EKS-ORA-00025
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORA-00025
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Jak323.41.4E-96462725264
StatusUnreviewed
Ensembl ProteinENSOANP00000016000
UniProt AccessionF6TJR2;
Protein NameTyrosine-protein kinase
Protein Synonyms/Alias
Gene NameJAK2
Gene Synonyms/Alias JAK2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOANG00000010092ENSOANP00000015999ENSOANT00000016002
ENSOANG00000010092ENSOANP00000016000ENSOANT00000016003
OrganismOrnithorhynchus anatinus
Functional Description
Protein Length940
Protein Sequence
(FASTA)
MFALMCETDR TWYPPNHVFH IDESTKHTVL YRIRFYFPHW YCNGDKRAYR HGISRGSEAP 60
LLDDYIMSYL FAQWRDDFVH GWIKVPVTHE TQEECLGMAV LDMMRIAKEK DQTPLAIYNS 120
ISYKTFLPKC VRAKIQDYHI LTRKRIRYRF RRFIQQFSQC KATARNLKLK YLINLETLQS 180
AFYSEKFEVK EPGRGPSGEE IFATIIITGN GGIQWSRGKH KESETLAEQD LQTYCDFPDI 240
IDVSIKQANQ EDSTESRVVT IHKQDSKNLE IEFLSLKEAL SFVSLIDGYY RLTADAHHYL 300
CKEVAPPTVL KNIQSNCHGP ISMEFAISKL KKAGNQTGLY VLRCSPKDFN KYFLTFAVER 360
EHVMDYKHCL ITKNENSEYN LSGTKKSFGN LKDLLNCYQM ETVRSDSIIF QFTKCCPPKP 420
KDKSNLLVFR SNGISDVLTS PTLQRHNNVN QMVFHKIRNE DLTFNESLGQ GTFTKIFKGV 480
RKEIGDYGLH QTEVLLKVLD KAHRNYSESF FEAASMMSQL SYKHLVLNYG VCVCGEENIL 540
VQEFVKFGSL DTYLKKNKNS INILWKLEVA KQLAWAMHFL EEKNLIHGNV CSKNILLIRE 600
EDRKSGNPPF IKLSDPGISI TVLPKDTDDE VLLERIPWVP PECIENPKNL SLATDKWSFG 660
TTLWEICSGG DKPLSALDSQ RKLQFYEDRH QLPAPKWTEL ANLINNCMEF EPDFRPSFRA 720
IIRDLNSLFT PDYELLTEND MLPNMRIGAL GFSGAFEDRD PTQFEERHLK FLQQLGKGNF 780
GSVEMCRYDP LQDNTGEVVA VKKLQHSTEE HLRDFEREIE ILKSLQHDNI VKYKGVCYSA 840
GRRNLRLIME YLPYGSLRDY LQKHKERLDH KKLLQYTSQI CKGMEYLGTK RYIHRDLATR 900
NILVENENRV KIGDFGLTKV LPQDKEYYKV KEPGESPIFW 940
Nucleotide Sequence
(FASTA)
ATGTTTGCTC TAATGTGTGA GACAGACAGG ACCTGGTATC CTCCCAACCA CGTCTTCCAT 60
ATAGACGAGT CAACCAAGCA CACCGTCCTG TACCGAATAA GGTTTTACTT TCCTCACTGG 120
TATTGTAATG GAGATAAGCG AGCCTACCGA CATGGGATTT CTCGAGGCTC TGAGGCCCCT 180
CTTCTTGATG ATTATATCAT GTCTTACCTC TTTGCTCAGT GGAGAGATGA CTTTGTTCAT 240
GGTTGGATAA AGGTGCCTGT AACTCATGAA ACACAGGAAG AATGTCTTGG GATGGCGGTC 300
CTGGATATGA TGAGAATAGC TAAGGAAAAA GACCAAACCC CCTTGGCCAT CTATAACTCT 360
ATCAGCTACA AGACTTTCTT ACCAAAATGT GTTCGAGCAA AGATTCAAGA CTATCACATT 420
TTGACGCGAA AGCGAATAAG GTACAGGTTC CGCAGATTTA TTCAGCAATT CAGCCAGTGC 480
AAAGCTACTG CCAGAAACTT GAAACTTAAG TATCTTATAA ATCTGGAAAC TCTTCAGTCT 540
GCCTTCTACT CAGAAAAATT TGAAGTAAAA GAGCCTGGCA GAGGTCCTTC AGGTGAGGAG 600
ATTTTTGCAA CCATTATAAT AACTGGAAAC GGTGGAATTC AGTGGTCAAG AGGGAAACAT 660
AAAGAAAGTG AGACACTGGC AGAACAGGAT TTACAAACAT ACTGTGACTT TCCTGATATT 720
ATCGATGTGA GCATTAAACA AGCAAACCAA GAAGACTCTA CTGAGAGTAG GGTGGTAACT 780
ATTCATAAGC AAGACAGCAA GAATTTGGAA ATTGAATTTC TCTCCTTAAA AGAAGCTCTG 840
TCTTTTGTGT CGCTGATCGA TGGGTATTAC AGATTGACTG CAGATGCACA CCATTACCTC 900
TGTAAAGAAG TCGCACCCCC GACAGTGCTT AAAAATATCC AAAGCAATTG TCACGGGCCC 960
ATTTCAATGG AATTTGCCAT CAGTAAACTG AAGAAAGCGG GTAACCAAAC GGGCCTCTAT 1020
