EKS-ORA-00245

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORA-00245

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	390.3	5.9E-117	336	629	294

Status

Unreviewed

Ensembl Protein

ENSOANP00000016692

UniProt Accession

F6YQ99;

Protein Name

Protein Synonyms/Alias

Gene Name

TGFBR2

Gene Synonyms/Alias

TGFBR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000010530	ENSOANP00000016692	ENSOANT00000016695

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

659

Protein Sequence
(FASTA)

MCVCVCPPLF THTERVPQPQ RLEKCEGLRD AAAVSCAPPP STSSSSSASP SRPSSSSSSS 60

SSPPVSVPPR AGPGRSLHPP GRGPPFPCRR AARPRPVLAA MGRPVLGLLT GLLGTCLAAT 120

VPPPGRTSDN LFPNHVAESA MKFPGLCKFC DVESTICTNQ GVCKSNCSIT SICENTFDIC 180

AAVWRKNDEN ITLETICHDQ RLPLHGFDLD DIGSSKCMMK EKKMLGETMF MCSCSSEECN 240

DLLYFSEEVA ANPELMAVTV ISLLPPLGIA VAVIVTFYCY RVQRRRKLNT AWEKSSKGRK 300

HMECSDRCAM MIDDDRSDIS STCANNLNHN TELLPIELDT LVGKGRFAEV YKAKLKQNTS 360

EQFETVAVKI FPYEEYASWK TEKDIFSDIN LKHENVLQFL TAEERKTELG KQYWLITAFH 420

SRGNLQEYLT RHVISWEDLW KLGSSLSRGI AHLHSDHTPC GRPKTPIVHR DLKSSNILVK 480

NDLTCCLCDF GLSLRLDPTL SVDDLANSGQ VGTARYMAPE VLESRMNLEN VESFKQTDVY 540

SMALVLWEMT SRCNGIGEVK DYEPPFGSKV REHPCVESMK DNVLRDRGRP EIPNTWLSHQ 600

GIQTVCETLT ECWDHDPEAR LTAQCVAERF GELEHLDRLS GRSCSEEKIP EDCSVNATK 659

Nucleotide Sequence
(FASTA)

