EKS-ORA-00198

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORA-00198

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE7	348.3	3.2E-104	78	359	282

Status

Unreviewed

Ensembl Protein

ENSOANP00000015470

UniProt Accession

F6Z152;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP2K1

Gene Synonyms/Alias

MAP2K1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000009750	ENSOANP00000015470	ENSOANT00000015473

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

391

Protein Sequence
(FASTA)

MPRKKPDPIQ LNPTPDGAAV NGTSSADTAP NAGPSRSSSS SYGTQPGLRP PARKMPMPRK 60

KPDPIQLNPT PDGAAVNGTS SAERLKTSGN GFFLQLIHLE IKPAIRNQII RELQVLHECN 120

SPYIVGFYGA FYSDGEISIC MEHMDGGSLD QVLKKAGRIP EQILGKVSIA VIKGLTYLRE 180

KHKIMHRDVK PSNILVNSRG EIKLCDFGVS GQLIDSMANS FVGTRSYMSP ERLQGTHYSV 240

QSDIWSMGLS LVEMAIGRYP IPPPDSKELE LMFGCTVEGD ASETSPRQRT PGRPISSYGL 300

DNRPPMAIFE LLDYIVNEPP PKLPNGVFSL EFQDFVNKCL IKNPAERADL KQLMVHAFIK 360

RAEAEDVDFA GWLCSTIGLN QPSTPTHAAG V 391

Nucleotide Sequence
(FASTA)

ATGCCCAGGA AGAAGCCCGA CCCCATCCAG CTCAACCCCA CCCCGGACGG GGCCGCCGTC 60

AACGGCACCA GCTCCGCCGA CACTGCGCCA AACGCTGGGC CGAGCCGGTC GTCGTCCTCC 120

TCATACGGAA CGCAGCCGGG CTTGCGGCCC CCCGCCCGCA AGATGCCCAT GCCCAGGAAG 180

AAGCCCGACC CCATCCAGCT CAACCCCACC CCGGACGGGG CCGCCGTCAA CGGCACCAGC 240

TCCGCCGAGA GACTGAAAAC AAGTGGAAAT GGGTTCTTTT TGCAGCTCAT CCACCTAGAG 300

ATCAAGCCAG CCATCCGGAA CCAGATCATC CGGGAGCTGC AGGTGCTCCA CGAATGCAAC 360

TCCCCTTACA TCGTGGGCTT CTATGGGGCC TTCTACAGTG ATGGCGAGAT CAGCATCTGC 420

ATGGAGCACA TGGATGGCGG GTCCTTGGAT CAGGTCCTGA AGAAAGCCGG AAGAATTCCA 480

GAGCAGATTC TGGGCAAAGT TAGCATTGCT GTAATAAAAG GTCTAACGTA TCTGAGGGAG 540

AAACATAAAA TTATGCACAG AGACGTGAAG CCGTCCAACA TCTTGGTGAA CTCCCGCGGT 600

GAGATCAAGC TCTGCGACTT CGGGGTCAGC GGGCAGCTGA TCGACTCCAT GGCCAACTCC 660

TTTGTGGGCA CGAGGTCCTA CATGTCGCCG GAGAGACTAC AAGGCACTCA TTATTCAGTG 720

CAGTCGGACA TCTGGAGCAT GGGCTTATCC TTGGTGGAGA TGGCTATTGG CAGGTACCCG 780

ATCCCTCCTC CCGATTCCAA GGAGCTGGAA CTGATGTTCG GATGCACGGT GGAGGGAGAC 840

GCTTCGGAGA CGTCGCCCCG ACAGCGGACC CCGGGGAGGC CCATTAGCTC TTACGGCCTG 900

GACAACAGAC CACCCATGGC CATCTTTGAA CTGCTGGACT ATATCGTCAA CGAGCCGCCG 960

CCCAAGCTGC CCAATGGAGT CTTCAGTCTT GAGTTTCAAG ATTTTGTGAA TAAATGCCTC 1020

ATCAAAAACC CGGCCGAGAG AGCCGACCTG AAGCAACTCA TGGTTCACGC TTTCATCAAG 1080

AGAGCCGAGG CGGAAGACGT GGACTTTGCG GGCTGGCTGT GCTCCACCAT AGGCCTGAAC 1140

CAGCCCAGCA CGCCCACCCA CGCCGCCGGA GTGTAA 1176

Domain Profile

S: 13    gvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyivkfyGafvsegd  72

         g+ +  + k sg+ +  + i+leik+++++qi+rel+vl+++ nspyiv+fyGaf+s+g+

Q: 78    GTSSAERLKTSGNGFFLQLIHLEIKPAIRNQIIRELQVLHEC-NSPYIVGFYGAFYSDGE  136

         5555566778888889999***********************.*****************

S: 73    vsicmelmdgtsldkvlkkvlekkkripekvlgkiavavvkaleylkeklkiiHRDvKPs  132

         +sicme+mdg+sld+vlkk    ++ripe++lgk+++av+k+l+yl+ek+ki+HRDvKPs

Q: 137   ISICMEHMDGGSLDQVLKK----AGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPS  192

         ******************9....8************************************

S: 133   NiLvnskGevKlCDFGvsgqlvdsiAksavGtksYmaPEriegkkkYsvksdvWslGltl  192

         NiLvns+Ge+KlCDFGvsgql+ds+A+s+vGt+sYm+PEr++g ++Ysv+sd+Ws+Gl+l

Q: 193   NILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQG-THYSVQSDIWSMGLSL  251

         *******************************************.****************

S: 193   velatgrypyeklke.........................................ilel  211

         ve+a+gryp++++++                                         i+el

Q: 252   VEMAIGRYPIPPPDSkelelmfgctvegdasetsprqrtpgrpissygldnrppmaIFEL  311

         *************999********************************************

S: 212   lkaivneeppklpeeefseefqefvskClkkdekeRpklkellkhafi  259

         l++ivne+ppklp+  fs efq+fv+kCl+k+++eR++lk+l+ hafi

Q: 312   LDYIVNEPPPKLPNGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI  359

         **********************************************97

Domain Sequence
(FASTA)

GTSSAERLKT SGNGFFLQLI HLEIKPAIRN QIIRELQVLH ECNSPYIVGF YGAFYSDGEI 60

SICMEHMDGG SLDQVLKKAG RIPEQILGKV SIAVIKGLTY LREKHKIMHR DVKPSNILVN 120

SRGEIKLCDF GVSGQLIDSM ANSFVGTRSY MSPERLQGTH YSVQSDIWSM GLSLVEMAIG 180

RYPIPPPDSK ELELMFGCTV EGDASETSPR QRTPGRPISS YGLDNRPPMA IFELLDYIVN 240

EPPPKLPNGV FSLEFQDFVN KCLIKNPAER ADLKQLMVHA FI 282

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004708	; F:MAP kinase kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0004728	; F:receptor signaling protein tyrosine phosphatase activity
GO:0007050	; P:cell cycle arrest
GO:0048870	; P:cell motility
GO:0090398	; P:cellular senescence
GO:0008285	; P:negative regulation of cell proliferation
GO:0045597	; P:positive regulation of cell differentiation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013