GTCCTTCGCT GCAGTCCTAA AGACTTTAAT AAATACTTCC TCACCTTTGC TGTTGAGCGG 1080
GAACATGTCA TGGATTACAA ACATTGCTTG ATTACTAAAA ATGAGAACAG CGAATACAAT 1140
CTCAGTGGAA CTAAGAAGAG CTTTGGTAAC CTTAAAGATC TTCTGAACTG CTATCAGATG 1200
GAAACTGTTC GCTCGGACAG CATCATTTTC CAGTTTACCA AGTGTTGCCC CCCTAAACCC 1260
AAAGATAAAT CTAATCTCTT AGTCTTCAGG AGCAATGGCA TTTCTGACGT ACTTACATCA 1320
CCCACATTGC AGAGACACAA TAATGTAAAC CAGATGGTTT TTCACAAAAT CAGAAATGAA 1380
GATTTGACGT TTAACGAAAG TCTGGGACAA GGTACCTTTA CCAAGATTTT CAAGGGTGTA 1440
AGGAAAGAAA TAGGAGACTA CGGTCTCCAT CAAACAGAAG TCCTTTTAAA AGTTCTGGAT 1500
AAAGCCCACA GAAACTATTC AGAGTCTTTT TTTGAAGCAG CAAGCATGAT GAGCCAACTT 1560
TCTTACAAGC ACCTTGTATT AAATTATGGA GTCTGTGTCT GTGGAGAGGA AAATATCCTG 1620
GTTCAAGAGT TTGTCAAATT TGGATCACTG GACACATACC TGAAGAAAAA CAAGAATTCT 1680
ATCAATATTT TGTGGAAGTT GGAAGTGGCC AAACAATTGG CATGGGCCAT GCATTTTCTA 1740
GAGGAAAAAA ATCTCATTCA TGGGAATGTG TGTTCAAAAA ATATTTTACT TATCAGGGAA 1800
GAGGACAGGA AATCAGGAAA CCCTCCTTTC ATCAAACTCA GCGATCCGGG CATTAGTATT 1860
ACAGTTTTGC CGAAAGACAC AGATGATGAA GTTCTTCTAG AGAGAATACC ATGGGTTCCA 1920
CCTGAATGCA TTGAAAACCC CAAAAATCTA AGCTTGGCAA CAGATAAATG GAGTTTTGGA 1980
ACCACTCTGT GGGAAATCTG CAGTGGAGGA GACAAACCAC TGAGTGCACT TGATTCTCAA 2040
AGAAAGCTAC AGTTTTACGA AGACAGGCAC CAACTTCCTG CACCAAAATG GACAGAATTA 2100
GCAAATCTTA TCAACAACTG TATGGAATTT GAACCAGATT TCAGACCTTC TTTCAGAGCC 2160
ATCATACGGG ATCTCAACAG TTTGTTCACT CCAGATTATG AACTTTTAAC AGAAAATGAC 2220
ATGTTACCCA ACATGAGAAT TGGTGCTCTT GGATTTTCTG GTGCATTTGA AGACAGGGAC 2280
CCCACACAGT TTGAAGAGAG ACACCTTAAA TTCCTACAAC AGCTCGGCAA GGGTAATTTT 2340
GGCAGTGTGG AGATGTGCCG ATACGACCCC CTGCAAGACA ATACTGGTGA GGTGGTAGCT 2400
GTGAAAAAGC TTCAGCACAG CACTGAAGAG CACTTGCGAG ATTTTGAAAG AGAAATTGAA 2460
ATTCTTAAAT CCCTGCAGCA TGATAACATT GTCAAATACA AGGGAGTCTG CTATAGTGCC 2520
GGTCGTCGTA ATCTGAGGCT GATCATGGAA TATTTGCCCT ACGGAAGTTT ACGTGATTAT 2580
CTCCAAAAGC ATAAGGAAAG GCTGGATCAT AAGAAGCTAT TACAGTACAC GTCTCAGATA 2640
TGCAAGGGCA TGGAGTATCT TGGAACAAAG AGATACATCC ATAGGGATCT GGCCACAAGA 2700
AATATCTTAG TGGAGAATGA GAACAGAGTT AAAATTGGAG ATTTTGGATT GACAAAAGTC 2760
CTGCCACAAG ATAAGGAATA TTACAAAGTG AAAGAACCTG GAGAAAGTCC CATATTCTGG 2820
TAA 2823
Domain Profile
S: 1     lkqiesLgkgtftkvfevredaegd..steeevalkvLkesgedisrdfkreaeilsqls  58
         l+++esLg+gtftk+f++ +++ gd   +++ev+lkvL+++++++s++f+++a+++sqls
Q: 462   LTFNESLGQGTFTKIFKGVRKEIGDygLHQTEVLLKVLDKAHRNYSESFFEAASMMSQLS  521
         6789****************977762257788****************************
S: 59    hehivklkgvcvaegenrlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYLe  118
         ++h+v ++gvcv+++en+lV+e+v+ GsLd+yL+k+k+++++ ++l+vakqla+am++Le
Q: 522   YKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINILWKLEVAKQLAWAMHFLE  581
         ************************************************************
S: 119   dkklvhrdvaarnvLveresn..egtppfvklsdpglakavnqdeYylvreerd....sr  172
         +k+l+h++v+ +n+L+ re++  +g+ppf+klsdpg++ +v      l+++  d    +r
Q: 582   EKNLIHGNVCSKNILLIREEDrkSGNPPFIKLSDPGISITV------LPKDTDDevllER  635
