EKS-ORA-00348
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORA-00348
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR536.83.0E-161623960338
StatusUnreviewed
Ensembl ProteinENSOANP00000014439
UniProt AccessionF7GDK0;
Protein Name
Protein Synonyms/Alias
Gene NameFLT3
Gene Synonyms/Alias FLT3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOANG00000009067ENSOANP00000014439ENSOANT00000014442
ENSOANG00000009067ENSOANP00000014440ENSOANT00000014443
OrganismOrnithorhynchus anatinus
Functional Description
Protein Length1008
Protein Sequence
(FASTA)
MGASRPPPAR AHHRLLAVVI SAVTVGSMTN QDPLGIRCVL LASKINNSST WISSTSPMVS 60
DGVSVEDLGC SLKHRGSAVA YQAIKPVEIS IFATATLQVT LSFLGNVSCR WISRHNSIDC 120
QPDFDSENRT VLSLVISKMT ETQAGEYLLS IHSGTMNCTV LFAVNVKPIS RFLQIGTLRK 180
PYFRKLEDQD SVDCVSDSFP EPVMEWLFCR TLSERCSCRK TSLASMKREE KVQHELLGTD 240
IWCCARNELG RECTKLFTLD LNKAPQAPLP QFFLKIGEPL LIRCKAVHKN HRFGLTWKVE 300
NKELQEGSYF EISGYQSNRN MARIMFAFVS SVGRSDAGHY TCSSSEDTSK TALVTVLEKG 360
FINASNTKED YEIDLNEEFC FAVKLRAYPQ ISCTWTFSQI SLPCKNSNLE DGYSVSRFCD 420
HKYQPGEYIF RAENGDAHFT KIFTLSVRRK PQVTMQVSAT QVSCFSSGYP SPSWVWKKCS 480
EDSPNCTEET TDRVWKERSR GGSPALGPWA SGSTMNMSQR ERGFWFECCA YNSVGSSCQR 540
FLNSPEAISV IQDNISFYAT IGFCLPFIAV LLLVISHKFK KQFRYESQLQ MIQMTGPEDN 600
EYFYIDFREF EYDLKWEFPR ENLEFGRVLG SGAFGKVVNA TAYGISKTGV SIQVAVKMLK 660
EKPDSSEKEA LMSELKMMTH IGSHENIVNL LGACTLSGPI YLIFEYCCYG DLLNYLRSKR 720
EKFHRTWTEI FKQHNFSFYP RLHLHSNTRL SLAGIGEVPI YKNPPLKGPA GGKGTSHHTY 780
RDPDYENRKK QDEEEDFNVL TYEDLLCFSY QVARGMEFLE LKLCVHRDLA ARNILVTHGK 840
VVKICDFGLA RDILNDSNYV VRGNARLPVK WMAPESLFEG IYTIKSDVWS FGILLWEIFS 900
LGVNPYPGIQ VDTSFYRLIQ SGFQMDPPFY ATGDVYLVMQ ACWASDSSKR PPFSQLTSFL 960
GCQLANAEAE SRNGGTRCHR QQEDQTGPLT FTRTKCPSLG VKLHRERN 1008
Nucleotide Sequence
(FASTA)
ATGGGGGCGT CCCGGCCGCC CCCCGCCCGC GCCCACCACC GGCTGCTCGC TGTGGTCATT 60
TCAGCAGTGA CTGTTGGTTC CATGACAAAC CAAGATCCAT TGGGAATTAG GTGTGTTTTA 120
CTTGCCTCCA AAATCAACAA TTCGTCAACA TGGATATCGT CAACATCACC TATGGTGTCG 180
GATGGAGTGT CGGTGGAAGA TCTTGGCTGC TCTCTGAAAC ACCGAGGTTC AGCAGTGGCC 240
TACCAAGCTA TTAAACCAGT GGAAATTAGT ATTTTTGCCA CTGCAACTCT GCAAGTGACA 300
CTGAGCTTTC TGGGAAATGT TTCATGCCGT TGGATCTCGA GACACAATTC CATTGACTGC 360
CAACCTGATT TTGACTCCGA AAACAGGACT GTTCTTTCTC TGGTCATTTC GAAAATGACA 420
GAAACCCAAG CCGGAGAATA CCTCCTCTCA ATTCACAGTG GAACGATGAA TTGCACAGTC 480
CTGTTTGCAG TGAATGTAAA ACCTATCTCT CGATTTCTTC AAATAGGAAC CTTAAGGAAG 540
CCCTACTTCA GGAAACTCGA AGACCAGGAT TCAGTGGATT GTGTGTCTGA TAGCTTCCCT 600
GAGCCCGTGA TGGAATGGCT GTTTTGCCGG ACCCTCAGCG AGAGATGTAG CTGCAGGAAG 660
ACAAGTCTCG CCAGCATGAA GAGAGAGGAA AAGGTACAGC ATGAATTATT AGGAACAGAC 720
ATCTGGTGTT GTGCGAGGAA TGAATTGGGC CGGGAGTGTA CCAAGCTCTT TACACTAGAT 780
CTAAATAAAG CACCACAAGC ACCCCTACCA CAATTCTTTC TTAAAATCGG GGAGCCGCTG 840
