EKS-ORA-00336
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORA-00336
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE11362.42.0E-108536792257
StatusUnreviewed
Ensembl ProteinENSOANP00000015019
UniProt AccessionF6ZXZ0;
Protein Name
Protein Synonyms/Alias
Gene NameMAP3K5
Gene Synonyms/Alias MAP3K5;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOANG00000009449ENSOANP00000015019ENSOANT00000015022
OrganismOrnithorhynchus anatinus
Functional Description
Protein Length1228
Protein Sequence
(FASTA)
FSADIAVVEM SDAFRQPSLF YHLGVRESFS MANNIILYCD TNSDSLQSLK EIICQKNTMC 60
TGNYTFVPYM ITPHNKVYCC DSSFMKGLTE LMQPNFELLL GPICLPLVDR FTQLLKVAQA 120
NSSQYFRESI LNDIRKARNL YTGKELAAEL ARIRQRVDNI EVLTSDIVIN LLLSYRDIQD 180
YDSIVKLVET LEKLPTFDLA SHHHVKFHYA FALNRRNLPG DRAKALDIMI PLVQCEGQVA 240
SDMYCLVGRI YKDMFLDSNF SDTESRDHGA AWFKKAFESE PTLQSGINYA VLLLAAGHQF 300
ESSFELRKVG VKLSSLLGKK GNLEKLQSYW EVGFFLGASV LANDHLRVIQ ASEKLFKLKT 360
PAWYLKSIVE TILIYKHFVK LTTEQPLAKQ ELVDFWMDFL VEATKADVTV VRFPVLILEP 420
TKIYQPSYLS INNEAEEKTV SIWHVLPDDK KGIYEWNFSA SSIRGVSISK FEERCCFLYV 480
LHNSDDFQIY FCTELHCKKF FEMVNTITEE KGKNTEEGDC DNDSLEYDYE YDENGDRVIL 540
GKGTYGIVYA GRDLSNQVRI AIKEIPERDS RYSQPLHEEI ALHKHLKHKN IVQYLGSFSE 600
NGFIKIFMEQ VPGGSLSALL RSKWGPLKDN EQTIGFYTKQ ILEGLKYLHD NQIVHRDIKG 660
DNVLINTYSG VLKISDFGTS KRLAGINPCT ETFTGTLQYM APEIIDKGPR GYGKAADIWS 720
LGCTIIEMAT GKPPFYELGE PQAAMFKVGM FKIHPEIPES MSAEAKAFLL RCFEPDPDKR 780
TFANELLVDE FLKVSCKKKK TQTKLSVLST GSNEYLRSIS LPVPVVVEDT SSSSEYGSVS 840
PDTDLKVDPF SFKSRAKSCG EKDVKGIRTL FLGIPDENFE DHSAPPSPEE KDSGFFMLRK 900
DSERRATLHR ILTEDQDKVV RNLLETLAQG AEELKLKWEH ITTLVTSLRE FVRSTDRKII 960
ATTLSKLKLE LDFDSHGISQ VQVVLFGFQD AVNKVLRNHN IKPHWMFALD SIIRKAVQTA 1020
ITILVPELRP HFSLASESDT ADQEDLEVDD DNEEQSQNQT SQRPPAITED AVATSGVSTL 1080
SSTVSHDSQN THRSLNVQLG RMKIQTNKLL EELVRKEREF QALLHQAIEE KDQEIKNLKL 1140
KSQPIDIPGL SVCHLSPTGL NAEDPELRPW LRENGADEDT INRFLAEDYT LMDVLYYVTR 1200
DDLKCLRLRG GMLCTLWKAI TDHREKHP 1228
Nucleotide Sequence
(FASTA)
TTCTCTGCAG ACATCGCCGT GGTGGAGATG AGCGACGCTT TCCGGCAGCC GTCCTTGTTT 60
TACCACCTTG GGGTGAGGGA GAGCTTCAGC ATGGCCAACA ACATCATCCT CTACTGTGAT 120
ACCAATTCAG ACTCTCTGCA GTCTTTGAAG GAAATTATTT GCCAGAAAAA TACTATGTGC 180
ACTGGTAACT ACACATTCGT TCCTTATATG ATAACACCAC ACAACAAAGT GTACTGTTGT 240
GATAGCAGCT TTATGAAGGG ATTGACAGAA CTAATGCAGC CCAATTTTGA GCTGCTGCTT 300