         ******************9998899***************9......777665522337*
S: 173   ipwlapeclseaknlstasdvWsFgvtlyelltcskgesplrseslerklelleekerlp  232
         ipw++pec+++ knls+a+d+WsFg+tl+e+  cs g++pl++ +++rkl+++e++++lp
Q: 636   IPWVPPECIENPKNLSLATDKWSFGTTLWEI--CSGGDKPLSALDSQRKLQFYEDRHQLP  693
         *******************************..***************************
S: 233   kpkcpaelaelmtnclsyepsqrpsFrailedl  265
         +pk++ ela+l++nc++ ep++rpsFrai++dl
Q: 694   APKWT-ELANLINNCMEFEPDFRPSFRAIIRDL  725
         *****.*************************98
Domain Sequence
(FASTA)
LTFNESLGQG TFTKIFKGVR KEIGDYGLHQ TEVLLKVLDK AHRNYSESFF EAASMMSQLS 60
YKHLVLNYGV CVCGEENILV QEFVKFGSLD TYLKKNKNSI NILWKLEVAK QLAWAMHFLE 120
EKNLIHGNVC SKNILLIREE DRKSGNPPFI KLSDPGISIT VLPKDTDDEV LLERIPWVPP 180
ECIENPKNLS LATDKWSFGT TLWEICSGGD KPLSALDSQR KLQFYEDRHQ LPAPKWTELA 240
NLINNCMEFE PDFRPSFRAI IRDL 264
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00026
EKS-ANC-00025
EKS-BOT-00031
EKS-CAJ-00030
EKS-CAF-00031
EKS-CAP-00032
EKS-CII-00224
EKS-DAR-00042
EKS-EQC-00028
EKS-FEC-00028
EKS-GAM-00013
EKS-GAG-00025
EKS-GAA-00046
EKS-GOG-00030
EKS-HOS-00032
EKS-LAC-00033
EKS-LOA-00030
EKS-MAM-00031
EKS-MEG-00027
EKS-MIM-00015
EKS-MOD-00030
EKS-MUM-00032
EKS-MUP-00032
EKS-MYL-00032
EKS-NOL-00029
EKS-OCP-00021
EKS-ORN-00046
EKS-ORC-00031
EKS-ORL-00043
EKS-OTG-00031
EKS-PAT-00029
EKS-PES-00027
EKS-POA-00028
EKS-PRC-00015
EKS-PTV-00030
EKS-RAN-00032
EKS-SAH-00029
EKS-SUS-00028
EKS-TAG-00028
EKS-TAR-00046
EKS-TEN-00050
EKS-XET-00030
EKS-XIM-00044
Gene Ontology
GO:0005901; C:caveola
GO:0005737; C:cytoplasm
GO:0005856; C:cytoskeleton
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0020037; F:heme binding
GO:0035401; F:histone kinase activity (H3-Y41 specific)
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0006915; P:apoptotic process
GO:0030154; P:cell differentiation
GO:0060396; P:growth hormone receptor signaling pathway
GO:0035722; P:interleukin-12-mediated signaling pathway
GO:0008285; P:negative regulation of cell proliferation
GO:0043392; P:negative regulation of DNA binding
GO:0010811; P:positive regulation of cell-substrate adhesion
GO:0050727; P:regulation of inflammatory response
GO:0046677; P:response to antibiotic
GO:0007262; P:STAT protein import into nucleus
GO:0033209; P:tumor necrosis factor-mediated signaling pathway
GO:0007260; P:tyrosine phosphorylation of STAT protein
KEGG
InterPros
IPR019749; Band_41_domain.
IPR019748; FERM_central.
IPR000299; FERM_domain.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR008266; Tyr_kinase_AS.
IPR016251; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020693; Tyr_kinase_non-rcpt_Jak2.
Pfam
PF07714; Pkinase_Tyr; 2.
PF00017; SH2; 1.
SMARTs
SM00295; B41; 1.
SM00252; SH2; 1.
Prosites
PS50057; FERM_3; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
Prints
PR01823; JANUSKINASE.
PR01825; JANUSKINASE2.
PR00109; TYRKINASE.
Created Date20-Feb-2013