ATGTGTGTAT GTGTGTGTCC CCCCCTTTTT ACACACACAG AGAGAGTCCC GCAGCCGCAG 60

CGCCTTGAGA AGTGCGAAGG CCTTAGGGAT GCCGCCGCTG TGAGCTGCGC CCCGCCTCCC 120

TCCACCTCCT CCTCCTCCTC CGCTTCCCCT TCCCGTCCTT CTTCCTCGTC GTCGTCGTCG 180

TCGTCCCCGC CGGTGTCCGT CCCTCCCCGG GCCGGGCCGG GCCGGTCCCT CCATCCGCCC 240

GGCCGAGGCC CGCCTTTCCC TTGCCGGAGG GCGGCCCGGC CCCGTCCGGT CCTCGCCGCC 300

ATGGGCCGGC CCGTCCTGGG GCTGCTGACC GGCCTCCTGG GGACCTGCCT GGCCGCCACC 360

GTCCCCCCTC CGGGCCGGAC TTCGGATAAT TTATTTCCTA ATCATGTGGC CGAGAGTGCC 420

ATGAAATTCC CCGGATTGTG CAAGTTTTGT GATGTGGAAT CAACTATCTG CACCAACCAG 480

GGGGTCTGCA AGAGCAACTG CAGCATCACT TCTATCTGTG AGAATACCTT TGACATCTGT 540

GCAGCTGTTT GGAGAAAGAA TGACGAAAAT ATAACCTTGG AGACCATCTG CCATGATCAG 600

AGGCTCCCAC TCCATGGCTT TGACCTAGAT GACATTGGAT CTTCAAAATG TATGATGAAG 660

GAAAAAAAAA TGCTTGGAGA AACAATGTTC ATGTGTTCCT GCAGCTCTGA GGAATGCAAT 720

GATTTGCTTT ACTTCTCAGA AGAAGTCGCC GCCAACCCAG AGCTGATGGC GGTGACGGTG 780

ATCAGCCTCC TCCCCCCGCT GGGGATCGCC GTCGCTGTGA TCGTCACCTT CTACTGCTAC 840

CGGGTGCAGC GCAGGCGGAA GCTGAACACG GCCTGGGAGA AGAGCTCGAA GGGCCGGAAG 900

CACATGGAGT GCAGCGACCG CTGCGCCATG ATGATCGACG ACGACCGCTC CGACATCAGC 960

TCCACCTGCG CCAACAACCT CAACCACAAC ACCGAGCTGC TGCCCATCGA GCTGGACACC 1020

CTGGTGGGGA AGGGAAGGTT CGCCGAGGTC TACAAGGCCA AGCTGAAGCA GAACACGTCC 1080

GAGCAGTTCG AGACGGTGGC GGTGAAGATC TTCCCCTACG AGGAGTACGC CTCCTGGAAG 1140

ACGGAGAAGG ACATCTTCTC CGACATCAAC CTGAAGCACG AGAACGTCCT CCAGTTCCTC 1200

ACGGCCGAGG AGCGGAAGAC GGAGCTGGGC AAGCAGTATT GGCTGATCAC CGCCTTCCAC 1260

TCGCGGGGGA ACCTGCAGGA GTACCTGACC CGGCACGTCA TCAGCTGGGA GGACCTGTGG 1320

AAGCTGGGCA GCTCCCTGTC GCGGGGCATC GCCCACCTGC ACAGCGACCA CACCCCTTGC 1380

GGGCGGCCCA AGACCCCCAT CGTGCACAGA GACCTGAAGA GTTCCAACAT CCTCGTCAAG 1440

AACGACCTGA CCTGCTGCCT CTGTGACTTC GGGCTGTCCC TGAGGCTGGA TCCCACGCTC 1500

TCCGTGGACG ACCTGGCCAA CAGCGGGCAG GTCGGCACAG CGAGATACAT GGCTCCTGAA 1560

GTCTTGGAGT CCCGAATGAA CTTAGAGAAC GTTGAGTCTT TCAAGCAAAC TGATGTGTAC 1620

TCCATGGCTC TGGTCCTCTG GGAGATGACC TCTCGCTGCA ACGGAATAGG AGAAGTTAAA 1680

GACTACGAAC CTCCCTTCGG TTCCAAGGTG AGAGAGCATC CCTGCGTAGA AAGCATGAAG 1740

GACAACGTGT TGAGAGATCG AGGACGGCCC GAGATACCCA ACACGTGGCT CAGTCACCAG 1800

GGGATCCAGA CGGTGTGCGA GACGCTGACA GAGTGCTGGG ATCACGACCC CGAAGCTCGG 1860

CTCACGGCTC AGTGCGTGGC GGAGCGGTTC GGCGAACTGG AGCACCTGGA CAGGCTGTCG 1920

GGGAGAAGTT GTTCGGAGGA GAAGATCCCC GAGGACTGCT CCGTGAACGC TACCAAATAG 1980

Domain Profile

S: 1     lklleligkGrygeVwkaklrg......eevAvKifstedeaswkrEkeiyqtvllrhen  54

         ++l +l+gkGr++eV+kakl++      e+vAvKif++e+ aswk+Ek+i++ ++l+hen

Q: 336   IELDTLVGKGRFAEVYKAKLKQntseqfETVAVKIFPYEEYASWKTEKDIFSDINLKHEN  395

         678899***************99999999*******************************

S: 55    ilqfiaadkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHe  114

         +lqf++a+++++++ ++++l+t++h +g+L++yL+r+++++e+l +l +sl++G+ahLH+

Q: 396   VLQFLTAEERKTELGKQYWLITAFHSRGNLQEYLTRHVISWEDLWKLGSSLSRGIAHLHS  455

         ************************************************************

S: 115   eivgtkgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtk  174

         + ++ +g+ K  i+HRDlks Nilvk+dltcc++D+GL+l+l+ + ++ dla++ qvGt

Q: 456   D-HTPCGRPKTPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTA  514

         *.8999******************************************************

S: 175   RYmaPEvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsd  234

         RYmaPEvle+++nl+++e+fk++DvYs++LvlWE++sRc+   +ev++y++pf ++v+++

Q: 515   RYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNG-IGEVKDYEPPFGSKVREH  573

         *****************************************.999***************

S: 235   PsleemkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290

         P++e+mk+ v++++ rP+ip++w +++ +++++++l+ecWd+dpeaRlta++v++r

Q: 574   PCVESMKDNVLRDRGRPEIPNTWLSHQGIQTVCETLTECWDHDPEARLTAQCVAER  629

         *****************************************************987

Domain Sequence
(FASTA)

IELDTLVGKG RFAEVYKAKL KQNTSEQFET VAVKIFPYEE YASWKTEKDI FSDINLKHEN 60

VLQFLTAEER KTELGKQYWL ITAFHSRGNL QEYLTRHVIS WEDLWKLGSS LSRGIAHLHS 120

DHTPCGRPKT PIVHRDLKSS NILVKNDLTC CLCDFGLSLR LDPTLSVDDL ANSGQVGTAR 180

YMAPEVLESR MNLENVESFK QTDVYSMALV LWEMTSRCNG IGEVKDYEPP FGSKVREHPC 240

VESMKDNVLR DRGRPEIPNT WLSHQGIQTV CETLTECWDH DPEARLTAQC VAER 294

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0043235	; C:receptor complex
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005026	; F:transforming growth factor beta receptor activity, type II
GO:0023014	; P:signal transduction by phosphorylation
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR017194	; Transform_growth_fac-b_typ-2.
IPR015013	; Transforming_GF_b_rcpt_2_ecto.

Pfam

PF08917	; ecTbetaR2; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013