EKS-ORA-00153

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORA-00153

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKC	344.1	6.5E-103	121	382	262

Status

Unreviewed

Ensembl Protein

ENSOANP00000014472

UniProt Accession

F7G7C3;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKCH

Gene Synonyms/Alias

PRKCH;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000009091	ENSOANP00000014472	ENSOANT00000014475

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

451

Protein Sequence
(FASTA)

SEQRFGINIP HKFHVHNYKV PTFCDHCGSL LWGIMRQGLQ CKMCRMNVHI RCQANVAPNC 60

GVNAVELAKT LAGMGLQPGS ISPTSQKLVS RSTLRRQGKE NFREDNGVGA PCANRHGIED 120

FEFIRVLGKG SFGKVLLART RATGDLYAVK VLKKDVILQD DDVECTMTEK RILALARSHP 180

FLTQLFCCFQ TPRRVQYTRS LQTRGVAPFH LRKTQKGPSE TAVDGRSLVS SALLVLAVKV 240

GRVHRMDLKL DNVLLDPEGH CKLADFGMCK EGICNGVTTA TFCGTPDYIA PEILQEMLYG 300

LAVDWWAMGV LLYEMLCGHA PFEAENEDDL FEAILNDEVV YPTWLHEDAT AILKAFMTKN 360

PNLRLGGENQ GGERAILAHP FFKEMDWDRL NQRQLEPPFR PRIKSREDVS NFDPDFIKEE 420

PVLTPIDEAH LPMINQEEFR NFSYISPELQ S 451

Nucleotide Sequence
(FASTA)

TCAGAACAGA GGTTCGGGAT CAACATTCCC CACAAGTTCC ACGTACACAA CTACAAGGTG 60

CCGACGTTCT GCGACCACTG CGGCTCCCTG CTCTGGGGGA TCATGCGCCA GGGCCTGCAG 120

TGTAAAATGT GCAGGATGAA CGTCCACATT CGCTGCCAAG CCAACGTGGC TCCCAACTGC 180

GGGGTCAACG CCGTGGAACT GGCCAAGACG CTGGCCGGGA TGGGGCTCCA GCCGGGAAGC 240

ATCTCCCCGA CCTCGCAGAA GCTAGTTTCC CGGTCAACGC TGAGGAGACA AGGAAAGGAA 300

AATTTCAGGG AAGACAACGG AGTCGGCGCT CCCTGTGCCA ACCGGCACGG GATCGAAGAC 360

TTCGAGTTCA TCCGCGTGCT GGGGAAGGGC AGCTTCGGGA AGGTGCTGCT GGCCCGGACC 420

AGGGCGACGG GGGACCTGTA CGCCGTCAAG GTGTTGAAGA AGGACGTCAT CCTTCAGGAC 480

GACGACGTGG AGTGCACCAT GACCGAGAAG CGGATCCTGG CGCTGGCCCG CAGCCACCCC 540

TTCCTCACCC AGCTCTTCTG CTGCTTCCAG ACCCCCAGGA GAGTTCAGTA CACGAGGAGC 600

TTGCAGACTA GGGGTGTTGC ACCGTTTCAC CTCCGTAAGA CCCAGAAGGG GCCCTCGGAA 660

ACTGCCGTTG ACGGGCGATC GCTGGTTAGC TCTGCGCTCC TGGTTCTTGC TGTGAAGGTG 720

GGGAGAGTCC ATCGGATGGA CCTGAAGCTG GACAACGTGC TACTGGACCC CGAGGGCCAC 780

TGCAAGCTGG CGGACTTCGG CATGTGCAAG GAGGGCATCT GCAACGGGGT GACCACCGCC 840

ACGTTCTGCG GCACCCCCGA CTACATCGCC CCAGAGATTC TGCAAGAGAT GCTCTACGGT 900

CTGGCCGTGG ACTGGTGGGC CATGGGGGTG CTGCTCTACG AGATGCTCTG CGGCCACGCT 960

CCCTTCGAGG CGGAGAACGA GGACGACCTG TTCGAGGCCA TACTGAACGA TGAGGTGGTC 1020

TATCCGACGT GGCTCCACGA AGATGCCACG GCCATCCTGA AAGCCTTCAT GACCAAGAAC 1080

CCCAACCTGC GCTTGGGAGG GGAGAACCAG GGCGGCGAGC GGGCCATCCT GGCCCACCCA 1140

TTCTTCAAGG AAATGGACTG GGACCGGCTG AACCAACGCC AGCTCGAGCC ACCGTTCAGG 1200

CCCAGGATCA AATCCCGAGA AGACGTCAGT AACTTCGACC CGGATTTTAT CAAGGAAGAG 1260

CCCGTGTTAA CCCCGATCGA CGAAGCCCAC CTCCCGATGA TCAACCAGGA GGAATTTAGA 1320

AACTTTTCCT ACATCTCTCC AGAACTGCAG TCCTAG 1356

Domain Profile

S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60

         fe+++vlGkGsfgkvlla+++ t +lya+kvlkkdv+lqdddve+t++ekr+lala+++p

Q: 121   FEFIRVLGKGSFGKVLLARTRATGDLYAVKVLKKDVILQDDDVECTMTEKRILALARSHP  180

         89**********************************************************

S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhek.  119

         fl+qlf+cfqt  r+ +     + G   fh++k++k + e a+   + +++al  l  k

Q: 181   FLTQLFCCFQTPRRVQYTRSLQTRGVAPFHLRKTQKGPSETAVDGRSLVSSALLVLAVKv  240

         *****************************************************9997654

S: 120   giiyr.dlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeyg  178

         g ++r dlkldnvlld eGh+kladfG+cke+i++g tt+tfcGtPdyiaPeil+e+ yg

Q: 241   GRVHRmDLKLDNVLLDPEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYG  300

         777776******************************************************

S: 179   ksvdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkd  238

          +vdwwa+Gvllyeml+g++Pfe+e+ed+lfe+il++ev+yP++l+++a++ilk+++tk+

Q: 301   LAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATAILKAFMTKN  360

         ************************************************************

S: 239   pekrlGvk.eegeedikehaff  259

         p+ rlG + + ge++i +h+ff

Q: 361   PNLRLGGEnQGGERAILAHPFF  382

         ******975899*********9

Domain Sequence
(FASTA)

FEFIRVLGKG SFGKVLLART RATGDLYAVK VLKKDVILQD DDVECTMTEK RILALARSHP 60

FLTQLFCCFQ TPRRVQYTRS LQTRGVAPFH LRKTQKGPSE TAVDGRSLVS SALLVLAVKV 120

GRVHRMDLKL DNVLLDPEGH CKLADFGMCK EGICNGVTTA TFCGTPDYIA PEILQEMLYG 180

LAVDWWAMGV LLYEMLCGHA PFEAENEDDL FEAILNDEVV YPTWLHEDAT AILKAFMTKN 240

PNLRLGGENQ GGERAILAHP FF 262

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0035556	; P:intracellular signal transduction
GO:0034351	; P:negative regulation of glial cell apoptotic process
GO:0050861	; P:positive regulation of B cell receptor signaling pathway
GO:0045618	; P:positive regulation of keratinocyte differentiation
GO:0010744	; P:positive regulation of macrophage derived foam cell differentiation
GO:0051092	; P:positive regulation of NF-kappaB transcription factor activity
GO:2000810	; P:regulation of tight junction assembly

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.

Pfam

PF00130	; C1_1; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00133	; S_TK_X; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013