtdsfctvleyvegndldfylkqhkllsekearsiimqivsalkyl  120

         dhprivklyd++sldtd+fctvley+egndldfylkqhkl+sekearsi+mqiv+al+yl

Q: 481   DHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYL  540

         ************************************************************

S: 121   neikppiihydlkpgnillvegtacgeikitdfglskimdddsydsddgleltsqgagty  180

         neikppiihydlkpgnillv+gtacgeikitdfglskimdddsy++d g++ltsqgagty

Q: 541   NEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVD-GMDLTSQGAGTY  599

         *********************************************99.************

S: 181   wylppecfvvgkeppkisnkvdvwsvgvifyqclygkkpfghnqsqqdileentilkate  240

         wylppecfvvgkeppkisnkvdvwsvgvif+qclyg+kpfghnqsqqdil+entilkate

Q: 600   WYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATE  659

         ************************************************************

S: 241   vqfpskpvvsseakafirrclayrkedridvqqlakdeyl  280

         vqfp+kpvvs+eakafirrclayrkedr+dv+qla+d+yl

Q: 660   VQFPVKPVVSNEAKAFIRRCLAYRKEDRFDVHQLANDPYL  699

         **************************************97

Domain Sequence
(FASTA)

YLLLHLLGRG GFSEVYKAFD LYEQRYAAVK IHQLNKSWRD EKKENYHKHA CREYRIHKEL 60

DHPRIVKLYD YFSLDTDTFC TVLEYCEGND LDFYLKQHKL MSEKEARSIV MQIVNALRYL 120

NEIKPPIIHY DLKPGNILLV DGTACGEIKI TDFGLSKIMD DDSYGVDGMD LTSQGAGTYW 180

YLPPECFVVG KEPPKISNKV DVWSVGVIFF QCLYGRKPFG HNQSQQDILQ ENTILKATEV 240

QFPVKPVVSN EAKAFIRRCL AYRKEDRFDV HQLANDPYL 279

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006886	; P:intracellular protein transport
GO:0035556	; P:intracellular signal transduction
GO:0001672	; P:regulation of chromatin assembly or disassembly

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013