CTGATAAGAT GCAAAGCTGT TCATAAAAAC CATCGGTTTG GACTCACGTG GAAGGTGGAA 900
AATAAAGAAT TACAAGAGGG CAGCTACTTT GAGATTAGTG GGTATCAAAG CAACAGAAAT 960
ATGGCACGGA TTATGTTCGC CTTTGTCTCA TCAGTGGGAA GAAGTGATGC TGGACATTAT 1020
ACTTGTTCTT CCTCAGAGGA TACCAGCAAA ACAGCTTTGG TTACAGTCTT GGAAAAAGGA 1080
TTCATAAATG CATCCAATAC GAAAGAAGAC TATGAAATTG ATCTGAATGA AGAATTTTGC 1140
TTTGCAGTCA AACTTAGAGC ATACCCACAA ATTAGCTGCA CATGGACATT TTCTCAAATA 1200
TCACTGCCTT GCAAAAACAG TAACCTTGAA GATGGATACA GCGTATCTCG ATTTTGCGAT 1260
CATAAGTATC AGCCAGGAGA GTACATATTC CGTGCCGAAA ACGGTGATGC ACATTTCACG 1320
AAAATATTTA CGCTGTCTGT GAGAAGAAAA CCACAGGTAA CAATGCAAGT ATCAGCCACC 1380
CAGGTCTCCT GCTTCTCCAG CGGCTACCCA TCACCATCTT GGGTCTGGAA GAAATGCTCA 1440
GAGGACTCTC CCAACTGCAC GGAAGAAACC ACTGACAGGG TTTGGAAGGA GAGATCCAGA 1500
GGGGGCAGTC CGGCACTGGG ACCCTGGGCG TCGGGCAGCA CGATGAACAT GAGCCAACGG 1560
GAGAGAGGAT TCTGGTTCGA GTGCTGTGCC TACAATTCTG TCGGCTCATC CTGCCAAAGG 1620
TTTCTCAACT CCCCAGAAGC TATTTCTGTC ATCCAAGACA ATATCTCATT CTATGCAACA 1680
ATTGGATTTT GTCTTCCATT TATAGCTGTT TTACTGCTAG TAATCTCTCA CAAATTCAAA 1740
AAGCAATTTA GATATGAGAG CCAACTGCAG ATGATTCAGA TGACGGGCCC TGAGGATAAT 1800
GAATATTTCT ACATTGACTT CAGGGAGTTC GAATATGACC TCAAGTGGGA ATTCCCGAGA 1860
GAAAATTTGG AATTTGGGCG AGTGCTTGGC TCTGGTGCCT TTGGCAAAGT GGTAAACGCT 1920
ACAGCATATG GAATCAGCAA AACGGGAGTC TCGATCCAGG TGGCCGTCAA AATGCTGAAA 1980
GAAAAGCCAG ACAGTTCAGA GAAAGAAGCT CTCATGTCGG AGCTCAAAAT GATGACCCAC 2040
ATTGGCAGCC ACGAGAACAT CGTGAATCTC CTGGGGGCCT GTACCCTCTC AGGACCTATT 2100
TACTTAATAT TTGAATATTG TTGCTATGGT GATCTTCTAA ACTACTTAAG AAGCAAAAGA 2160
GAAAAATTTC ACAGGACCTG GACAGAGATC TTCAAGCAAC ACAATTTCAG TTTTTACCCC 2220
CGCCTCCACT TACATTCAAA CACCAGGCTG TCTCTTGCTG GGATTGGAGA GGTACCAATT 2280
TACAAAAACC CTCCGTTGAA GGGCCCAGCA GGAGGAAAGG GAACATCTCA CCACACATAT 2340
AGAGATCCTG ACTATGAAAA CAGAAAAAAG CAGGACGAGG AGGAAGATTT CAACGTGCTT 2400
ACGTATGAAG ATCTTCTCTG TTTCTCGTAC CAAGTTGCCA GAGGAATGGA ATTTCTCGAA 2460
TTGAAGTTGT GTGTCCACCG AGACCTTGCC GCCAGGAACA TCCTCGTGAC ACATGGGAAA 2520
GTGGTGAAGA TATGTGACTT TGGCCTGGCC AGGGACATCC TGAATGATTC CAACTATGTG 2580
GTCAGAGGCA ATGCTCGTTT ACCGGTGAAG TGGATGGCCC CGGAAAGCCT GTTTGAAGGG 2640
ATCTACACAA TCAAGAGCGA TGTCTGGTCT TTTGGAATAC TACTGTGGGA AATATTCTCT 2700
CTCGGTGTCA ATCCCTACCC CGGCATCCAA GTGGATACGA GCTTCTACAG GCTCATTCAG 2760
AGTGGATTTC AGATGGACCC ACCCTTCTAT GCCACAGGAG ATGTGTACCT GGTCATGCAG 2820
GCCTGCTGGG CATCTGACTC CAGTAAGCGA CCACCCTTTT CCCAACTGAC CTCCTTTCTG 2880
GGCTGCCAGC TGGCAAATGC AGAAGCAGAG AGCAGAAATG GGGGAACCCG CTGCCATCGG 2940
CAACAGGAGG ACCAGACCGG CCCCTTAACG TTCACCAGAA CCAAGTGTCC CAGCCTCGGG 3000
GTGAAGCTTC ACAGAGAGCG AAAC 3024
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         le+G+vlGsGafGkvv+atayG+sk++++++vavkmlk++ +ssekealmselk+++h+G
Q: 623   LEFGRVLGSGAFGKVVNATAYGISKTGVSIQVAVKMLKEKPDSSEKEALMSELKMMTHIG  682
