EKS-ORA-00331

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORA-00331

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	232.5	6.5E-69	1	180	180

Status

Unreviewed

Ensembl Protein

ENSOANP00000014216

UniProt Accession

F7D2W4;

Protein Name

Protein Synonyms/Alias

Gene Name

LOC100089454

Gene Synonyms/Alias

LOC100089454;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000008928	ENSOANP00000014216	ENSOANT00000014219

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

506

Protein Sequence
(FASTA)

MEYAEGGSLY NVLHGAEPLP YYTAAHAMSW CLQCSQGVAY LHSMQPKALI HRDLKPPNLL 60

LVAGGTVLKI CDFGTACDIQ THMTNNKGSA AWMAPEVFEG SNYSEKCDVF SWGIILWEVI 120

TRRKPFDEIG GPAFRIMWAV HNGTRPPLIK NLPKPIESLM TRCWSKDPSQ RPSMEEIVKI 180

MTHLMRYFPG ADEPLQYPCQ YSDEGQSNSA TSTGSFMDIT STNTSNKSDT NLEQVPATND 240

TIKRLESKLA QTMKNQAKQQ SDTGRLSLGA SRGSSVESLP PSESKRMSAD MSEIEARIAA 300

TTAYSKPKRG HRKTASFGNI LDVPEIVISA GNGQPRRRSV QDLSVAGTES NQVSSRSSSP 360

SVRMITTSGP TSEKPARGHP WTPDDSADTN GSDNSIPMAY LTLDHQLQPL APCPNSKESM 420

AVFEQHCKMA QEYMKVQTEI ALLLQRKQEL VAELDQDEKD QQNTSRLVQE HKKLLDENKS 480

LSTYFQQCKK QLEVIRSQQQ KRQGTS 506

Nucleotide Sequence
(FASTA)

ATGGAATATG CGGAAGGAGG CTCTCTCTAC AATGTGCTCC ATGGTGCCGA ACCCTTGCCG 60

TACTACACTG CCGCCCATGC GATGAGCTGG TGTTTGCAGT GCTCCCAGGG AGTGGCCTAT 120

CTTCACAGCA TGCAGCCCAA AGCCCTGATC CACCGAGACC TCAAACCACC CAACCTGTTA 180

CTGGTAGCCG GAGGGACAGT CCTAAAAATC TGTGACTTTG GCACTGCATG TGACATACAG 240

ACACACATGA CCAATAACAA GGGAAGTGCT GCGTGGATGG CACCCGAAGT GTTTGAAGGT 300

AGCAATTACA GTGAAAAATG TGACGTGTTC AGTTGGGGTA TTATCCTTTG GGAAGTGATA 360

ACCCGCAGGA AACCCTTTGA TGAGATTGGT GGTCCAGCTT TCCGCATAAT GTGGGCAGTT 420

CATAATGGTA CTCGACCACC GCTGATCAAA AATTTACCCA AACCTATTGA GAGTTTAATG 480

ACTCGGTGTT GGTCTAAGGA TCCTTCTCAA CGACCTTCCA TGGAGGAGAT TGTGAAAATA 540

ATGACACATT TGATGCGGTA CTTTCCAGGA GCAGATGAGC CTCTGCAGTA TCCTTGTCAG 600

TATTCAGATG AAGGACAAAG CAATTCTGCC ACCAGCACAG GCTCATTCAT GGACATCACA 660

TCTACAAATA CGAGTAACAA GAGTGACACG AACTTGGAGC AAGTCCCAGC TACGAATGAT 720

ACCATTAAGC GTTTAGAATC AAAGTTGGCG CAAACGATGA AGAACCAGGC GAAGCAGCAG 780

AGCGACACTG GGCGCTTAAG CTTGGGAGCA TCTCGTGGGA GCAGCGTGGA GAGCCTGCCC 840

CCGTCGGAGA GCAAGCGGAT GAGCGCAGAC ATGTCTGAAA TAGAAGCGAG AATAGCTGCG 900

ACCACAGCCT ATTCCAAGCC TAAACGGGGC CATCGTAAAA CTGCTTCATT TGGCAACATT 960

CTGGATGTCC CTGAGATCGT CATATCAGCA GGCAACGGGC AGCCGAGGCG AAGATCTGTT 1020

CAGGACCTCA GTGTTGCTGG AACCGAATCC AATCAGGTGA GCAGTAGATC ATCCAGCCCC 1080

AGTGTCAGAA TGATCACCAC CTCAGGACCA ACGTCGGAGA AGCCAGCCCG CGGCCACCCT 1140

TGGACACCTG ATGATTCTGC AGATACAAAT GGATCCGATA ACTCTATCCC AATGGCCTAT 1200

CTCACCCTGG ATCATCAATT GCAGCCTCTT GCACCATGCC CAAACTCCAA AGAATCTATG 1260

GCTGTGTTTG AACAGCATTG TAAAATGGCA CAAGAATATA TGAAAGTGCA GACAGAAATC 1320

GCCCTACTGT TGCAGAGAAA GCAAGAGCTA GTAGCAGAAC TGGACCAGGA TGAAAAAGAT 1380

CAGCAAAACA CATCTCGTCT GGTACAAGAG CATAAAAAGC TTTTAGATGA AAACAAAAGT 1440

CTTTCTACAT ACTTCCAGCA ATGCAAAAAA CAGCTGGAGG TCATTAGAAG TCAGCAGCAA 1500

AAGCGGCAAG GCACTTCATG A 1521

Domain Profile

S: 75    meyveggsLsnvlhe.kskreidlevlvswalqiArGmaYLhseapkkiihrdLksknvL  133

         mey+eggsL+nvlh+ +  + ++ ++++sw+lq+++G+aYLhs++pk++ihrdLk++n+L

Q: 1     MEYAEGGSLYNVLHGaEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLL  60

         9**************778899***************************************

S: 134   lseekktlkicdFGtarelskstkmsaagtlawmaPEvlkeekvseksDvwSygvvLWel  193

         l +  ++lkicdFGta++++ +++++++g++awmaPEv++ +++sek+Dv+S+g++LWe+

Q: 61    LVAGGTVLKICDFGTACDIQ-THMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEV  119

         ******************99.9**************************************

S: 194   ltrevPykdlse..laiaykvalkglrlpipsscpeklkkLmkecwnedpekRpsfseiv  251

         +tr++P++++    ++i+++v ++g+r+p+++++p+++++Lm++cw++dp++Rps++eiv

Q: 120   ITRRKPFDEIGGpaFRIMWAV-HNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIV  178

         ********9987447889999.99***********************************9

S: 252   ks  253

k+

Q: 179   KI  180

Domain Sequence
(FASTA)

MEYAEGGSLY NVLHGAEPLP YYTAAHAMSW CLQCSQGVAY LHSMQPKALI HRDLKPPNLL 60

LVAGGTVLKI CDFGTACDIQ THMTNNKGSA AWMAPEVFEG SNYSEKCDVF SWGIILWEVI 120

TRRKPFDEIG GPAFRIMWAV HNGTRPPLIK NLPKPIESLM TRCWSKDPSQ RPSMEEIVKI 180

Keyword

Complete proteome; Kinase; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004709	; F:MAP kinase kinase kinase activity
GO:0000186	; P:activation of MAPKK activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR017421	; MAPKKK7.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013