GGACCTATCT GTTTGCCTCT AGTGGATCGC TTTACTCAAC TTTTGAAGGT GGCACAAGCC 360
AATTCCAGCC AGTATTTCCG GGAATCTATT CTCAATGATA TCAGGAAGGC TCGCAATCTA 420
TATACAGGTA AAGAACTGGC AGCTGAACTC GCCAGGATAC GACAGCGTGT GGATAATATT 480
GAAGTCCTGA CATCCGACAT TGTCATAAAT CTGCTGTTAT CCTACAGGGA TATCCAGGAC 540
TATGACTCTA TAGTGAAGCT GGTAGAGACT TTAGAAAAGC TGCCAACCTT TGATTTGGCT 600
TCCCATCATC ATGTGAAGTT CCATTATGCA TTTGCACTGA ATAGGAGAAA TCTCCCTGGA 660
GACAGAGCAA AAGCTCTTGA TATTATGATT CCCCTGGTTC AATGTGAAGG CCAAGTTGCT 720
TCAGATATGT ATTGCCTAGT GGGTCGAATC TACAAAGACA TGTTTTTGGA CTCTAACTTT 780
TCCGACACTG AAAGTAGAGA CCACGGAGCC GCCTGGTTCA AGAAGGCCTT TGAGTCTGAG 840
CCAACACTAC AGTCAGGAAT TAATTATGCT GTCCTCCTCC TGGCAGCTGG TCATCAGTTT 900
GAATCTTCCT TTGAGTTGCG GAAAGTTGGA GTGAAGCTAA GTAGCCTCCT TGGTAAGAAG 960
GGAAACTTGG AAAAACTCCA AAGCTACTGG GAAGTTGGAT TTTTCCTTGG TGCCAGTGTC 1020
CTGGCCAATG ACCATCTCAG AGTAATTCAG GCTTCTGAAA AACTCTTCAA ACTGAAGACA 1080
CCTGCATGGT ACCTCAAGTC TATTGTAGAG ACAATATTGA TATATAAGCA TTTTGTAAAA 1140
CTGACTACAG AACAGCCTCT AGCTAAGCAG GAGCTTGTGG ACTTTTGGAT GGATTTCCTG 1200
GTTGAAGCCA CAAAGGCAGA TGTGACTGTG GTAAGGTTTC CGGTTTTAAT ATTAGAACCA 1260
ACAAAAATCT ATCAGCCGTC CTATCTCTCT ATCAACAATG AGGCAGAAGA GAAAACTGTA 1320
TCCATCTGGC ATGTGCTTCC TGATGACAAG AAAGGTATTT ATGAGTGGAA CTTTAGTGCT 1380
TCTTCCATTA GGGGAGTAAG TATTTCCAAG TTTGAGGAGC GATGCTGTTT TCTTTATGTG 1440
CTTCACAACT CAGATGATTT TCAAATCTAT TTCTGCACAG AACTTCACTG CAAGAAATTT 1500
TTTGAGATGG TGAATACTAT CACTGAAGAA AAAGGGAAAA ACACCGAGGA AGGGGATTGT 1560
GACAATGATT CCTTGGAGTA TGACTATGAA TATGATGAAA ACGGTGACAG AGTCATTTTG 1620
GGGAAAGGCA CTTATGGCAT AGTTTATGCT GGACGGGATC TGAGCAATCA AGTCAGAATT 1680
GCTATTAAAG AAATTCCAGA GAGAGATAGC AGGTATTCCC AACCTTTACA TGAGGAAATA 1740
GCTTTGCATA AGCATCTGAA GCATAAAAAT ATTGTTCAGT ACCTGGGATC ATTCAGTGAG 1800
AACGGTTTCA TCAAGATTTT CATGGAACAG GTCCCAGGAG GAAGCCTTTC AGCCCTTCTG 1860
CGGTCAAAGT GGGGCCCCCT GAAAGATAAT GAGCAGACCA TCGGCTTTTA TACAAAACAA 1920
ATTCTGGAGG GATTAAAGTA TCTCCACGAT AATCAGATAG TGCACCGGGA CATAAAGGGT 1980
GACAATGTGT TAATCAATAC ATACAGTGGA GTTCTCAAGA TCTCAGACTT TGGTACATCA 2040
AAGAGACTTG CCGGAATCAA TCCATGTACT GAAACTTTCA CTGGCACTCT TCAATACATG 2100
GCACCAGAAA TAATAGATAA AGGACCAAGA GGCTATGGAA AAGCAGCAGA TATATGGTCT 2160
TTGGGCTGCA CCATCATTGA AATGGCCACA GGAAAACCAC CATTTTATGA ATTGGGAGAA 2220
CCACAGGCTG CAATGTTCAA AGTGGGAATG TTTAAAATCC ATCCTGAAAT CCCTGAATCC 2280
