EKS-ORA-00270
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORA-00270
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE20354.24.9E-106269520252
StatusUnreviewed
Ensembl ProteinENSOANP00000015646
UniProt AccessionF6ZSD4;
Protein Name
Protein Synonyms/Alias
Gene NamePAK1
Gene Synonyms/Alias PAK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOANG00000009867ENSOANP00000015646ENSOANT00000015649
OrganismOrnithorhynchus anatinus
Functional Description
Protein Length544
Protein Sequence
(FASTA)
MSSNGVETQD KPPAPPMRNT STMIGTGGKE AGAPNHGSKP LPPNPEEKKK RDRFYRSILP 60
GDKANKKKEK ERPEISLPSD FEHTIHVGFD AVTGEFTGMP EQWARLLQTS NITKLEQKKN 120
PQAVLDVLEF YNAKKASNSQ KYMSFTDKSA EEYSSSSSLL PLISSSGSLG DPPVGGPRLL 180
NKEDGRPSSF LPYREGPGGC RGSRRRKGMG WARKIKINSK DQSEESLVWI RVTRASRCLG 240
CWQGKENKGS TSFSSAGSIV SVGDPKKKYM NFEKIGQGAS GTVYTAVEVA TGQEVAIKQM 300
NLQQQPKKEL IINEILVMRE NKNPNIVNYL NSYLVGEELW VVMEYLAGGS LTDVVTETCM 360
DEGQIAAVCR ECLQALEFLH SNQVIHRDIK SDNILLGTDG SVKLTDFGFC AQITPEQSKR 420
STMVGTPYWM APEVVTRKAY GPKVDIWSLG IMAIEMVEGE PPYLNENPLR ALYLIATNGT 480
PELQNPEKLS PMFQNFLNCC LEMDVERRSS ARDLLQHQFL KIARPLSSLT PLIAAAKEAA 540
KNNH 544
Nucleotide Sequence
(FASTA)
ATGTCCAGCA ACGGCGTGGA AACCCAGGAC AAGCCCCCAG CCCCTCCCAT GAGAAACACC 60
AGCACGATGA TCGGCACGGG CGGAAAAGAG GCCGGAGCCC CGAACCACGG CTCCAAACCT 120
TTGCCACCGA ACCCCGAGGA GAAGAAGAAG CGAGATCGAT TCTACCGCTC CATCCTGCCC 180
GGCGACAAAG CAAACAAAAA GAAAGAGAAG GAGCGGCCAG AGATCTCCCT CCCTTCCGAT 240
TTTGAGCACA CGATTCACGT TGGCTTCGAT GCTGTTACCG GGGAGTTCAC CGGAATGCCA 300
GAGCAGTGGG CTCGTCTGCT CCAGACCTCA AACATCACCA AGTTAGAGCA GAAGAAGAAT 360
CCCCAGGCGG TGCTGGATGT GCTGGAATTC TACAATGCCA AGAAAGCCTC CAACAGCCAG 420
AAATATATGA GCTTCACAGA TAAGTCCGCA GAGGAATACA GCTCTTCAAG CTCCCTGCTT 480
CCCCTGATTT CATCATCGGG CAGCCTGGGG GACCCTCCAG TTGGTGGACC CAGATTATTG 540
AACAAGGAAG ATGGCAGGCC CTCCTCTTTC CTCCCCTATC GGGAGGGCCC AGGGGGCTGC 600
AGAGGAAGCA GGAGGAGGAA GGGAATGGGG TGGGCAAGGA AGATTAAAAT AAATAGCAAG 660
GATCAGAGTG AAGAGAGTTT GGTATGGATC AGGGTGACTA GGGCATCCCG GTGCCTGGGG 720
TGTTGGCAAG GGAAAGAAAA CAAGGGTTCA ACATCTTTCT CTTCTGCAGG GAGCATTGTG 780
AGTGTGGGAG ACCCCAAAAA GAAGTACATG AACTTTGAGA AGATCGGACA AGGTGCTTCG 840
GGCACCGTGT ACACCGCGGT GGAAGTTGCC ACAGGACAGG AGGTGGCCAT CAAACAGATG 900
AACCTGCAGC AGCAACCCAA GAAAGAGCTG ATCATCAACG AGATTCTGGT TATGAGGGAA 960
AATAAAAACC CCAACATCGT CAACTACCTG AACAGCTACC TTGTGGGAGA AGAACTGTGG 1020
GTGGTCATGG AGTACCTGGC CGGAGGCTCC CTGACAGACG TGGTGACGGA GACCTGCATG 1080
GATGAAGGGC AGATAGCCGC GGTGTGCCGG GAGTGCCTTC AGGCCCTGGA GTTCTTGCAT 1140
TCGAACCAAG TCATCCACCG AGACATCAAG AGTGACAACA TCCTGCTCGG GACCGACGGC 1200
TCCGTCAAGC TCACCGACTT CGGCTTCTGT GCTCAGATCA CCCCCGAGCA GAGCAAGCGC 1260
AGCACCATGG TGGGGACGCC TTACTGGATG GCCCCCGAAG TGGTGACTCG GAAAGCCTAC 1320
GGGCCCAAGG TGGACATCTG GTCCCTGGGC ATCATGGCCA TTGAGATGGT GGAGGGAGAG 1380
CCCCCGTACC TCAACGAGAA CCCCCTGAGG GCCCTGTACC TCATCGCCAC CAACGGCACG 1440
