EKS-ORA-00004
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORA-00004
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph516.11.3E-155630886257
StatusUnreviewed
Ensembl ProteinENSOANP00000014218
UniProt AccessionF7D2V3;
Protein Name
Protein Synonyms/Alias
Gene NameEPHA7
Gene Synonyms/Alias EPHA7;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOANG00000008930ENSOANP00000014218ENSOANT00000014221
OrganismOrnithorhynchus anatinus
Functional Description
Protein Length995
Protein Sequence
(FASTA)
MVVRPSWIIA CYLWLLRLAR PGEAQAAREV ILLDSKSQQT ELEWISSPSN GWEEISGLDE 60
NYTPIRTYQV CQVMEPNQNN WLRTSWIAKG NAQRIFVELK FTLRDCNSLP GVLGTCKETF 120
NLYYYETDYD TGRNIRENLY VKIDTIAADE SFTQGDLGER KMKLNTEVRE IGPLSKKGFY 180
LAFQDVGACI ALVSVKVYYK KCWSIIENLA IFPDTVTGSE FSSLVEVRGT CVHSAEEEAE 240
NSPRMHCSAE GEWLVPIGKC ICKAGYQQKG DTCEPCGRGF YKSSSQDLQC SRCPSHSFSD 300
KEGSSRCDCE DGYYRALADP PYVACTRPPS APQNLIFNIN QTTVSLEWNP PADNGGRNDV 360
TYRVLCKRCS WEQGECVPCG SNVGYLPQQS GLADNFVTVT DLLAHANYTF EVEAVNGVSD 420
LSRSQRLFAA VSITTGQAAP SQVSGVMKER VLQRSVELSW QEPEHPNGVI TEYEIKYYEK 480
DQRERTYSTV KTKSTSVSIN NLKPGTVYVF QIRAFTAAGY GNYSPRLDVA TLEEATGKMF 540
EATAVSSEQN PVIIIAVVAV AGTIILVFMV FGFIIGRRHC GYSKADQEGD EELYFHFKFP 600
GTKTYIDPET YEDPNRAVHQ FAKELDASCI KIERVIGAGE FGEVCSGRLK LPGKRDVAVA 660
IKTLKVGYTE KQRRDFLCEA SIMGQFDHPN VVHLEGVVTR GKPVMIVIEY MENGALDAFL 720
RKHDGQFTVI QLVGMLRGIA AGMRYLADMG YVHRDLAARN ILVNSNLVCK VSDFGLSRVI 780
EDDPEAVYTT TGGKIPVRWT APEAIQYRKF TSASDVWSYG IVMWEVMSYG ERPYWDMSNQ 840
DVIKAIEEGY RLPAPMDCPA GLHQLMLDCW QKDRGERPKF EQIVGILDKM IRNPNSLKTP 900
LGTCSRPISP LLDQNTPDFT TFCSVGEWLQ AIKMERYKDN FTAAGYNSLE SVARMTIEDV 960
MSLGITLVGH QKKIMSSIQT MRAQMLHLHG TGIQV 995
Nucleotide Sequence
(FASTA)
ATGGTGGTCC GCCCCTCCTG GATTATCGCA TGCTACCTCT GGCTGCTCCG CCTGGCGCGC 60
CCGGGGGAGG CTCAGGCGGC GAGAGAAGTA ATACTGCTGG ACTCAAAATC ACAACAGACA 120
GAATTGGAAT GGATTTCTTC TCCTTCCAAT GGGTGGGAAG AAATTAGTGG ATTGGATGAA 180
AACTACACCC CTATACGGAC ATACCAGGTA TGCCAGGTTA TGGAACCTAA TCAAAACAAC 240
TGGCTTCGGA CTAGCTGGAT TGCAAAAGGC AATGCACAAA GGATTTTTGT AGAACTGAAA 300
TTCACCCTGA GGGATTGTAA CAGTCTTCCT GGAGTCCTGG GCACATGTAA AGAAACCTTT 360
AATTTGTATT ATTATGAAAC AGACTACGAC ACTGGCAGGA ATATAAGAGA AAACCTGTAT 420
GTAAAAATAG ACACTATCGC TGCCGATGAA AGCTTTACCC AGGGTGACCT TGGTGAGAGA 480
AAGATGAAAC TTAACACTGA GGTGAGAGAG ATCGGACCTT TGTCTAAAAA GGGCTTCTAC 540
CTTGCCTTTC AGGATGTAGG GGCCTGTATT GCTCTCGTGT CAGTCAAAGT GTACTACAAG 600
AAGTGCTGGT CCATTATTGA GAACTTAGCT ATCTTTCCAG ATACAGTGAC CGGCTCAGAG 660
TTTTCCTCCC TAGTTGAGGT GCGCGGGACC TGTGTTCACA GTGCGGAAGA GGAGGCCGAG 720
AATTCTCCTC GGATGCACTG CAGCGCTGAA GGAGAATGGC TGGTCCCTAT TGGAAAGTGT 780
ATCTGCAAAG CTGGCTACCA GCAGAAAGGA GACACTTGTG AACCTTGTGG ACGCGGATTC 840
