EKS-ORA-00053

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORA-00053

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	338.8	2.7E-101	26	335	310

Status

Unreviewed

Ensembl Protein

ENSOANP00000014404

UniProt Accession

F7D295;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK8

Gene Synonyms/Alias

CDK8;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000009050	ENSOANP00000014404	ENSOANT00000014407

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

471

Protein Sequence
(FASTA)

MDYDFKVKLS GERERVEDLF EYEGCKVGRG TYGHVYKAKR KDGKDDKDYA LKQIEGTGIS 60

MSACREIALL RELKHPNVIS LQKVFLSHAD RKVWLLFDYA EHDLWHIIKF HRASKANKKP 120

VQLPRGMVKS LLYQILDGIH YLHANWVLHR DLKPANILVM GEGPERGRVK IADMGFARLF 180

NSPLKPLADL DPVVVTFWYR APELLLGARH YTKAIDIWAI GCIFAELLTS EPIFHCRQED 240

IKTSNPYHHD QLDRIFNVMG FPADKDWEDI KKMPEHSTLM KDFRRNTYTN CSLIKYMEKH 300

KVKPDSKAFH LLQKLLTMDP IKRITSEQAM QDPYFLEDPL PTSDVFAGCQ IPYPKREFLT 360

EEEPDDKGDK VSIEPIEKNQ QQQQGNNHTN GTGHPGNQDS GHTQGPPLKK VRVVPPTTTS 420

GGLIMTSDYQ RSNPHAAYPN PGPSTSQPQS SMGYSTTSQQ PPQYSHQTHR Y 471

Nucleotide Sequence
(FASTA)

