EKS-ORA-00439

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORA-00439

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/BRD	N/A	N/A	N/A	N/A	N/A

Status

Unreviewed

Ensembl Protein

ENSOANP00000013848

UniProt Accession

F6PHB2;

Protein Name

Protein Synonyms/Alias

Gene Name

BRD4

Gene Synonyms/Alias

BRD4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000008694	ENSOANP00000013850	ENSOANT00000013853
ENSOANG00000008694	ENSOANP00000013848	ENSOANT00000013851

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

1330

Protein Sequence
(FASTA)

MSMESGPGTR LRNLPGMGDG LETPQMSTTQ AQAQPQQGST AGSNPPPPET SNPNKPKRQT 60

NQLQYLLKVV LKTLWKHQFA WPFQQPVDAV KLNLPDYYKI IKTPMDMGTI RKRLENNYYW 120

NAHECIQDFN TMFTNCYIYN KPGDDIVLMA EALEKLFLQK ISELPSEETE IVIVQAKGRG 180

RGRKEAVTAK PGASTVPNTT QASTPPQTQT PQPNLQPVPT THSFPSVTPD LIVQTPIITV 240

VSPQTLQTPP PPPPPPPPPP PPAPQPIQTH TPILTTAAQP VKTKKGVKRK ADTTTPTTMD 300

PIHESPSLAA EPKSAKLGPR RESSRPVKPP KKDVPDSQQH VAEKSNKISE QLKYCSGIIK 360

EMFAKKHAAY AWPFYKPVDV EALGLHDYCD IIKHPMDLST IKSKLENREY RDAQEFAADV 420

RLMFSNCYKY NPPDHEVVAM ARKLQDVFEM RFAKMPDEPE EPVVAVSSPV LPPPTKVVAP 480

PSSSDSSSDS SSDSDSSSDD SEEERAQRLA ELQEQLKAVH EQLAALSQPQ QNKPKKKEKD 540

KKEKKKEKHK KKEDVEDNKK SKVKEPPPKK AKKSNNNNNS NASKKEPMPV KNKPPPAYES 600

EEEDKCKPMS YEEKRQLSLD INKLPGEKLG RVVHIIQSRE PSLKNSNPDE IEIDFETLKP 660

STLRELERYV TSCLRKKRKP QAEKVDVIAG SSKMKGFSSS ESESTSESSS SDSEDSETEM 720

APKSKKKGHP GREQKKHHHH HQPVQPVQPP PPLQQLPQQP PPPPSMSQQA PPPPKSSPPP 780

FIAAQVAGLE HALPGNVFDS IPHFPQPILH IPQPELPPHL PQPPEHSTPP HLNQHAVVSP 840

PALHNALPQQ PSRPSNRAAA LPPKPTRPPA VSPALSQQPL LPQPPLPQPP QVLLEDEESP 900

APPLTSIQMQ LYLQQLQKVQ PSTPLLPSVK VQSQPPPPLP PPSHPSVPQL QQHQPPPRPV 960

HMPFPPHIQQ QQPPPPPPQQ PSHPPQGQQP PPPQPAKPQQ VIQHHPSPRH HKSDPYSTGH 1020

LREAPSPLMI HSPQMPQFQG LVQQSPPQQS VQTKKQELRA ASVVQPQPLV VQVKEEKIHS 1080

PIIRHEPFSP SLRQEPPKHP EGIKAPAHIP QRPDMKPLDS GRPVIRPPEQ GGPPPGGQDK 1140

DKQKQEPKTP VAPKKDLKIK NMGSWASLVQ KHPTTPSSTA KSSSDSFEQF RRAAREKEER 1200

EKALKAQAEQ AEKEKERLRR EQERMRSRDD EDALEQARRV HEEVRRRQEH HHQQQQPPPP 1260

QQQQQQQVAA AASAPQAQSS HPQASQSMLD HQREMARKRE QERRRREAMT ATIDMNFQSD 1320

LLAIFEENLF 1330

Nucleotide Sequence
(FASTA)

