EKS-ORA-00262

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORA-00262

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/EGFR	497.3	9.5E-150	715	972	258

Status

Unreviewed

Ensembl Protein

ENSOANP00000016946

UniProt Accession

F6T945;

Protein Name

Protein Synonyms/Alias

Gene Name

EGFR

Gene Synonyms/Alias

EGFR;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOANG00000010685	ENSOANP00000016946	ENSOANT00000016949

Organism

Ornithorhynchus anatinus

Functional Description

Protein Length

1215

Protein Sequence
(FASTA)

MGPRLPGAPA LLPLGLLLLG GHLCPAAALE EKRVCQGTGN KLTQLGTLDD HFLSLQRMYN 60

NCEVVLGNLE ITYVQRNYDL SFLKTIQEVA GYVLIALNSV ETIPLVNLQI IRGNVLYEGF 120

ALAVLSNYGM NKTGLKELPM RNLLEILTGG VRFSNNPALC NMDTIQWKDI VNTGQLNNIS 180

IDNQNQLDKC PKCDLNCPNG SCWGPGPQNC QTLTKTICAQ QCSGRCRGRS PSDCCHNQCA 240

AGCTGPRESD CLVCRKFRDE ATCKDTCPTL MLYNPTTYQM DVNPEGKYSF GATCVKKCPH 300

NYVVTDHGSC VRSCNAETYE VEEDGVRKCK KCEGPCSKVC TGIGTGEFKD VLSINATNIK 360

RFQNCTKING DLHILPVAFK GDAFTKTPQL NPEELNIFKT IKEISGFLLI QDWPANMTSL 420

DVFENLEIIR GRTKQHGRFS LAIVNLNISY LGLRSLKEIS DGDVIISKNK NLCYANTICW 480

KKLFSTQNQN YKIENNRNEN ECNATGQVCH PLCSSDGCWG PEPNHCFSCR YVSRSKECVE 540

KCNILDGFPR EFVEKSECLQ CHPECQPQPK NSTCTGHGPD NCIKCAHFID GPHCVKTCPA 600

GIMGENDTLV WKYADAHHVC QLCHPNCTHG CNGPGLEGCP MNSSKIPSIA AGIVGSLLCL 660

VMVGLIIGLY MRRRHIVRKR TLRRLLQERE LVEPLTPSGE APNQALLRIL KETEFKKIKV 720

LGSGAFGTVY KGLWIPEGEK VKIPVAIKEL REATSPKANK EILDEAYVMA SVDNPHVCRL 780

LGICLTSTVQ LITQLMPFGC LLDYIREHKD NIGSQYLLNW CVQIAKGMNY LEERRLVHRD 840

LAARNVLVKT PQHVKITDFG LAKLLGAEEK EYHAEGGKVP IKWMALESIL HRIYTHQSDV 900

WSYGVTVWEL MTFGSKPYDG IPASEISSIL EKGERLPQPP ICTIDVYMIM VKCWMIDADS 960

RPKFRELILE FSKMARDPQR YLVIQGDERM HLPSPTDSKF YRTLMEEEDM EDIVDADEYL 1020

IPHQGFFNSP STSRTPLLSS LSATSNNSTT ACIDRNGQGC ALKEDSFVQR YSSDPTTVFF 1080

EDSLEDGFLP VPEYINQSAP QRPPGSAVQN PVYHNQPLNP NSTKDSHYQN SHSNAVDNPE 1140

YLNTGQPTFI QKAFDGSSYW DQKANHQINL DNPDYQQDFL PKEAKPNGVF KFPAAENPEY 1200

LRVAAPKSEF IEASA 1215

Nucleotide Sequence
(FASTA)