         79**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +henivnllGact +Gpiy+i+eyccyGdllnylr+kre+f+++++e++k+++++++ + 
Q: 683   SHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKQHNFSFYPR-  741
         *********************************************************99.
S: 121   lladkslrsksslssesseeyvdlkkd..vsdvssskadklasekkksalerevkaalee  178
              +l+s++ ls  + +e v + k+  ++     k ++++ ++  ++++r+ +   ee
Q: 742   ----LHLHSNTRLSLAGIGE-VPIYKNppLKGPAGGKGTSHHTYRDPDYENRKKQ--DEE  794
         ....4799999999999999.5555432277777788888888888899888776..678
S: 179   edsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardim  238
         ed +vl++edll+fsyqva+Gmefl+ k cvhrdlaarn+l+t+GkvvkicdfGlardi+
Q: 795   EDFNVLTYEDLLCFSYQVARGMEFLELKLCVHRDLAARNILVTHGKVVKICDFGLARDIL  854
         899*********************************************************
S: 239   kdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdsk  298
         +dsnyvv+Gnarlpvkwmapes+f+++yt+ksdvws+GillweifslG++pypg+ vd+ 
Q: 855   NDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSFGILLWEIFSLGVNPYPGIQVDTS  914
         ************************************************************
S: 299   fyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         fy+li++G++m+ p+yat ++y +mq+cw+++++krp+f+ql+++l
Q: 915   FYRLIQSGFQMDPPFYATGDVYLVMQACWASDSSKRPPFSQLTSFL  960
         *******************************************986
Domain Sequence
(FASTA)
LEFGRVLGSG AFGKVVNATA YGISKTGVSI QVAVKMLKEK PDSSEKEALM SELKMMTHIG 60
SHENIVNLLG ACTLSGPIYL IFEYCCYGDL LNYLRSKREK FHRTWTEIFK QHNFSFYPRL 120
HLHSNTRLSL AGIGEVPIYK NPPLKGPAGG KGTSHHTYRD PDYENRKKQD EEEDFNVLTY 180
EDLLCFSYQV ARGMEFLELK LCVHRDLAAR NILVTHGKVV KICDFGLARD ILNDSNYVVR 240
GNARLPVKWM APESLFEGIY TIKSDVWSFG ILLWEIFSLG VNPYPGIQVD TSFYRLIQSG 300
FQMDPPFYAT GDVYLVMQAC WASDSSKRPP FSQLTSFL 338
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00375
EKS-ANC-00393
EKS-BOT-00404
EKS-CAJ-00408
EKS-CAF-00404
EKS-CAP-00433
EKS-DAR-00790
EKS-EQC-00396
EKS-FEC-00388
EKS-GAG-00343
EKS-GOG-00396
EKS-HOS-00410
EKS-ICT-00383
EKS-LOA-00413
EKS-MAM-00403
EKS-MEG-00337
EKS-MOD-00392
EKS-MUM-00436
EKS-MUP-00397
EKS-MYL-00399
EKS-NOL-00369
EKS-OCP-00084
EKS-ORC-00379
EKS-OTG-00406
EKS-PAT-00382
EKS-PES-00360
EKS-POA-00395
EKS-SAH-00374
EKS-SUS-00354
EKS-TAG-00475
EKS-TUT-00119
EKS-XET-00516
Gene Ontology
GO:0009986; C:cell surface
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0045578; P:negative regulation of B cell differentiation
GO:0008285; P:negative regulation of cell proliferation
GO:0046777; P:protein autophosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR013151; Immunoglobulin.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF00047; ig; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013