CCGGAGCTGC AGAACCCAGA GAAGCTGAGT CCCATGTTCC AGAACTTCCT CAACTGCTGT 1500
CTGGAAATGG ACGTGGAGCG GAGAAGCTCC GCTAGAGACC TGCTGCAGCA CCAGTTCCTG 1560
AAGATCGCCA GACCCCTCTC CAGCCTCACC CCCCTGATCG CCGCCGCCAA GGAGGCCGCC 1620
AAGAACAACC ACTGA 1635
Domain Profile
S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60
         y  +e+ig+Ga+g+vy+a e+ tg+ vaik++nl++q+k+e++++ei v+++ k+pniv+
Q: 269   YMNFEKIGQGASGTVYTAVEVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVN  328
         67789*******************************************************
S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120
         yl+s+l+ eelw+vmeylagGsl+d+v+   ++ ++E qia+++re+l+aLe+lHs++vi
Q: 329   YLNSYLVGEELWVVMEYLAGGSLTDVVT---ETCMDEGQIAAVCRECLQALEFLHSNQVI  385
         ****************************...9****************************
S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdek  180
         Hrdik++niLl ++g+VkL+dfg++aq++ +++kr+t+vgtpywmAPEv++  +k Y  k
Q: 386   HRDIKSDNILLGTDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVT--RKAYGPK  443
         ***************************************************..9******
S: 181   aDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqk  240
         +DiwslGI+aie++egepP+ +++pl+al++i++n +p+l++++k+s+ f++f++ cl+ 
Q: 444   VDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPMFQNFLNCCLEM  503
         ************************************************************
S: 241   npekRpsasellkhkFl  257
         ++e+R+sa++ll+h+Fl
Q: 504   DVERRSSARDLLQHQFL  520
         ****************7
Domain Sequence
(FASTA)
YMNFEKIGQG ASGTVYTAVE VATGQEVAIK QMNLQQQPKK ELIINEILVM RENKNPNIVN 60
YLNSYLVGEE LWVVMEYLAG GSLTDVVTET CMDEGQIAAV CRECLQALEF LHSNQVIHRD 120
IKSDNILLGT DGSVKLTDFG FCAQITPEQS KRSTMVGTPY WMAPEVVTRK AYGPKVDIWS 180
LGIMAIEMVE GEPPYLNENP LRALYLIATN GTPELQNPEK LSPMFQNFLN CCLEMDVERR 240
SSARDLLQHQ FL 252
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Gene Ontology
GO:0030424; C:axon
GO:0005911; C:cell-cell junction
GO:0005794; C:Golgi apparatus
GO:0030426; C:growth cone
GO:0005634; C:nucleus
GO:0043234; C:protein complex
GO:0001726; C:ruffle
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0031532; P:actin cytoskeleton reorganization
GO:0060244; P:negative regulation of cell proliferation involved in contact inhibition
GO:0033148; P:positive regulation of intracellular estrogen receptor signaling pathway
GO:0043507; P:positive regulation of JUN kinase activity
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation
GO:0051496; P:positive regulation of stress fiber assembly
GO:0043113; P:receptor clustering
GO:0042060; P:wound healing
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000095; PAK_box_Rho-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00786; PBD; 1.
PF00069; Pkinase; 1.
SMARTs
SM00285; PBD; 1.
SM00220; S_TKc; 1.
Prosites
PS50108; CRIB; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013