ATGGGCCCGC GGCTGCCCGG AGCCCCTGCC CTGCTGCCCC TCGGGCTCCT CCTGCTCGGG 60

GGGCACCTGT GCCCGGCCGC CGCGCTGGAG GAGAAGAGAG TTTGCCAAGG CACGGGAAAT 120

AAATTGACCC AGTTGGGTAC TCTAGATGAC CACTTTCTAA GCCTCCAAAG GATGTACAAT 180

AACTGTGAAG TTGTTCTTGG AAATCTGGAG ATCACCTATG TGCAAAGGAA TTATGACCTG 240

TCCTTCCTGA AGACCATCCA GGAGGTTGCT GGTTACGTAC TGATTGCGCT GAACTCAGTG 300

GAGACAATAC CATTGGTAAA CCTGCAGATC ATTCGAGGAA ACGTGCTCTA CGAAGGTTTT 360

GCCCTGGCGG TCTTATCCAA TTATGGGATG AATAAAACAG GACTGAAGGA GCTGCCCATG 420

AGAAACCTCT TAGAAATCCT TACTGGTGGT GTGCGATTCA GCAACAATCC TGCACTGTGC 480

AACATGGATA CAATCCAGTG GAAAGACATT GTAAACACGG GACAGTTAAA CAACATATCC 540

ATAGACAATC AAAACCAACT GGACAAATGT CCAAAATGTG ATCTTAATTG TCCCAATGGA 600

AGCTGCTGGG GTCCGGGACC ACAGAACTGT CAGACTTTGA CCAAGACCAT CTGTGCCCAG 660

CAGTGTTCGG GCCGGTGCCG GGGAAGGTCA CCCAGCGACT GCTGTCACAA CCAGTGTGCT 720

GCTGGCTGTA CAGGCCCCAG AGAGAGTGAC TGCTTGGTCT GTCGCAAATT TCGGGATGAA 780

GCCACGTGCA AGGACACCTG CCCTACCCTG ATGTTGTACA ACCCCACAAC CTACCAAATG 840

GACGTCAACC CAGAAGGGAA ATACAGCTTT GGAGCCACCT GTGTCAAAAA GTGCCCACAC 900

AACTACGTAG TGACAGATCA TGGTTCCTGT GTCCGCTCTT GCAATGCAGA GACCTACGAA 960

GTGGAAGAAG ACGGTGTCCG AAAATGCAAA AAATGTGAAG GGCCGTGCAG TAAAGTTTGC 1020

ACTGGAATTG GAACTGGTGA ATTTAAGGAT GTTCTTTCTA TAAATGCCAC GAACATCAAA 1080

CGATTCCAAA ATTGTACCAA GATCAACGGG GATCTTCATA TCCTGCCTGT GGCATTTAAA 1140

GGGGATGCTT TCACAAAAAC TCCACAGCTG AACCCGGAGG AACTGAACAT CTTTAAAACC 1200

ATCAAAGAAA TATCAGGGTT TTTACTGATT CAGGATTGGC CCGCAAACAT GACCAGCCTT 1260

GATGTTTTTG AAAATCTGGA AATTATCCGA GGCAGAACTA AGCAGCATGG CCGGTTTTCG 1320

CTTGCTATTG TTAACCTGAA CATAAGTTAT CTGGGATTAC GATCGCTCAA GGAAATAAGT 1380

GATGGAGATG TAATCATTTC AAAAAACAAA AACTTGTGCT ATGCAAACAC GATATGCTGG 1440

AAGAAACTGT TTAGCACACA GAATCAGAAC TATAAAATTG AAAACAACAG GAATGAAAAT 1500

GAATGCAATG CCACCGGTCA AGTTTGTCAC CCCTTGTGTT CCTCTGATGG ATGTTGGGGT 1560

CCAGAGCCAA ACCATTGTTT TTCTTGCCGA TACGTCAGTC GAAGCAAGGA GTGTGTGGAG 1620

AAATGCAACA TATTAGATGG GTTCCCAAGA GAGTTTGTGG AGAAGTCAGA GTGCTTGCAG 1680

TGCCACCCAG AATGTCAACC CCAGCCTAAG AACTCAACCT GTACAGGGCA CGGTCCAGAC 1740

AACTGCATAA AGTGTGCCCA CTTCATAGAT GGTCCTCACT GTGTTAAAAC ATGTCCCGCT 1800

GGAATTATGG GGGAAAATGA TACCTTGGTC TGGAAATACG CTGATGCACA TCATGTGTGT 1860

CAACTGTGTC ATCCAAATTG CACACATGGA TGTAATGGGC CAGGTCTCGA AGGCTGTCCA 1920

ATGAATAGCT CCAAGATCCC CTCCATCGCT GCTGGGATTG TGGGGAGCCT CCTCTGCCTG 1980

GTGATGGTGG GCCTCATCAT CGGACTCTAC ATGAGAAGGC GGCACATTGT TCGTAAACGC 2040

ACGCTGCGCA GGCTACTTCA GGAAAGGGAG CTCGTTGAGC CCCTCACACC CAGTGGAGAA 2100

GCTCCCAATC AGGCCCTTCT GAGGATCCTC AAGGAGACAG AATTTAAGAA GATCAAAGTT 2160

CTTGGCTCTG GGGCATTCGG CACAGTGTAC AAGGGGTTGT GGATTCCCGA AGGAGAGAAG 2220

GTCAAAATTC CAGTTGCTAT TAAGGAATTG AGAGAGGCGA CCTCCCCAAA AGCCAACAAG 2280

GAAATTCTTG ATGAAGCCTA CGTCATGGCC AGTGTGGACA ACCCCCACGT TTGCCGCCTG 2340

CTTGGGATCT GCCTCACGTC TACCGTCCAG CTCATCACTC AGCTCATGCC GTTCGGTTGC 2400

CTCCTGGACT ATATTCGGGA GCACAAGGAC AACATCGGCT CCCAGTACCT TCTCAACTGG 2460

TGTGTGCAGA TCGCGAAGGG AATGAATTAC TTGGAAGAAC GCCGGCTGGT CCACCGAGAC 2520

TTGGCAGCCA GAAATGTCCT GGTGAAGACG CCCCAGCACG TGAAGATCAC AGATTTTGGA 2580

TTAGCCAAGC TGCTTGGGGC TGAGGAGAAG GAATACCATG CAGAAGGAGG CAAAGTTCCT 2640

ATCAAATGGA TGGCTTTGGA ATCTATTTTA CACCGGATCT ACACCCACCA GAGTGATGTT 2700

