EKS-ORA-00118

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORA-00118

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/Akt	504.8	5.9E-152	172	429	258

Status

Unreviewed

Ensembl Protein

ENSOANP00000016278

UniProt Accession

F6YTS3;

Protein Name

Protein Synonyms/Alias

Gene Name

AKT3

Gene Synonyms/Alias

AKT3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000010258	ENSOANP00000016278	ENSOANT00000016281

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

477

Protein Sequence
(FASTA)

MKMFHIALQI ILRLLNICCP SKSNSPVSPG MKMNGLRITG EYIKNWRPRY FLLKTDGSFI 60

GYKEKPQDVD LPYPLNNFSV AKCQLMKTER PKPNTFIIRC LQWTTVIERT FHVDTPEERE 120

EWTEAIQGVA DRLQRQEEER MNCSPTSQID NIGEEEMDAS TTHHKRKTMN DFDYLKLLGK 180

GTFGKVILVR EKASGKYYAM KILKKEVIIA KDEVAHTLTE SRVLKNTRHP FLTSLKYSFQ 240

TKDRLCFVME YVNGGELFFH LSRERVFSED RTRFYGAEIV SALDYLHSGK IVYRDLKLEN 300

LMLDKDGHIK ITDFGLCKEG ITDAATMKTF CGTPEYLAPE VLEDNDYGRA VDWWGLGVVM 360

YEMMCGRLPF YNQDHEKLFE LILMEDIKFP RTLSSDAKSL LSGLLIKDPN KRLGGGPDDA 420

KEIMRHSFFV GLNWQDVYDK KLVPPFKPQV TSETDTRYFD EEFTAQTITI TPPEKCK 477

Nucleotide Sequence
(FASTA)

ATGAAGATGT TTCATATTGC ACTGCAGATC ATTCTTAGGC TCCTAAATAT TTGCTGTCCA 60

AGTAAATCAA ACTCTCCCGT GTCACCAGGC ATGAAAATGA ATGGGCTTCG CATCACTGGA 120

GAATATATAA AAAACTGGAG ACCAAGATAC TTCCTTTTGA AGACAGATGG CTCCTTCATA 180

GGATACAAGG AGAAACCTCA AGATGTGGAT TTACCTTATC CCCTCAACAA CTTTTCCGTG 240

GCAAAGTGCC AGCTAATGAA AACAGAACGC CCAAAGCCAA ACACATTTAT TATCCGATGT 300

CTCCAGTGGA CCACTGTCAT AGAAAGAACA TTTCATGTGG ATACTCCAGA GGAAAGGGAA 360

GAATGGACAG AAGCTATCCA GGGCGTAGCA GACAGACTTC AGAGACAAGA AGAAGAGAGA 420

ATGAACTGTA GTCCAACGTC CCAGATTGAC AACATAGGGG AGGAGGAGAT GGATGCTTCC 480

ACAACCCATC ATAAAAGAAA GACAATGAAT GATTTTGACT ATTTGAAACT ACTGGGTAAA 540

GGCACTTTTG GGAAAGTTAT TTTGGTTCGA GAAAAAGCAA GTGGGAAATA TTATGCTATG 600

AAGATTTTGA AGAAAGAAGT TATTATTGCA AAGGATGAAG TGGCACACAC TCTCACAGAA 660

AGCAGAGTAT TAAAGAACAC TAGACATCCC TTTTTAACGT CTTTGAAATA TTCCTTCCAG 720

ACAAAAGATC GTTTGTGTTT TGTGATGGAA TACGTTAATG GGGGAGAGCT GTTTTTCCAT 780

TTGTCGAGAG AACGGGTGTT CTCCGAGGAC CGCACACGCT TCTACGGTGC AGAGATTGTC 840

TCCGCTCTGG ACTATCTGCA TTCCGGAAAG ATTGTGTACC GGGATCTCAA GCTGGAGAAT 900

TTGATGCTGG ATAAGGACGG TCACATAAAA ATTACGGATT TTGGACTTTG CAAAGAGGGG 960

ATCACTGATG CGGCTACCAT GAAGACGTTC TGTGGGACAC CAGAATACCT GGCACCAGAG 1020

GTCTTAGAAG ACAACGACTA CGGCCGGGCA GTGGATTGGT GGGGCCTCGG GGTTGTCATG 1080

TATGAAATGA TGTGTGGGAG ATTGCCATTC TACAACCAGG ATCACGAGAA GCTTTTTGAA 1140

CTGATTCTAA TGGAGGATAT TAAATTCCCC CGGACCCTCT CTTCAGATGC AAAATCTTTG 1200

CTTTCAGGAC TCCTAATAAA GGACCCTAAT AAACGCCTTG GTGGAGGTCC AGATGATGCG 1260

AAAGAAATTA TGAGGCACAG TTTCTTTGTT GGACTAAACT GGCAAGATGT ATATGATAAA 1320

AAGCTGGTAC CGCCTTTTAA ACCTCAAGTG ACATCTGAGA CGGATACCAG ATATTTCGAT 1380

GAAGAATTTA CAGCTCAGAC AATTACCATA ACACCTCCGG AAAAATGTAA GTAA 1434

Domain Profile

S: 1     fdllkllGkGtfGkvilvrekatqklyalkilkkevivakdevahtlterrvlkrtkhpf  60

         fd+lkllGkGtfGkvilvreka++k+ya+kilkkevi+akdevahtlte+rvlk+t+hpf

Q: 172   FDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPF  231

         9***********************************************************

S: 61    lvalkysfqtkeklclvleyvnGGelffhlskervfsedrarfygaeivsaldylhskdv  120

         l++lkysfqtk++lc+v+eyvnGGelffhls+ervfsedr+rfygaeivsaldylhs ++

Q: 232   LTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKI  291

         ************************************************************

S: 121   vyrdlklenllldkdGhikitdfGlckeeikdgdktktfcGtpeylapevlededygkav  180

         vyrdlklenl+ldkdGhikitdfGlcke+i+d++++ktfcGtpeylapevled+dyg+av

Q: 292   VYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAV  351

         ************************************************************

S: 181   dwwglGvvlyemlcGrlpfynkdheklfelilleelkfprklseeaksllsGllkkdpkk  240

         dwwglGvv+yem+cGrlpfyn+dheklfelil+e++kfpr+ls++aksllsGll kdp+k

Q: 352   DWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNK  411

         ************************************************************

S: 241   rlGggkddakeireheff  258

         rlGgg+ddakei++h+ff

Q: 412   RLGGGPDDAKEIMRHSFF  429

         *****************9

Domain Sequence
(FASTA)

FDYLKLLGKG TFGKVILVRE KASGKYYAMK ILKKEVIIAK DEVAHTLTES RVLKNTRHPF 60

LTSLKYSFQT KDRLCFVMEY VNGGELFFHL SRERVFSEDR TRFYGAEIVS ALDYLHSGKI 120

VYRDLKLENL MLDKDGHIKI TDFGLCKEGI TDAATMKTFC GTPEYLAPEV LEDNDYGRAV 180

DWWGLGVVMY EMMCGRLPFY NQDHEKLFEL ILMEDIKFPR TLSSDAKSLL SGLLIKDPNK 240

RLGGGPDDAK EIMRHSFF 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00169	; PH; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013