ATGTCTATGG AGAGCGGCCC TGGAACGAGA CTGAGAAATT TGCCAGGAAT GGGGGATGGA 60

CTAGAAACTC CACAAATGTC TACCACGCAG GCCCAGGCCC AACCCCAGCA AGGCAGTACT 120

GCAGGCAGTA ACCCCCCACC CCCTGAGACT TCCAACCCCA ACAAGCCCAA GAGACAGACC 180

AACCAACTGC AATATCTGCT CAAAGTGGTG CTCAAGACAC TATGGAAACA TCAGTTTGCG 240

TGGCCTTTCC AGCAGCCTGT GGACGCTGTC AAGCTCAACC TCCCTGATTA TTATAAGATT 300

ATTAAAACTC CTATGGATAT GGGAACAATA AGGAAGCGCT TGGAAAATAA CTACTACTGG 360

AATGCTCACG AATGTATCCA GGACTTCAAT ACTATGTTTA CAAATTGTTA CATCTACAAT 420

AAGCCAGGAG ATGACATAGT CTTAATGGCG GAAGCTCTAG AGAAGCTCTT CCTGCAGAAA 480

ATCTCTGAAT TGCCCTCAGA AGAAACCGAA ATTGTAATAG TCCAGGCGAA AGGACGAGGA 540

CGTGGGAGGA AAGAAGCAGT AACAGCTAAA CCTGGAGCCT CAACGGTACC AAACACAACT 600

CAAGCATCAA CCCCACCCCA GACACAGACC CCACAGCCGA ATCTTCAGCC TGTGCCGACA 660

ACTCATTCCT TTCCCTCCGT CACTCCCGAT CTTATCGTTC AGACGCCGAT AATAACAGTG 720

GTGTCTCCCC AGACTCTCCA AACTCCGCCG CCCCCGCCGC CCCCTCCTCC GCCACCTCCG 780

CCCCCTGCTC CCCAGCCAAT TCAGACCCAT ACACCTATAC TCACAACTGC AGCACAGCCC 840

GTGAAGACAA AAAAGGGGGT GAAGAGGAAA GCGGATACTA CCACCCCCAC CACCATGGAT 900

CCCATTCACG AATCGCCCTC ACTCGCCGCC GAGCCGAAAT CTGCCAAGTT GGGCCCCCGC 960

AGGGAAAGCA GCCGCCCCGT GAAGCCTCCG AAGAAGGACG TCCCCGACTC TCAGCAGCAC 1020

GTGGCGGAAA AGAGTAACAA GATATCAGAG CAGTTGAAGT ATTGCAGCGG CATCATCAAG 1080

GAGATGTTTG CCAAGAAGCA CGCGGCCTAT GCCTGGCCTT TCTACAAACC TGTGGATGTG 1140

GAAGCCCTGG GACTGCATGA TTATTGCGAT ATCATCAAGC ACCCCATGGA CCTGAGCACA 1200

ATCAAATCCA AACTAGAAAA CCGGGAATAC AGAGATGCTC AGGAATTTGC TGCGGACGTC 1260

CGATTGATGT TTTCAAATTG TTACAAGTAC AACCCTCCTG ACCACGAGGT GGTAGCCATG 1320

GCCCGTAAAC TGCAGGATGT ATTTGAGATG CGTTTTGCAA AGATGCCCGA TGAGCCCGAA 1380

GAACCAGTTG TAGCCGTGTC CTCTCCTGTG CTGCCGCCCC CCACCAAGGT CGTGGCTCCC 1440

CCGTCGTCCA GTGACAGCAG CAGCGACAGC TCCTCCGACA GCGACAGCTC ATCTGACGAC 1500

TCCGAGGAGG AGCGGGCCCA GCGGCTGGCC GAGCTTCAGG AACAGCTCAA GGCAGTACAT 1560

GAGCAGCTTG CTGCTCTCTC CCAGCCTCAA CAGAACAAAC CAAAGAAAAA GGAGAAAGAC 1620

AAGAAAGAAA AGAAAAAGGA GAAGCACAAA AAGAAAGAGG ACGTCGAGGA CAACAAGAAA 1680

AGCAAAGTCA AGGAACCACC TCCCAAAAAG GCCAAGAAAA GTAACAACAA CAACAACAGT 1740

AATGCCAGTA AGAAGGAGCC CATGCCAGTG AAGAATAAGC CCCCTCCTGC CTATGAGTCA 1800

GAGGAGGAAG ACAAGTGTAA GCCAATGTCC TACGAGGAGA AGAGGCAACT GAGCTTGGAC 1860

ATTAACAAAC TTCCCGGAGA GAAACTAGGC CGGGTGGTCC ATATCATCCA GTCACGAGAA 1920

CCCTCGCTGA AAAACTCCAA CCCTGATGAA ATCGAAATTG ACTTTGAGAC CTTGAAGCCC 1980

TCCACCTTGC GGGAGCTGGA GCGATATGTC ACCTCGTGTT TGCGGAAAAA GAGGAAACCC 2040

CAAGCCGAGA AAGTGGATGT GATCGCTGGG TCCTCTAAAA TGAAGGGCTT CTCGTCCTCA 2100

GAGTCTGAGA GCACCAGTGA GTCGAGCTCC TCTGACAGCG AAGACTCAGA AACAGAAATG 2160

GCACCAAAAT CTAAGAAGAA GGGGCATCCT GGGCGGGAGC AGAAGAAGCA TCACCACCAC 2220

CATCAGCCAG TGCAGCCGGT GCAGCCGCCT CCACCCCTGC AGCAGCTGCC GCAGCAGCCG 2280

CCACCCCCAC CTTCGATGTC TCAGCAGGCG CCGCCACCCC CCAAGTCCTC TCCTCCCCCC 2340

TTCATTGCAG CCCAGGTGGC TGGCCTAGAG CACGCGCTCC CAGGGAATGT ATTTGATTCC 2400