TATAAATCTT CTTCCCAAGA CCTGCAGTGC TCACGGTGTC CAAGCCACAG TTTTTCAGAC 900
AAAGAAGGAT CTTCCCGATG TGATTGTGAG GATGGCTACT ACCGAGCTCT CGCTGATCCT 960
CCGTATGTCG CTTGCACAAG GCCACCATCT GCACCACAGA ACCTCATTTT CAATATTAAC 1020
CAGACGACGG TGAGCTTGGA GTGGAACCCT CCAGCAGATA ACGGAGGAAG GAATGACGTT 1080
ACCTACCGAG TGTTGTGTAA GCGATGCAGT TGGGAGCAGG GCGAGTGCGT TCCTTGCGGA 1140
AGTAACGTTG GCTACTTGCC CCAGCAAAGT GGATTAGCAG ATAACTTCGT CACGGTCACG 1200
GACCTGCTAG CCCATGCCAA TTACACATTT GAAGTTGAGG CTGTGAATGG GGTCTCCGAC 1260
CTGAGCCGTT CCCAGAGACT TTTTGCTGCC GTCAGTATCA CCACAGGCCA AGCAGCTCCT 1320
TCACAAGTTA GCGGCGTCAT GAAGGAAAGA GTACTGCAAA GGAGTGTCGA GCTTTCCTGG 1380
CAGGAACCAG AGCATCCCAA TGGAGTCATC ACGGAATACG AAATCAAGTA TTATGAGAAA 1440
GATCAAAGGG AACGGACCTA CTCAACAGTT AAAACCAAAT CCACTTCCGT CTCCATTAAT 1500
AATCTGAAAC CAGGAACAGT GTATGTGTTC CAGATCCGGG CTTTCACTGC TGCCGGTTAT 1560
GGAAATTACA GTCCCAGACT TGATGTTGCT ACACTAGAGG AAGCTACAGG TAAAATGTTT 1620
GAAGCCACTG CAGTCTCCAG TGAACAGAAC CCTGTCATTA TCATAGCTGT GGTTGCTGTG 1680
GCCGGAACAA TCATACTGGT CTTCATGGTT TTTGGCTTCA TCATTGGCAG AAGGCATTGT 1740
GGCTATAGCA AAGCAGACCA AGAAGGAGAC GAAGAACTTT ACTTTCATTT TAAATTTCCA 1800
GGCACCAAAA CCTACATTGA CCCTGAAACC TATGAGGACC CAAATAGAGC TGTCCATCAA 1860
TTCGCCAAGG AGCTAGACGC CTCTTGTATT AAAATTGAGC GTGTGATTGG CGCAGGAGAA 1920
TTTGGAGAAG TATGCAGCGG TCGTCTGAAA CTCCCAGGCA AGAGAGACGT GGCGGTAGCC 1980
ATAAAAACGT TGAAAGTTGG CTACACAGAA AAACAAAGGC GGGACTTCCT GTGTGAAGCA 2040
AGCATCATGG GACAGTTTGA CCACCCAAAT GTTGTTCACT TAGAAGGAGT TGTTACCAGG 2100
GGGAAGCCAG TCATGATCGT AATAGAATAC ATGGAAAATG GAGCCCTAGA TGCATTTCTT 2160
CGAAAACACG ATGGACAGTT TACCGTCATT CAGCTTGTGG GCATGCTGAG AGGAATCGCC 2220
GCCGGAATGA GATATTTGGC CGATATGGGC TACGTTCACA GGGACCTAGC AGCTCGTAAT 2280
ATCCTGGTCA ACAGCAACCT TGTTTGCAAA GTGTCCGATT TCGGCCTGTC CAGAGTGATT 2340
GAAGATGACC CAGAAGCTGT CTATACAACG ACCGGTGGAA AAATTCCGGT CCGGTGGACA 2400
GCACCTGAAG CCATCCAATA TCGGAAATTT ACGTCAGCTA GCGATGTGTG GAGTTATGGA 2460
ATAGTTATGT GGGAAGTGAT GTCATACGGA GAACGACCTT ATTGGGATAT GTCAAATCAA 2520
GATGTTATAA AAGCAATCGA AGAAGGTTAT CGTTTGCCAG CACCCATGGA CTGCCCAGCT 2580
GGCCTTCACC AGTTGATGCT GGATTGTTGG CAAAAGGATC GTGGCGAAAG GCCAAAGTTT 2640
GAACAGATAG TTGGAATTCT GGACAAAATG ATTCGGAATC CAAATAGCCT GAAAACACCC 2700
CTGGGAACCT GTAGCCGACC AATCAGTCCT CTTCTGGATC AAAACACTCC TGATTTCACC 2760
ACTTTCTGCT CTGTTGGAGA ATGGCTACAA GCCATCAAAA TGGAACGGTA TAAAGACAAC 2820
TTCACGGCAG CTGGCTACAA CTCTCTGGAA TCAGTGGCCA GGATGACCAT TGAAGATGTG 2880
ATGAGTTTAG GGATCACATT GGTGGGCCAT CAAAAGAAAA TCATGAGTAG CATTCAAACC 2940
ATGAGAGCAC AAATGCTTCA TTTACACGGC ACTGGGATCC AGGTGTGA 2988
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         +kie+viGaGefGevcsGrlklpgkr++avaiktlk g+tekqrrdfl+easi+Gqfdhp