ATGTCAGCAG AAGCCAAAGC TTTCCTCTTG CGCTGTTTTG AACCAGACCC TGATAAGAGA 2340
ACCTTCGCTA ATGAGTTGCT TGTGGATGAG TTCTTAAAGG TTTCATGCAA GAAGAAGAAG 2400
ACCCAAACTA AGCTCTCAGT TCTTTCAACA GGATCAAATG AATACCTTAG GAGTATATCT 2460
CTGCCGGTAC CTGTGGTAGT GGAAGATACA AGCAGCAGCA GCGAATATGG CTCGGTTTCA 2520
CCCGACACAG ACTTAAAGGT GGATCCCTTC TCTTTCAAAT CAAGAGCCAA ATCCTGTGGG 2580
GAAAAAGATG TGAAAGGGAT CCGGACCCTC TTTCTGGGCA TCCCAGATGA GAATTTTGAA 2640
GATCACAGTG CCCCACCCTC CCCCGAAGAA AAGGATTCTG GATTCTTTAT GCTGAGGAAG 2700
GATAGTGAAC GGAGAGCGAC CCTGCATAGG ATACTAACAG AAGACCAGGA TAAGGTTGTG 2760
AGGAACTTAC TGGAAACCTT GGCTCAGGGA GCTGAAGAAC TCAAACTGAA GTGGGAGCAT 2820
ATCACCACGC TGGTCACCAG CTTGAGAGAG TTTGTGAGAT CCACTGATCG GAAAATCATA 2880
GCCACCACTT TGTCCAAGCT GAAACTGGAG TTAGACTTTG ACAGCCATGG AATCAGTCAA 2940
GTTCAAGTGG TGCTGTTTGG ATTTCAAGAC GCTGTCAATA AAGTCCTCCG GAACCATAAC 3000
ATCAAACCAC ACTGGATGTT TGCCTTGGAC AGTATCATTC GAAAGGCTGT GCAGACAGCA 3060
ATTACCATTC TGGTTCCAGA ACTGAGGCCA CATTTTAGCC TGGCATCTGA GAGTGATACA 3120
GCTGACCAGG AAGATCTCGA AGTTGATGAT GACAATGAGG AGCAATCTCA GAATCAAACA 3180
AGCCAACGAC CTCCTGCTAT AACAGAAGAT GCTGTGGCCA CCTCAGGGGT GAGCACGCTC 3240
AGTTCAACTG TCTCCCATGA TTCCCAGAAT ACGCACAGAT CGCTAAATGT GCAGCTGGGG 3300
AGGATGAAAA TACAGACCAA TAAGCTGTTG GAAGAATTAG TGCGGAAGGA GAGAGAATTC 3360
CAAGCTCTAT TGCATCAAGC TATTGAAGAA AAGGATCAAG AAATTAAAAA CCTGAAGCTT 3420
AAGTCGCAGC CAATAGATAT TCCTGGACTA TCAGTGTGCC ATCTTAGTCC AACGGGCCTA 3480
AACGCCGAAG ACCCAGAACT GAGACCCTGG TTGAGAGAGA ACGGGGCTGA TGAAGACACC 3540
ATAAACAGGT TTTTGGCTGA AGATTACACA CTGATGGATG TTCTGTACTA TGTGACAAGG 3600
GATGATCTGA AATGCCTGAG GTTAAGGGGA GGAATGCTGT GCACACTTTG GAAGGCCATC 3660
ACTGACCATC GGGAAAAACA CCCTTGA 3687
Domain Profile
S: 3     krevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkHen  62
         +r ++gkG++g vya++d++++ ++a+Ke+   pe++s+  ++++l+eEi+l+k+lkH+n
Q: 536   DRVILGKGTYGIVYAGRDLSNQVRIAIKEI---PERDSR--YSQPLHEEIALHKHLKHKN  590
         5789**************************...888775..9******************
S: 63    ivkyyGveveeeelkiflEyvegGslsslle.kygkle..esvikkytkqileglayLHe  119
         iv+y+G+ +e++ +kif+E+v+gGsls+ll+ k+g+l+  e++i +ytkqilegl+yLH+
Q: 591   IVQYLGSFSENGFIKIFMEQVPGGSLSALLRsKWGPLKdnEQTIGFYTKQILEGLKYLHD  650
         *******************************9*****9999*******************