TGGAGTTATG GAGTCACCGT TTGGGAGCTG ATGACGTTTG GCTCAAAACC CTACGATGGA 2760

ATTCCGGCTA GTGAGATTTC ATCCATCTTG GAGAAAGGGG AGCGTTTGCC TCAGCCACCC 2820

ATCTGCACTA TTGATGTCTA CATGATCATG GTCAAATGTT GGATGATCGA TGCAGATAGT 2880

CGCCCCAAGT TTCGAGAGCT GATACTTGAA TTCTCCAAAA TGGCCCGTGA TCCTCAGCGC 2940

TATCTGGTCA TTCAGGGGGA TGAACGAATG CATCTGCCGA GCCCCACGGA CTCCAAGTTT 3000

TACCGCACTC TGATGGAGGA GGAGGACATG GAAGATATCG TCGACGCCGA TGAGTACCTC 3060

ATTCCTCACC AAGGGTTCTT CAATAGCCCT TCCACATCCA GAACTCCCCT CTTGAGTTCT 3120

CTGAGTGCTA CCAGCAACAA TTCCACCACT GCCTGCATTG ACAGAAACGG GCAGGGTTGT 3180

GCCTTGAAGG AAGACAGCTT CGTCCAGAGG TACAGTTCAG ATCCCACCAC TGTCTTCTTT 3240

GAAGATAGCC TAGAAGATGG CTTTCTGCCC GTTCCAGAAT ACATCAACCA GTCAGCCCCA 3300

CAGAGGCCTC CAGGTTCTGC GGTTCAGAAC CCTGTCTACC ACAACCAGCC TTTAAATCCC 3360

AATTCTACTA AAGACTCTCA CTACCAGAAC TCGCACAGTA ATGCAGTGGA CAACCCAGAA 3420

TATCTCAACA CGGGACAACC CACCTTCATC CAAAAGGCAT TCGACGGCTC TTCCTACTGG 3480

GACCAAAAAG CCAACCATCA GATTAACCTG GACAATCCTG ACTACCAGCA GGACTTCCTA 3540

CCCAAGGAAG CCAAGCCTAA CGGGGTCTTT AAATTTCCTG CAGCCGAAAA TCCCGAGTAC 3600

CTTCGGGTGG CAGCGCCCAA AAGTGAATTC ATCGAAGCGT CGGCATGA 3648

Domain Profile

S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60

         +kk+kvlGsGafGtvykG+wipege+vkipvaik+l+e+t++kanke+ldea+v+as+d+

Q: 715   FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDN  774

         59**********************************************************

S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120

         ++++rllg+cl+st+ql+tql+p+Gclldy+rehkd++Gsq+llnwcvqiakGm+ylee+

Q: 775   PHVCRLLGICLTSTVQLITQLMPFGCLLDYIREHKDNIGSQYLLNWCVQIAKGMNYLEER  834

         ************************************************************

S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180

         rlvhrdlaarnvlvk+p+hvkitdfGlakll a+eke++aeggkvpikw+alesil+r+y

Q: 835   RLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIY  894

         ************************************************************

S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240

         thqsdvwsyGvtvwel+tfG+kpydgipa+ei+++lekGerl+qppictidvym++vkcw

Q: 895   THQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCW  954

         ************************************************************

S: 241   midaesrpkfkelaeefs  258

         mida+srpkf+el+ efs

Q: 955   MIDADSRPKFRELILEFS  972

         ***************996

Domain Sequence
(FASTA)

FKKIKVLGSG AFGTVYKGLW IPEGEKVKIP VAIKELREAT SPKANKEILD EAYVMASVDN 60

PHVCRLLGIC LTSTVQLITQ LMPFGCLLDY IREHKDNIGS QYLLNWCVQI AKGMNYLEER 120

RLVHRDLAAR NVLVKTPQHV KITDFGLAKL LGAEEKEYHA EGGKVPIKWM ALESILHRIY 180

THQSDVWSYG VTVWELMTFG SKPYDGIPAS EISSILEKGE RLPQPPICTI DVYMIMVKCW 240

MIDADSRPKF RELILEFS 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004716	; F:receptor signaling protein tyrosine kinase activity
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0023014	; P:signal transduction by phosphorylation
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR021157	; Cyt_c1_TM_anchor_C.
IPR000494	; EGF_rcpt_L.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016245	; Tyr_kinase_EGF/ERB/XmrK_rcpt.

Pfam

PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00261	; FU; 4.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013