ATCCCTCACT TCCCCCAGCC CATCCTGCAT ATCCCCCAGC CTGAGCTGCC TCCTCACCTC 2460

CCCCAGCCTC CTGAGCACAG CACTCCACCT CATCTAAACC AGCATGCGGT GGTATCTCCT 2520

CCAGCTTTGC ACAACGCTCT GCCCCAGCAG CCATCGAGAC CCAGCAACCG AGCCGCCGCC 2580

CTGCCTCCCA AACCGACCCG CCCCCCAGCC GTGTCGCCTG CACTCTCCCA GCAGCCCCTT 2640

CTCCCTCAGC CACCCCTGCC CCAGCCGCCC CAGGTCCTGC TGGAGGATGA AGAGTCCCCC 2700

GCCCCACCCC TAACCTCAAT CCAGATGCAG CTGTATCTGC AGCAGTTGCA GAAGGTGCAG 2760

CCGTCCACAC CTCTCCTCCC TTCCGTGAAG GTGCAGTCCC AGCCCCCGCC GCCTCTCCCC 2820

CCGCCCTCTC ATCCCTCAGT GCCGCAGCTG CAGCAGCACC AGCCCCCACC GCGGCCCGTC 2880

CACATGCCGT TCCCCCCGCA TATTCAGCAG CAGCAGCCGC CGCCGCCTCC CCCCCAGCAG 2940

CCTTCTCACC CACCCCAGGG GCAGCAACCA CCCCCACCAC AGCCAGCCAA ACCTCAGCAA 3000

GTCATTCAGC ACCACCCCTC GCCCCGACAC CACAAATCTG ACCCCTACTC GACGGGTCAC 3060

CTGCGGGAAG CCCCGTCCCC TCTCATGATA CATTCCCCCC AGATGCCCCA GTTTCAGGGC 3120

CTGGTCCAAC AGTCACCGCC TCAGCAGAGC GTCCAGACTA AGAAGCAGGA GCTCCGGGCG 3180

GCCTCAGTGG TGCAGCCCCA GCCCCTGGTG GTACAGGTGA AGGAGGAAAA GATCCACTCA 3240

CCCATCATTC GCCATGAGCC CTTCAGTCCC TCCCTACGGC AGGAGCCCCC CAAACACCCA 3300

GAGGGCATCA AGGCCCCGGC GCACATCCCC CAGCGGCCCG ACATGAAGCC ACTGGACAGT 3360

GGGAGGCCCG TGATCCGCCC TCCGGAGCAG GGCGGCCCGC CGCCTGGAGG CCAGGACAAA 3420

GACAAGCAGA AGCAGGAACC CAAGACCCCT GTCGCTCCCA AAAAGGATCT GAAGATCAAG 3480

AACATGGGTT CTTGGGCTAG CCTGGTCCAG AAACATCCCA CCACCCCCTC TTCCACGGCC 3540

AAGTCATCCA GCGACAGCTT TGAGCAGTTC CGCCGGGCCG CGCGGGAGAA GGAAGAGCGC 3600

GAGAAGGCGC TCAAGGCTCA GGCGGAGCAA GCGGAGAAGG AGAAGGAGAG ACTGCGGAGG 3660

GAGCAAGAGA GAATGCGGAG CCGCGATGAT GAGGACGCTC TGGAGCAAGC CCGGCGGGTG 3720

CACGAGGAGG TGAGGCGGCG CCAAGAGCAT CATCATCAGC AGCAGCAGCC GCCGCCACCC 3780

CAACAGCAAC AGCAGCAGCA AGTGGCTGCA GCAGCCTCTG CTCCCCAAGC ACAGAGCTCC 3840

CATCCCCAGG CCTCTCAGTC TATGCTGGAC CACCAGAGAG AGATGGCCAG GAAACGAGAA 3900

CAGGAGAGAA GGCGAAGGGA GGCGATGACA GCTACCATTG ACATGAATTT CCAGAGTGAT 3960

CTGTTGGCAA TATTTGAAGA GAATCTTTTC 3990

Domain Profile

N/A

Domain Sequence
(FASTA)

N/A

Keyword

Bromodomain; Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0000794	; C:condensed nuclear chromosome
GO:0005737	; C:cytoplasm
GO:0000790	; C:nuclear chromatin
GO:0003677	; F:DNA binding
GO:0007059	; P:chromosome segregation
GO:0044154	; P:histone H3-K14 acetylation
GO:0043983	; P:histone H4-K12 acetylation
GO:0043388	; P:positive regulation of DNA binding
GO:0010971	; P:positive regulation of G2/M transition of mitotic cell cycle
GO:0032968	; P:positive regulation of transcription elongation from RNA polymerase II promoter
GO:0006468	; P:protein phosphorylation
GO:0000114	; P:regulation of transcription involved in G1 phase of mitotic cell cycle

KEGG

InterPros

IPR001487	; Bromodomain.
IPR018359	; Bromodomain_CS.

Pfam

PF00439

; Bromodomain; 2.

SMARTs

SM00297

; BROMO; 2.

Prosites

PS00633	; BROMODOMAIN_1; 1.
PS50014	; BROMODOMAIN_2; 2.

Prints

PR00503

; BROMODOMAIN.

Created Date

20-Feb-2013