S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikk  178
         ++ivHRDiKg+N+l+++ sgv+k+sDFG+skrla +n++   +e++tGtl+ymaPE+i+k
Q: 651   NQIVHRDIKGDNVLINTySGVLKISDFGTSKRLAGINPC---TETFTGTLQYMAPEIIDK  707
         ***************************************...8*****************
S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238
         + +gyg++aDiWslgc++iem+tgk+Pf el+e++a+mfkvg+ k++Peipe++s+e+k+
Q: 708   GPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKIHPEIPESMSAEAKA  767
         ************************************************************
S: 239   flekcleldpkkrpsaeeLLkhefl  263
         fl +c+e dp+kr+ a+eLL +efl
Q: 768   FLLRCFEPDPDKRTFANELLVDEFL  792
         **********************996
Domain Sequence
(FASTA)
DRVILGKGTY GIVYAGRDLS NQVRIAIKEI PERDSRYSQP LHEEIALHKH LKHKNIVQYL 60
GSFSENGFIK IFMEQVPGGS LSALLRSKWG PLKDNEQTIG FYTKQILEGL KYLHDNQIVH 120
RDIKGDNVLI NTYSGVLKIS DFGTSKRLAG INPCTETFTG TLQYMAPEII DKGPRGYGKA 180
ADIWSLGCTI IEMATGKPPF YELGEPQAAM FKVGMFKIHP EIPESMSAEA KAFLLRCFEP 240
DPDKRTFANE LLVDEFL 257
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00361
EKS-ANC-00378
EKS-BOT-00387
EKS-CAE-00316
EKS-CAF-00390
EKS-CAP-00418
EKS-DAR-00769
EKS-DRM-00182
EKS-EQC-00380
EKS-FEC-00376
EKS-GAG-00327
EKS-GAA-00475
EKS-GOG-00384
EKS-HOS-00395
EKS-LAC-00401
EKS-LOA-00395
EKS-MAM-00386
EKS-MAE-00046
EKS-MEG-00320
EKS-MIM-00057
EKS-MOD-00376
EKS-MUM-00421
EKS-MUP-00382
EKS-MYL-00386
EKS-NOL-00355
EKS-ORN-00500
EKS-ORC-00364
EKS-ORL-00460
EKS-OTG-00390
EKS-PAT-00368
EKS-PES-00346
EKS-POA-00379
EKS-RAN-00402
EKS-SAH-00359
EKS-TAG-00460
EKS-TAR-00496
EKS-TEN-00496
EKS-TUT-00109
EKS-XET-00502
EKS-XIM-00493
Gene Ontology
GO:0005524; F:ATP binding
GO:0008656; F:cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0000187; P:activation of MAPK activity
GO:0000186; P:activation of MAPKK activity
GO:0070301; P:cellular response to hydrogen peroxide
GO:0010421; P:hydrogen peroxide-mediated programmed cell death
GO:0008631; P:intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0007254; P:JNK cascade
GO:0043065; P:positive regulation of apoptotic process
KEGG
InterPros
IPR025136; DUF4071.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR013761; SAM/pointed.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF13281; DUF4071; 1.
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013