ATGGACTATG ACTTCAAAGT GAAGCTGAGC GGCGAGCGGG AGCGGGTGGA GGACCTGTTC 60

GAGTACGAGG GCTGCAAAGT CGGCCGGGGC ACTTACGGGC ACGTCTACAA AGCCAAGAGG 120

AAAGACGGGA AAGATGATAA AGACTATGCT TTAAAACAAA TAGAAGGTAC TGGGATTTCT 180

ATGTCAGCAT GCAGAGAAAT AGCGTTGCTA CGAGAACTTA AACACCCGAA CGTCATCTCC 240

CTACAAAAAG TGTTCCTATC CCATGCTGAC CGAAAAGTGT GGCTTCTGTT CGACTACGCG 300

GAACATGACC TCTGGCATAT AATCAAGTTT CACAGAGCTT CTAAAGCAAA CAAGAAGCCA 360

GTTCAATTAC CTCGGGGAAT GGTGAAGTCA CTATTATATC AGATCCTAGA TGGTATTCAC 420

TACCTGCATG CTAACTGGGT GTTGCACAGG GATTTGAAAC CTGCTAATAT TTTAGTTATG 480

GGCGAAGGTC CCGAGCGAGG AAGAGTAAAA ATTGCTGACA TGGGGTTTGC CCGATTATTT 540

AATTCACCTC TGAAGCCTTT AGCAGATTTG GACCCAGTAG TTGTAACATT CTGGTACCGA 600

GCTCCAGAAC TCCTTCTTGG AGCAAGACAT TATACCAAAG CTATTGATAT TTGGGCTATA 660

GGGTGTATAT TTGCAGAACT ACTGACGTCA GAACCAATAT TTCATTGTCG ACAAGAGGAC 720

ATCAAAACTA GTAATCCTTA TCACCATGAC CAGCTGGACA GAATATTCAA TGTAATGGGA 780

TTTCCTGCAG ATAAAGATTG GGAAGATATT AAAAAGATGC CTGAACATTC AACGTTAATG 840

AAAGATTTCA GAAGAAACAC GTATACCAAC TGCAGCCTTA TCAAATATAT GGAAAAACAT 900

AAAGTTAAAC CAGATAGTAA AGCATTCCAC TTGCTTCAAA AATTGCTTAC TATGGACCCA 960

ATAAAGCGAA TTACCTCAGA ACAGGCTATG CAGGATCCAT ATTTCTTAGA AGATCCACTT 1020

CCTACATCAG ATGTTTTCGC AGGTTGCCAG ATCCCCTATC CCAAACGAGA ATTTTTAACC 1080

GAAGAAGAAC CTGATGACAA AGGAGACAAA GTAAGTATTG AACCAATTGA GAAGAACCAG 1140

CAGCAGCAGC AAGGCAATAA CCATACTAAT GGAACTGGTC ACCCAGGGAA TCAAGACAGC 1200

GGTCATACCC AGGGACCCCC GTTGAAAAAA GTGAGAGTTG TTCCTCCTAC CACTACCTCA 1260

GGTGGACTGA TCATGACCTC AGACTATCAG CGTTCCAATC CACATGCTGC CTACCCCAAC 1320

CCCGGACCAA GCACATCACA GCCACAGAGC AGCATGGGAT ATTCAACTAC CTCCCAGCAG 1380

CCTCCACAGT ACTCCCATCA AACCCACCGG TACTGA 1416

Domain Profile

S: 6     kigeGtygkvykakdke..tgevvAlKkirlekekegvpitalrEisllkelkhknivkL  63

         k+g+Gtyg+vykak+k+  +++ +AlK+i    e +g++++a+rEi+ll+elkh+n+++L

Q: 26    KVGRGTYGHVYKAKRKDgkDDKDYALKQI----EGTGISMSACREIALLRELKHPNVISL  81

         79************986447778******....999************************

S: 64    levva.kdkkklyLvfefleqdLkkllkkkkkk.......klsleevkslllqlleglay  115

         ++v+  ++++k++L+f+++e+dL++++k ++++       +l++ +vksll+q+l+g++y

Q: 82    QKVFLsHADRKVWLLFDYAEHDLWHIIKFHRASkankkpvQLPRGMVKSLLYQILDGIHY  141

         ****94555*********************9999999999********************

S: 116   lHsnkilHRDlKpqNlLiske....gklklaDfGlarafssplk...tytkevvTlwYra  168

         lH+n++lHRDlKp+N+L++ e    g++k+aD+G+ar f+splk   +++++vvT+wYra

Q: 142   LHANWVLHRDLKPANILVMGEgperGRVKIADMGFARLFNSPLKplaDLDPVVVTFWYRA  201

         *******************9988889*************99999665699**********

S: 169   PelLlgakeYstavDiWsvgcilaelltrkplfqgkse.........idqlerifkllgt  219

         PelLlga++Y++a+DiW++gci+aellt++p+f++++e         +dql+rif+++g

Q: 202   PELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEdiktsnpyhHDQLDRIFNVMGF  261

         ************************************************************

S: 220   psekvwpevsklpeyk...ksfpkkkkk..klkekvkklk....ekaldllekllaldpk  270

         p +k+w++++k+pe++   k+f++++++  +l ++++k k    +ka++ll+kll++dp

Q: 262   PADKDWEDIKKMPEHStlmKDFRRNTYTncSLIKYMEKHKvkpdSKAFHLLQKLLTMDPI  321

         ***************96644777777764455666644333354679*************

S: 271   kRisakealqhkyf  284

         kRi++++a+q++yf

Q: 322   KRITSEQAMQDPYF  335

         *************9

Domain Sequence
(FASTA)

KVGRGTYGHV YKAKRKDGKD DKDYALKQIE GTGISMSACR EIALLRELKH PNVISLQKVF 60

LSHADRKVWL LFDYAEHDLW HIIKFHRASK ANKKPVQLPR GMVKSLLYQI LDGIHYLHAN 120

WVLHRDLKPA NILVMGEGPE RGRVKIADMG FARLFNSPLK PLADLDPVVV TFWYRAPELL 180

LGARHYTKAI DIWAIGCIFA ELLTSEPIFH CRQEDIKTSN PYHHDQLDRI FNVMGFPADK 240

DWEDIKKMPE HSTLMKDFRR NTYTNCSLIK YMEKHKVKPD SKAFHLLQKL LTMDPIKRIT 300

SEQAMQDPYF 310

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0016592	; C:mediator complex
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013