Q: 630   IKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHP  689
         79**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         n+++leGvvt++kpvmiv+eymengald+flrk+dgqftviqlvgmlrGia+gm+yl+dm
Q: 690   NVVHLEGVVTRGKPVMIVIEYMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYLADM  749
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180
         gyvhrdlaarnilvnsnlvckvsdfGlsrv+edd+ea+ytt+ggkip+rwtapeai+yrk
Q: 750   GYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRK  809
         ************************************************************
S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240
         ftsasdvwsyGiv+wev+syGerpywdmsnqdvikaieegyrlp+pmdcpa+l+qlmldc
Q: 810   FTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCPAGLHQLMLDC  869
         ************************************************************
S: 241   wqkdraerpkfeqivsi  257
         wqkdr erpkfeqiv i
Q: 870   WQKDRGERPKFEQIVGI  886
         **************987
Domain Sequence
(FASTA)
IKIERVIGAG EFGEVCSGRL KLPGKRDVAV AIKTLKVGYT EKQRRDFLCE ASIMGQFDHP 60
NVVHLEGVVT RGKPVMIVIE YMENGALDAF LRKHDGQFTV IQLVGMLRGI AAGMRYLADM 120
GYVHRDLAAR NILVNSNLVC KVSDFGLSRV IEDDPEAVYT TTGGKIPVRW TAPEAIQYRK 180
FTSASDVWSY GIVMWEVMSY GERPYWDMSN QDVIKAIEEG YRLPAPMDCP AGLHQLMLDC 240
WQKDRGERPK FEQIVGI 257
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00003
EKS-BOT-00010
EKS-CAJ-00004
EKS-CAF-00004
EKS-CAP-00003
EKS-CII-00002
EKS-DAR-00005
EKS-EQC-00004
EKS-FEC-00002
EKS-GAG-00004
EKS-GOG-00003
EKS-HOS-00004
EKS-LAC-00004
EKS-LOA-00004
EKS-MAM-00004
EKS-MEG-00003
EKS-MOD-00004
EKS-MUM-00004
EKS-MUP-00003
EKS-MYL-00004
EKS-NOL-00014
EKS-OCP-00001
EKS-ORN-00005
EKS-ORC-00003
EKS-ORL-00002
EKS-OTG-00002
EKS-PAT-00003
EKS-POA-00008
EKS-RAN-00004
EKS-SOA-00002
EKS-SUS-00003
EKS-TAG-00003
EKS-TEN-00018
EKS-TUT-00003
EKS-VIP-00001
EKS-XET-00004
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0008046; F:axon guidance receptor activity
GO:0045499; F:chemorepellent activity
GO:0005004; F:GPI-linked ephrin receptor activity
GO:0007411; P:axon guidance
GO:0043525; P:positive regulation of neuron apoptotic process
GO:0022407; P:regulation of cell-cell adhesion
GO:0043281; P:regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0070372; P:regulation of ERK1 and ERK2 cascade
GO:0050730; P:regulation of peptidyl-tyrosine phosphorylation
GO:0031952; P:regulation of protein autophosphorylation
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR009030; Growth_fac_rcpt.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07699; GCC2_GCC3; 1.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013